HBV VIS Detail Information

> This page shows VIS [1020274] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 1020274
Chromosome chrX
GRCh38 Location 111765779, 111765796
Disease   
Sample cell line
Target Gene PAK3  
Literature Information
PubMed PMID 31897927
Year 2020 Apr;56(2):168-173
Journal Virus genes
Title Integration of hepatitis B virus DNA into p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells.
Author Ruan P,Dai X,Sun J,He C,Huang C,Zhou R,Chemin I
Evidence Integration of HBV DNA into host chromosomes was found in most of the patients with chronic hepatitis B (CHB). In this study, using inverse nested PCR (invPCR), we found the integration site chrX: 111,009,033, which inserted into the p21-activated kinase 3 (PAK3) gene in HepG2.2.15 cells. The viral-human chimeric transcripts were also observed and, significant differences of the copy numbers of integration site chrX: 111,009,033 (P = 0.012) and intra-cell HBV DNA levels (P = 0.027) were found between the cells with and without H(2)O(2) treatment, respectively. This study may provide a novel insight into the elucidation of etiology of HBV integration.
Contents
Description
  • Site Information
Detail information of site [1020274]
  • Literature Information
The details of literature that this site is associated with.