All Curated Mutation Sites in HBV 
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 The Virus Mutation(VM) module provides researchers the annotations of reported pathogenic mutations in HBV related to human diseases. The curated VM information includes mutation site, mutation level, virus gene/protein/region, virus-associated disease, genotype/subtype, literature evidence, etc.


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S
  
BCP
  
X
  
C
  
Core Promoter
  
Core Upstream Regulatory Sequence
  
DR1
  
EnhI
  
EnhII
  
PreC
  
P
  
PreC Promoter
  
PreS
  
PreS1
  
PreS1 Promoter
  
PreS2
  
RT
  
S Promoter
  
S1 Promoter
  
S2 Promoter
  
X Promoter
  

Keyword: Hepatitis B, Chronic-36325017
ID PMID Mutation Gene/Protein/Region Encoding Gene/Protein Disease Description Detail
1 36325017 A102V
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
2 36325017 A1479G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
3 36325017 A1617T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
4 36325017 A1630G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
5 36325017 A1635T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
6 36325017 A1752G
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
7 36325017 A1762T
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
8 36325017 A1934T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
9 36325017 A2020T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
10 36325017 A2092C
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
11 36325017 A2177G
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
12 36325017 A2246G
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
13 36325017 A28N
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
14 36325017 A28T
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
15 36325017 A39V
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
16 36325017 A47T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
17 36325017 A69G
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
18 36325017 A80S
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
19 36325017 A80T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
20 36325017 C1473A
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
21 36325017 C1480A
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
22 36325017 C1480G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
23 36325017 C1491T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
24 36325017 C1509T
X
X
Hepatitis B, Chronic
G
R
S
I
C
L
View
25 36325017 C1665A
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
26 36325017 C1678T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
27 36325017 C1687T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
28 36325017 C1766G
BCP;PreC;C
C
Hepatitis B, Chronic
G
R
S
C
L
View
29 36325017 C1766T
BCP;PreC;C
C
Hepatitis B, Chronic
G
R
S
C
L
View
30 36325017 C1773T
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
31 36325017 C1788G
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
32 36325017 C1799G
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
33 36325017 C2100A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
34 36325017 C2106G
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
35 36325017 C2136A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
36 36325017 C2289A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
37 36325017 C2366T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
38 36325017 C256S
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
39 36325017 C26R
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
40 36325017 C26S
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
41 36325017 C76Y
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
42 36325017 D119N
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
43 36325017 D134E
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
44 36325017 D263E
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
45 36325017 D29H
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
46 36325017 E11D
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
47 36325017 E271D
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
48 36325017 E40D
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
49 36325017 E40Q
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
50 36325017 E64D
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
51 36325017 F132Y
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
52 36325017 F221Y
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
53 36325017 F22L
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
54 36325017 F46S
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
55 36325017 G130R
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
56 36325017 G1512A
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
57 36325017 G153C
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
58 36325017 G1658C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
59 36325017 G1728A
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
60 36325017 G1757A
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
61 36325017 G1764A
BCP;PreC;C
C
Hepatitis B, Chronic
G
R
S
C
L
View
62 36325017 G1764T
BCP;PreC;C
C
Hepatitis B, Chronic
G
R
S
C
L
View
63 36325017 G1896A
PreC
C
Hepatitis B, Chronic
G
R
S
I
C
L
View
64 36325017 G1899A
PreC
C
Hepatitis B, Chronic
G
R
S
C
L
View
65 36325017 G1985C
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
66 36325017 G2018C
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
67 36325017 G2138A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
68 36325017 G2138T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
69 36325017 G2153A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
70 36325017 G2352A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
71 36325017 G2357T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
72 36325017 G29D
PreC
C
Hepatitis B, Chronic
G
R
S
C
L
View
73 36325017 H139D
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
74 36325017 H54Y
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
75 36325017 H60D
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
76 36325017 H86R
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
77 36325017 I116V
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
78 36325017 I127D
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
79 36325017 I127G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
80 36325017 I127T
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
81 36325017 I195M
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
82 36325017 I266R
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
83 36325017 I42T
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
84 36325017 I74L
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
85 36325017 I88C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
86 36325017 I88F
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
87 36325017 K130M
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
88 36325017 K270R
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
89 36325017 K95N
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
90 36325017 L123W
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
91 36325017 L145M
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
92 36325017 L180M
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
93 36325017 L213I
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
94 36325017 L216to
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
95 36325017 L216X
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
96 36325017 L260F
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
97 36325017 L34I
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
98 36325017 L42P
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
99 36325017 L42R
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
100 36325017 L49R
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
101 36325017 L91I
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
102 36325017 L98I
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
103 36325017 M204
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
104 36325017 M204V
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
105 36325017 M309K
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
106 36325017 M93V
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
107 36325017 N103D
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
108 36325017 N337T
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
109 36325017 N33D
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
110 36325017 N3T
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
111 36325017 N76D
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
112 36325017 P120T
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
113 36325017 P130Q
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
114 36325017 P156S
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
115 36325017 P211R
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
116 36325017 P237T
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
117 36325017 P40S
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
118 36325017 P41H
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
119 36325017 P46S
X
X
Hepatitis B, Chronic
G
R
S
I
C
L
View
120 36325017 P52L
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
121 36325017 P78T
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
122 36325017 P79Q
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
123 36325017 Q101H
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
124 36325017 Q149K
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
125 36325017 Q215S
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
126 36325017 Q267H
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
127 36325017 Q267R
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
128 36325017 Q267Y
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
129 36325017 R110G
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
130 36325017 R151Q
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
131 36325017 R153W
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
132 36325017 R166P
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
133 36325017 R16K
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
134 36325017 R18K
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
135 36325017 S155T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
136 36325017 S193L
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
137 36325017 S202G
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
138 36325017 S207R
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
139 36325017 S21T
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
140 36325017 S38P
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
141 36325017 S39P
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
142 36325017 S41P
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
143 36325017 S43P
X
X
Hepatitis B, Chronic
G
R
S
I
C
L
View
144 36325017 S85C
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
145 36325017 S90L
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
146 36325017 T105M
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
147 36325017 T11N
PreS2
S
Hepatitis B, Chronic
G
R
S
C
L
View
148 36325017 T126S
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
149 36325017 T128N
RT
P
Hepatitis B, Chronic
D
G
R
S
C
L
View
150 36325017 T12S
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
151 36325017 T1449A
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
152 36325017 T1449C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
153 36325017 T1485C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
154 36325017 T1488C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
155 36325017 T1494C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
156 36325017 T1498C
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
157 36325017 T1500C
X
X
Hepatitis B, Chronic
G
R
S
I
C
L
View
158 36325017 T1636G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
159 36325017 T1741G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
160 36325017 T1753A
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
161 36325017 T1753C
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
162 36325017 T1753G
BCP
Hepatitis B, Chronic
G
R
S
C
L
View
163 36325017 T1768A
BCP;PreC;C
C
Hepatitis B, Chronic
G
R
S
C
L
View
164 36325017 T1961A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
165 36325017 T2121G
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
166 36325017 T2363A
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
167 36325017 T36D
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
168 36325017 T36G
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
169 36325017 T40P
PreS1
S
Hepatitis B, Chronic
G
R
S
C
L
View
170 36325017 T57I
S
S
Hepatitis B, Chronic
G
R
S
C
L
View
171 36325017 T67N
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
172 36325017 T82S
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
173 36325017 V131I
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
174 36325017 V131L
X
X
Hepatitis B, Chronic
G
R
S
C
L
View
175 36325017 V74G
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
176 36325017 V85I
C
C
Hepatitis B, Chronic
G
R
S
C
L
View
177 36325017 W257Y
RT
P
Hepatitis B, Chronic
G
R
S
C
L
View
178 36325017 W28X
PreC
C
Hepatitis B, Chronic
G
R
S
I
C
L
View
179 36325017 Y134F
S
S
Hepatitis B, Chronic
G
R
S
I
C
L
View
Contents
Description

The table shows all curated mutation sites of HBV in each literature

Table Description Column Note
D
The study mentioned a certain treatment method, such as drug resistance caused by mutations.
G
The study mentioned the virus genotype/subtype information.
R
The study mentioned the reference sequence used for comparison, or the original strain of the virus used for site-directed mutagenesis.
S
The study provided sequence information or accession numbers.
L
The study provided the geographic region/country of data origin.
C
The study provided clinical baseline information.
I
The study involved information related to immune.
T
The study involved host target genes.