HIV Mutation Detail Information

Virus Mutation HIV Mutation I85V


Basic Characteristics of Mutations
Mutation Site I85V
Mutation Site Sentence Only in one TC, including 4 individuals (5.9%) infected with B subtype, a virus strain carrying a protease inhibitor resistant mutation (I85V) was found (Figure 1).
Mutation Level Amino acid level
Mutation Type nonsynonymous substitution
Gene/Protein/Region PR
Standardized Encoding Gene gag-pol  
Genotype/Subtype HIV-1 B
Viral Reference B reference
Functional Impact and Mechanisms
Disease HIV Infections    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information Y
Treatment PIs
Location Lazio Region
Literature Information
PMID 33503987
Title Molecular Transmission Dynamics of Primary HIV Infections in Lazio Region, Years 2013-2020
Author Fabeni L,Rozera G,Berno G,Giombini E,Gori C,Orchi N,De Carli G,Pittalis S,Puro V,Pinnetti C,Mondi A,Camici M,Plazzi MM,Antinori A,Capobianchi MR,Abbate I
Journal Viruses
Journal Info 2021 Jan 25;13(2):176
Abstract Molecular investigation of primary HIV infections (PHI) is crucial to describe current dynamics of HIV transmission. Aim of the study was to investigate HIV transmission clusters (TC) in PHI referred during the years 2013-2020 to the National Institute for Infectious Diseases in Rome (INMI), that is the Lazio regional AIDS reference centre, and factors possibly associated with inclusion in TC. These were identified by phylogenetic analysis, based on population sequencing of pol; a more in depth analysis was performed on TC of B subtype, using ultra-deep sequencing (UDS) of env. Of 270 patients diagnosed with PHI during the study period, 229 were enrolled (median follow-up 168 (IQR 96-232) weeks). Median age: 39 (IQR 32-48) years; 94.8% males, 86.5% Italians, 83.4% MSM, 56.8% carrying HIV-1 subtype B. Of them, 92.6% started early treatment within a median of 4 (IQR 2-7) days after diagnosis; median time to sustained suppression was 20 (IQR 8-32) weeks. Twenty TC (median size 3, range 2-9 individuals), including 68 patients, were identified. A diagnosis prior to 2015 was the unique factor associated with inclusion in a TC. Added value of UDS was the identification of shared quasispecies components in transmission pairs within TC.
Sequence Data B.FR.83.HXB2_LAI_IIIB_BRU.K03455;B.NL.86.3202A21_ACH3202A21.U34604;B.GA.88.OYI_397.M26727;B.EC.89.EC003.AY173959;B.KR.92.HP_10_02SHJ8_6986.KJ140255;B.TW.94.TWCYS_LM49.AF086817;B.GE.98.98GEMZ003.DQ207943;B.CU.99.Cu19.AY586542;B.AR.00.ARMS008.AY037269;B.CN.01.CNHN24.AY180905;B.BR.02.02BR002.DQ358805;B.AU.03.PS2008_Day182.DQ676875;B.CY.05.CY018.FJ388890;B.CA.06.502_1027_wg01.JF320413;B.PE.07.502_2649_wg8.JF320019;B.PL.08.BP00074_LH01.JN687691;B.RU.11.11RU21n.JX500708
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.