RABV Mutation Detail Information

Virus Mutation RABV Mutation P25A


Basic Characteristics of Mutations
Mutation Site P25A
Mutation Site Sentence However, a comparison of the M of the isolates revealed that JX90-17(fb) contained N2K, N10S, and P25A substitutions (GenBank #GU233763), which have not been found in other Chinese isolates.
Mutation Level Amino acid level
Mutation Type Nonsynonymous substitution
Gene/Protein/Region M
Standardized Encoding Gene M
Genotype/Subtype Genotype 1
Viral Reference -
Functional Impact and Mechanisms
Disease Rabies Virus infection    
Immune -
Target Gene -
Clinical and Epidemiological Correlations
Clinical Information -
Treatment -
Location China
Literature Information
PMID 20109507
Title Characterization of a rabies virus isolate from a ferret badger (Melogale moschata) with unique molecular differences in glycoprotein antigenic site III
Author Zhang S,Zhao J,Liu Y,Fooks AR,Zhang F,Hu R
Journal Virus research
Journal Info 2010 May;149(2):143-51
Abstract Rabies virus was isolated from the brain of a Chinese ferret badger (Melogale moschata) and identified as having an R333Q substitution within its glycoprotein antigenic site III. Additionally, compared with vaccine strains and other rabies virus isolates from dogs and ferret badgers in China, the isolate had five other amino acid substitutions in its glycoprotein: P(-17)L in the signal peptide, R88H, L225M, and D422E in the ectoplasmic region, and G478E in the cytoplasmic region. This isolate possessed high virulence in suckling, weanling and adult mice. These data indicate that this is a unique rabies virus with a molecular signature that differentiates it from other strains circulating in terrestrial mammals in China. We propose that rabies virus circulates in some ferret badgers in an independent epidemiological cycle unique to China following spillover from domestic dogs or other hosts infected with rabies.
Sequence Data GU233763;GU233764
Mutation Information
Note
Basic Characteristics of Mutations
  • Mutation Site: The specific location in a gene or protein sequence where a change occurs.
  • Mutation Level: The level at which a mutation occurs, including the nucleotide or amino acid level.
  • Mutation Type: The nature of the mutation, such as missense mutation, nonsense mutation, synonymous mutation, etc.
  • Gene/Protein/Region: Refers to the specific region of the virus where the mutation occurs. Including viral genes, viral proteins, or a specific viral genome region. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main
  • Gene/Protein/Region studied in the article is marked.
  • Genotype/Subtype: Refers to the viral genotype or subtype where the mutation occurs. If the article does not specifically indicate the relationship between the mutation and its correspondence, the main Genotype/Subtype studied in the article is marked.
  • Viral Reference: Refers to the standard virus strain used to compare and analyze viral sequences.
Functional Impact and Mechanisms
  • Disease: An abnormal physiological state with specific symptoms and signs caused by viral infection.
  • Immune: The article focuses on the study of mutations and immune.
  • Target Gene: Host genes that viral mutations may affect.
Clinical and Epidemiological Correlations
  • Clinical Information: The study is a clinical or epidemiological study and provides basic information about the population.
  • Treatment: The study mentioned a certain treatment method, such as drug resistance caused by mutations. If the study does not specifically indicate the relationship between mutations and their correspondence treatment, the main treatment studied in the article is marked.
  • Location: The source of the research data.
Literature Information
  • Sequence Data: The study provides the data accession number.