HPV Target gene Detail Information

> EP300 Gene Search Result


Gene Information
Gene Name EP300
Gene ID 2033
Gene Full Name E1A binding protein p300
Gene Alias KAT3B|MKHK2|RSTS2|p300
Transcripts ENSG00000100393
Virus HPV
Gene Type protein-coding
HPA Location Info Nucleoplasm;
Membrane Info Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q09472
HGNC ID HGNC:3373
OMIM ID 602700
Summary This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Target gene [EP300] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5010115 chr22 11 30 0 41 View
5013383 chr22 58 22 6 86 View
5017455 chr22 173 11 0 184 View
5017456 chr22 16 1 1 18 View
5017457 chr22 18 10 3 31 View
5017458 chr22 12 9 3 24 View
5017459 chr22 10 6 0 16 View
5017460 chr22 20 8 1 29 View
5017461 chr22 35 6 0 41 View
5017462 chr22 0 2 0 2 View
5017463 chr22 6 4 2 12 View
5017464 chr22 5 4 7 16 View
5017465 chr22 54 1 0 55 View
5017466 chr22 0 1 0 1 View
5017467 chr22 2 7 5 14 View
5017468 chr22 14 10 3 27 View
5017469 chr22 18 0 0 18 View
5017470 chr22 14 2 0 16 View
5017471 chr22 217 80 41 338 View
5017472 chr22 188 42 8 238 View
5017473 chr22 188 42 8 238 View

Target gene [EP300] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE183048 		Chip-seq 24 Illumina HiSeq 4000 (Homo sapiens)
GSE226620 scRNA-seq 30 HiSeq X Ten (Homo sapiens)
GSE40774 Expression array 134 Agilent-026652 Whole Human Genome Microarray 4x44K v2 (Probe Name version)
GSE139324 scRNA-seq 63 Illumina NextSeq 500 (Homo sapiens)
GSE169622 Methylation profiling (Array) 9 Infinium MethylationEPIC
GSE65858 Expression array 270 Illumina HumanHT-12 V4.0 expression beadchip
GSE181805 Expression array 25 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE196215 RNA-seq 8 Illumina NovaSeq 6000 (Homo sapiens)
GSE164690 scRNA-seq 51 Illumina NextSeq 500 (Homo sapiens)
GSE138080 Expression array 35 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
GSE140662 Expression array 8 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version]
GSE55542 Expression array 36 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
C
  GSE143026 		ATAC-seq;Chip-seq;RNA-seq 30 Illumina HiSeq 2500 (Homo sapiens)
TCGA_CESC DNA methylation sequencing;RNA-seq 288 TCGA
GSE51993 Expression array 48 Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip
GSE197461 scRNA-seq 16 Illumina NovaSeq 6000 (Homo sapiens)
GSE55550 Expression array 155 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
GSE165883 RNA-seq 20 Illumina NextSeq 500 (Homo sapiens)


When the gene can detect a peak in the dataset, a peak plot will be displayed.


> Dataset: GSE183048 - EP300 peak across samples

Peak Plot

> Dataset: GSE143026 - EP300 peak across samples

Peak Plot