Gene Information
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Gene Name
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HAS2 |
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Gene ID
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3037
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Gene Full Name
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hyaluronan synthase 2 |
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Gene Alias
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- |
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Transcripts
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ENSG00000170961
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Virus
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HPV |
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Gene Type
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protein-coding |
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HPA Location Info
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Membrane Info
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Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters |
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Uniport_ID
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Q92819
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HGNC ID
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HGNC:4819
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OMIM ID
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601636 |
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Summary
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Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008] |
Target gene [HAS2] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 5009937 |
chr8 |
54 |
385 |
351 |
790 |
View |
Target gene [HAS2] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
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GSE226620
|
scRNA-seq |
30 |
HiSeq X Ten (Homo sapiens) |
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GSE169622
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Methylation profiling (Array) |
9 |
Infinium MethylationEPIC |
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GSE65858
|
Expression array |
270 |
Illumina HumanHT-12 V4.0 expression beadchip |
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GSE181805
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Expression array |
25 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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GSE196215
|
RNA-seq |
8 |
Illumina NovaSeq 6000 (Homo sapiens) |
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S GSE164690
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scRNA-seq |
51 |
Illumina NextSeq 500 (Homo sapiens) |
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GSE140662
|
Expression array |
8 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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GSE55542
|
Expression array |
36 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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C GSE143026
|
ATAC-seq;Chip-seq;RNA-seq |
30 |
Illumina HiSeq 2500 (Homo sapiens) |
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TCGA_CESC
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DNA methylation sequencing;RNA-seq |
288 |
TCGA |
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GSE51993
|
Expression array |
48 |
Illumina Human v2 MicroRNA expression beadchip;Illumina HumanHT-12 V4.0 expression beadchip |
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GSE55550
|
Expression array |
155 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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GSE165883
|
RNA-seq |
20 |
Illumina NextSeq 500 (Homo sapiens) |
When the query gene is differentially changed in the dataset, a feature/violin plot will be displayed.
> Dataset: GSE164690 - Gene expression in cell subsets
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HPV Target gene Detail Information
