Gene Name	HNF1A
Gene ID	6927
Gene Full Name	HNF1 homeobox A
Gene Alias	HNF-1-alpha|HNF-1A|HNF1|HNF1alpha|HNF4A|IDDM20|LFB1|MODY3|TCF-1|TCF1
Transcripts	ENSG00000135100
Virus	HBV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Cancer-related genes, Human disease related genes, Predicted intracellular proteins
HGNC ID	HGNC:11621
OMIM ID	142410
Summary	The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	37772469	A1762T	BCP		Carcinoma, Hepatocellular	G R I L T	View
2	37772469	G1764A	BCP		Carcinoma, Hepatocellular	G R I L T	View
3	36167927	A1762T	Core Promoter		Hepatitis B Virus Infection	L T	View
4	36167927	G1764A	Core Promoter		Hepatitis B Virus Infection	L T	View
5	36919573	C2729T	PreS1 Promoter		Hepatitis B Virus Infection	G C L T	View

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1004533	chr12	39	27	12	78	View
1008820	chr3	3	1	15	19	View
1041079	chr12	217	189	124	530	View

Data ID	Experiment type	Sample number	Platform
GSE236281	RNA-seq	12	Illumina MiSeq (Homo sapiens)
C   GSE35465	Chip-seq;RNA-seq	6	Illumina HiSeq 2000 (Homo sapiens)
C   GSE68402	Chip-seq	26	Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
TCGA_LIHC_HBV	DNA methylation sequencing;RNA-seq	97	TCGA
C   GSE270130	Chip-seq	27	Illumina NovaSeq 6000 (Homo sapiens)
GSE224901	RNA-seq	21	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE100400	Chip-seq;RNA-seq;4C_cccDNA	31	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897	RNA-seq	95	Illumina HiSeq 4000 (Homo sapiens)
GSE262515	RNA-seq	21	Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345	RNA-seq	4	Illumina HiSeq 2500 (Homo sapiens)
C   GSE131257	ATAC-seq;RNA-seq	19	Illumina HiSeq 2500 (Homo sapiens)
E   GSE94660	RNA-seq	42	Illumina HiSeq 2500 (Homo sapiens)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE100400 - HNF1A expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE94660 - HNF1A expression across samples

Volcano Plot

Bar Plot