HBV Target gene Detail Information

> HP Gene Search Result


Gene Information
Gene Name HP
Gene ID 3240
Gene Full Name haptoglobin
Gene Alias BP|HP2ALPHA2|HPA1S
Transcripts ENSG00000257017
Virus HBV
Gene Type protein-coding
HPA Location Info Vesicles;Secreted to blood;
Membrane Info Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins
Uniport_ID P00738
HGNC ID HGNC:5141
OMIM ID 140100
Summary This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Target gene [HP] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007049 chr16 23 8 0 31 View
1007053 chr16 20 11 0 31 View
1007353 chr16 16 12 0 28 View
1007355 chr16 16 12 0 28 View
1007857 chr16 12 8 4 24 View
1007859 chr16 12 8 4 24 View
1008009 chr16 17 4 2 23 View
1009232 chr16 10 7 0 17 View
1014279 chr16 4 0 0 4 View
1039481 chr16 26 7 2 35 View
1039482 chr16 36 19 1 56 View
1039483 chr16 27 10 0 37 View
1039484 chr16 22 21 1 44 View
1039485 chr16 22 19 0 41 View
1039486 chr16 23 19 0 42 View
1039487 chr16 23 19 0 42 View
1039488 chr16 23 19 0 42 View
1039489 chr16 23 19 0 42 View
1039490 chr16 23 19 0 42 View
1039491 chr16 2 0 0 2 View

Target gene [HP] related to Omics data
Data ID Experiment type Sample number Platform
S
  GSE252863 		scRNA-seq 10 Illumina HiSeq 2500 (Homo sapiens)
GSE236281 RNA-seq 12 Illumina MiSeq (Homo sapiens)
C
  GSE68402 		Chip-seq 26 Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
S
  GSE247322 		scRNA-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
TCGA_LIHC_HBV DNA methylation sequencing;RNA-seq 97 TCGA
C
  GSE270130 		Chip-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
GSE224901 RNA-seq 21 Illumina NovaSeq 6000 (Homo sapiens)
E
 
C
  GSE100400 		Chip-seq;RNA-seq;4C_cccDNA 31 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897 RNA-seq 95 Illumina HiSeq 4000 (Homo sapiens)
GSE262515 RNA-seq 21 Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus)
GSE110345 RNA-seq 4 Illumina HiSeq 2500 (Homo sapiens)
C
  GSE131257 		ATAC-seq;RNA-seq 19 Illumina HiSeq 2500 (Homo sapiens)
E
  GSE94660 		RNA-seq 42 Illumina HiSeq 2500 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE100400 - HP expression across samples

Volcano Plot

Bar Plot

> Dataset: GSE94660 - HP expression across samples

Volcano Plot

Bar Plot