Gene Name	LINC00673
Gene ID	100499467
Gene Full Name	long intergenic non-protein coding RNA 673
Gene Alias	ERRLR01|HI-LNC75|HILNC75|LUCAIR1|RASON|SLNCR|SLNCR1
Transcripts	ENSG00000227036
Virus	HIV
Gene Type	ncRNA
HGNC ID	HGNC:44354
OMIM ID	617079
Summary	This gene produces a long non-protein coding RNA that is involved in the regulation of gene expression during tumor progression. This transcript can promote cell proliferation in gastric cancer through interaction with enhancer of zeste 2 and other epigenetic suppressors of gene expression, thereby downregulating target genes including Kruppel like factors 2 and 4. This transcript may also act as a tumor suppressor by promoting interaction between protein tyrosine phosphatase, non-receptor type 11 (Ptpn11) and ubiquitin ligase, resulting in degradation of Ptpn11 and lowered oncogenic signalling. Naturally-occurring variation at this locus results in the formation of a binding site for miR-1231, which negatively regulates activity of this transcript. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004771	chr17	6	25	8	39	View

Data ID	Experiment type	Sample number	Platform
C   GSE220859	Chip-seq	11	Illumina NovaSeq 6000 (Homo sapiens)
GSE128121	RNA-seq	16	Illumina HiSeq 4000 (Homo sapiens)
C   GSE211651	Chip-seq;RNA-seq;PRO-seq	39	Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE162914	RNA-seq	211	Illumina HiSeq 2500 (Homo sapiens)
C   GSE221688	Chip-seq;scATAC-Seq;scRNA-Seq	12	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE165703	ATAC-seq	82	Illumina HiSeq 4000 (Homo sapiens)
GSE68028	MeDIP-chip	1	NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
GSE165132	RNA-seq	56	NextSeq 550 (Homo sapiens)
GSE279982	Methylation profiling (Array)	576	Infinium MethylationEPIC
C   GSE100376	ATAC-seq	24	Illumina NextSeq 500 (Homo sapiens)
GSE205204	RNA-seq	14	Illumina NovaSeq 6000 (Homo sapiens)
GSE167211	RNA-seq	1	Illumina HiSeq 2000 (Homo sapiens)
GSE246082	RNA-seq	6	Illumina HiSeq 4000 (Homo sapiens)
C   GSE165705	Chip-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE100266	ATAC-seq;Chip-seq;RNA-seq	32	Illumina HiSeq 2500 (Homo sapiens)
C   GSE144329	ATAC-seq	96	NextSeq 550 (Homo sapiens)
GSE125686	RNA-seq	62	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens)
GSE164264	RNA-seq	6	BGISEQ-500 (Homo sapiens)

• Genome binding/occupancy profiling

When the gene can detect a peak in the dataset, a peak plot will be displayed.

> Dataset: GSE220859 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE211651 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE221688 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE165703 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE100376 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE165705 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE100266 - LINC00673 peak across samples

Peak Plot

> Dataset: GSE144329 - LINC00673 peak across samples

Peak Plot