Gene Name	PML
Gene ID	5371
Gene Full Name	PML nuclear body scaffold
Gene Alias	MYL|PP8675|RNF71|TRIM19
Transcripts	ENSG00000140464
Virus	HCMV
Gene Type	protein-coding
HPA Location Info	Nuclear bodies;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P29590
HGNC ID	HGNC:9113
OMIM ID	102578
Summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	11602710	K450R	IE1	UL123	Cell line	T	View
2	11602710	L174P	IE1	UL123	Cell line	T	View
3	11861864	K450R	IE72	UL123	Cell line	T	View
4	30258013	L174P	IE1	UL123	Cell line	T	View

Data ID	Experiment type	Sample number	Platform
GSE152114	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE280380	RNA-seq	54	Illumina NovaSeq 6000 (Homo sapiens)
E   GSE163707	RNA-seq	96	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (blank sample)
GSE168598	RNA-seq	154	Illumina HiSeq 3000 (Homo sapiens)
GSE248772	RNA-seq	84	Illumina NovaSeq 6000 (Homo sapiens)
C   GSE164861	Chip-seq;RNA-seq;ATAC-seq	79	Illumina NextSeq 500 (Homo sapiens);Illumina HiSeq 4000 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5);Illumina HiSeq 4000 (Human betaherpesvirus 5);Illumina NovaSeq 6000 (Human betaherpesvirus 5);Illumina HiSeq 4000 (Homo sapiens; Human betaherpesvirus 5)
GSE182788	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
C   GSE53271	Chip-seq	2	Illumina HiSeq 2000 (Homo sapiens)
C   GSE185618	Chip-seq	25	Illumina HiSeq 4000 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens)
GSE193759	RNA-seq	12	Illumina HiSeq 2000 (Homo sapiens);Illumina HiSeq 2000 (Homo sapiens; Human betaherpesvirus 5)
GSE94724	RNA-seq	4	Illumina HiSeq 2000 (Homo sapiens)
GSE254735	RNA-seq	4	Illumina NovaSeq 6000 (Homo sapiens)
GSE136217	RNA-seq	7	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
GSE73853	RNA-seq	13	Illumina HiSeq 2000 (Homo sapiens)
GSE217832	RNA-seq	8	Illumina NextSeq 500 (Homo sapiens)
GSE164843	RNA-seq	10	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE254741	ATAC-seq;ChIP-seq;HiChIP;RNA-seq	30	Illumina NovaSeq 6000 (Homo sapiens)
GSE164839	RNA-seq	4	Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Homo sapiens; Human betaherpesvirus 5)
C   GSE171518	Chip-seq	16	Illumina NovaSeq 6000 (Homo sapiens; Human betaherpesvirus 5)

• Expression profiling
• Genome binding/occupancy profiling

When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.

> Dataset: GSE163707 - PML expression across samples

Volcano Plot

Bar Plot