Gene Information
|
Gene Name
|
PRKN |
|
Gene ID
|
5071
|
|
Gene Full Name
|
parkin RBR E3 ubiquitin protein ligase |
|
Gene Alias
|
AR-JP|LPRS2|PARK2|PDJ |
|
Transcripts
|
ENSG00000185345
|
|
Virus
|
EBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nuclear speckles;Cytosol; 
|
|
Membrane Info
|
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
|
Uniport_ID
|
O60260
|
|
HGNC ID
|
HGNC:8607
|
|
OMIM ID
|
602544 |
|
Summary
|
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008] |
Target gene [PRKN] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 3000066 |
chr6 |
111 |
45 |
159 |
315 |
View |
| 3000851 |
chr6 |
3 |
0 |
0 |
3 |
View |
| 3001500 |
chr6 |
172 |
54 |
167 |
393 |
View |
| 3001501 |
chr6 |
4 |
0 |
1 |
5 |
View |
Target gene [PRKN] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE42867
|
Expression array |
12 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
C GSE246060
|
Chip-seq |
26 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE198334
|
Chip-seq |
4 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE100458
|
Expression array |
14 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v21] |
|
GSE165194
|
RNA-seq |
3 |
Illumina NextSeq 500 (Homo sapiens) |
|
C GSE246059
|
ATAC-seq |
8 |
Illumina NextSeq 500 (Homo sapiens);Illumina NovaSeq 6000 (Homo sapiens) |
|
GSE177046
|
RNA-seq |
6 |
Illumina HiSeq 2000 (Homo sapiens) |
|
C GSE225248
|
Chip-seq |
12 |
Illumina NextSeq 500 (Homo sapiens) |
|
GSE102203
|
Expression array |
10 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [probe set (exon) version] |
|
GSE85599
|
Expression array |
17 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
|
GSE181906
|
RNA-seq |
24 |
Illumina NovaSeq 6000 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE246060 - PRKN peak across samples
|
Peak Plot
|
> Dataset: GSE198334 - PRKN peak across samples
|
Peak Plot
|
> Dataset: GSE246059 - PRKN peak across samples
|
Peak Plot
|
> Dataset: GSE225248 - PRKN peak across samples
|
Peak Plot
|
|
|
EBV Target gene Detail Information
