HBV Target gene Detail Information

> PRKN Gene Search Result


Gene Information
Gene Name PRKN
Gene ID 5071
Gene Full Name parkin RBR E3 ubiquitin protein ligase
Gene Alias AR-JP|LPRS2|PARK2|PDJ
Transcripts ENSG00000185345
Virus HBV
Gene Type protein-coding
HPA Location Info Nuclear speckles;Cytosol;
Membrane Info Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Uniport_ID O60260
HGNC ID HGNC:8607
OMIM ID 602544
Summary The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Target gene [PRKN] related to VISs

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section


DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1006499 chr6 34 3 0 37 View
1007323 chr6 20 6 2 28 View
1008819 chr6 15 3 1 19 View
1009021 chr6 12 6 0 18 View
1009262 chr6 14 2 0 16 View
1012730 chr6 6 0 0 6 View
1012857 chr6 1 4 1 6 View
1012860 chr6 1 4 1 6 View
1013313 chr6 1 4 0 5 View
1013321 chr6 1 4 0 5 View
1013353 chr6 1 4 0 5 View
1013403 chr6 1 4 0 5 View
1013470 chr6 1 4 0 5 View
1013472 chr6 1 4 0 5 View
1013909 chr6 2 2 0 4 View
1013932 chr6 2 2 0 4 View
1014013 chr6 2 2 0 4 View
1014033 chr6 2 2 0 4 View
1014103 chr6 2 2 0 4 View
1014110 chr6 2 2 0 4 View
1014120 chr6 2 2 0 4 View
1014132 chr6 2 2 0 4 View
1014133 chr6 2 2 0 4 View
1014138 chr6 2 2 0 4 View
1043202 chr6 50 24 47 121 View
1043203 chr6 0 2 0 2 View

Target gene [PRKN] related to Omics data
Data ID Experiment type Sample number Platform
C
  GSE35465 		Chip-seq;RNA-seq 6 Illumina HiSeq 2000 (Homo sapiens)
C
  GSE68402 		Chip-seq 26 Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens)
TCGA_LIHC_HBV DNA methylation sequencing;RNA-seq 97 TCGA
C
  GSE270130 		Chip-seq 27 Illumina NovaSeq 6000 (Homo sapiens)
GSE224901 RNA-seq 21 Illumina NovaSeq 6000 (Homo sapiens)
E
 
C
  GSE100400 		Chip-seq;RNA-seq;4C_cccDNA 31 Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus)
GSE173897 RNA-seq 95 Illumina HiSeq 4000 (Homo sapiens)
C
  GSE131257 		ATAC-seq;RNA-seq 19 Illumina HiSeq 2500 (Homo sapiens)
GSE94660 RNA-seq 42 Illumina HiSeq 2500 (Homo sapiens)


When the query gene is differentially changed in the dataset, a volcano/bar plot will be displayed.


> Dataset: GSE100400 - PRKN expression across samples

Volcano Plot

Bar Plot