| Evidence Sentence: |
Results demonstrated increased expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA, as well as decreased pain threshold, in a rat model of chronic neuropathic pain after electroacupuncture. |
| Evidence Sentence: |
The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. |
| Evidence Sentence: |
Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. |
| Evidence Sentence: |
EA increased hippocampal acetylcholinesterase (AChE) activity |
| Evidence Sentence: |
Compared with the normal control group, acetylcholinesterase (AChE) expression did not change in the hippocampal CA1 region of the CCI and OVX + CCI groups (P > 0.05). |
| Evidence Sentence: |
However, compared with the CCI group, AChE expression significantly increased in the CCI + EA 2W group (P < 0.05). |
| Evidence Sentence: |
In addition, AChE activity significantly increased in the OVX + CCI + EA 2W group compared with the OVX + CCI group (P < 0.05). |
| Evidence Sentence: |
In the CCI + EA 2W group, AChE expression was significantly greater than in the OVX + CCI + EA 2W group (P < 0.05; Figure 2). |
