Evidence Details for Ache
PMID Title Journal Year Abstract
26889195 Electroacupuncture promotes the recovery of motor neuron function in the anterior horn of the injured spinal cord. Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. 2015 Dec Acupuncture has been shown to lessen the inflammatory reaction after acute spinal cord injury and reduce secondary injury. However, the mechanism of action remains unclear. In this study, a rat model of spinal cord injury was established by compressing the T8-9 segments using a modified Nystrom method. Twenty-four hours after injury, Zusanli (ST36), Xuanzhong (GB39), Futu (ST32) and Sanyinjiao (SP6) were stimulated with electroacupuncture. Rats with spinal cord injury alone were used as controls. At 2, 4 and 6 weeks after injury, acetylcholinesterase (AChE) activity at the site of injury, the number of medium and large neurons in the spinal cord anterior horn, glial cell line-derived neurotrophic factor (GDNF) mRNA expression, and Basso, Beattie and Bresnahan locomotor rating scale scores were greater in the electroacupuncture group compared with the control group. These results demonstrate that electroacupuncture increases AChE activity, up-regulates GDNF mRNA expression, and promotes the recovery of motor neuron function in the anterior horn after spinal cord injury."

Evidence Sentence: At 2, 4 and 6 weeks after injury, acetylcholinesterase (AChE) activity at the site of injury, the number of medium and large neurons in the spinal cord anterior horn, glial cell line-derived neurotrophic factor (GDNF) mRNA expression, and Basso, Beattie and Bresnahan locomotor rating scale scores were greater in the electroacupuncture group compared with the control group.
Evidence Sentence: These results demonstrate that electroacupuncture increases AChE activity, up-regulates GDNF mRNA expression, and promotes the recovery of motor neuron function in the anterior horn after spinal cord injury.
Evidence Sentence: Effects of electroacupuncture on AChE activity in rats with SCI
Evidence Sentence: At 4 weeks after electroacupuncture, AChE activity diminished, and staining was weak in motor neurons of the anterior horn of the spinal cord (Figure 5).
Evidence Sentence: Compared with the control group (Figure 5A), AChE staining at the injury site was slightly darker in the electroacupuncture group (Figure 5B).
Evidence Sentence: At 2, 4 and 6 weeks after electroacupuncture, the gray value was significantly less in the electroacupuncture group compared with the control group (P < 0.01), suggesting that electroacupuncture increased AChE activity in motor neurons in the anterior horn in the early stage of SCI.
Evidence Sentence: These results demonstrate that AChE activity was lowest at 4 weeks after electroacupuncture, and gradually increased by 6 weeks.