| 35487121 |
Electroacupuncture attenuates brain injury through alpha7 nicotinic acetylcholine receptor-mediated suppression of neuroinflammation in a rat model of asphyxial cardiac arrest. |
J Neuroimmunol. 2022 Jun 15;367:577873. doi: 10.1016/j.jneuroim.2022.577873. Epub 2022 Apr 20. |
2022 Jun 15 |
We determined whether electroacupuncture (EA) ameliorated brain injury following asphyxial cardiac arrest (CA) and evaluated the role of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR)-mediated anti-inflammatory pathway. In CA-induced rats, EA reduced brain injury and promoted behavioral recovery. Morris water maze escape latency time reduced after Baihui (GV20) and Shuigou (DU26) stimulation. EA reduced alpha7nAChR downregulation after cardiopulmonary resuscitation (CPR), reducing tumor necrosis factor alpha, interleukin-1, and interleukin-6 expression and ionized calcium binding adapter molecule 1 production. The alpha7nAChR antagonist methyllycaconitine reversed EA effect. EA stimulation of acupuncture points alleviated brain damage after CPR and reduced the inflammatory response via alpha7nAChR activation."
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