Evidence Details for Gal
PMID Title Journal Year Abstract
25530777 Alteration of behavioral changes and hippocampus galanin expression in chronic unpredictable mild stress-induced depression rats and effect of electroacupuncture treatment. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. 2014 To explore new noninvasive treatment options for depression, this study investigated the effects of electric acupuncture (EA) for depression rat models. Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days. Eighteen male Sprague-Dawley rats were randomly assigned into three groups: control, model, and EA groups. Rats were treated by EA once daily for 21 days. The results showed that body weight and sucrose consumption were significantly increased in EA group than in the model group. The crossing numbers and rearing numbers in the open field test significantly decreased in the model group but not in the EA group. And EA treatments upregulated levels of hippocampus galanin (Gal) in UCMS rats back to relative normal levels. The present study suggested that EA had antidepressant effects on UCMS model rats. The potential antidepressant effect may be related to upregulating Gal expression in hippocampus."

Evidence Sentence: And EA treatments upregulated levels of hippocampus galanin (Gal) in UCMS rats back to relative normal levels.
Evidence Sentence: The potential antidepressant effect may be related to upregulating Gal expression in hippocampus.
Evidence Sentence: Effects of EA Treatment on GAL mRNA
Evidence Sentence: As shown in Figure 5, GAL mRNA expression in hippocampus of model group decreased significantly in comparison with that in control group with statistically significant differences (P < 0.01), while GAL mRNA expression in hippocampus of EA group was increased remarkably in comparison with those in model group with statistical significance (P < 0.01).
Evidence Sentence: These results indicated that EA increased the expression of GAL in hippocampal tissue.
Evidence Sentence: Effects of EA Treatment on GAL Protein Expression
Evidence Sentence: As shown in Figure 6, GAL protein expression in hippocampus of model group decreased significantly in comparison with that in control group with statistically significant differences (P < 0.01), while GAL protein expression in hippocampus of EA group was increased in comparison with those in model group with statistical significance (P < 0.05).
Evidence Sentence: Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment