Evidence Details for Gdnf
PMID Title Journal Year Abstract
25206697 Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats. Neural Regen Res. 2013 Feb 25;8(6):540-9. doi: 10.3969/j.issn.1673-5374.2013.06.007. 2013 Feb 25 Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment. These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease. Thus, electroacupuncture may be useful in the treatment of Parkinson's disease."

Evidence Sentence: Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment.
Evidence Sentence: These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease.
Evidence Sentence: Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the rat substantia nigra
Evidence Sentence: A 219-bp fragment of brain-derived neurotrophic factor mRNA and a 242-bp fragment of glial cell line-derived neurotrophic factor mRNA were obtained by PCR amplification (Figure 1).
Evidence Sentence: Image analysis system demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression was lower in the Parkinson's disease model group compared with the blank and sham-surgery groups (P < 0.01).
Evidence Sentence: However, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly greater in the electroacupuncture group than in the model group (P < 0.01; Table 1).