Evidence Details for Gdnf
| PMID | Title | Journal | Year | Abstract |
|---|---|---|---|---|
| 25206816 | Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | 2014 Feb 1 | Drugs can cause obvious damage to the brain. To verify the relationship between acupuncture, neurotrophic factor expression and brain cell structural changes, this study established a rat model of heroin relapse using intramuscular injection of increasing amounts of heroin. During the detoxification period, rat models received acupuncture at Baihui (DU20) and Dazhui (DU14). Electron microscopy demonstrated that the structure of the ventral tegmental area in heroin relapse rats gradually became normalized after acupuncture treatment. Immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. Moreover, the effects were similar to that of methadone, a type of medicine called an opioid. Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression." |
| Evidence Sentence: | Immunohistochemical staining exhibited that the expression of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor increased in the ventral tegmental area following acupuncture. |
| Evidence Sentence: | Results suggested that acupuncture at Baihui and Dazhui protected brain neurons against injury in rats with heroin relapse by promoting brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression. |
| Evidence Sentence: | Acupuncture increased glial cell line-derived neurotrophic factor expression in the ventral tegmental area of heroin relapse rats |
| Evidence Sentence: | Immunohistochemical staining showed that compared with the normal group, the number of glial cell line-derived neurotrophic factor-positive cells and mean absorbance were greater in the ventral tegmental area of heroin relapse rats (P < 0.05). |
| Evidence Sentence: | The number of glial cell line-derived neurotrophic factor-positive cells and mean absorbance were increased after treatment with methadone or acupuncture (P < 0.05). |
| Evidence Sentence: | The number of glial cell line-derived neurotrophic factor-positive cells and mean absorbance were greater in the acupuncture group compared with the methadone group (P < 0.05; Figure 2, Table 1). |