Evidence Details for Gdnf
PMID Title Journal Year Abstract
26889195 Electroacupuncture promotes the recovery of motor neuron function in the anterior horn of the injured spinal cord. Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. 2015 Dec Acupuncture has been shown to lessen the inflammatory reaction after acute spinal cord injury and reduce secondary injury. However, the mechanism of action remains unclear. In this study, a rat model of spinal cord injury was established by compressing the T8-9 segments using a modified Nystrom method. Twenty-four hours after injury, Zusanli (ST36), Xuanzhong (GB39), Futu (ST32) and Sanyinjiao (SP6) were stimulated with electroacupuncture. Rats with spinal cord injury alone were used as controls. At 2, 4 and 6 weeks after injury, acetylcholinesterase (AChE) activity at the site of injury, the number of medium and large neurons in the spinal cord anterior horn, glial cell line-derived neurotrophic factor (GDNF) mRNA expression, and Basso, Beattie and Bresnahan locomotor rating scale scores were greater in the electroacupuncture group compared with the control group. These results demonstrate that electroacupuncture increases AChE activity, up-regulates GDNF mRNA expression, and promotes the recovery of motor neuron function in the anterior horn after spinal cord injury."

Evidence Sentence: At 2, 4 and 6 weeks after injury, acetylcholinesterase (AChE) activity at the site of injury, the number of medium and large neurons in the spinal cord anterior horn, glial cell line-derived neurotrophic factor (GDNF) mRNA expression, and Basso, Beattie and Bresnahan locomotor rating scale scores were greater in the electroacupuncture group compared with the control group.
Evidence Sentence: These results demonstrate that electroacupuncture increases AChE activity, up-regulates GDNF mRNA expression, and promotes the recovery of motor neuron function in the anterior horn after spinal cord injury.
Evidence Sentence: Effects of electroacupuncture on GDNF mRNA expression in rats with SCI
Evidence Sentence: GDNF mRNA expression was high.
Evidence Sentence: PCR amplification of RNA from the control and electroacupuncture groups (Figure 3C, Table 1) demonstrated that GDNF mRNA expression increased slightly and gradually after SCI, but no significant differences were detected at the various time points (P > 0.05).
Evidence Sentence: Compared with the control group, GDNF mRNA expression increased significantly over time in the electroacupuncture group (P < 0.01).
Evidence Sentence: Significant differences in GDNF mRNA expression were detectable in the electroacupuncture group at the various time points (P < 0.05).
Evidence Sentence: These results suggest that electroacupuncture effectively increases GDNF mRNA expression in rats with SCI.