Evidence Details for Hes1
PMID Title Journal Year Abstract
25810743 Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. 2015 Acupuncture is a potential strategy for the treatment of Alzheimer's disease (AD) and the possible mechanisms worth to be explored. In this study, we proposed and tested the hypothesis that whether Notch signaling pathway is involved in the effect of electroacupuncture (EA) treatment. Rats that received EA treatment on the acupoints of Baihui (Du 20) and Shenshu (BL 23) had shorter latency and remained in the original platform quadrant longer and crossed the former platform contained quadrant more frequently compared to the Abeta injection rats without EA treatment. EA obviously alleviated the cell apoptosis resulted by Abeta infusion in hippocampus CA1 regions through upregulating the expression of Bcl-2 and downregulating the expression of Bax. EA could further obviously promote the expression of synapsin-1 and synaptophysin in hippocampus. Abeta injection significantly increased the expression of Notch1, Jag1, and Hes1 mRNA, while EA treatment downregulated the level of Notch1 and Hes1 mRNA in hippocampus, but not Jag1 mRNA. Our data suggested that EA treatment improved learning and memory function in the AD rat model partially through downregulating Notch signaling pathway."

Evidence Sentence: Abeta injection significantly increased the expression of Notch1, Jag1, and Hes1 mRNA, while EA treatment downregulated the level of Notch1 and Hes1 mRNA in hippocampus, but not Jag1 mRNA.
Evidence Sentence: To investigate the mechanisms underlying the beneficial activity of EA, real-time PCR analysis for Notch1, Jag1, and Hes1 genes, which are major Notch pathway components in the central nervous system, was performed.
Evidence Sentence: Abeta injection obviously stimulated the expression of Notch1, Jag1, and Hes1 mRNA (P < 0.05 and P < 0.01).
Evidence Sentence: The Notch1 and Hes1 mRNA in hippocampus in EA group was downregulated compared with model group (P < 0.05 and P < 0.01).
Evidence Sentence: Compared to the sham-EA group, rats from EA group showed a much lower level of Hes1 mRNA (P < 0.01; Figures 4(a)-4(c)).