| Evidence Sentence: |
Radioimmunoassay and high-performance liquid chromatography were used to evaluate the expression of 5-hydroxytryptamine (HT) in the plasma and three-key structure of the descending pain modulatory system. |
| Evidence Sentence: |
Furthermore, we found that the level of 5-HT in plasma was significantly increased, and it was significantly decreased in the descending pain modulatory system in Model group. |
| Evidence Sentence: |
that is, the level of 5-HT was increased in the rostroventromedial medulla (RVM) and trigeminal nucleus caudalis (TNC) region and decreased in the plasma. |
| Evidence Sentence: |
In the peripheral nervous system, there is a consistent increase in plasma serotonin (5-hydroxytryptamine, 5-HT) release concomitant with a decrease in 5-hydroxyindoleacetic acid (HIAA) content during migraine attacks |
| Evidence Sentence: |
In the peripheral nervous system, there is a consistent increase in plasma serotonin (5-hydroxytryptamine, 5-HT) release concomitant with a decrease in 5-hydroxyindoleacetic acid (HIAA) content during migraine attacks |
| Evidence Sentence: |
Conversely, low plasma 5-HT and high 5-HIAA levels have been found between migraine attacks |
| Evidence Sentence: |
High-performance liquid chromatography (HPLC) with electrochemical detector was used to assess the 5-HT level from the cerebral homogenate samples. |
| Evidence Sentence: |
Repetitive electrical stimulation on the dura significantly increased the serum levels of 5-HT in the Model group compared to the Control group (221.77 ± 60.52 ng/mL versus 75.18 ± 15.34 ng/mL, p < 0.001; |
| Evidence Sentence: |
The repetitive electrical stimulation-induced serum 5-HT increase in rats was significantly inhibited following EA pretreatment at GB20 (EA group versus Model group: 107.94 ± 28.58 ng/mL versus 221.77 ± 60.52 ng/mL, p < 0.01; |
| Evidence Sentence: |
According to the result of the specificity experiment, 5-HT was eluted at around 18 min |
