Evidence Details for Il1b
PMID Title Journal Year Abstract
25206407 Efficacy of suspended moxibustion in stroke rats is associated with a change in tail temperature. Neural Regen Res. 2013 Apr 25;8(12):1132-8. doi: 10.3969/j.issn.1673-5374.2013.12.008. 2013 Apr 25 Suspended moxibustion-produced heat can transfer from the acupoint to other sites of the body. The suspended moxibustion should be terminated when clinical propagated sensation disappears, because this implies that the quantity of moxibustion is sufficient. We wanted to investigate if this phenomenon also occurs in experimental animals. In the present study, a rat model of stroke was established and treated with suspended moxibustion at Dazhui (DU14) for 60 minutes. Results showed that the increase in tail temperature began at 15 minutes after suspended moxibustion and decreased gradually at 40 minutes. In addition, neurological function was significantly improved in stroke rats with tail temperature increase following suspended moxibustion, and this effect was associated with significantly reduced tumor necrosis factor alpha and interleukin 1beta mRNA. However, there was no significant difference between 40- and 60-minute suspended moxibustion. The findings indicate that elevated tail temperature began to decrease at 40 minutes after suspended moxibustion, and further suspended moxibustion was not useful in the recovery of stroke rats."

Evidence Sentence: In addition, neurological function was significantly improved in stroke rats with tail temperature increase following suspended moxibustion, and this effect was associated with significantly reduced tumor necrosis factor alpha and interleukin 1beta mRNA.
Evidence Sentence: Suspended moxibustion suppressed cortical tumor necrosis factor-alpha and interleukin-1beta mRNA expression in tail temperature increase rats
Evidence Sentence: To investigate the level of inflammation in the cortex following transient middle cerebral artery occlusion, tumor necrosis factor-alpha and interleukin-1beta mRNA was measured using real time PCR at the inflammatory peak (the 1 or 3 days testing point).
Evidence Sentence: Results showed that the M40-tail temperature increase (P < 0.01) or M60-tail temperature increase (P < 0.01) group attenuated the increase of tumor necrosis factor-alpha and interleukin-1beta mRNA caused by transient middle cerebral artery occlusion at 1 day post ischemia, while other treatment groups had no effect on these inflammatory mediators compared to the ischemic control group.
Evidence Sentence: At 3 days post ischemia, both tumor necrosis factor-alpha and interleukin-1beta mRNA levels were reduced in M40-non-tail temperature increase, M60-non-tail temperature increase, M40-tail temperature increase and M60-tail temperature increase groups, while M15 had no effect on tumor necrosis factor-alpha and interleukin-1beta mRNA compared to ischemic control group.
Evidence Sentence: The suppression of tumor necrosis factor-alpha and interleukin-1beta mRNA in the M40-tail temperature increase and M60-tail temperature increase groups was more evident than in the M40-non-tail temperature increase or M60-non-tail temperature increase groups at 3 days post ischemia.
Evidence Sentence: In addition, there was no significant difference in tumor necrosis factor-alpha and interleukin-1beta mRNA expression between M40-tail temperature increase and M60-tail temperature increase groups at 1 or 3 days.
Evidence Sentence: Low expression of tumor necrosis factor-alpha and interleukin-1beta mRNA was detected in the sham-surgery group (Figure 3).