Evidence Details for Il6
PMID Title Journal Year Abstract
27594888 Changes in the Interstitial Cells of Cajal and Immunity in Chronic Psychological Stress Rats and Therapeutic Effects of Acupuncture at the Zusanli Point (ST36). Evid Based Complement Alternat Med. 2016;2016:1935372. doi: 10.1155/2016/1935372. Epub 2016 Aug 3. 2016 Now, chronic psychological stress (CPS) related diseases are increasing. Many CPS patients have gastrointestinal complaints, immune suppression, and immune imbalance. Increasing evidence is indicating that acupuncture (AP) at the Zusanli point (ST36) can alleviate functional gastrointestinal disorders (FGID), immune suppression, and immune imbalance. However, few studies have investigated the potential mechanisms. In this study, CPS rat models were established, and electroacupuncture (EA) at ST36 was done for CPS rats. Daily food intake, weight, intestinal sensitivity, the morphology of interstitial cell of Cajal (ICC) in the small intestine, and serum indexes were measured. The study found that, in CPS rats, EA at ST36 could improve food intake, weight, visceral hypersensitivity, and immunity; in CPS rats, in small intestine, the morphology of ICCs was abnormal and the number was decreased, which may be part causes of gastrointestinal motility dysfunction. EA at ST36 showed useful therapeutic effects. The mechanisms may be partially related to its repairing effects on ICCs damages; in CPS rats, there were immune suppression and immune imbalance, which may be part causes of visceral hypersensitivity. EA at ST36 showed useful therapeutic effects. The mechanisms may be partially related to its regulation on immunity."

Evidence Sentence: The serum interleukin-2 (IL-2) and interleukin-6 (IL-6) levels were measured using commercially available sandwich ELISA kits (Boster Biotechnology, Wuhan, China) in accordance with the manufacturer's instructions.
Evidence Sentence: The serum interleukin-2 (IL-2) and interleukin-6 (IL-6) levels were measured using commercially available sandwich ELISA kits (Boster Biotechnology, Wuhan, China) in accordance with the manufacturer's instructions.
Evidence Sentence: and the serum IL-6 level was significantly higher than that in the control group
Evidence Sentence: Whatever the serum IgG, IgM, IL-2, or IL-6 level, there was no significant difference between the model group and the sham-AP group.
Evidence Sentence: In this study, the serum IgG, IgM, and IL-2 levels were lower and the serum IL-6 level was higher in CPS rats than those in control rats.
Evidence Sentence: IL-6 is a proinflammatory cytokine and correlates with immunoreaction closely [30, 31].
Evidence Sentence: the serum IgG, IgM, and IL-2 levels of CPS rats increased markedly, and the serum IL-6 level decreased markedly.