Evidence Details for Mbp
PMID Title Journal Year Abstract
33328963 Acupuncture Improves White Matter Perfusion and Integrity in Rat Model of Vascular Dementia: An MRI-Based Imaging Study. Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. 2020 White matter lesions induced by chronic cerebral hypoperfusion are associated with cognitive impairment in vascular dementia (VaD). Previous studies have shown that acupuncture can ameliorate the cognitive deficits of individuals with VaD. However, the neuroimaging mechanisms of acupuncture on white matter perfusion and integrity remain elusive. In this study, the VaD model was induced by bilateral common carotid arteries occlusion (BCCAO) in rats. Novel object recognition task and Morris water maze were performed to evaluate short-term memory and spatial learning and memory. Arterial spin labeling and diffusion tensor imaging (DTI) were used to measure the cerebral blood flow (CBF) and the white matter integrity. Pathological examinations detected the myelin loss and concomitant neuroinflammation. The results demonstrate that BCCAO rats with reduced CBF exhibited worse performance and altered DTI parameters, including decreased fractional anisotropy, increased radial diffusivity, and axial diffusivity in white matter regions. Acupuncture ameliorated cognitive impairment, increased CBF, and protected the myelin sheath integrity but not the axons of BCCAO rats. These protective effects of acupuncture on white matter were significantly correlated with improved CBF. Pathological examination confirmed that the loss of myelin basic protein and microglial accumulation associated IL-1beta and IL-6 production were attenuated by acupuncture treatment. Our findings suggest that acupuncture protects cognitive function of BCCAO rats by improving white matter perfusion and integrity."

Evidence Sentence: To evaluate the pathological changes of all types of glia in the white matter region, we quantified the expression of myelin basic protein (MBP, located at membrane of oligodendrocyte), Iba-1, and GFAP (Figures 5A-C).
Evidence Sentence: We found that the positive expression area and the quantification of MBP were reduced significantly at the 14th day after BCCAO surgery (compared with the SHAM group, positive area: p = 0.0001, expression: p = 0.011), while acupuncture treatment alleviated the MBP loss effectively in CC (compared with the BCCAO group, positive expression area: p = 0.001, protein quantification: p = 0.039).
Evidence Sentence: Pathological examination confirmed that the loss of myelin basic protein and microglial accumulation associated IL-1beta and IL-6 production were attenuated by acupuncture treatment.