Evidence Details for Mpzl2
PMID Title Journal Year Abstract
25983633 Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis. Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. 2015 Mar Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication."

Evidence Sentence: Myelin protein zero-like 2 (Mpzl2) is also known as Eva and Eva1.
Evidence Sentence: Myelin protein zero-like 2 (Mpzl2) is also known as Eva and Eva1.
Evidence Sentence: In human choroid plexus epithelial cells and a subset of CD4 T lymphocytes, Mpzl2 is expressed at high levels.
Evidence Sentence: Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation.
Evidence Sentence: Myelin protein zero-like 2 (Mpzl2) is also known as Eva and Eva1.
Evidence Sentence: Mpzl2 expressed in choroid plexus cells may regulate the permeability of the blood-cerebrospinal fluid (CSF) barrier, suggesting a novel mechanism of CNS immune surveillance regulation.
Evidence Sentence: In the current study, Mpzl2 was up-regulated in the MPTP group compared to controls; however, acupuncture stimulation at GB34 and LR3 maintained Mpzl2 gene expression at levels similar to those in control animals.
Evidence Sentence: These results also suggest that acupuncture suppresses the Mpzl2 overexpression that can be caused by MPTP neuronal loss.
Evidence Sentence: The microarray results indicate that Slc6a4 and Tph2, which are involved in PD, and Mpzl2 and Serping1, which are involved in inflammation, are primary causes of neurodegenerative disorders, and their expression can be maintained at similar to normal levels by acupuncture.