Evidence Details for Nes
PMID Title Journal Year Abstract
28913350 Neuronal Regeneration after Electroacupuncture Treatment in Ischemia-Reperfusion-Injured Cerebral Infarction Rats. Biomed Res Int. 2017;2017:3178014. doi: 10.1155/2017/3178014. Epub 2017 Aug 24. 2017 Adult neuronal cells which can regenerate have been reported. The present study investigated whether acupuncture enhances neuronal regeneration in ischemic stroke rats. We established an ischemic stroke rat model by occluding the cerebral blood flow of the right middle cerebral artery for 15 minutes and then allowing reperfusion in Sprague-Dawley rats. The results indicated that, in these rats, 2 Hz electroacupuncture (EA) at both Zusanli (ST36) and Shangjuxu (ST37) acupoints reduced the infarction/hemisphere ratio 8 days after reperfusion and reduced the modified neurological severity score (mNSS) and increased the rotarod test time 4 and 8 days after reperfusion, respectively. In addition, 2 Hz reduced nestin immunoreactive cells in the penumbra area and the ischemic core area; 2 Hz EA also reduced Ki67 immunoreactive cells and increased glial fibrillary acidic protein immunoreactive cells in the penumbra area. These findings suggest that 2 Hz EA at the ST36 and ST37 acupoints has a neuroprotective role. However, additional studies are needed to further investigate these preliminary results."

Evidence Sentence: In addition, 2 Hz reduced nestin immunoreactive cells in the penumbra area and the ischemic core area; 2 Hz EA also reduced Ki67 immunoreactive cells and increased glial fibrillary acidic protein immunoreactive cells in the penumbra area.
Evidence Sentence: Effect of EA on Ki67, GFAP, and Nestin Immunoreactive Cells in Ischemia-Reperfusion-Injured Rats
Evidence Sentence: In the penumbra area, no prominent nestin immunoreactive cells were noted in the normal group (Figure 4).
Evidence Sentence: Additionally, the number of nestin immunoreactive cells in the control and sham groups was higher than that in the EA1 and EA2 groups (all p < 0.05; Table 2, Figure 4).
Evidence Sentence: The number of nestin immunoreactive cells was also higher in the EA2 group than that in the EA1 group (p < 0.05; Table 2, Figure 4).
Evidence Sentence: Finally, the number of nestin immunoreactive cells was similar between the control and sham groups (p > 0.05; Table 2, Figure 4).
Evidence Sentence: In the ischemic core area, no prominent nestin immunoreactive cells were noted in the normal group (Figure 4).
Evidence Sentence: The number of nestin immunoreactive cells in the control and sham groups was also higher than that in the EA1 and EA2 groups (all p < 0.05; Table 2, Figure 4).
Evidence Sentence: Furthermore, the number of nestin immunoreactive cells was higher in the EA2 group than in the EA1 group (p < 0.05; Table 2, Figure 4), and the number of such cells was similar between the control and sham groups (p > 0.05; Table 2, Figure 4).