Evidence Details for Olr1
PMID Title Journal Year Abstract
26237832 Effect of electro-acupuncture on gene expression in heart of rats with stress-induced pre-hypertension based on gene chip technology. J Tradit Chin Med. 2015 Jun;35(3):285-94. doi: 10.1016/s0254-6272(15)30099-6. 2015 Jun OBJECTIVE: To explore electro-acupuncture's (EA's) effect on gene expression in heart of rats with stress-induced pre-hypertension and try to reveal its biological mechanism based on gene chip technology. METHODS: Twenty-seven Wistar male rats were randomly divided into 3 groups. The stress-induced hypertensive rat model was prepared by electric foot-shocks combined with generated noise. Molding cycle lasted for 14 days and EA intervene was applied,on rats in model + EA group during model preparation. Rat Gene 2.0 Sense Target Array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction (RT-PCR) method. RESULTS: Compared with blank control group, 390 genes were changed in model group; compared with model control group, 330 genes were changed in model+EA group. Significance analysis of gene function showed that the differentially expressed genes are those involved in biological process, molecular function and cellular components. RT-PCR result of the screened key genes is consistent with that of gene chip test. CONCLUTION: EA could significantly lower blood pressure of stress-induced pre-hypertension rats and affect its gene expression profile in heart. Genes that related to the contraction of vascular smooth muscle may be involved in EA's anti-hypertensive mechanism."

Evidence Sentence: The expression of heat shock 70 kDa protein (HSPA1A) (P < 0.01), heat shock protein beta-1 (HSPB1) (P < 0.01), oxidized low-density lipoprotein receptor 1 (OLR1) (P = 0.035), phospholipase A2 (PLA2G4A) (P < 0.01) and prostaglandin-endoperoxide synthase 2 (PTGS2) (P = 0.041) was significantly higher in model control group compared to blank control group.
Evidence Sentence: HSPA1A (P < 0.01), HSPB1 (P < 0.01), OLR1 (P < 0.01), PLA2G4A (P < 0.01) and PTGS2 (P = 0.015) expression was significantly lower in model + EA group when compared to model control group.
Evidence Sentence: Altered genes including PLA2G4A (FC = 1.70934), HSPB1 (FC = 1.88297), HSPA1A (FC = 1.70622), PTGS2 (FC = 2.24993), OLR1 (FC = 2.11512), which are related to the cytoskeleton and the contraction of vascular smooth muscle, up-regulated in model control group when compared with blank control group, but down-regulated in model + EA group, PLA2G4A (FC = - 1.54617), HSPB1 (FC = -2.52067), HSPA1A (FC = -1.92875), PTGS2 (FC = - 1.85358), OLR1 (FC = - 2.29848), when compared with model control.
Evidence Sentence: OLR1 is the specific receptor of oxiding low density lipoprotein (Ox-LDL).
Evidence Sentence: In recent years, studies have shown that Ox-LDL can initiate CD40/CD40L endothelial cell signaling pathway through OLR1 and participate in the expression of inflammatory molecules and activation, dysfunction and injury of endothelial cells
Evidence Sentence: Our study showed that OLR1 gene may be one of the target genes in stress-induced pre-hypertension and closely related to development of stress-induced hypertension.
Evidence Sentence: EA's antihypertensive effect may be related with the regulation of OLR1 gene, with the underlying mechanism to be further studied.