Evidence Details for P2rx3
PMID Title Journal Year Abstract
25206727 Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity. Neural Regen Res. 2013 Mar 25;8(9):802-8. doi: 10.3969/j.issn.1673-5374.2013.09.004. 2013 Mar 25 Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia."

Evidence Sentence: Immunohistochemistry revealed that P2X3 receptor expression increased in dorsal root ganglia from rats with visceral hypersensitivity (P < 0.01), suggesting that P2X3 participated in visceral hypersensitivity.
Evidence Sentence: Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity
Evidence Sentence: Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity.
Evidence Sentence: Simultaneously, P2X2 and P2X3 receptor expression increased in dorsal root ganglia.
Evidence Sentence: After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X2 and P2X3 receptor expression decreased in rats with visceral hypersensitivity.
Evidence Sentence: These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X2 and P2X3 receptor expression in dorsal root ganglia.
Evidence Sentence: Bilateral electroacupuncture at Shangjuxu and Tianshu diminishes P2X3 receptor expression in dorsal root ganglion of rats with visceral hypersensitivity
Evidence Sentence: However, P2X3 receptor expression was reduced in model rats following electroacupuncture (P < 0.05), suggesting that electroacupuncture regulated visceral hypersensitivity using the P2X3 receptor pathway (Figure 3).