Evidence Details for Rps6
PMID Title Journal Year Abstract
25767501 Effects of electroacupuncture on the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of rats with vascular dementia. Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. 2012 Jan 25 This study investigated the mechanism underlying electroacupuncture therapy for vascular dementia through electroacupuncture at the acupoints of Baihui (DU20), Dazhui (DU14), and bilateral Shenshu (BL23) in a rat model of vascular dementia produced by bilateral middle cerebral artery occlusion. Morris water maze test showed that electroacupuncture improved the learning ability of vascular dementia rats. Western blot assay revealed that the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in vascular dementia rats was significantly increased after electroacupuncture, compared with the model group that was not treated with acupuncture. The average escape latency was also shortened after electroacupuncture, and escape strategies in the spatial probe test improved from edge and random searches, to linear and trending swim pathways. The experimental findings indicate that electroacupuncture improves learning and memory ability by up-regulating expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of vascular dementia rats."

Evidence Sentence: Western blot assay was used to detect the expression of p70S6 kinase protein and ribosomal protein S6 in the rat hippocampus (Figures -(Figures2,2, -,3).3).
Evidence Sentence: The experimental findings indicate that electroacupuncture improves learning and memory ability by up-regulating expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in the hippocampus of vascular dementia rats.
Evidence Sentence: p70 ribosomal protein S6 (p70S6) kinase/ribosomal protein S6 signaling pathway has been shown to promote neuronal growth and long-term potentiation[13,14,15,16,17,18].
Evidence Sentence: We hypothesized that the p70S6 kinase/ribosomal protein S6 pathway may be related to VD.
Evidence Sentence: This study sought to analyze the expression of p70S6 kinase and ribosomal protein S6 in the hippocampus of VD rats by western blot assay, and further investigated the effects of electroacupuncture on the expression of p70S6 kinase and ribosomal protein S6 in VD rats.
Evidence Sentence: Compared with the model group, the expression of p70S6 kinase protein and ribosomal protein S6 was significantly increased in the hippocampus of VD rats in the electroacupuncture group (P < 0.05).
Evidence Sentence: p70S6 kinase is activated by kinases such as mammalian target of rapamycin and mitogen-activated protein kinase[19,20,21,22], which results in ribosomal protein S6 phosphorylation[23,24],
Evidence Sentence: The present study showed that the expression of p70S6 kinase and ribosomal protein S6 in the hippocampus of VD rats was less than that of normal rats.
Evidence Sentence: This is evidence that p70S6 kinase/ribosomal protein S6 pathway is involved in the pathogenesis of VD.
Evidence Sentence: To further explore its mechanism, this study confirmed that electroacupuncture was able to increase the expression of p70S6 kinase and ribosomal protein S6 in the hippocampus of VD rats,
Evidence Sentence: In conclusion, data from this study demonstrated that the decreasing expression of p70S6 kinase and ribosomal protein S6 plays important roles in the pathogenesis of VD.
Evidence Sentence: The following primary antibodies were used: rabbit anti-rat p70S6 kinase monoclonal antibody, rabbit anti-rat ribosomal protein S6 monoclonal antibody, and rabbit anti-rat glyceraldehyde-3-phosphate dehydrogenase monoclonal antibody (Cell Signal Biotechnology, Boston, MA, USA).
Evidence Sentence: The result of p70S6 kinase and ribosomal protein S6 was corrected by GAPDH, and the relative expression level ratio of ribosomal protein S6/GAPDH and absorbance ratio of p70S6 kinase/GAPDH was respectively represented as the relative amount of ribosomal protein S6 and p70S6 kinase in rat hippocampus.
Evidence Sentence: Western blot assay revealed that the expression of p70 ribosomal protein S6 kinase and ribosomal protein S6 in vascular dementia rats was significantly increased after electroacupuncture,
Evidence Sentence: We hypothesized that the p70S6 kinase/ribosomal protein S6 pathway may be related to VD.
Evidence Sentence: Western blot assay was used to detect the expression of p70S6 kinase protein and ribosomal protein S6 in the rat hippocampus (Figures -(Figures2,2, -,3).3).
Evidence Sentence: Compared with the model group, the expression of p70S6 kinase protein and ribosomal protein S6 was significantly increased in the hippocampus of VD rats in the electroacupuncture group (P < 0.05).
Evidence Sentence: p70S6 kinase is activated by kinases such as mammalian target of rapamycin and mitogen-activated protein kinase[19,20,21,22],
Evidence Sentence: Thus, dysregulation of p70S6 kinase and ribosomal protein S6 may be important in the pathogenesis of VD.
Evidence Sentence: The present study showed that the expression of p70S6 kinase and ribosomal protein S6 in the hippocampus of VD rats was less than that of normal rats.
Evidence Sentence: This is evidence that p70S6 kinase/ribosomal protein S6 pathway is involved in the pathogenesis of VD.
Evidence Sentence: In conclusion, data from this study demonstrated that the decreasing expression of p70S6 kinase and ribosomal protein S6 plays important roles in the pathogenesis of VD.