| Evidence Sentence: |
The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. |
| Evidence Sentence: |
EA increased hippocampal vesicular acetylcholine transporter (VAChT) expression |
| Evidence Sentence: |
A larger gray value represents lower VAChT expression. |
| Evidence Sentence: |
Compared with the normal control group, VAChT expression significantly decreased in the hippocampal CA1 region (P < 0.05; Figure 1). |
| Evidence Sentence: |
At 2 weeks after EA, VAChT expression significantly increased in the CCI + EA 2W group (P < 0.05). |
| Evidence Sentence: |
Following CCI, VAChT expression significantly decreased in the OVX + CCI group compared with the CCI group (P < 0.05; Figure 1). |
| Evidence Sentence: |
In comparison with the OVX + CCI group, VAChT expression significantly increased in the OVX + CCI + EA 2D and OVX + CCI + EA 2W groups (P < 0.05). |
| Evidence Sentence: |
In addition, VAChT expression was significantly less in the CCI + EA 2W group than in the OVX + CCI + EA 2W group (P < 0.05), suggesting a weakened effect of repeated EA in upregulating hippocampal VAChT expression in OVX rats. |
| Evidence Sentence: |
The present study observed the effects of repeated electroacupuncture of Zusanli (ST36) and Yanglingquan (GB34) on expression of hippocampal acetylcholinesterase, vesicular acetylcholine transporter, and muscarinic M1 receptor mRNA in chronic constrictive injury (neuropathic pain) and/or ovariotomy rats. |
| Evidence Sentence: |
Results indicated that repeated electroacupuncture has a cumulative analgesic effect, which is closely associated with upregulation of acetylcholinesterase and vesicular acetylcholine transporter activity, as well as M1 receptor mRNA expression and memory. |
