Evidence Details for Sod1
PMID Title Journal Year Abstract
24803946 Neuroprotective effects of different modalities of acupuncture on traumatic spinal cord injury in rats. Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. 2014 Spinal cord injury (SCI) can induce a series of histological, biochemical, and functional changes. Acupuncture is commonly used for SCI patients. Using male rats of spinal cord injury with the New York University (NYU) Impactor, we investigated the response of electroacupuncture (EA), manual acupuncture (MA), and transcutaneous acupoint electrical stimulation (TAES) at Shuigou (DU26) and Fengfu (DU16) acupoints to understand the effects and mechanisms of acupuncture in neuroprotection and neuronal function recovery after SCI. Histological study showed a restored neural morphology and an increase in the quantity of neurons after EA, MA, and TAES administrations. Acupuncture's antioxidation effects were demonstrated by alleviation of the post-SCI superoxide dismutase (SOD) activity increase and malondialdehyde (MDA) level decrease. The anti-inflammation effect of acupuncture was shown as the reduced expression of inflammatory cytokines including interleukin-1 beta (IL-1 beta ), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF- alpha ) when SCI was treated. And the antiapoptosis role was approved by TUNEL staining. Our data confirmed that the role of acupuncture in neuroprotection and dorsal neuronal function recovery after rat SCI, especially, EA stimulating at Shuigou (DU26) and Fengfu (DU16) can greatly promote neuronal function recovery, which may result from antioxidation, anti-inflammation, and antiapoptosis effects of acupuncture."

Evidence Sentence: Acupuncture's antioxidation effects were demonstrated by alleviation of the post-SCI superoxide dismutase (SOD) activity increase and malondialdehyde (MDA) level decrease.
Evidence Sentence: Acupuncture's antioxidation effects were demonstrated by alleviation of the post-SCI superoxide dismutase (SOD) activity increase and malondialdehyde (MDA) level decrease.
Evidence Sentence: The assay of SOD activity was based on its ability to inhibit the oxidation of oxymine by superoxide anion produced from the xanthine-xanthine oxidase system.
Evidence Sentence: SOD activity of the spinal cord tissues from the sham group was 2.28 ± 0.17kU/g.
Evidence Sentence: In the control group, SCI caused a significant decrease in SOD activity (0.50 ± 0.04 kU/g, P < 0.01) and an increase in MDA level (6.87 ± 0.05umol/g, P < 0.01).
Evidence Sentence: Compared with the control group, EA treatment after SCI dramatically increased the SOD activity to 1.60 ± 0.02kU/g (P < 0.01) and decreased MDA level to 3.8 ± 0.02umol/g (P < 0.01), and MA treatment increased the SOD activity to 0.93 ± 0.07kU/g (P < 0.01) and decreased MDA level to 4.7 ± 0.09umol/g (P < 0.01), while TAES treatment increased the SOD activity to 0.73 ± 0.04kU/g (P < 0.01) and decreased MDA level to 5.31 ± 0.05umol/g (P < 0.01).
Evidence Sentence: Meanwhile, compared with TAES and MA groups, EA group induced a more obvious change of SOD and MDA (P < 0.05).
Evidence Sentence: EA stimulating decreased SOD activity and increased MDA level, as well as deduced expression of inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6 compared to the other two types of treatments.