Evidence Details for Tac1
PMID Title Journal Year Abstract
36003380 Electroacupuncture attenuates surgical pain-induced delirium-like behavior in mice via remodeling gut microbiota and dendritic spine. Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. 2022 Surgical pain is associated with delirium in patients, and acupuncture can treat pain. However, whether electroacupuncture can attenuate the surgical pain-associated delirium via the gut-brain axis remains unknown. Leveraging a mouse model of foot incision-induced surgical pain and delirium-like behavior, we found that electroacupuncture stimulation at specific acupoints (e.g., DU20+KI1) attenuated both surgical pain and delirium-like behavior in mice. Mechanistically, mice with incision-induced surgical pain and delirium-like behavior showed gut microbiota imbalance, microglia activation in the spinal cord, somatosensory cortex, and hippocampus, as well as an enhanced dendritic spine elimination in cortex revealed by two-photon imaging. The electroacupuncture regimen that alleviated surgical pain and delirium-like behavior in mice also effectively restored the gut microbiota balance, prevented the microglia activation, and reversed the dendritic spine elimination. These data demonstrated a potentially important gut-brain interactive mechanism underlying the surgical pain-induced delirium in mice. Pending further studies, these findings revealed a possible therapeutic approach in preventing and/or treating postoperative delirium by using perioperative electroacupuncture stimulation in patients."

Evidence Sentence: We found that the mice with SP by plantar incision showed significant postural changes in hind paw, as evidenced by the appearance of ventroflexed toes and everted paw, compared to those with sham condition (Figure 1B).
Evidence Sentence: Next, we used our established methods to determine the interaction of SP and EA stimulation on delirium-like behavior in mice at 9 h after the SP (Figure 2A).
Evidence Sentence: To assess the interaction of SP and EA stimulation on dendritic spine turnover, transcranial in vivo two-photon imaging was performed in mice (Figure 5A).