Evidence Details for Taichong
PMID Title Journal Year Abstract
36181105 Research status, hotspots and trends of acupuncture and moxibustion in the treatment of Alzheimer's disease: A bibliometric analysis. Medicine (Baltimore). 2022 Sep 30;101(39):e30858. doi: 10.1097/MD.0000000000030858. 2022 Sep 30 BACKGROUND: Acupuncture and moxibustion (AM) are utilized to treat Alzheimer's disease (AD). However, no bibliometric analysis has explored this issue. Thus, this study investigated the status, hotspots and trends of AM in the treatment of AD. METHODS: CiteSpace and VOSviewer softwares were used to analyze the literature on the AM for AD in the Web of Science Core Collection database. We analyzed the data of countries/regions, institutions, journals, authors, keywords, and cited references. RESULTS: After removing duplicates, 193 articles were retrieved. The number of publications on this topic has increased gradually. The most productive and collaborative country was China (143 documents), followed by South Korea (19). The top 3 active academic institutions were Beijing University of Chinese Medicine, Capital Medicine University, and Guangzhou University of Chinese Medicine. The most productive journal was Evidence-based Complementary and Alternative Medicine (13 documents), followed by the Frontiers in Aging Neuroscience (10), Medicine (10), and Neural Regeneration Research (10). The top 3 co-cited journals were Evidence-based Complementary and Alternative Medicine (156 citations), Acupuncture Electro-therapeutics Research (152), and Acupuncture in Medicine (146). The research hotspots in this domain are dementia, memory, hippocampus, mouse models, and Parkinson's disease. Major frontiers are comparing the therapeutic effects of acupuncture and donepezil and electroacupuncture at different frequencies in this field. CONCLUSION: This bibliometric study identified relevant hotspots and trends in research on AM in the treatment of AD, which can provide researchers with key information in this domain and help further explore new research directions."

Evidence Sentence: Lai et al[61] reported that acupuncture at Shenmen (HT7) could improve cerebral glucose metabolism in the hippocampus, thalamus, hypothalamus, frontal lobe/temporal lobe of AD rats and enhance memory ability through the modality of 18F-2-fluoro-deoxy-d-glucose positron emission tomography. Zhang et al[62] suggested that acupuncture at Dazhui (GV20) and Shenshu (BL23) could improve cognitive impairment in AD rats by activating PPAR-γ and inhibiting the expression of P-P38 MAPK. Wang et al[52] and Zheng et al[53] applied fMRI to elucidate the repair effect of acupuncture on hippocampal connections in AD patients, showing enhanced functional connectivity between the hippocampus and the anterior central gyrus in AD patients after acupuncture at Taichong (Liv3) and Hegu (LI 4).