Evidence Details for Tomm40
PMID Title Journal Year Abstract
30431067 'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion. Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. 2019 Jan Acupuncture is a traditional Chinese medicinal therapy, which is used for the amelioration of cognitive dysfunction. The aim of this study was to investigate the effectiveness and relevancy mechanisms of 'governor vessel鈥憉nblocking and mind鈥憆egulating' acupuncture therapy for cognitive dysfunction in rats with ischemia. For this purpose, we used the middle cerebral artery occlusion (MCAO) method to induce cognitive dysfunction in rats. The behavioral changes in the rats were examined using the Morris water maze (MWM) test. The effects of the treatment on oxidative stress response and the function of the mitochondria in brain tissues were also assessed. The results revealed that 'governor vessel鈥憉nblocking and mind鈥憆egulating' acupuncture therapy markedly improved the cognitive ability of the rats with cognitive dysfunction. The production of pro鈥憃xidative stress factors, including nitric oxide (NO) and inducible nitric oxide synthase (iNOS), was also blocked along with the amelioration of cognitive function, while the production of adenosine triphosphate (ATP), superoxide dismutase (SOD) and cyclooxygenase (COX) was restored. At the molecular level, the accumulation of amyloid beta (Abeta) in the mitochondria was suppressed by 'governor vessel鈥憉nblocking and mind鈥憆egulating' acupuncture therapy, which may be attributed to the inhibition of the function of translocase of outer mitochondrial membrane 40 (TOMM40) and translocase of inner mitochondrial membrane 17A (TIMM17A). On the whole, the findings of the present study confirm the effects of 'governor vessel鈥憉nblocking and mind鈥憆egulating' acupuncture therapy on cognitive dysfunction induced by brain ischemia in rats, and that the mechanisms underlying the effects of this treatment might be mediated through the inhibition of TOMM40 and TIMM17A synthesis, which can relieve mitochondrial dysfunction from the accumulation of Abeta."

Evidence Sentence: At the molecular level, the accumulation of amyloid beta (Abeta) in the mitochondria was suppressed by 'governor vessel-unblocking and mind-regulating' acupuncture therapy, which may be attributed to the inhibition of the function of translocase of outer mitochondrial membrane 40 (TOMM40) and translocase of inner mitochondrial membrane 17A (TIMM17A).
Evidence Sentence: On the whole, the findings of the present study confirm the effects of 'governor vessel-unblocking and mind-regulating' acupuncture therapy on cognitive dysfunction induced by brain ischemia in rats, and that the mechanisms underlying the effects of this treatment might be mediated through the inhibition of TOMM40 and TIMM17A synthesis, which can relieve mitochondrial dysfunction from the accumulation of Abeta.
Evidence Sentence: 'governor vessel-unblocking and mind-regulating' acupunc- ture therapy downregulates the expression of TOMM40 and TIMM17A
Evidence Sentence: In the current study, the theory was taken one step further by focusing on the mediators of Abeta, including TOMM40 and TIMM17A.
Evidence Sentence: As illustrated by immunochemical detection, following the establishment of the cognitive dysfunction model, the production and distribution of TOMM40, TIMM17A and Abeta were all increased in the rat brain tissues (Fig.
Evidence Sentence: Apart from the quantification of the expression of TOMM40, TIMM17A and COX, the following two assays also detected the precursor of Abeta and APP.
Evidence Sentence: Given the effects of 'governor vessel-unblocking and mind-regulating' acupuncture therapy on TOMM40 and TIMM17A expression, representing its potential for modulating the influx of Abeta into the mitochondria, the effects of 'governor vessel-unblocking and mind-regulating' acupuncture therapy on the transition between Abeta and APP may also infer the function of 'governor vessel-unblocking and mind-regulating' acupuncture therapy to restrict the synthesis of Abeta as well.