Detail information
ID ENCL000001
Year 2023
Disease Osteoarthritis, Knee
Surgery Arthroplasty, Replacement, Knee
Acupoint
Acupoint Code
Zusanli ST36
Yinlingquan SP9
Yanglingquan GB34
Futu ST32
Side at the surgical limb
Description Futu (Stomach 32, ST32), Zusanli (Stomach 36, ST36), Yinlingquan (Spleen 9, SP9), and Yanglingquan (Gall Bladder 34, GB34)
Experimental Description Forty patients with postoperative acute pain were recruited and randomly divided electroacupuncture group (n=20) and sham‐acupuncture group (n=20)
Sample Count 40
Age 60-80
Control
Sham
sham acupuncture group(n=20)
Experiment electroacupuncture group(n=20)
Indicator Numeric rating scale(NRS) Zung Self-Rating Depression Scale(SDS) score Rs-fMRI
Auxiliary Medication Nonsteroidal anti-inflammatory
Stimulation Method EA
Induction Method
Electroacupuncture Instrument Model Manufacturer Frequency Waveform Strength Induction Time
Hwato SDZ-II Hwato,Suzhou Medical Appliances Co., Ltd., Suzhou, China 2 Hz continuous wave 1-5 mA 20 min

Acupuncture_Needle Needle_Manufacturer Needle_Depth
0.25×40 mm - 20-35 mm

Description After skin disinfection, sterile adhesive pads were placed on ST32, ST36, SP9, and GB34, and the sterile disposable acupuncture needles (0.25 mm diameter, 40 mm length, stainless steel) were inserted through the adhesive pads approximately 20–35 mm in to the skin, depending on the thickness of the local tissues. The inserted needles were moved until the “Deqi” sensation (a composite of sensations including soreness, numbness, distention, heaviness) was achieved without causing a sharp pain. Then the needles, which were connected to an EA machine (SDZ‐II, Huatuo, Suzhou, China), with a pair of electrodes connecting GB 34 with ST 32, and another pair of electrodes connecting ST36 to SP9 (Zhong et al., 2019), put through a continuous wave of 2 Hz and 1 to 5 mA current intensity into the skin. The electric stimulation was enhanced gradually to the highest tolerable level for the patient without causing pain, and retained for 20 min.
Anesthesia Method
GA
Clinical Trial Type randomized, single‐blind, and sham‐acupuncture controlled study.
Adverse Effects No skin ulcer, hematoma, infection, liver or kidney injury, or other adverse events was observed.
Effector EA reduced pain intensity and depression tendency after TKA. The analgesia effect of EA may be achieved through regulating the plasticity of brain functional activities. EA relieves acute pain after TKA by increasing right cuneus, right angular gyrus, bilateral MOG, left MTG, and precuneus functional activity.
Positive
Literature
PMID 36749304
Title Electroacupuncture alleviates pain after total knee arthroplasty through regulating neuroplasticity: A resting-state functional magnetic resonance imaging study.
Abstract INTRODUCTION: We aimed to evaluate the efficacy of electroacupuncture in relieving acute pain after total knee arthroplasty (TKA) and related mechanism. METHODS: In this randomized, single-blind, and sham-acupuncture controlled study. Forty patients with postoperative acute pain were recruited and randomly divided electroacupuncture group (n = 20) and sham-acupuncture group (n = 20) from November 2020 to October 2021. All patients received electroacupuncture or sham-acupuncture for 5 days after TKA. Their brain regions were scanned with resting-state functional magnetic resonance imaging before and after intervention. Pain was scaled. Another 40 matched healthy controls underwent scanning once. The amplitude of low-frequency fluctuation (ALFF) values was compared. Pearson's correlation analysis was utilized to explore the correlation of ALFF with clinical variables in patients after intervention. RESULTS: Compared with the HCs, patients with acute pain following TKA had significantly decreased ALFF value in right middle frontal gyrus, right supplementary motor area, bilateral precuneus, right calcarine fissure and surrounding cortex, and left triangular part of inferior frontal gyrus (false discovery rate corrected p < .05). Patients had higher ALFF value in bilateral precuneus, right cuneus, right angular gyrus, bilateral middle occipital gyrus, and left middle temporal gyrus after electroacupuncture (AlphaSim corrected p < .01). Correlation analysis revealed that the change (postoperative day 7 to postoperative day 3) of ALFF in bilateral precuneus were negatively correlated with the change of NRS scores (r = -0.706; p = .002; 95% CI = -0.890 to -0.323) in EA group. CONCLUSIONS: The functional activities of related brain regions decreased in patients with acute pain after TKA. The enhancement of the functional activity of precuneus may be the neurobiological mechanism of electroacupuncture in treating pain following TKA."
Souce Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7.