Description bilateral Feishu (BL13), Hegu (L14), and Zusanli (ST36)
Experimental Description
Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS.
Sample Count
144
Age
≥18
Control
Sham
sham TEAS group(n=72)
Experiment
TEAS group(n=72)
Indicator
NK cellTNF-αIL-6Mean arterial pressure(MAP)Heart rate(HR)HypoxemiaPostoperative Nausea and Vomiting(PONV)Duration of hospital stay
Auxiliary Medication
Anesthesia induction was initiated by experienced anesthesiologists with 0.1 mg/kg midazolam, 4 μg/kg fentanyl, 0.4 mg/kg etomidate, and 0.6 mg/kg rocuronium.
Stimulation Method
TEAS
Induction Method
Electroacupuncture Instrument Model
Manufacturer
Frequency
Waveform
Strength
Induction Time
HANS LH-202
Nanjing Jisheng Medical Technology Co., Ltd., Nanjing, Jiangsu, China
2/100 Hz
dilatational wave
5-30 mA;5 -10 mA (upper limb);10-30 mA (lower limbs and trunk)
continuously throughout the procedure
Acupuncture_Needle
Needle_Manufacturer
Needle_Depth
-
-
-
Description The TEAS was maintained continuously throughout the procedure with a dilatational wave at a frequency of 2/100 Hz.16 The intensity of the current ranged from 5 to 30 mA for TEAS, from 5 to 10mA for the upper limbs, and from 10 to 30 mA for the lower limbs and trunk.17?The presence of?de qi?sensation was used to establish the efficacy of the acupoint stimulation.
Anesthesia Method
AAA
Clinical Trial Type
random
Effector
The quantities of NK cells were decreased in group sham TEAS after intubation compared to that in group TEAS, while the quantities of NK cells in group TEAS were similar at T0?to T5. Meanwhile, the quantities of NK cells in group sham TEAS at T1 (P = .012), T2 (P < .001), T3 (P = .027), T4 (P = .045), and T5 (P = .021) were lower than those in group TEAS. In group TEAS, the serum levels of TNF-α were lower at T1 to T5, while the levels of IL-6 were lower at T2 to T5. Furthermore, the intraoperative MAP and HR were more stable, the total propofol and remifentanil consumptions were lower, and the length of hospital stay was shorter than those in group sham TEAS. The application of TEAS can effectively reverse the decrease in NK cells, decrease the serum levels of TNF-α and IL-6, maintain hemodynamic stability during the perioperative period, decrease the consumption of propofol and remifentanil, and shorten the length of the hospital stay.
Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy.
Abstract
The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS. TEAS on bilateral Feishu (BL13), Hegu (L14), and Zusanli (ST36) was performed continuously throughout the procedure. The primary outcome was the quantities of natural killer (NK) cells at 30 minutes before induction (T(0)), 5 minutes after intubation (T(1)), at the beginning of the operation (T(2)), at the beginning of the lobectomy (T(3)), at the beginning of the lymphadenectomy (T(4)), and immediately after extubation (T(5)). The secondary outcomes were the serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) at T(0) to T(5), the mean arterial pressure (MAP) and heart rate (HR), the intraoperative consumption of propofol and remifentanil, the incidence of hypoxemia, postoperative nausea and vomiting (PONV), and the length of hospital stay. The quantities of NK cells were decreased in group sham TEAS after intubation compared to that in group TEAS, while the quantities of NK cells in group TEAS were similar at T(0) to T(5). Meanwhile, the quantities of NK cells in group sham TEAS at T(1) ( P = .012), T(2) ( P < .001), T(3) ( P = .027), T(4) ( P = .045), and T(5) ( P = .021) were lower than those in group TEAS. In group TEAS, the serum levels of TNF-alpha were lower at T(1) to T(5), while the levels of IL-6 were lower at T(2) to T(5). Furthermore, the intraoperative MAP and HR were more stable, the total propofol and remifentanil consumptions were lower, and the length of hospital stay was shorter than those in group sham TEAS. The application of TEAS can effectively reverse the decrease in NK cells, decrease the serum levels of TNF-alpha and IL-6, maintain hemodynamic stability during the perioperative period, decrease the consumption of propofol and remifentanil, and shorten the length of the hospital stay."
Souce
Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477.
