Description bilateral acupuncture points like Neiguan, Zhigou, Houxi, Hegu
Experimental Description
A total of 110 patients undergoing pneumonectomy were randomly divided into group A and group B, with 55 cases in each group. Group A was treated with combined 2Hz acupuncture anesthesia, while group B was treated with combined 2Hz/100Hz acupuncture anesthesia.
Sample Count
110
Control
Freq
treated with combined 2Hz acupuncture anesthesia(n=55)
Experiment
treated with combined 2Hz/100Hz acupuncture anesthesia(n=55)
Indicator
Propofol and fentanyI dosageHeart rate(HR)Systolic blood pressure(SBP)IL-4IL-10Visual analog scale(VAS)
Auxiliary Medication
For intravenous combined general anesthesia, provide intravenous infusion of 1-2 mg/Kg propofol during general anesthesia which was intraoperatively maintained at 3-6 mg/Kg/h, intravenous infusion of 5 ug/Kg fentanyI which was intraoperatively maintained at 2-5 ug/Kg/hour, intravenous infusion of 0.05 mg/Kg midazolam, 0.1 mg/Kg vecuronium bromide which was maintained intraoperatively at 0.05 mg/Kg/h. The speed was maintained at the level set by the infusion pump until the surgery ends.
Stimulation Method
EA
Induction Method
Electroacupuncture Instrument Model
Manufacturer
Frequency
Waveform
Strength
Induction Time
HANS
-
2 Hz(Group A);2/100 Hz(Group B)
-
-
30 min
Acupuncture_Needle
Needle_Manufacturer
Needle_Depth
-
-
-
Description Group A was treated with combined 2Hz acupuncture anesthesia. For the specific method, for bilateral acupuncture points like Neiguan, Zhigou, Houxi, Hegu, nerve Han's acupuncture point stimulator was selected for electro-acupuncture, with frequency adjusted to 2Hz. After acupuncture insertion, electro-acupuncture was joined at the needle handle by mild reinforcing-attenuating, with current intensity adjusted based on the patient's pain degree; electro-acupuncture stimulation was maintained by venous induction 30 minutes later. Group B was treated with combined 2Hz/100Hz acupuncture anesthesia. Han's acupoint stimulator was alternately applied at frequencies of 2Hz and 100Hz.
Anesthesia Method
AAA
Clinical Trial Type
A randomised controlled trial (RCT)
Contraindications
With skin infections on the meridian points
Effector
There was no statistically significant difference between group A and group B in the intraoperative additional propofol and fentanyl dosags (p=0.541 and 0.719, respectively). There is no statistical difference in heart rate and systolic blood pressure between group A and group B at 5 minutes before and during extubation (p=0.151, 0.660 and 0.734, 0.528, respectively). There is no statistical difference between group A and group B in serum IL-4 and IL-10 levels 10 minutes after surgical incision (p=0.916 and 0.841, respectively). However, serum IL-4 and IL-2 levels in group A are statistically lower than that of group B at 24 hours after surgery (all p<0.001). The VAS score at 24 hours after surgery in group A was 2.44 ±0.71 points, which was significantly lower than that of group B (3.82 ±0.77 points, p<0.001). Combined 2 Hz, 2 Hz/100 Hz acupuncture anesthesia need few anesthetic dosages of propofol and fentanyl to stabilise the patient's blood pressure and heart rate when intubated under general anesthesia; but combined 2 Hz acupuncture anesthesia can reduce IL-4 and IL-10 levels during surgery stress to a greater extent than the latter, and can effectively lower patients' serum IL-4, IL-10 expression after surgery.
"Effect of Combined Acupuncture Anesthesia on Surgical Dosage and Serum IL-4, IL-10 of Pneumonectomy Patients."
Abstract
OBJECTIVE: To analyse the effects of combined acupuncture anesthesia on surgical dosage and serum interleukin-4 (IL-4), interleukin-10 (IL-10) of pneumonectomy patients. STUDY DESIGN: A randomised controlled trial (RCT). PLACE AND DURATION OF STUDY: Lanzhou University Second Hospital, Lanzhou, China, from January 2016 to November 2017. METHODOLOGY: A total of 110 patients undergoing pneumonectomy were randomly divided into group A and group B, with 55 cases in each group. Group A was treated with combined 2Hz acupuncture anesthesia, while group B was treated with combined 2Hz/100Hz acupuncture anesthesia. The additional propofol, fentanyl dosage, and changes in heart rate and systolic blood pressure 5 min before and during extubation were compared between the two groups. The serum IL-4 and IL-10 levels were measured 10 minutes after skin incision and 24 hours after surgery using ELISA. Pain was rated by visual analogue scale (VAS) at 24 hours after surgery. RESULTS: There was no statistically significant difference between group A and group B in the intraoperative additional propofol and fentanyl dosags (p=0.541 and 0.719, respectively). There is no statistical difference in heart rate and systolic blood pressure between group A and group B at 5 minutes before and during extubation (p=0.151, 0.660 and 0.734, 0.528, respectively). There is no statistical difference between group A and group B in serum IL-4 and IL-10 levels 10 minutes after surgical incision (p=0.916 and 0.841, respectively). However, serum IL-4 and IL-2 levels in group A are statistically lower than that of group B at 24 hours after surgery (all p<0.001). The VAS score at 24 hours after surgery in group A was 2.44 +/-0.71 points, which was significantly lower than that of group B (3.82 +/-0.77 points, p<0.001). CONCLUSION: Combined 2 Hz, 2 Hz/100 Hz acupuncture anesthesia need few anesthetic dosages of propofol and fentanyl to stabilise the patient's blood pressure and heart rate when intubated under general anesthesia; but combined 2 Hz acupuncture anesthesia can reduce IL-4 and IL-10 levels during surgery stress to a greater extent than the latter, and can effectively lower patients' serum IL-4, IL-10 expression after surgery."
