Ninety patients scheduled spine surgery were randomly assigned into 2 groups using a random number table: control group (group C) and electro-acupuncture group (group EA).
Sample Count
90
Age
>65
Control
Std
control group (group C)(n=45)
Experiment
electro-acupuncture group (group EA)(n=45)
Indicator
IL-6IL-10S100-βTotal dose of remifentanil and propofolMini-mental state examination(MMSE)
Auxiliary Medication
The patients were induced using 0.1 to 2 μg/kg sulfentanil, 0.05 to 0.2 mg/kg midazolam, 0.3 mg/kg etomidate, and 0.6 mg/kg cisatracurium. A reinforced catheter was inserted after 2 minutes of cisatracurium administration. The entire course of anesthesia was maintained using propofol 4 to 6 mg/(kgh) and remifentanil 0.1 to 0.3 μg/(kgmin), which sustained the changing of BP and HR within 20% of the initial levels and the BIS value range from 40 to 60.
Stimulation Method
EA
Induction Method
Electroacupuncture Instrument Model
Manufacturer
Frequency
Waveform
Strength
Induction Time
G6805
SMIF, Shanghai, China
2/15 Hz
sparse-dense wave
1 mA
After entering the operating room, continued until the end of surgery
Acupuncture_Needle
Needle_Manufacturer
Needle_Depth
-
-
-
Description sparse-dense wave (2/15 Hz) and intensity at 1 mA. EA treatment continued until the end of surgery
Anesthesia Method
AAA
Clinical Trial Type
random
Effector
The results showed that compared with group C, score of MMSE increased after surgery, the serum concentration of IL-6, IL-10, and S100β decreased at 1?hour after skin incision, and surgery completed in group EA. Moreover, the total dose of remifentanil and propofol reduced during surgery in group EA. The present study suggests that preconditioning of electro-acupuncture could improve the postoperative cognitive function, and the reduction of inflammatory reaction and brain injury may be involved in the mechanism.
"Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial."
Abstract
Electro-acupuncture is a burgeoning treatment using the needle inserting into the body acupoints and the low-frequency pulse current being electrified by an electric acupuncture machine. This study was designed to evaluate the effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly.Ninety patients scheduled spine surgery were randomly assigned into 2 groups using a random number table: control group (group C) and electro-acupuncture group (group EA). In group EA, electro-acupuncture was applied on Baihui, Dazhui, and Zusanli acupoints 30 minutes before anesthesia. At 0 minute before treatment of electro-acupuncture, 1 hour after skin incision and surgery completed (T1-3), blood samples were taken for detection of interleukin (IL)-6, IL-10, and S100beta by enzyme-linked immunosorbent assay. The total dose of remifentanil and propofol during surgery were recorded. Mini-Mental State Examination was applied to evaluate the cognitive function of patients at 1 day before surgery and 7th and 30th day after surgery.The results showed that compared with group C, score of MMSE increased after surgery, the serum concentration of IL-6, IL-10, and S100beta decreased at 1 hour after skin incision, and surgery completed in group EA. Moreover, the total dose of remifentanil and propofol reduced during surgery in group EA.The present study suggests that preconditioning of electro-acupuncture could improve the postoperative cognitive function, and the reduction of inflammatory reaction and brain injury may be involved in the mechanism."
Souce
Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375.
