Description Fengfu acupoint (Du16) and Fengchi acupoint (GB20)
Experimental Description
A total of 32 patients, who would go through craniocerebral tumor resection under general anesthesia, were randomly assigned to two groups, 16 in each group.
Sample Count
32
Age
18-60
Control
Std
control group(n=16)
Experiment
EA group(n=16)
Indicator
S100-βNeuron-specific enolase(NSE)
Auxiliary Medication
Anesthesia was maintained with remifentanil at the dose of 4-8 mg/kg per hour, pumped intravenous drip of vecuronium at 1.0-2.0 μg/kg each hour, and discontinuous intravenous dripped with vecuronium bromide at 0.5-1 mg.
Stimulation Method
EA
Induction Method
Electroacupuncture Instrument Model
Manufacturer
Frequency
Waveform
Strength
Induction Time
G6805-II
Industrial Co., Ltd. Qingdao Xinsheng
2/15 Hz
Density wave
1-4 mA
30 min
Acupuncture_Needle
Needle_Manufacturer
Needle_Depth
-
-
-
Description The stimulus is 1–4 mA with a density wave frequency of 2/15 Hz.Patients in the EA group underwent 30 min of EA pretreatment.
Anesthesia Method
GA
Clinical Trial Type
random
Contraindications
Patients with liver or renal dysfunction or patients with the operation time more than three hours were excluded
Effector
The serum level of S100β and NSE did not change before skin incision. The serum level of NSE increased significantly and the level of S100β increased insignificantly after the tumor resection. The serum levels of S100β and NSE in the EA group and the control group were 1.16±0.28 μg/L vs 1.47± 0.33 μg/L, 24.7±13.3 μg/L vs 31.4±14.1 μg/L at the end of the operation, respectively. Twenty-four h after operation, the correspondence indices were 1.18±0.31 μg/L vs 1.55±0.26 μg/L, and 25.5±12.4 μg/L vs 32.4± 11.7 μg/L. The two indices at these two time points were significantly increased than those before operation, respectively (P<0.05). At the end of the operation and 24 h post-operation, the serum levels of S100β and NSE in the EA group were significantly lower than those in the control group (P<0.05). Electroacupuncture Fengchi and Fengfu for 30 min before craniocerbral tumor operation could decrease the serum level of S100β and NSE, thus may have potential protective effect on brain damage, which needs to befurther studied.
Effect of electroacupuncture preconditioning on serum S100beta and NSE in patients undergoing craniocerebral tumor resection.
Abstract
OBJECTIVE: To investigate the effect of electroacupuncture preconditioning on the serum level of S100 calcium-binding protein beta (S100beta) and neuron-specific enolase (NSE) in patients undergoing craniocerebral tumor operation. METHODS: A total of 32 patients, who would go through craniocerebral tumor resection under general anesthesia, were randomly assigned to two groups, 16 in each group. Patients in the electroacupuncture (EA) group received electroacupuncture on Fengfu acupoint (Du16) and Fengchi acupoint (GB20) for 30 min, 2 h before operation. The stimulus is 1-4 mA with a density wave frequency of 2/15 Hz. Patients in the control group received no pretreatment. Anesthesia was maintained with remifentanil at the dose of 4-8 mg/kg per hour, pumped intravenous drip of vecuronium at 1.0-2.0 microg/kg each hour, and discontinuous intravenous dripped with vecuronium bromide at 0.5-1 mg. The serum levels of S100beta and NSE were measured with ELISA before operation, before skin incision, after tumor removal, at the end of operation, and at 24 h after operation. RESULTS: The serum level of S100beta and NSE did not change before skin incision. The serum level of NSE increased significantly and the level of S100beta increased insignificantly after the tumor resection. The serum levels of S100beta and NSE in the EA group and the control group were 1.16+/-0.28 microg/L vs 1.47+/- 0.33 microg/L, 24.7+/-13.3 microg/L vs 31.4+/-14.1 microg/L at the end of the operation, respectively. Twenty-four h after operation, the correspondence indices were 1.18+/-0.31 microg/L vs 1.55+/-0.26 microg/L, and 25.5+/-12.4 microg/L vs 32.4+/- 11.7 microg/L. The two indices at these two time points were significantly increased than those before operation, respectively (P<0.05). At the end of the operation and 24 h post-operation, the serum levels of S100beta and NSE in the EA group were significantly lower than those in the control group (P<0.05). CONCLUSION: Electroacupuncture Fengchi and Fengfu for 30 min before craniocerbral tumor operation could decrease the serum level of S100beta and NSE, thus may have potential protective effect on brain damage, which needs to be further studied."
