Description The incisor of upper jaw : introduction of needle from 'Shuigou' (1/3 below the lower edge of nasal septum) to 'Yingxiang' (nasolabial sulcus), 'Sibai' (infraorbital block point).
The canine of upper jaw ; introduction of needle from 'Shuigou' to 'Yingxiang', 'Quanliao' (block point of mandibular nerve) .
The premolar of upper jaw : 'Xiaguan' (lower border or zygomatic arch, block point of maxillary nerve), 'Quanliao'. The molar of upper jaw : 'Quanliao', 'Jiache' (1cm before the mandible).
The incisor of lower jaw : 'Chenhjiang' (middle of mentolabial sulcus, on the median line), 'Jiache', 'Yidian' (block point of mental nerve).
The canine of lower jaw : introduction of needle from 'Chengjiang' to 'Daying' (concave area of the mandible), 'jiache'.
The premolar of upper jaw : *Chengjiang', 'Jiache'.
The molar of lower jaw : 'Chengjiang', 'Jiache', 'Xiaquan'.
In addition, 'Hegu' (between the lower edges of the 1st and2nd metacarpal bone, which is considered to have a great effect of raising pain threshold of the neck and head, was always selected bilaterally.
Experimental Description
DPA was administered orally to 18 patients 30 minutes before AA. This group consisted of 8 males and 10 females, and their mean age was 46.3 years. The dose of DPA was 2.0g for 6 and 4.0g for 12 patients. On the other hand, placebo(4.0g) was administered orally to 38 patients 30 minutes before AA. In this group there were 20 males and 18 females, and their mean age was 42.3 years.
Sample Count
56
Age
mean age was 42.3
Control
Placebo
placebo+AA(n=38)
Experiment
DPA+AA(n=18)
Indicator
Analgesic effect
Auxiliary Medication
DPA was administered orally to 18 patients 30 minutes before AA. When the analgesic effect of AA was insufficient, a local anesthetic, Xylocaine, was infiltrated around the tooth to be extracted.
Stimulation Method
EA
Induction Method
Electroacupuncture Instrument Model
Manufacturer
Frequency
Waveform
Strength
Induction Time
LAUS-MX 1001 unit
Nihon Medix
3 Hz
two-direction exponential wave
6 V;17 mA
30 min
Acupuncture_Needle
Needle_Manufacturer
Needle_Depth
50×0.28 mm
Seirin Kasei
15 mm
Description A 50mm No.28 needle (stainless steel, 50mm in length and 0.28mm in diameter, by Seirin Kasei) was inserted deep (about 15mm) in these meridian points and low frequency electricity (3 Herz, two-direction exponential waves, continuous application system) was applied after "needle echo sensation" was obtained. This needle was slightly thicker than that for therapy. The low frequency apparatus used was an LAUS-MX 1001 unit (Nihon Medix [phonetic] ). The amount of electricity was raised to the maximum which the patients could bear. After the start of electric conduction, the output was raised gradually when the patient became used to the conditions. Tooth extraction was begun after electricity was conducted for about 30 minutes.The electricity was continuously conducted also during the operation. The mean voltage was about 6 Vp-p and electric current 17mAp-p.
Anesthesia Method
AAA
Clinical Trial Type
randomly
Effector
In the "placebo + AA" group, the results were excellent in 8 (218), good in 8 (21%), fair in 17 (45%) and poor in 5 (138) among 38 patients. In contrast, with the "DPA + AA" group those who showed the corresponding results were 8(44%), 6(33%), 3(17%) and 1 (68). respectively, among 18 patients. Excellent cases were increased 23%, good ones 12% and poor ones were decreased 7%. When "excellent and good" cases in the 2 groups were compared, the effect of acupuncture therapy was increased 35% in the DPA administration group. This was statistically significant (P<0.01).
Studies on the enhanced effect of acupuncture analgesia and acupuncture anesthesia by D-phenylalanine (2nd report)--schedule of administration and clinical effects in low back pain and tooth extraction.
Abstract
D-phenylalanine (DPA) is known to block the activity of carboxypeptidase, an enzyme which degrades enkephalins, endogenous morphine-like substances. Therefore, it is considered that DPA administered as an inhibiting drug of this degrading enzyme might prolong analgesia induced by acupuncture. 1) Thirty patients suffering from chronic low back pain were treated with acupuncture 30 minutes after the oral administration of 4.0 grams of DPA. The results were: excellent in 7 cases, good in 11, fair in 6 and poor in 6. Cases graded excellent and good were then compared with a placebo group. The effect was increased 26% in the DPA-acupuncture group, which shows no statistically significant difference (P less than 0.1). 2) In 56 patients, tooth extraction was performed under acupuncture anesthesia: 18 had received 4.0 gram of DPA (P.O.) 30 minutes earlier. The results were excellent in 8, good in 6, fair in 3, and poor in 1. The excellent and good cases were compared with 38 placebo group cases. The effect in the DPA-acupuncture anesthesia group was significantly increased by 35% (P less than 0.01). 3) In order to determine the optimum time for the administration of DPA, two schedules of administration were compared. [1] DPA was given on the previous day in three 0.5 gram doses (26 cases). [2] A single 4 gram dose was administered 30 minutes before treatment (30 cases). The results from the ""excellent"", ""good"" and ""fair"" cases showed a 16% increase in effectiveness when DPA was administered the day before, not a statistically significant difference (P less than 0.1), but a clear tendency to increase was observed. The above findings show that DPA has an enhancing effect on acupuncture analgesia and anesthesia in clinical practice."
