Gene symbol: Naip6

Also known as: Naip; Birc1; Naip2; Birc1a; Birc1b

Organism: Rattus norvegicus

Summary: Predicted to enable ATP binding activity. Involved in response to amino acid and response to axon injury. Located in cytoplasm; neuron projection; and perikaryon. Biomarker of brain ischemia. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 191568 Ensembl:ENSRNOG00000033693 AllianceGenome:RGD:621281


GO Annotation


Category Term ID Term description
Process GO:0001101 Response to acid chemical
Process GO:0001959 Regulation of cytokine-mediated signaling pathway
Process GO:0001960 Negative regulation of cytokine-mediated signaling pathway
Process GO:0002376 Immune system process
Process GO:0006915 Apoptotic process
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0006954 Inflammatory response
Process GO:0006955 Immune response
Process GO:0008219 Cell death
Process GO:0009595 Detection of biotic stimulus
Process GO:0009605 Response to external stimulus
Process GO:0009607 Response to biotic stimulus
Process GO:0009611 Response to wounding
Process GO:0009617 Response to bacterium
Process GO:0009719 Response to endogenous stimulus
Process GO:0009725 Response to hormone
Process GO:0009892 Negative regulation of metabolic process
Process GO:0009966 Regulation of signal transduction
Process GO:0009967 Positive regulation of signal transduction
Process GO:0009968 Negative regulation of signal transduction
Process GO:0009987 Cellular process
Process GO:0010033 Response to organic substance
Process GO:0010243 Response to organonitrogen compound
Process GO:0010466 Negative regulation of peptidase activity
Process GO:0010605 Negative regulation of macromolecule metabolic process
Process GO:0010646 Regulation of cell communication
Process GO:0010647 Positive regulation of cell communication
Process GO:0010648 Negative regulation of cell communication
Process GO:0010803 Regulation of tumor necrosis factor-mediated signaling pathway
Process GO:0010804 Negative regulation of tumor necrosis factor-mediated signaling pathway
Process GO:0010941 Regulation of cell death
Process GO:0010951 Negative regulation of endopeptidase activity
Process GO:0012501 Programmed cell death
Process GO:0016045 Detection of bacterium
Process GO:0019222 Regulation of metabolic process
Process GO:0023051 Regulation of signaling
Process GO:0023056 Positive regulation of signaling
Process GO:0023057 Negative regulation of signaling
Process GO:0030162 Regulation of proteolysis
Process GO:0032870 Cellular response to hormone stimulus
Process GO:0032872 Regulation of stress-activated MAPK cascade
Process GO:0032874 Positive regulation of stress-activated MAPK cascade
Process GO:0042221 Response to chemical
Process GO:0042742 Defense response to bacterium
Process GO:0042981 Regulation of apoptotic process
Process GO:0043066 Negative regulation of apoptotic process
Process GO:0043067 Regulation of programmed cell death
Process GO:0043069 Negative regulation of programmed cell death
Process GO:0043086 Negative regulation of catalytic activity
Process GO:0043154 Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Process GO:0043200 Response to amino acid
Process GO:0043207 Response to external biotic stimulus
Process GO:0043281 Regulation of cysteine-type endopeptidase activity involved in apoptotic process
Process GO:0043408 Regulation of MAPK cascade
Process GO:0043410 Positive regulation of MAPK cascade
Process GO:0043627 Response to estrogen
Process GO:0044092 Negative regulation of molecular function
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0045087 Innate immune response
Process GO:0045861 Negative regulation of proteolysis
Process GO:0046328 Regulation of JNK cascade
Process GO:0046330 Positive regulation of JNK cascade
Process GO:0048518 Positive regulation of biological process
Process GO:0048519 Negative regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048523 Negative regulation of cellular process
Process GO:0048583 Regulation of response to stimulus
Process GO:0048584 Positive regulation of response to stimulus
Process GO:0048585 Negative regulation of response to stimulus
Process GO:0048678 Response to axon injury
Process GO:0050789 Regulation of biological process
Process GO:0050790 Regulation of catalytic activity
Process GO:0050794 Regulation of cellular process
Process GO:0050896 Response to stimulus
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051172 Negative regulation of nitrogen compound metabolic process
Process GO:0051246 Regulation of protein metabolic process
Process GO:0051248 Negative regulation of protein metabolic process
Process GO:0051336 Regulation of hydrolase activity
Process GO:0051346 Negative regulation of hydrolase activity
Process GO:0051606 Detection of stimulus
Process GO:0051707 Response to other organism
Process GO:0051716 Cellular response to stimulus
Process GO:0052547 Regulation of peptidase activity
Process GO:0052548 Regulation of endopeptidase activity
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060548 Negative regulation of cell death
Process GO:0060759 Regulation of response to cytokine stimulus
Process GO:0060761 Negative regulation of response to cytokine stimulus
Process GO:0065007 Biological regulation
Process GO:0065009 Regulation of molecular function
Process GO:0070269 Pyroptosis
Process GO:0070302 Regulation of stress-activated protein kinase signaling cascade
Process GO:0070304 Positive regulation of stress-activated protein kinase signaling cascade
Process GO:0070887 Cellular response to chemical stimulus
Process GO:0071310 Cellular response to organic substance
Process GO:0071391 Cellular response to estrogen stimulus
Process GO:0071495 Cellular response to endogenous stimulus
Process GO:0080090 Regulation of primary metabolic process
Process GO:0080134 Regulation of response to stress
Process GO:0080135 Regulation of cellular response to stress
Process GO:0098542 Defense response to other organism
Process GO:0098543 Detection of other organism
Process GO:0098581 Detection of external biotic stimulus
Process GO:1901698 Response to nitrogen compound
Process GO:1901700 Response to oxygen-containing compound
Process GO:1902531 Regulation of intracellular signal transduction
Process GO:1902533 Positive regulation of intracellular signal transduction
Process GO:2000116 Regulation of cysteine-type endopeptidase activity
Process GO:2000117 Negative regulation of cysteine-type endopeptidase activity
Component GO:0005622 Intracellular anatomical structure
Component GO:0005737 Cytoplasm
Component GO:0005829 Cytosol
Component GO:0032991 Protein-containing complex
Component GO:0036477 Somatodendritic compartment
Component GO:0042995 Cell projection
Component GO:0043005 Neuron projection
Component GO:0043025 Neuronal cell body
Component GO:0043204 Perikaryon
Component GO:0044297 Cell body
Component GO:0061702 Inflammasome complex
Component GO:0072557 IPAF inflammasome complex
Component GO:0110165 Cellular anatomical entity
Component GO:0120025 Plasma membrane bounded cell projection
Function GO:0000166 Nucleotide binding
Function GO:0004857 Enzyme inhibitor activity
Function GO:0004866 Endopeptidase inhibitor activity
Function GO:0004869 Cysteine-type endopeptidase inhibitor activity
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0005524 ATP binding
Function GO:0017076 Purine nucleotide binding
Function GO:0019899 Enzyme binding
Function GO:0019900 Kinase binding
Function GO:0019901 Protein kinase binding
Function GO:0030234 Enzyme regulator activity
Function GO:0030414 Peptidase inhibitor activity
Function GO:0030554 Adenyl nucleotide binding
Function GO:0032553 Ribonucleotide binding
Function GO:0032555 Purine ribonucleotide binding
Function GO:0032559 Adenyl ribonucleotide binding
Function GO:0035639 Purine ribonucleoside triphosphate binding
Function GO:0036094 Small molecule binding
Function GO:0043027 Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Function GO:0043028 Cysteine-type endopeptidase regulator activity involved in apoptotic process
Function GO:0043167 Ion binding
Function GO:0043168 Anion binding
Function GO:0043169 Cation binding
Function GO:0046872 Metal ion binding
Function GO:0061134 Peptidase regulator activity
Function GO:0061135 Endopeptidase regulator activity
Function GO:0097159 Organic cyclic compound binding
Function GO:0097367 Carbohydrate derivative binding
Function GO:0098772 Molecular function regulator activity
Function GO:0120283 Protein serine/threonine kinase binding
Function GO:1901265 Nucleoside phosphate binding
Function GO:1901363 Heterocyclic compound binding

Pathway annotation


Category Term ID Term description
KEGG rno04621 NOD-like receptor signaling pathway
KEGG rno05132 Salmonella infection
KEGG rno05134 Legionellosis

Expression profile of Naip6 in omics data



ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.761264303
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.918983324
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.805251684
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.636697321
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.859869671
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 4.154224488

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.964232
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.15086
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.001737
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.299379
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.059505
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.459046

ID GSE2982
Title Effect of inhaled anesthetic to cultured cortical neurons
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM61779 Cell Culture Exposure (control1) Cy3 label;Cy5; 0.0379
GSM61796 Cell Culture Exposure (control2) Cy3; Cy5 0.126
GSM61797 Cell Culture Exposure (control3) Cy3; Cy5 -0.0736
GSM61798 Cell Culture Exposure (1MAC Halo1) Cy3; Cy5 0.191
GSM61799 Cell Culture Exposure (1MAC Halo2) Cy3; Cy5 0.116
GSM61800 Cell Culture Exposure (1MAC Halo3) Cy3; Cy5 0.0499
GSM61801 Cell Culture Exposure (3MAC Halo1) Cy3; Cy5 0.000389
GSM61802 Cell Culture Exposure (3MAC Halo2) Cy3; Cy5 0.0375
GSM61803 Cell Culture Exposure (3MAC Halo3) Cy3; Cy5 0.153
GSM61804 Cell Culture Exposure (3MAC ISO1) Cy3; Cy5 0.00966
GSM61805 Cell Culture Exposure (3MAC ISO2) Cy3; Cy5 -0.334
GSM61806 Cell Culture Exposure (3MAC ISO3) Cy3; Cy5 0.209