Gene symbol: mt-Co2

Also known as: COII; COX2

Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)

Summary: Predicted to enable copper ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Involved in several processes, including lactation; positive regulation of cellular biosynthetic process; and positive regulation of necrotic cell death. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Biomarker of colorectal carcinoma and type 2 diabetes mellitus. Orthologous to several human genes including MTCO2P12 (MT-CO2 pseudogene 12). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 26198 AllianceGenome:RGD:621872


Pathway annotation


Category Term ID Term description
KEGG rno00190 Oxidative phosphorylation
KEGG rno01100 Metabolic pathways
KEGG rno04260 Cardiac muscle contraction
KEGG rno04714 Thermogenesis
KEGG rno04932 Non-alcoholic fatty liver disease
KEGG rno05010 Alzheimer disease
KEGG rno05012 Parkinson disease
KEGG rno05014 Amyotrophic lateral sclerosis
KEGG rno05016 Huntington disease
KEGG rno05020 Prion disease
KEGG rno05022 Pathways of neurodegeneration - multiple diseases
KEGG rno05208 Chemical carcinogenesis - reactive oxygen species
KEGG rno05415 Diabetic cardiomyopathy