Gene symbol: Atxn7l3

Also known as: RGD1311493

Organism: Rattus norvegicus

Summary: Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in protein modification by small protein conjugation or removal and regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of DUBm complex and SAGA complex. Orthologous to human ATXN7L3 (ataxin 7 like 3). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 287734 Ensembl:ENSRNOG00000020930 AllianceGenome:RGD:1311493


GO Annotation


Category Term ID Term description
Process GO:0006325 Chromatin organization
Process GO:0006355 Regulation of transcription, DNA-templated
Process GO:0006357 Regulation of transcription by RNA polymerase II
Process GO:0006473 Protein acetylation
Process GO:0006475 Internal protein amino acid acetylation
Process GO:0006508 Proteolysis
Process GO:0006513 Protein monoubiquitination
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006996 Organelle organization
Process GO:0008152 Metabolic process
Process GO:0009889 Regulation of biosynthetic process
Process GO:0009891 Positive regulation of biosynthetic process
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009987 Cellular process
Process GO:0010390 Histone monoubiquitination
Process GO:0010468 Regulation of gene expression
Process GO:0010556 Regulation of macromolecule biosynthetic process
Process GO:0010557 Positive regulation of macromolecule biosynthetic process
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0016043 Cellular component organization
Process GO:0016567 Protein ubiquitination
Process GO:0016570 Histone modification
Process GO:0016573 Histone acetylation
Process GO:0016574 Histone ubiquitination
Process GO:0016578 Histone deubiquitination
Process GO:0016579 Protein deubiquitination
Process GO:0018193 Peptidyl-amino acid modification
Process GO:0018205 Peptidyl-lysine modification
Process GO:0018393 Internal peptidyl-lysine acetylation
Process GO:0018394 Peptidyl-lysine acetylation
Process GO:0019219 Regulation of nucleobase-containing compound metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019538 Protein metabolic process
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031325 Positive regulation of cellular metabolic process
Process GO:0031326 Regulation of cellular biosynthetic process
Process GO:0031328 Positive regulation of cellular biosynthetic process
Process GO:0032446 Protein modification by small protein conjugation
Process GO:0035520 Monoubiquitinated protein deubiquitination
Process GO:0035521 Monoubiquitinated histone deubiquitination
Process GO:0035522 Monoubiquitinated histone H2A deubiquitination
Process GO:0036211 Protein modification process
Process GO:0043170 Macromolecule metabolic process
Process GO:0043412 Macromolecule modification
Process GO:0043543 Protein acylation
Process GO:0043966 Histone H3 acetylation
Process GO:0044238 Primary metabolic process
Process GO:0045893 Positive regulation of transcription, DNA-templated
Process GO:0045935 Positive regulation of nucleobase-containing compound metabolic process
Process GO:0048518 Positive regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051173 Positive regulation of nitrogen compound metabolic process
Process GO:0051252 Regulation of RNA metabolic process
Process GO:0051254 Positive regulation of RNA metabolic process
Process GO:0051276 Chromosome organization
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0065007 Biological regulation
Process GO:0070646 Protein modification by small protein removal
Process GO:0070647 Protein modification by small protein conjugation or removal
Process GO:0071704 Organic substance metabolic process
Process GO:0071840 Cellular component organization or biogenesis
Process GO:0080090 Regulation of primary metabolic process
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1902680 Positive regulation of RNA biosynthetic process
Process GO:1903506 Regulation of nucleic acid-templated transcription
Process GO:1903508 Positive regulation of nucleic acid-templated transcription
Process GO:2001141 Regulation of RNA biosynthetic process
Component GO:0000123 Histone acetyltransferase complex
Component GO:0000124 SAGA complex
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005654 Nucleoplasm
Component GO:0031248 Protein acetyltransferase complex
Component GO:0031974 Membrane-enclosed lumen
Component GO:0031981 Nuclear lumen
Component GO:0032991 Protein-containing complex
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0043233 Organelle lumen
Component GO:0070013 Intracellular organelle lumen
Component GO:0070461 SAGA-type complex
Component GO:0071819 DUBm complex
Component GO:0110165 Cellular anatomical entity
Component GO:0140513 Nuclear protein-containing complex
Component GO:0140535 Intracellular protein-containing complex
Component GO:1902493 Acetyltransferase complex
Component GO:1902494 Catalytic complex
Component GO:1905368 Peptidase complex
Component GO:1990234 Transferase complex
Function GO:0003712 Transcription coregulator activity
Function GO:0003713 Transcription coactivator activity
Function GO:0005488 Binding
Function GO:0008270 Zinc ion binding
Function GO:0030374 Nuclear receptor coactivator activity
Function GO:0043167 Ion binding
Function GO:0043169 Cation binding
Function GO:0046872 Metal ion binding
Function GO:0046914 Transition metal ion binding
Function GO:0140110 Transcription regulator activity

Expression profile of Atxn7l3 in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 3.6157901
GSM2685202 MX2 tissue: Myocardium gender: female 2.8486967
GSM2685203 MX3 tissue: Myocardium gender: female 3.6983094
GSM2685204 MX4 tissue: Myocardium gender: male 4.3118887
GSM2685205 DZ1 tissue: Myocardium gender: male 3.6004355
GSM2685206 DZ2 tissue: Myocardium gender: male 3.5008464
GSM2685207 DZ3 tissue: Myocardium gender: female 3.7216942
GSM2685208 DZ4 tissue: Myocardium gender: female 4.4274564
GSM2685209 JJ1 tissue: Myocardium gender: male 4.4133267
GSM2685210 JJ2 tissue: Myocardium gender: female 2.978376
GSM2685211 JJ3 tissue: Myocardium gender: female 3.335656
GSM2685212 JJ4 tissue: Myocardium gender: male 3.7413216
GSM2685213 NG1 tissue: Myocardium gender: male 4.0926843
GSM2685214 NG2 tissue: Myocardium gender: female 3.2248447
GSM2685215 NG3 tissue: Myocardium gender: male 3.1797411
GSM2685216 NG4 tissue: Myocardium gender: female 3.8522232
GSM2685217 YL1 tissue: Myocardium gender: male 3.8402984
GSM2685218 YL2 tissue: Myocardium gender: male 2.740888
GSM2685219 YL3 tissue: Myocardium gender: female 4.2955084
GSM2685220 YL4 tissue: Myocardium gender: female 4.165705
GSM2685221 QC1 tissue: Myocardium gender: male 3.4153607
GSM2685222 QC2 tissue: Myocardium gender: male 3.3351512
GSM2685223 QC3 tissue: Myocardium gender: female 2.6982627
GSM2685224 QC4 tissue: Myocardium gender: female 2.6572914

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.240007661
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.340838694
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.315767698
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.240576905
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.169530304
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.018616404

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 8.236136
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 8.077169
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 8.242316
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 8.045951
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 8.084167
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 8.187292

ID GSE1616
Title Genomics of preconditioning
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM27484 APC_a (anesthetic-preconditioning, 1st replicate) 375.6
GSM27485 APC_b (anesthetic-preconditioning, 2nd replicate) 203.6
GSM27486 APC_c (anesthetic-preconditioning, 3rd replicate) 266.4
GSM27487 APC_d (anesthetic-preconditioning, 4th replicate) 191.5
GSM27488 APC_e (anesthetic-preconditioning, 5th replicate) 218.4
GSM27489 APC_TRI_a (trigger of anesthetic-preconditioning, 1st replicate) 377.9
GSM27490 APC_TRI_b (trigger of anesthetic-preconditioning, 2nd replicate) 326.1
GSM27491 APC_TRI_c (trigger of anesthetic-preconditioning, 3rd replicate) 305.3
GSM27492 APC_TRI_d (trigger of anesthetic-preconditioning, 4th replicate) 261.4
GSM27493 APC_TRI_e (trigger of anesthetic-preconditioning, 5th replicate) 312.8
GSM27494 CTL_a (control, 1st replicate) 308.9
GSM27495 CTL_b (control, 2nd replicate) 301.3
GSM27496 CTL_c (control, 3rd replicate) 351.8
GSM27497 CTL_d (control, 4th replicate) 277.3
GSM27498 CTL_e (control, 5th replicate) 334.9
GSM27499 IPC_a (ischemic preconditioning, 1st replicate) 228.6
GSM27500 IPC_b (ischemic preconditioning, 2nd replicate) 249.0
GSM27501 IPC_c (ischemic preconditioning, 3rd replicate) 218.0
GSM27502 IPC_d (ischemic preconditioning, 4th replicate) 249.8
GSM27503 IPC_e (ischemic preconditioning, 5th replicate) 292.7
GSM27504 IPC_TRI_a (trigger of ischemic preconditioning, 1st replicate) 313.1
GSM27505 IPC_TRI_b (trigger of ischemic preconditioning, 2nd replicate) 346.0
GSM27506 IPC_TRI_c (trigger of ischemic preconditioning, 3rd replicate) 242.4
GSM27507 IPC_TRI_d (trigger of ischemic preconditioning, 4th replicate) 299.4
GSM27508 IPC_TRI_e (trigger of ischemic preconditioning, 5th replicate) 450.5
GSM27509 ISCH_a (ischemia, 1st replicate) 486.0
GSM27510 ISCH_b (ischemia, 2nd replicate) 286.6
GSM27511 ISCH_c (ischemia, 3rd replicate) 288.7
GSM27512 ISCH_d (ischemia, 4th replicate) 287.5
GSM27513 ISCH_e (ischemia, 5th replicate) 330.9

ID GSE359
Title Isoflurane Single Exposures
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5120 Isoflurane single exposure control-1 125.3
GSM5121 Isoflurane single exposure control-2 149.8
GSM5122 Isoflurane single exposure control-3 104.7
GSM5124 Isoflurane single exposure 1 hr-1 168.8
GSM5126 Isoflurane single exposure 1 hr-2 120.0
GSM5127 Isoflurane single exposure 2 hr-1 120.7
GSM5130 Isoflurane single exposure 2 hr-2 163.7
GSM5131 Isoflurane single exposure 2 hr-3 120.7

ID GSE752
Title Halothane/Isoflurane Repetitive Exposures
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5082 Control 1 121.4
GSM5084 Control 2 127.0
GSM5085 Control 3 112.7
GSM5086 Control 4 133.7
GSM5087 Control 5 124.3
GSM5090 Control 6 137.0
GSM5105 Control 7 119.2
GSM5106 Control 8 120.8
GSM5107 Control 9 114.2
GSM5108 Halothane 10 exposure-1 100.8
GSM5109 Halothane 10 exposures-2 99.3
GSM5110 Halothane 10 exposures-3 127.5
GSM5111 Halothane 5 exposures-1 103.4
GSM5112 Halothane 5 exposures-2 123.7
GSM5113 Halothane 5 exposures-3 123.7
GSM5114 Isoflurane 10 exposures-1 113.0
GSM5115 Isoflurane 10 exposures-2 160.7
GSM5116 Isoflurane 10 exposures-3 110.1
GSM5117 Isoflurane 5 exposures-1 124.6
GSM5118 Isoflurane 5 exposures-2 124.0
GSM5119 Isoflurane 5 exposures-3 114.2
GSM11379 Control 10 125.2
GSM11380 Control 11 112.5
GSM11381 Control 12 104.2