Gene symbol: Nova1

Also known as: Nova-1

Organism: Rattus norvegicus

Summary: Predicted to enable mRNA 3'-UTR binding activity and sequence-specific mRNA binding activity. Involved in regulation of mRNA processing and spinal cord development. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human NOVA1 (NOVA alternative splicing regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 298992 Ensembl:ENSRNOG00000031440 AllianceGenome:RGD:621345


GO Annotation


Category Term ID Term description
Process GO:0000375 RNA splicing, via transesterification reactions
Process GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
Process GO:0000381 Regulation of alternative mRNA splicing, via spliceosome
Process GO:0000398 mRNA splicing, via spliceosome
Process GO:0006139 Nucleobase-containing compound metabolic process
Process GO:0006396 RNA processing
Process GO:0006397 mRNA processing
Process GO:0006725 Cellular aromatic compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0007275 Multicellular organism development
Process GO:0007399 Nervous system development
Process GO:0007417 Central nervous system development
Process GO:0008152 Metabolic process
Process GO:0008380 RNA splicing
Process GO:0009892 Negative regulation of metabolic process
Process GO:0009987 Cellular process
Process GO:0010467 Gene expression
Process GO:0010468 Regulation of gene expression
Process GO:0016070 RNA metabolic process
Process GO:0016071 mRNA metabolic process
Process GO:0019219 Regulation of nucleobase-containing compound metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0021510 Spinal cord development
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0043170 Macromolecule metabolic process
Process GO:0043484 Regulation of RNA splicing
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0046483 Heterocycle metabolic process
Process GO:0048024 Regulation of mRNA splicing, via spliceosome
Process GO:0048513 Animal organ development
Process GO:0048519 Negative regulation of biological process
Process GO:0048731 System development
Process GO:0048856 Anatomical structure development
Process GO:0050684 Regulation of mRNA processing
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051239 Regulation of multicellular organismal process
Process GO:0051241 Negative regulation of multicellular organismal process
Process GO:0051252 Regulation of RNA metabolic process
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0071704 Organic substance metabolic process
Process GO:0080090 Regulation of primary metabolic process
Process GO:0090304 Nucleic acid metabolic process
Process GO:0120161 Regulation of cold-induced thermogenesis
Process GO:0120163 Negative regulation of cold-induced thermogenesis
Process GO:1901360 Organic cyclic compound metabolic process
Process GO:1903311 Regulation of mRNA metabolic process
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005737 Cytoplasm
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0110165 Cellular anatomical entity
Function GO:0003676 Nucleic acid binding
Function GO:0003723 RNA binding
Function GO:0003729 mRNA binding
Function GO:0003730 mRNA 3-UTR binding
Function GO:0005488 Binding
Function GO:0097159 Organic cyclic compound binding
Function GO:1901363 Heterocyclic compound binding
Function GO:1990825 Sequence-specific mRNA binding

Expression profile of Nova1 in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 4.226157
GSM2685202 MX2 tissue: Myocardium gender: female 3.3906634
GSM2685203 MX3 tissue: Myocardium gender: female 4.459609
GSM2685204 MX4 tissue: Myocardium gender: male 4.554419
GSM2685205 DZ1 tissue: Myocardium gender: male 5.3085012
GSM2685206 DZ2 tissue: Myocardium gender: male 4.7062163
GSM2685207 DZ3 tissue: Myocardium gender: female 5.02386
GSM2685208 DZ4 tissue: Myocardium gender: female 5.277398
GSM2685209 JJ1 tissue: Myocardium gender: male 5.4980865
GSM2685210 JJ2 tissue: Myocardium gender: female 5.381919
GSM2685211 JJ3 tissue: Myocardium gender: female 5.0057645
GSM2685212 JJ4 tissue: Myocardium gender: male 5.106628
GSM2685213 NG1 tissue: Myocardium gender: male 5.0169144
GSM2685214 NG2 tissue: Myocardium gender: female 4.7138777
GSM2685215 NG3 tissue: Myocardium gender: male 4.4649315
GSM2685216 NG4 tissue: Myocardium gender: female 4.121854
GSM2685217 YL1 tissue: Myocardium gender: male 2.3701637
GSM2685218 YL2 tissue: Myocardium gender: male 4.4018936
GSM2685219 YL3 tissue: Myocardium gender: female 4.707291
GSM2685220 YL4 tissue: Myocardium gender: female 4.23035
GSM2685221 QC1 tissue: Myocardium gender: male 3.4646583
GSM2685222 QC2 tissue: Myocardium gender: male 4.9111195
GSM2685223 QC3 tissue: Myocardium gender: female 5.1648183
GSM2685224 QC4 tissue: Myocardium gender: female 5.4041567

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.715056398
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.726529851
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.62371424
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.277280585
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.373857146
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 5.97857986

ID GSE138454
Title Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4108997 Sample 1 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 57.0
GSM4108998 Sample 2 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 51.0
GSM4108999 Sample 3 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 31.0
GSM4109000 Sample 4 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 57.0
GSM4109001 Sample 5 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 40.0
GSM4109002 Sample 6 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 56.0
GSM4109003 Sample 7 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 56.0
GSM4109004 Sample 8 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 103.0
GSM4109005 Sample9 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 70.0
GSM4109006 Sample10 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 122.0
GSM4109007 Sample11 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 58.0
GSM4109008 Sample12 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 132.0
GSM4109009 Sample13 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 55.0
GSM4109010 Sample14 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 49.0
GSM4109011 Sample 15 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 58.0
GSM4109012 Sample16 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 81.0

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 7.489034
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 7.78331
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 7.794203
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 7.531178
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 7.662706
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 7.736571

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 44.504
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 40.266
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 57.06
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 47.768
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 43.157

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 13.1031
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 13.2652
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 10.0489
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 10.1804
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 11.5901
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 11.8049
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 12.5789
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 12.6317
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 12.8675
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 13.251
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 9.8297
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 9.95543
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 11.8048
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 11.7216
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 13.07
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 12.653

ID GSE232804
Title EGR3 regulates opioid-related nociception and motivation in male rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7383519 ww01_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 269.0
GSM7383520 ww02_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 321.0
GSM7383521 ww03_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 344.0
GSM7383522 ww05_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 356.0
GSM7383523 ww06_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 348.0
GSM7383524 ww07_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 453.0
GSM7383525 ww08_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 395.0
GSM7383526 ww10_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 370.0
GSM7383527 ww12_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 396.0
GSM7383528 ww13_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 474.0
GSM7383529 ww14_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 254.0
GSM7383530 ww15_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 338.0
GSM7383531 ww16_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 435.0
GSM7383532 ww17_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 526.0
GSM7383533 ww18_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 395.0
GSM7383534 ww20_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 324.0
GSM7383535 ww21_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 283.0
GSM7383536 ww22_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 326.0
GSM7383537 ww23_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 317.0
GSM7383538 ww24_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 310.0
GSM7383539 ww26_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 336.0
GSM7383540 ww27_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 449.0
GSM7383541 ww28_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 362.0
GSM7383542 ww30_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 302.0
GSM7383543 ww31_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 363.0
GSM7383544 ww32_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 409.0
GSM7383545 ww34_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 493.0
GSM7383546 ww35_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 298.0
GSM7383547 ww36_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 368.0
GSM7383548 ww37_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 427.0
GSM7383549 ww38_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 498.0
GSM7383550 www09_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 474.0
GSM7383551 www19_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 466.0
GSM7383552 www29_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 484.0
GSM7383553 www33_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 343.0
GSM7383554 www39_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 377.0

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 0.879075
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 1.024049
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 1.101806
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 0.412238

ID GSE2982
Title Effect of inhaled anesthetic to cultured cortical neurons
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM61779 Cell Culture Exposure (control1) Cy3 label;Cy5; -0.18
GSM61796 Cell Culture Exposure (control2) Cy3; Cy5 0.0214
GSM61797 Cell Culture Exposure (control3) Cy3; Cy5 -0.0985
GSM61798 Cell Culture Exposure (1MAC Halo1) Cy3; Cy5 -0.0292
GSM61799 Cell Culture Exposure (1MAC Halo2) Cy3; Cy5 -0.0483
GSM61800 Cell Culture Exposure (1MAC Halo3) Cy3; Cy5 -0.149
GSM61801 Cell Culture Exposure (3MAC Halo1) Cy3; Cy5 -0.00583
GSM61802 Cell Culture Exposure (3MAC Halo2) Cy3; Cy5 0.0535
GSM61803 Cell Culture Exposure (3MAC Halo3) Cy3; Cy5 0.0686
GSM61804 Cell Culture Exposure (3MAC ISO1) Cy3; Cy5 -0.168
GSM61805 Cell Culture Exposure (3MAC ISO2) Cy3; Cy5 -0.0445
GSM61806 Cell Culture Exposure (3MAC ISO3) Cy3; Cy5 -0.112

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.609609
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.617867
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.582419
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.48812
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.619108
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.847206
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.742211
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.61373
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.930413
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.762799
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.922582
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.603728
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.513164
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.796594
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.826217
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.895822
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.702743
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.720526
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.493901
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.803527
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.513821
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 7.077507
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.861835
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.843575

ID GSE55573
Title Using DNA microarray to screen intracellular signal pathways of hypoglycemic activity by electroacupuncture of Zusanli (ST36) acupoints in streptozotocin-induced rats with diabetes
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1339443 Mock skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 196.7114
GSM1339444 EA (electroacupuncture) skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 263.8223