Gene symbol: Adcy1

Also known as: Ac1

Organism: Rattus norvegicus

Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including cAMP biosynthetic process; circadian rhythm; and response to lithium ion. Located in nucleus. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 305509 EnsemblRapid:ENSRNOG00000059479 AllianceGenome:RGD:1309318


GO Annotation


Category Term ID Term description
Process GO:0000902 Cell morphogenesis
Process GO:0000904 Cell morphogenesis involved in differentiation
Process GO:0001505 Regulation of neurotransmitter levels
Process GO:0003008 System process
Process GO:0006139 Nucleobase-containing compound metabolic process
Process GO:0006163 Purine nucleotide metabolic process
Process GO:0006164 Purine nucleotide biosynthetic process
Process GO:0006171 cAMP biosynthetic process
Process GO:0006355 Regulation of transcription, DNA-templated
Process GO:0006725 Cellular aromatic compound metabolic process
Process GO:0006753 Nucleoside phosphate metabolic process
Process GO:0006793 Phosphorus metabolic process
Process GO:0006796 Phosphate-containing compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0006954 Inflammatory response
Process GO:0007154 Cell communication
Process GO:0007165 Signal transduction
Process GO:0007186 G protein-coupled receptor signaling pathway
Process GO:0007188 Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Process GO:0007189 Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Process GO:0007275 Multicellular organism development
Process GO:0007399 Nervous system development
Process GO:0007409 Axonogenesis
Process GO:0007417 Central nervous system development
Process GO:0007420 Brain development
Process GO:0007610 Behavior
Process GO:0007611 Learning or memory
Process GO:0007613 Memory
Process GO:0007616 Long-term memory
Process GO:0007623 Circadian rhythm
Process GO:0008152 Metabolic process
Process GO:0009058 Biosynthetic process
Process GO:0009117 Nucleotide metabolic process
Process GO:0009150 Purine ribonucleotide metabolic process
Process GO:0009152 Purine ribonucleotide biosynthetic process
Process GO:0009165 Nucleotide biosynthetic process
Process GO:0009187 Cyclic nucleotide metabolic process
Process GO:0009190 Cyclic nucleotide biosynthetic process
Process GO:0009259 Ribonucleotide metabolic process
Process GO:0009260 Ribonucleotide biosynthetic process
Process GO:0009410 Response to xenobiotic stimulus
Process GO:0009653 Anatomical structure morphogenesis
Process GO:0009889 Regulation of biosynthetic process
Process GO:0009987 Cellular process
Process GO:0010035 Response to inorganic substance
Process GO:0010038 Response to metal ion
Process GO:0010226 Response to lithium ion
Process GO:0010468 Regulation of gene expression
Process GO:0010556 Regulation of macromolecule biosynthetic process
Process GO:0010646 Regulation of cell communication
Process GO:0010647 Positive regulation of cell communication
Process GO:0016043 Cellular component organization
Process GO:0017157 Regulation of exocytosis
Process GO:0018130 Heterocycle biosynthetic process
Process GO:0019219 Regulation of nucleobase-containing compound metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019438 Aromatic compound biosynthetic process
Process GO:0019637 Organophosphate metabolic process
Process GO:0019693 Ribose phosphate metabolic process
Process GO:0022008 Neurogenesis
Process GO:0023051 Regulation of signaling
Process GO:0023052 Signaling
Process GO:0023056 Positive regulation of signaling
Process GO:0030030 Cell projection organization
Process GO:0030154 Cell differentiation
Process GO:0030182 Neuron differentiation
Process GO:0031175 Neuron projection development
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031326 Regulation of cellular biosynthetic process
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0032793 Positive regulation of CREB transcription factor activity
Process GO:0032879 Regulation of localization
Process GO:0032989 Cellular component morphogenesis
Process GO:0032990 Cell part morphogenesis
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0034654 Nucleobase-containing compound biosynthetic process
Process GO:0035556 Intracellular signal transduction
Process GO:0042221 Response to chemical
Process GO:0042752 Regulation of circadian rhythm
Process GO:0044093 Positive regulation of molecular function
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044249 Cellular biosynthetic process
Process GO:0044271 Cellular nitrogen compound biosynthetic process
Process GO:0044281 Small molecule metabolic process
Process GO:0046058 cAMP metabolic process
Process GO:0046390 Ribose phosphate biosynthetic process
Process GO:0046483 Heterocycle metabolic process
Process GO:0046928 Regulation of neurotransmitter secretion
Process GO:0048167 Regulation of synaptic plasticity
Process GO:0048468 Cell development
Process GO:0048511 Rhythmic process
Process GO:0048513 Animal organ development
Process GO:0048518 Positive regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048666 Neuron development
Process GO:0048667 Cell morphogenesis involved in neuron differentiation
Process GO:0048699 Generation of neurons
Process GO:0048731 System development
Process GO:0048812 Neuron projection morphogenesis
Process GO:0048856 Anatomical structure development
Process GO:0048858 Cell projection morphogenesis
Process GO:0048869 Cellular developmental process
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0050804 Modulation of chemical synaptic transmission
Process GO:0050806 Positive regulation of synaptic transmission
Process GO:0050877 Nervous system process
Process GO:0050890 Cognition
Process GO:0050896 Response to stimulus
Process GO:0051046 Regulation of secretion
Process GO:0051049 Regulation of transport
Process GO:0051090 Regulation of DNA-binding transcription factor activity
Process GO:0051091 Positive regulation of DNA-binding transcription factor activity
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051252 Regulation of RNA metabolic process
Process GO:0051588 Regulation of neurotransmitter transport
Process GO:0051716 Cellular response to stimulus
Process GO:0052652 Cyclic purine nucleotide metabolic process
Process GO:0055086 Nucleobase-containing small molecule metabolic process
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060322 Head development
Process GO:0060627 Regulation of vesicle-mediated transport
Process GO:0061564 Axon development
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0065009 Regulation of molecular function
Process GO:0071704 Organic substance metabolic process
Process GO:0071840 Cellular component organization or biogenesis
Process GO:0072521 Purine-containing compound metabolic process
Process GO:0072522 Purine-containing compound biosynthetic process
Process GO:0080090 Regulation of primary metabolic process
Process GO:0090407 Organophosphate biosynthetic process
Process GO:0099177 Regulation of trans-synaptic signaling
Process GO:0120036 Plasma membrane bounded cell projection organization
Process GO:0120039 Plasma membrane bounded cell projection morphogenesis
Process GO:0150076 Neuroinflammatory response
Process GO:1900271 Regulation of long-term synaptic potentiation
Process GO:1900273 Positive regulation of long-term synaptic potentiation
Process GO:1901135 Carbohydrate derivative metabolic process
Process GO:1901137 Carbohydrate derivative biosynthetic process
Process GO:1901293 Nucleoside phosphate biosynthetic process
Process GO:1901360 Organic cyclic compound metabolic process
Process GO:1901362 Organic cyclic compound biosynthetic process
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901566 Organonitrogen compound biosynthetic process
Process GO:1901576 Organic substance biosynthetic process
Process GO:1903305 Regulation of regulated secretory pathway
Process GO:1903506 Regulation of nucleic acid-templated transcription
Process GO:1903530 Regulation of secretion by cell
Process GO:2000300 Regulation of synaptic vesicle exocytosis
Process GO:2001141 Regulation of RNA biosynthetic process
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005737 Cytoplasm
Component GO:0005886 Plasma membrane
Component GO:0005887 Integral component of plasma membrane
Component GO:0014069 Postsynaptic density
Component GO:0016020 Membrane
Component GO:0016021 Integral component of membrane
Component GO:0030054 Cell junction
Component GO:0031224 Intrinsic component of membrane
Component GO:0031226 Intrinsic component of plasma membrane
Component GO:0032279 Asymmetric synapse
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0045202 Synapse
Component GO:0045211 Postsynaptic membrane
Component GO:0071944 Cell periphery
Component GO:0097060 Synaptic membrane
Component GO:0098590 Plasma membrane region
Component GO:0098685 Schaffer collateral - CA1 synapse
Component GO:0098686 Hippocampal mossy fiber to CA3 synapse
Component GO:0098794 Postsynapse
Component GO:0098839 Postsynaptic density membrane
Component GO:0098936 Intrinsic component of postsynaptic membrane
Component GO:0098948 Intrinsic component of postsynaptic specialization membrane
Component GO:0098978 Glutamatergic synapse
Component GO:0098984 Neuron to neuron synapse
Component GO:0099055 Integral component of postsynaptic membrane
Component GO:0099060 Integral component of postsynaptic specialization membrane
Component GO:0099061 Integral component of postsynaptic density membrane
Component GO:0099146 Intrinsic component of postsynaptic density membrane
Component GO:0099240 Intrinsic component of synaptic membrane
Component GO:0099572 Postsynaptic specialization
Component GO:0099634 Postsynaptic specialization membrane
Component GO:0099699 Integral component of synaptic membrane
Component GO:0110165 Cellular anatomical entity
Function GO:0000166 Nucleotide binding
Function GO:0003824 Catalytic activity
Function GO:0004016 Adenylate cyclase activity
Function GO:0005488 Binding
Function GO:0005524 ATP binding
Function GO:0008294 Calcium- and calmodulin-responsive adenylate cyclase activity
Function GO:0009975 Cyclase activity
Function GO:0016829 Lyase activity
Function GO:0016849 Phosphorus-oxygen lyase activity
Function GO:0017076 Purine nucleotide binding
Function GO:0030554 Adenyl nucleotide binding
Function GO:0032553 Ribonucleotide binding
Function GO:0032555 Purine ribonucleotide binding
Function GO:0032559 Adenyl ribonucleotide binding
Function GO:0035639 Purine ribonucleoside triphosphate binding
Function GO:0036094 Small molecule binding
Function GO:0043167 Ion binding
Function GO:0043168 Anion binding
Function GO:0043169 Cation binding
Function GO:0046872 Metal ion binding
Function GO:0097159 Organic cyclic compound binding
Function GO:0097367 Carbohydrate derivative binding
Function GO:1901265 Nucleoside phosphate binding
Function GO:1901363 Heterocyclic compound binding

Pathway annotation


Category Term ID Term description
RCTM RNO-111885 Opioid Signalling
RCTM RNO-111931 PKA-mediated phosphorylation of CREB
RCTM RNO-111933 Calmodulin induced events
RCTM RNO-111996 Ca-dependent events
RCTM RNO-111997 CaM pathway
RCTM RNO-112040 G-protein mediated events
RCTM RNO-112043 PLC beta mediated events
RCTM RNO-112314 Neurotransmitter receptors and postsynaptic signal transmission
RCTM RNO-112315 Transmission across Chemical Synapses
RCTM RNO-112316 Neuronal System
RCTM RNO-1489509 DAG and IP3 signaling
RCTM RNO-162582 Signal Transduction
RCTM RNO-163615 PKA activation
RCTM RNO-170660 Adenylate cyclase activating pathway
RCTM RNO-170670 Adenylate cyclase inhibitory pathway
RCTM RNO-372790 Signaling by GPCR
RCTM RNO-388396 GPCR downstream signalling
RCTM RNO-418594 G alpha (i) signalling events
RCTM RNO-418597 G alpha (z) signalling events
RCTM RNO-5358351 Signaling by Hedgehog
RCTM RNO-5610787 Hedgehog off state
RCTM RNO-9006925 Intracellular signaling by second messengers
RCTM RNO-977443 GABA receptor activation
RCTM RNO-977444 GABA B receptor activation
RCTM RNO-991365 Activation of GABAB receptors
WikiPathways WP1281 Hypothetical network for drug addiction
WikiPathways WP140 Myometrial relaxation and contraction pathways
WikiPathways WP73 G protein signaling pathways

Expression profile of Adcy1 in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 4.821068
GSM2685202 MX2 tissue: Myocardium gender: female 5.079762
GSM2685203 MX3 tissue: Myocardium gender: female 4.5737014
GSM2685204 MX4 tissue: Myocardium gender: male 4.6105013
GSM2685205 DZ1 tissue: Myocardium gender: male 4.459609
GSM2685206 DZ2 tissue: Myocardium gender: male 4.255167
GSM2685207 DZ3 tissue: Myocardium gender: female 3.6067746
GSM2685208 DZ4 tissue: Myocardium gender: female 4.051935
GSM2685209 JJ1 tissue: Myocardium gender: male 4.700442
GSM2685210 JJ2 tissue: Myocardium gender: female 4.366623
GSM2685211 JJ3 tissue: Myocardium gender: female 3.6146226
GSM2685212 JJ4 tissue: Myocardium gender: male 4.5383234
GSM2685213 NG1 tissue: Myocardium gender: male 4.769492
GSM2685214 NG2 tissue: Myocardium gender: female 4.4152827
GSM2685215 NG3 tissue: Myocardium gender: male 4.189702
GSM2685216 NG4 tissue: Myocardium gender: female 3.9766865
GSM2685217 YL1 tissue: Myocardium gender: male 2.6407566
GSM2685218 YL2 tissue: Myocardium gender: male 3.799416
GSM2685219 YL3 tissue: Myocardium gender: female 4.108109
GSM2685220 YL4 tissue: Myocardium gender: female 4.217172
GSM2685221 QC1 tissue: Myocardium gender: male 5.1161
GSM2685222 QC2 tissue: Myocardium gender: male 4.435039
GSM2685223 QC3 tissue: Myocardium gender: female 4.865937
GSM2685224 QC4 tissue: Myocardium gender: female 5.052435

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.440482601
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.730588884
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.603591576
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.285477296
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.188463392
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.008390678

ID GSE138454
Title Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4108997 Sample 1 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 69.0
GSM4108998 Sample 2 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 120.0
GSM4108999 Sample 3 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 277.0
GSM4109000 Sample 4 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 72.0
GSM4109001 Sample 5 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 52.0
GSM4109002 Sample 6 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 51.0
GSM4109003 Sample 7 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 28.0
GSM4109004 Sample 8 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 101.0
GSM4109005 Sample9 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 37.0
GSM4109006 Sample10 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 411.0
GSM4109007 Sample11 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 47.0
GSM4109008 Sample12 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 94.0
GSM4109009 Sample13 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 30.0
GSM4109010 Sample14 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 47.0
GSM4109011 Sample 15 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 49.0
GSM4109012 Sample16 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 32.0

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 10.01059
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 10.08745
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 10.18663
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 9.93572
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 10.10929
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 9.929617

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 54.319
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 59.466
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 63.712
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 49.204
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 59.258

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 8.5804
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 7.78988
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 6.55173
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 5.52667
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 7.55346
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 7.81084
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 9.61092
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 9.83853
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 6.7167
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 7.38958
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 5.68133
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 4.78145
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 6.57765
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 6.94741
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 8.85818
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 9.18759

ID GSE205202
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM6208507 Rat_Baseline_0h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 5.642662
GSM6208508 Rat_Baseline_0h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 5.682691
GSM6208509 Rat_Baseline_0h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 5.381693
GSM6208510 Rat_Baseline_0h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 5.512622
GSM6208511 Rat_Baseline_0h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 5.971437
GSM6208512 Rat_Vehicle_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 5.329161
GSM6208513 Rat_Vehicle_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 5.711215
GSM6208514 Rat_Vehicle_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 5.616294
GSM6208515 Rat_Vehicle_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 5.333973
GSM6208516 Rat_Vehicle_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 5.353587
GSM6208517 Rat_Vehicle_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 5.59567
GSM6208518 Rat_Vehicle_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 5.617591
GSM6208519 Rat_Vehicle_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 5.309968
GSM6208520 Rat_Vehicle_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 5.58231
GSM6208521 Rat_Vehicle_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 5.59561
GSM6208522 Rat_Vehicle_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 5.477474
GSM6208523 Rat_Vehicle_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 5.59779
GSM6208524 Rat_Vehicle_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 5.649767
GSM6208525 Rat_Vehicle_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 5.699303
GSM6208526 Rat_Vehicle_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 5.495424
GSM6208527 Rat_Vehicle_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 5.394312
GSM6208528 Rat_Vehicle_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 5.602691
GSM6208529 Rat_Vehicle_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 5.465571
GSM6208530 Rat_Vehicle_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 5.584301
GSM6208531 Rat_Vehicle_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 5.613292
GSM6208532 Rat_APAP_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 5.652853
GSM6208533 Rat_APAP_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 5.540695
GSM6208534 Rat_APAP_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 5.500413
GSM6208535 Rat_APAP_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 5.543731
GSM6208536 Rat_APAP_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 5.316419
GSM6208537 Rat_APAP_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 4.972389
GSM6208538 Rat_APAP_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 5.660481
GSM6208539 Rat_APAP_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 5.422988
GSM6208540 Rat_APAP_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 5.54539
GSM6208541 Rat_APAP_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 5.514088
GSM6208542 Rat_APAP_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 5.386915
GSM6208543 Rat_APAP_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 5.394898
GSM6208544 Rat_APAP_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 5.445303
GSM6208545 Rat_APAP_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 5.436611
GSM6208546 Rat_APAP_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 5.215114
GSM6208547 Rat_APAP_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 5.59283
GSM6208548 Rat_APAP_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 5.426554
GSM6208549 Rat_APAP_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 5.132786
GSM6208550 Rat_APAP_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 5.425736
GSM6208551 Rat_APAP_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 5.465068

ID GSE232804
Title EGR3 regulates opioid-related nociception and motivation in male rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7383519 ww01_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 3150.0
GSM7383520 ww02_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 3576.0
GSM7383521 ww03_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 3447.0
GSM7383522 ww05_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 4393.0
GSM7383523 ww06_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 4394.0
GSM7383524 ww07_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 4966.0
GSM7383525 ww08_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Salin 3884.0
GSM7383526 ww10_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 3669.0
GSM7383527 ww12_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 4025.0
GSM7383528 ww13_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 4990.0
GSM7383529 ww14_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 3358.0
GSM7383530 ww15_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 4243.0
GSM7383531 ww16_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 4386.0
GSM7383532 ww17_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 4616.0
GSM7383533 ww18_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 4459.0
GSM7383534 ww20_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 3508.0
GSM7383535 ww21_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 3943.0
GSM7383536 ww22_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 3602.0
GSM7383537 ww23_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 3999.0
GSM7383538 ww24_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 3408.0
GSM7383539 ww26_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 3824.0
GSM7383540 ww27_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 5495.0
GSM7383541 ww28_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 3886.0
GSM7383542 ww30_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 4209.0
GSM7383543 ww31_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4168.0
GSM7383544 ww32_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4393.0
GSM7383545 ww34_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 5757.0
GSM7383546 ww35_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 3638.0
GSM7383547 ww36_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4630.0
GSM7383548 ww37_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4520.0
GSM7383549 ww38_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4790.0
GSM7383550 www09_Saline_Saline tissue: Brain / mPFC pain: Saline drug: Saline 5812.0
GSM7383551 www19_Saline_OXY tissue: Brain / mPFC pain: Saline drug: OXY 5175.0
GSM7383552 www29_CFA_Saline tissue: Brain / mPFC pain: CFA drug: Saline 5448.0
GSM7383553 www33_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4137.0
GSM7383554 www39_CFA_OXY tissue: Brain / mPFC pain: CFA drug: OXY 4593.0

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 2.857956
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 2.324038
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 5.27
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 6.990891

ID GSE2982
Title Effect of inhaled anesthetic to cultured cortical neurons
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM61779 Cell Culture Exposure (control1) Cy3 label;Cy5; 0.01338
GSM61796 Cell Culture Exposure (control2) Cy3; Cy5 0.0184355
GSM61797 Cell Culture Exposure (control3) Cy3; Cy5 0.005749999999999998
GSM61798 Cell Culture Exposure (1MAC Halo1) Cy3; Cy5 -0.0015000000000000013
GSM61799 Cell Culture Exposure (1MAC Halo2) Cy3; Cy5 0.0312
GSM61800 Cell Culture Exposure (1MAC Halo3) Cy3; Cy5 -0.03106
GSM61801 Cell Culture Exposure (3MAC Halo1) Cy3; Cy5 0.012649999999999998
GSM61802 Cell Culture Exposure (3MAC Halo2) Cy3; Cy5 0.03178
GSM61803 Cell Culture Exposure (3MAC Halo3) Cy3; Cy5 0.032975000000000004
GSM61804 Cell Culture Exposure (3MAC ISO1) Cy3; Cy5 0.03775
GSM61805 Cell Culture Exposure (3MAC ISO2) Cy3; Cy5 0.0027999999999999995
GSM61806 Cell Culture Exposure (3MAC ISO3) Cy3; Cy5 0.019499999999999997

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.669623
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.527406
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.509153
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.620032
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.590368
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.557113
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.608217
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.398531
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.400126
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.696559
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.632709
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.667566
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.490823
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.476821
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.341541
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.600988
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.653905
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.659674
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.593895
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.504705
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.538268
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.586395
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.577383
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.641852

ID GSE55573
Title Using DNA microarray to screen intracellular signal pathways of hypoglycemic activity by electroacupuncture of Zusanli (ST36) acupoints in streptozotocin-induced rats with diabetes
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1339443 Mock skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 121.8063
GSM1339444 EA (electroacupuncture) skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 117.9776