Gene symbol: Foxp3

Also known as: RGD1562112

Organism: Rattus norvegicus

Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; asthma; bronchiolitis obliterans; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 317382 Ensembl:ENSRNOG00000011702 AllianceGenome:RGD:1562112


GO Annotation


Category Term ID Term description
Process GO:0000018 Regulation of DNA recombination
Process GO:0000122 Negative regulation of transcription by RNA polymerase II
Process GO:0001775 Cell activation
Process GO:0001776 Leukocyte homeostasis
Process GO:0001782 B cell homeostasis
Process GO:0001816 Cytokine production
Process GO:0001817 Regulation of cytokine production
Process GO:0001818 Negative regulation of cytokine production
Process GO:0001819 Positive regulation of cytokine production
Process GO:0001885 Endothelial cell development
Process GO:0002064 Epithelial cell development
Process GO:0002200 Somatic diversification of immune receptors
Process GO:0002204 Somatic recombination of immunoglobulin genes involved in immune response
Process GO:0002208 Somatic diversification of immunoglobulins involved in immune response
Process GO:0002237 Response to molecule of bacterial origin
Process GO:0002249 Lymphocyte anergy
Process GO:0002250 Adaptive immune response
Process GO:0002252 Immune effector process
Process GO:0002253 Activation of immune response
Process GO:0002260 Lymphocyte homeostasis
Process GO:0002262 Myeloid cell homeostasis
Process GO:0002263 Cell activation involved in immune response
Process GO:0002285 Lymphocyte activation involved in immune response
Process GO:0002312 B cell activation involved in immune response
Process GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Process GO:0002366 Leukocyte activation involved in immune response
Process GO:0002376 Immune system process
Process GO:0002377 Immunoglobulin production
Process GO:0002381 Immunoglobulin production involved in immunoglobulin-mediated immune response
Process GO:0002429 Immune response-activating cell surface receptor signaling pathway
Process GO:0002440 Production of molecular mediator of immune response
Process GO:0002443 Leukocyte mediated immunity
Process GO:0002449 Lymphocyte mediated immunity
Process GO:0002456 T cell mediated immunity
Process GO:0002460 Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Process GO:0002507 Tolerance induction
Process GO:0002513 Tolerance induction to self antigen
Process GO:0002517 T cell tolerance induction
Process GO:0002520 Immune system development
Process GO:0002521 Leukocyte differentiation
Process GO:0002562 Somatic diversification of immune receptors via germline recombination within a single locus
Process GO:0002637 Regulation of immunoglobulin production
Process GO:0002638 Negative regulation of immunoglobulin production
Process GO:0002643 Regulation of tolerance induction
Process GO:0002645 Positive regulation of tolerance induction
Process GO:0002652 Regulation of tolerance induction dependent upon immune response
Process GO:0002654 Positive regulation of tolerance induction dependent upon immune response
Process GO:0002658 Regulation of peripheral tolerance induction
Process GO:0002660 Positive regulation of peripheral tolerance induction
Process GO:0002664 Regulation of T cell tolerance induction
Process GO:0002666 Positive regulation of T cell tolerance induction
Process GO:0002667 Regulation of T cell anergy
Process GO:0002669 Positive regulation of T cell anergy
Process GO:0002676 Regulation of chronic inflammatory response
Process GO:0002677 Negative regulation of chronic inflammatory response
Process GO:0002682 Regulation of immune system process
Process GO:0002683 Negative regulation of immune system process
Process GO:0002684 Positive regulation of immune system process
Process GO:0002694 Regulation of leukocyte activation
Process GO:0002695 Negative regulation of leukocyte activation
Process GO:0002696 Positive regulation of leukocyte activation
Process GO:0002697 Regulation of immune effector process
Process GO:0002698 Negative regulation of immune effector process
Process GO:0002699 Positive regulation of immune effector process
Process GO:0002700 Regulation of production of molecular mediator of immune response
Process GO:0002701 Negative regulation of production of molecular mediator of immune response
Process GO:0002703 Regulation of leukocyte mediated immunity
Process GO:0002704 Negative regulation of leukocyte mediated immunity
Process GO:0002705 Positive regulation of leukocyte mediated immunity
Process GO:0002706 Regulation of lymphocyte mediated immunity
Process GO:0002707 Negative regulation of lymphocyte mediated immunity
Process GO:0002708 Positive regulation of lymphocyte mediated immunity
Process GO:0002709 Regulation of T cell mediated immunity
Process GO:0002710 Negative regulation of T cell mediated immunity
Process GO:0002711 Positive regulation of T cell mediated immunity
Process GO:0002712 Regulation of B cell mediated immunity
Process GO:0002713 Negative regulation of B cell mediated immunity
Process GO:0002718 Regulation of cytokine production involved in immune response
Process GO:0002719 Negative regulation of cytokine production involved in immune response
Process GO:0002724 Regulation of T cell cytokine production
Process GO:0002725 Negative regulation of T cell cytokine production
Process GO:0002757 Immune response-activating signal transduction
Process GO:0002764 Immune response-regulating signaling pathway
Process GO:0002768 Immune response-regulating cell surface receptor signaling pathway
Process GO:0002819 Regulation of adaptive immune response
Process GO:0002820 Negative regulation of adaptive immune response
Process GO:0002821 Positive regulation of adaptive immune response
Process GO:0002822 Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Process GO:0002823 Negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Process GO:0002824 Positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Process GO:0002831 Regulation of response to biotic stimulus
Process GO:0002832 Negative regulation of response to biotic stimulus
Process GO:0002870 T cell anergy
Process GO:0002889 Regulation of immunoglobulin mediated immune response
Process GO:0002890 Negative regulation of immunoglobulin mediated immune response
Process GO:0002911 Regulation of lymphocyte anergy
Process GO:0002913 Positive regulation of lymphocyte anergy
Process GO:0003158 Endothelium development
Process GO:0006139 Nucleobase-containing compound metabolic process
Process GO:0006259 DNA metabolic process
Process GO:0006310 DNA recombination
Process GO:0006351 Transcription, DNA-templated
Process GO:0006355 Regulation of transcription, DNA-templated
Process GO:0006357 Regulation of transcription by RNA polymerase II
Process GO:0006366 Transcription by RNA polymerase II
Process GO:0006473 Protein acetylation
Process GO:0006475 Internal protein amino acid acetylation
Process GO:0006725 Cellular aromatic compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0006954 Inflammatory response
Process GO:0006955 Immune response
Process GO:0007154 Cell communication
Process GO:0007162 Negative regulation of cell adhesion
Process GO:0007165 Signal transduction
Process GO:0007166 Cell surface receptor signaling pathway
Process GO:0007275 Multicellular organism development
Process GO:0007399 Nervous system development
Process GO:0007417 Central nervous system development
Process GO:0008152 Metabolic process
Process GO:0008283 Cell population proliferation
Process GO:0008284 Positive regulation of cell population proliferation
Process GO:0008285 Negative regulation of cell population proliferation
Process GO:0009058 Biosynthetic process
Process GO:0009059 Macromolecule biosynthetic process
Process GO:0009314 Response to radiation
Process GO:0009605 Response to external stimulus
Process GO:0009607 Response to biotic stimulus
Process GO:0009615 Response to virus
Process GO:0009617 Response to bacterium
Process GO:0009628 Response to abiotic stimulus
Process GO:0009888 Tissue development
Process GO:0009889 Regulation of biosynthetic process
Process GO:0009890 Negative regulation of biosynthetic process
Process GO:0009891 Positive regulation of biosynthetic process
Process GO:0009892 Negative regulation of metabolic process
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009987 Cellular process
Process GO:0010033 Response to organic substance
Process GO:0010243 Response to organonitrogen compound
Process GO:0010467 Gene expression
Process GO:0010468 Regulation of gene expression
Process GO:0010556 Regulation of macromolecule biosynthetic process
Process GO:0010557 Positive regulation of macromolecule biosynthetic process
Process GO:0010558 Negative regulation of macromolecule biosynthetic process
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0010605 Negative regulation of macromolecule metabolic process
Process GO:0010628 Positive regulation of gene expression
Process GO:0010629 Negative regulation of gene expression
Process GO:0014045 Establishment of endothelial blood-brain barrier
Process GO:0014070 Response to organic cyclic compound
Process GO:0016064 Immunoglobulin mediated immune response
Process GO:0016070 RNA metabolic process
Process GO:0016444 Somatic cell DNA recombination
Process GO:0016445 Somatic diversification of immunoglobulins
Process GO:0016447 Somatic recombination of immunoglobulin gene segments
Process GO:0016570 Histone modification
Process GO:0016573 Histone acetylation
Process GO:0018130 Heterocycle biosynthetic process
Process GO:0018193 Peptidyl-amino acid modification
Process GO:0018205 Peptidyl-lysine modification
Process GO:0018393 Internal peptidyl-lysine acetylation
Process GO:0018394 Peptidyl-lysine acetylation
Process GO:0019219 Regulation of nucleobase-containing compound metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019438 Aromatic compound biosynthetic process
Process GO:0019538 Protein metabolic process
Process GO:0019724 B cell mediated immunity
Process GO:0022407 Regulation of cell-cell adhesion
Process GO:0022408 Negative regulation of cell-cell adhesion
Process GO:0022409 Positive regulation of cell-cell adhesion
Process GO:0023052 Signaling
Process GO:0030097 Hemopoiesis
Process GO:0030098 Lymphocyte differentiation
Process GO:0030154 Cell differentiation
Process GO:0030155 Regulation of cell adhesion
Process GO:0030217 T cell differentiation
Process GO:0030855 Epithelial cell differentiation
Process GO:0031056 Regulation of histone modification
Process GO:0031057 Negative regulation of histone modification
Process GO:0031058 Positive regulation of histone modification
Process GO:0031063 Regulation of histone deacetylation
Process GO:0031064 Negative regulation of histone deacetylation
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031324 Negative regulation of cellular metabolic process
Process GO:0031325 Positive regulation of cellular metabolic process
Process GO:0031326 Regulation of cellular biosynthetic process
Process GO:0031327 Negative regulation of cellular biosynthetic process
Process GO:0031328 Positive regulation of cellular biosynthetic process
Process GO:0031347 Regulation of defense response
Process GO:0031348 Negative regulation of defense response
Process GO:0031399 Regulation of protein modification process
Process GO:0031400 Negative regulation of protein modification process
Process GO:0031401 Positive regulation of protein modification process
Process GO:0032088 Negative regulation of NF-kappaB transcription factor activity
Process GO:0032101 Regulation of response to external stimulus
Process GO:0032102 Negative regulation of response to external stimulus
Process GO:0032496 Response to lipopolysaccharide
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0032649 Regulation of interferon-gamma production
Process GO:0032653 Regulation of interleukin-10 production
Process GO:0032660 Regulation of interleukin-17 production
Process GO:0032663 Regulation of interleukin-2 production
Process GO:0032673 Regulation of interleukin-4 production
Process GO:0032674 Regulation of interleukin-5 production
Process GO:0032675 Regulation of interleukin-6 production
Process GO:0032680 Regulation of tumor necrosis factor production
Process GO:0032689 Negative regulation of interferon-gamma production
Process GO:0032693 Negative regulation of interleukin-10 production
Process GO:0032700 Negative regulation of interleukin-17 production
Process GO:0032703 Negative regulation of interleukin-2 production
Process GO:0032713 Negative regulation of interleukin-4 production
Process GO:0032714 Negative regulation of interleukin-5 production
Process GO:0032715 Negative regulation of interleukin-6 production
Process GO:0032720 Negative regulation of tumor necrosis factor production
Process GO:0032753 Positive regulation of interleukin-4 production
Process GO:0032774 RNA biosynthetic process
Process GO:0032792 Negative regulation of CREB transcription factor activity
Process GO:0032829 Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Process GO:0032831 Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
Process GO:0032905 Transforming growth factor beta1 production
Process GO:0032908 Regulation of transforming growth factor beta1 production
Process GO:0032914 Positive regulation of transforming growth factor beta1 production
Process GO:0032943 Mononuclear cell proliferation
Process GO:0032944 Regulation of mononuclear cell proliferation
Process GO:0032945 Negative regulation of mononuclear cell proliferation
Process GO:0032946 Positive regulation of mononuclear cell proliferation
Process GO:0033077 T cell differentiation in thymus
Process GO:0033079 Immature T cell proliferation
Process GO:0033080 Immature T cell proliferation in thymus
Process GO:0033083 Regulation of immature T cell proliferation
Process GO:0033084 Regulation of immature T cell proliferation in thymus
Process GO:0033091 Positive regulation of immature T cell proliferation
Process GO:0033092 Positive regulation of immature T cell proliferation in thymus
Process GO:0033993 Response to lipid
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0034654 Nucleobase-containing compound biosynthetic process
Process GO:0035065 Regulation of histone acetylation
Process GO:0035066 Positive regulation of histone acetylation
Process GO:0035067 Negative regulation of histone acetylation
Process GO:0035710 CD4-positive, alpha-beta T cell activation
Process GO:0035739 CD4-positive, alpha-beta T cell proliferation
Process GO:0036211 Protein modification process
Process GO:0042098 T cell proliferation
Process GO:0042102 Positive regulation of T cell proliferation
Process GO:0042110 T cell activation
Process GO:0042113 B cell activation
Process GO:0042127 Regulation of cell population proliferation
Process GO:0042129 Regulation of T cell proliferation
Process GO:0042130 Negative regulation of T cell proliferation
Process GO:0042221 Response to chemical
Process GO:0042592 Homeostatic process
Process GO:0043170 Macromolecule metabolic process
Process GO:0043207 Response to external biotic stimulus
Process GO:0043367 CD4-positive, alpha-beta T cell differentiation
Process GO:0043370 Regulation of CD4-positive, alpha-beta T cell differentiation
Process GO:0043371 Negative regulation of CD4-positive, alpha-beta T cell differentiation
Process GO:0043372 Positive regulation of CD4-positive, alpha-beta T cell differentiation
Process GO:0043412 Macromolecule modification
Process GO:0043433 Negative regulation of DNA-binding transcription factor activity
Process GO:0043543 Protein acylation
Process GO:0044092 Negative regulation of molecular function
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044249 Cellular biosynthetic process
Process GO:0044260 Cellular macromolecule metabolic process
Process GO:0044271 Cellular nitrogen compound biosynthetic process
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0045066 Regulatory T cell differentiation
Process GO:0045190 Isotype switching
Process GO:0045191 Regulation of isotype switching
Process GO:0045321 Leukocyte activation
Process GO:0045446 Endothelial cell differentiation
Process GO:0045472 Response to ether
Process GO:0045580 Regulation of T cell differentiation
Process GO:0045581 Negative regulation of T cell differentiation
Process GO:0045582 Positive regulation of T cell differentiation
Process GO:0045589 Regulation of regulatory T cell differentiation
Process GO:0045591 Positive regulation of regulatory T cell differentiation
Process GO:0045595 Regulation of cell differentiation
Process GO:0045596 Negative regulation of cell differentiation
Process GO:0045597 Positive regulation of cell differentiation
Process GO:0045619 Regulation of lymphocyte differentiation
Process GO:0045620 Negative regulation of lymphocyte differentiation
Process GO:0045621 Positive regulation of lymphocyte differentiation
Process GO:0045622 Regulation of T-helper cell differentiation
Process GO:0045623 Negative regulation of T-helper cell differentiation
Process GO:0045785 Positive regulation of cell adhesion
Process GO:0045829 Negative regulation of isotype switching
Process GO:0045892 Negative regulation of transcription, DNA-templated
Process GO:0045893 Positive regulation of transcription, DNA-templated
Process GO:0045910 Negative regulation of DNA recombination
Process GO:0045934 Negative regulation of nucleobase-containing compound metabolic process
Process GO:0045935 Positive regulation of nucleobase-containing compound metabolic process
Process GO:0045944 Positive regulation of transcription by RNA polymerase II
Process GO:0046483 Heterocycle metabolic process
Process GO:0046631 Alpha-beta T cell activation
Process GO:0046632 Alpha-beta T cell differentiation
Process GO:0046633 Alpha-beta T cell proliferation
Process GO:0046634 Regulation of alpha-beta T cell activation
Process GO:0046635 Positive regulation of alpha-beta T cell activation
Process GO:0046636 Negative regulation of alpha-beta T cell activation
Process GO:0046637 Regulation of alpha-beta T cell differentiation
Process GO:0046638 Positive regulation of alpha-beta T cell differentiation
Process GO:0046639 Negative regulation of alpha-beta T cell differentiation
Process GO:0046640 Regulation of alpha-beta T cell proliferation
Process GO:0046642 Negative regulation of alpha-beta T cell proliferation
Process GO:0046649 Lymphocyte activation
Process GO:0046651 Lymphocyte proliferation
Process GO:0048289 Isotype switching to IgE isotypes
Process GO:0048293 Regulation of isotype switching to IgE isotypes
Process GO:0048294 Negative regulation of isotype switching to IgE isotypes
Process GO:0048302 Regulation of isotype switching to IgG isotypes
Process GO:0048468 Cell development
Process GO:0048513 Animal organ development
Process GO:0048518 Positive regulation of biological process
Process GO:0048519 Negative regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048523 Negative regulation of cellular process
Process GO:0048534 Hematopoietic or lymphoid organ development
Process GO:0048583 Regulation of response to stimulus
Process GO:0048584 Positive regulation of response to stimulus
Process GO:0048585 Negative regulation of response to stimulus
Process GO:0048731 System development
Process GO:0048856 Anatomical structure development
Process GO:0048869 Cellular developmental process
Process GO:0048872 Homeostasis of number of cells
Process GO:0050670 Regulation of lymphocyte proliferation
Process GO:0050671 Positive regulation of lymphocyte proliferation
Process GO:0050672 Negative regulation of lymphocyte proliferation
Process GO:0050687 Negative regulation of defense response to virus
Process GO:0050688 Regulation of defense response to virus
Process GO:0050727 Regulation of inflammatory response
Process GO:0050728 Negative regulation of inflammatory response
Process GO:0050776 Regulation of immune response
Process GO:0050777 Negative regulation of immune response
Process GO:0050778 Positive regulation of immune response
Process GO:0050789 Regulation of biological process
Process GO:0050793 Regulation of developmental process
Process GO:0050794 Regulation of cellular process
Process GO:0050851 Antigen receptor-mediated signaling pathway
Process GO:0050852 T cell receptor signaling pathway
Process GO:0050863 Regulation of T cell activation
Process GO:0050864 Regulation of B cell activation
Process GO:0050865 Regulation of cell activation
Process GO:0050866 Negative regulation of cell activation
Process GO:0050867 Positive regulation of cell activation
Process GO:0050868 Negative regulation of T cell activation
Process GO:0050869 Negative regulation of B cell activation
Process GO:0050870 Positive regulation of T cell activation
Process GO:0050896 Response to stimulus
Process GO:0051052 Regulation of DNA metabolic process
Process GO:0051053 Negative regulation of DNA metabolic process
Process GO:0051090 Regulation of DNA-binding transcription factor activity
Process GO:0051093 Negative regulation of developmental process
Process GO:0051094 Positive regulation of developmental process
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051172 Negative regulation of nitrogen compound metabolic process
Process GO:0051173 Positive regulation of nitrogen compound metabolic process
Process GO:0051239 Regulation of multicellular organismal process
Process GO:0051240 Positive regulation of multicellular organismal process
Process GO:0051241 Negative regulation of multicellular organismal process
Process GO:0051246 Regulation of protein metabolic process
Process GO:0051247 Positive regulation of protein metabolic process
Process GO:0051248 Negative regulation of protein metabolic process
Process GO:0051249 Regulation of lymphocyte activation
Process GO:0051250 Negative regulation of lymphocyte activation
Process GO:0051251 Positive regulation of lymphocyte activation
Process GO:0051252 Regulation of RNA metabolic process
Process GO:0051253 Negative regulation of RNA metabolic process
Process GO:0051254 Positive regulation of RNA metabolic process
Process GO:0051707 Response to other organism
Process GO:0051716 Cellular response to stimulus
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060429 Epithelium development
Process GO:0060856 Establishment of blood-brain barrier
Process GO:0061028 Establishment of endothelial barrier
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0065009 Regulation of molecular function
Process GO:0070661 Leukocyte proliferation
Process GO:0070663 Regulation of leukocyte proliferation
Process GO:0070664 Negative regulation of leukocyte proliferation
Process GO:0070665 Positive regulation of leukocyte proliferation
Process GO:0071604 Transforming growth factor beta production
Process GO:0071634 Regulation of transforming growth factor beta production
Process GO:0071636 Positive regulation of transforming growth factor beta production
Process GO:0071704 Organic substance metabolic process
Process GO:0080090 Regulation of primary metabolic process
Process GO:0080134 Regulation of response to stress
Process GO:0090304 Nucleic acid metabolic process
Process GO:0090311 Regulation of protein deacetylation
Process GO:0097305 Response to alcohol
Process GO:0097659 Nucleic acid-templated transcription
Process GO:1901355 Response to rapamycin
Process GO:1901360 Organic cyclic compound metabolic process
Process GO:1901362 Organic cyclic compound biosynthetic process
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901576 Organic substance biosynthetic process
Process GO:1901654 Response to ketone
Process GO:1901698 Response to nitrogen compound
Process GO:1901700 Response to oxygen-containing compound
Process GO:1901983 Regulation of protein acetylation
Process GO:1901984 Negative regulation of protein acetylation
Process GO:1901985 Positive regulation of protein acetylation
Process GO:1902105 Regulation of leukocyte differentiation
Process GO:1902106 Negative regulation of leukocyte differentiation
Process GO:1902107 Positive regulation of leukocyte differentiation
Process GO:1902679 Negative regulation of RNA biosynthetic process
Process GO:1902680 Positive regulation of RNA biosynthetic process
Process GO:1903037 Regulation of leukocyte cell-cell adhesion
Process GO:1903038 Negative regulation of leukocyte cell-cell adhesion
Process GO:1903039 Positive regulation of leukocyte cell-cell adhesion
Process GO:1903131 Mononuclear cell differentiation
Process GO:1903506 Regulation of nucleic acid-templated transcription
Process GO:1903507 Negative regulation of nucleic acid-templated transcription
Process GO:1903508 Positive regulation of nucleic acid-templated transcription
Process GO:1903555 Regulation of tumor necrosis factor superfamily cytokine production
Process GO:1903556 Negative regulation of tumor necrosis factor superfamily cytokine production
Process GO:1903706 Regulation of hemopoiesis
Process GO:1903707 Negative regulation of hemopoiesis
Process GO:1903708 Positive regulation of hemopoiesis
Process GO:2000026 Regulation of multicellular organismal development
Process GO:2000316 Regulation of T-helper 17 type immune response
Process GO:2000317 Negative regulation of T-helper 17 type immune response
Process GO:2000319 Regulation of T-helper 17 cell differentiation
Process GO:2000320 Negative regulation of T-helper 17 cell differentiation
Process GO:2000514 Regulation of CD4-positive, alpha-beta T cell activation
Process GO:2000515 Negative regulation of CD4-positive, alpha-beta T cell activation
Process GO:2000516 Positive regulation of CD4-positive, alpha-beta T cell activation
Process GO:2000561 Regulation of CD4-positive, alpha-beta T cell proliferation
Process GO:2000562 Negative regulation of CD4-positive, alpha-beta T cell proliferation
Process GO:2000756 Regulation of peptidyl-lysine acetylation
Process GO:2000757 Negative regulation of peptidyl-lysine acetylation
Process GO:2000758 Positive regulation of peptidyl-lysine acetylation
Process GO:2001141 Regulation of RNA biosynthetic process
Process GO:0002849 Regulation of peripheral T cell tolerance induction
Process GO:0002851 Positive regulation of peripheral T cell tolerance induction
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005654 Nucleoplasm
Component GO:0005737 Cytoplasm
Component GO:0031974 Membrane-enclosed lumen
Component GO:0031981 Nuclear lumen
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0043233 Organelle lumen
Component GO:0070013 Intracellular organelle lumen
Component GO:0110165 Cellular anatomical entity
Function GO:0000976 Transcription cis-regulatory region binding
Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Function GO:0000987 Cis-regulatory region sequence-specific DNA binding
Function GO:0001067 Transcription regulatory region nucleic acid binding
Function GO:0001217 DNA-binding transcription repressor activity
Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Function GO:0003676 Nucleic acid binding
Function GO:0003677 DNA binding
Function GO:0003690 Double-stranded DNA binding
Function GO:0003700 DNA-binding transcription factor activity
Function GO:0003712 Transcription coregulator activity
Function GO:0003714 Transcription corepressor activity
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0008134 Transcription factor binding
Function GO:0019899 Enzyme binding
Function GO:0035035 Histone acetyltransferase binding
Function GO:0042802 Identical protein binding
Function GO:0042803 Protein homodimerization activity
Function GO:0042826 Histone deacetylase binding
Function GO:0043167 Ion binding
Function GO:0043169 Cation binding
Function GO:0043565 Sequence-specific DNA binding
Function GO:0046872 Metal ion binding
Function GO:0046983 Protein dimerization activity
Function GO:0051525 NFAT protein binding
Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Function GO:0097159 Organic cyclic compound binding
Function GO:0140110 Transcription regulator activity
Function GO:0140297 DNA-binding transcription factor binding
Function GO:1901363 Heterocyclic compound binding
Function GO:1990837 Sequence-specific double-stranded DNA binding

Pathway annotation


Category Term ID Term description
RCTM RNO-212436 Generic Transcription Pathway
RCTM RNO-73857 RNA Polymerase II Transcription
RCTM RNO-74160 Gene expression (Transcription)
RCTM RNO-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RCTM RNO-8878171 Transcriptional regulation by RUNX1
KEGG rno04659 Th17 cell differentiation
KEGG rno05321 Inflammatory bowel disease

Expression profile of Foxp3 in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 6.764842
GSM2685202 MX2 tissue: Myocardium gender: female 6.5572567
GSM2685203 MX3 tissue: Myocardium gender: female 6.8585196
GSM2685204 MX4 tissue: Myocardium gender: male 6.669032
GSM2685205 DZ1 tissue: Myocardium gender: male 6.622334
GSM2685206 DZ2 tissue: Myocardium gender: male 6.772315
GSM2685207 DZ3 tissue: Myocardium gender: female 6.4869494
GSM2685208 DZ4 tissue: Myocardium gender: female 6.4847345
GSM2685209 JJ1 tissue: Myocardium gender: male 6.521773
GSM2685210 JJ2 tissue: Myocardium gender: female 6.457154
GSM2685211 JJ3 tissue: Myocardium gender: female 6.533517
GSM2685212 JJ4 tissue: Myocardium gender: male 6.7382197
GSM2685213 NG1 tissue: Myocardium gender: male 6.5253077
GSM2685214 NG2 tissue: Myocardium gender: female 6.3761053
GSM2685215 NG3 tissue: Myocardium gender: male 6.41105
GSM2685216 NG4 tissue: Myocardium gender: female 6.3415675
GSM2685217 YL1 tissue: Myocardium gender: male 6.403142
GSM2685218 YL2 tissue: Myocardium gender: male 6.415151
GSM2685219 YL3 tissue: Myocardium gender: female 6.6346445
GSM2685220 YL4 tissue: Myocardium gender: female 6.1451535
GSM2685221 QC1 tissue: Myocardium gender: male 6.6835265
GSM2685222 QC2 tissue: Myocardium gender: male 6.8006954
GSM2685223 QC3 tissue: Myocardium gender: female 6.6230793
GSM2685224 QC4 tissue: Myocardium gender: female 6.8911495

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.352074696
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.194126154
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.267348291
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.208557734
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.33712569
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.273923738

ID GSE138454
Title Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4108997 Sample 1 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 2.0
GSM4108998 Sample 2 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4108999 Sample 3 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 4.0
GSM4109000 Sample 4 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 4.0
GSM4109001 Sample 5 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 1.0
GSM4109002 Sample 6 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 2.0
GSM4109003 Sample 7 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 2.0
GSM4109004 Sample 8 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 4.0
GSM4109005 Sample9 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 3.0
GSM4109006 Sample10 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 1.0
GSM4109007 Sample11 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109008 Sample12 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 1.0
GSM4109009 Sample13 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 3.0
GSM4109010 Sample14 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 1.0
GSM4109011 Sample 15 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 2.0
GSM4109012 Sample16 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 3.0

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.458176
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.758302
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.599334
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.863444
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.568088
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.467123

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.981
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.715
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 1.015
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.745
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.772

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 3.69927
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 3.85258
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 3.67068
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 3.77192
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 3.43049
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 3.75278
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 3.73633
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 4.21141
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 3.23461
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 3.38936
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 3.38249
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 3.89076
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 3.55679
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 3.2729
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 3.41227
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 3.15123

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 0.941609
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 0.082345
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 0.46039
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 0.820601

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.600789
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.511808
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.588946
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.46136
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.504525
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.674941
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.576401
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.467989
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.508792
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.485163
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.491064
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.42571
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.577786
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.401654
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.607676
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.519543
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.598274
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.505279
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.648705
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.508295
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.676551
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.587926
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.685678
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.404327

ID GSE55573
Title Using DNA microarray to screen intracellular signal pathways of hypoglycemic activity by electroacupuncture of Zusanli (ST36) acupoints in streptozotocin-induced rats with diabetes
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1339443 Mock skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 121.6859
GSM1339444 EA (electroacupuncture) skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 132.4564