Gene symbol: Defb28

Also known as: Gm1635

Organism: Mus musculus

Summary: Orthologous to human DEFB115 (defensin beta 115). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 545475 Ensembl:ENSMUSG00000074679 AllianceGenome:MGI:3650536


GO Annotation


Category Term ID Term description
Process GO:0002376 Immune system process
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0006955 Immune response
Process GO:0009605 Response to external stimulus
Process GO:0009607 Response to biotic stimulus
Process GO:0009617 Response to bacterium
Process GO:0042742 Defense response to bacterium
Process GO:0043207 Response to external biotic stimulus
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0045087 Innate immune response
Process GO:0050896 Response to stimulus
Process GO:0051707 Response to other organism
Process GO:0098542 Defense response to other organism
Component GO:0005576 Extracellular region
Component GO:0110165 Cellular anatomical entity

Pathway annotation


Category Term ID Term description
RCTM MMU-1461957 Beta defensins
RCTM MMU-1461973 Defensins
RCTM MMU-168249 Innate Immune System
RCTM MMU-168256 Immune System
RCTM MMU-6803157 Antimicrobial peptides

Expression profile of Defb28 in omics data



ID GSE109165
Title Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway
Organism Mus musculus
GSM Sample info Characteristics Value
GSM2934457 WT_Naive_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934458 WT_Naive_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934459 WT_Naive_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934460 WT_Naive_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 0.0
GSM2934461 KO_Naive_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 1.0
GSM2934462 KO_Naive_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934463 KO_Naive_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934464 KO_Naive_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 0.0
GSM2934465 WT_Morphine_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934466 WT_Morphine_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934467 WT_Morphine_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934468 WT_Morphine_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 0.0
GSM2934469 KO_Morphine_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0
GSM2934470 KO_Morphine_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0
GSM2934471 KO_Morphine_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0
GSM2934472 KO_Morphine_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 0.0

ID GSE125076
Title A mouse model of acute post-surgical pain
Organism Mus musculus
GSM Sample info Characteristics Value
GSM3562188 DRG_WT_sham_1 strain: C57BL/6 gender: male age: 8 weeks treatment: naïve 0.0
GSM3562189 DRG_WT_sham_2 strain: C57BL/6 gender: male age: 8 weeks treatment: naïve 0.0
GSM3562190 DRG_WT_sham_3 strain: C57BL/6 gender: male age: 8 weeks treatment: naïve 0.0
GSM3562191 DRG_WT_PSP_1 strain: C57BL/6 gender: male age: 8 weeks treatment: 24h post surgery 0.0
GSM3562192 DRG_WT_PSP_2 strain: C57BL/6 gender: male age: 8 weeks treatment: 24h post surgery 0.0
GSM3562193 DRG_WT_PSP_3 strain: C57BL/6 gender: male age: 8 weeks treatment: 24h post surgery 0.0

ID GSE138802
Title Mesocorticolimbic circuit mechanisms underlying the effects of ketamine on dopamine: a translational imaging study
Organism Mus musculus
GSM Sample info Characteristics Value
GSM4119733 PLc_1_Sal strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Saline 0.0
GSM4119734 PLc_10_Sal strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Saline 0.0
GSM4119735 PLc_6_Sal strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Saline 0.0
GSM4119736 PLc_5_Ket strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Ketamine 0.0
GSM4119737 PLc_3_Ket strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Ketamine 0.0
GSM4119738 PLc_9_Ket strain: C57Bl/6 age: 9 weeks tissue: Pre-limbic cortex treatment: Ketamine 0.0

ID GSE163828
Title Regulation of electro-acupuncture(EA) and astragalus membranaceus (AM) on genes in bone marrow
Organism Mus musculus
GSM Sample info Characteristics Value
GSM4988039 BH190126-1_control tissue: bone marrow 4.67
GSM4988040 BH190126-1_treatment of astragalus membranaceus tissue: bone marrow 4.25
GSM4988041 BH190126-1_cisplatin tissue: bone marrow 4.27
GSM4988042 BH190126-1_treatment of electro-acupuncture tissue: bone marrow 4.29

ID GSE223541
Title Oxycodone withdrawal induces HDAC1/2-dependent transcriptional maladaptations in the reward pathway in a murine model of peripheral nerve injury
Organism Mus musculus
GSM Sample info Characteristics Value
GSM6958536 B1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sa 0.0
GSM6958537 C1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958538 F1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958539 H1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 1.0
GSM6958540 B2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958541 C2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958542 F2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958543 H2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958544 B3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 1.0
GSM6958545 C3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 1.0
GSM6958546 F3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958547 H3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958548 B4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958549 C4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958550 F4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958551 H4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0

ID GSE24829
Title Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM611081 Control mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 4.33099
GSM611082 Control mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 4.2865
GSM611083 MPTP-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 4.37358
GSM611084 MPTP-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 4.0193
GSM611085 MPTP and acupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 4.08866
GSM611086 MPTP and acupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 4.41622
GSM611087 MPTP and nonacupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 4.17741
GSM611088 MPTP and nonacupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 4.0692

ID GSE24830
Title Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM611089 Control mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 3.29478
GSM611090 Control mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 2.99603
GSM611091 MPTP-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 3.2532
GSM611092 MPTP-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 3.11866
GSM611093 MPTP and acupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.37668
GSM611094 MPTP and acupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.18919
GSM611095 MPTP and nonacupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 3.24139
GSM611096 MPTP and nonacupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 2.88456

ID GSE24838
Title Gene expression data from brain striatal and spinal cord regions of MPTP-intoxicated mouse following acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM611081 Control mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 4.33099
GSM611082 Control mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: Control 4.2865
GSM611083 MPTP-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 4.37358
GSM611084 MPTP-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP-treated 4.0193
GSM611085 MPTP and acupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 4.08866
GSM611086 MPTP and acupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 4.41622
GSM611087 MPTP and nonacupoints acupuncture-treated mouse 1 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 4.17741
GSM611088 MPTP and nonacupoints acupuncture-treated mouse 2 striatal regions gender: Male strain: C57BL/6 tissue: Striatal tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 4.0692
GSM611089 Control mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 3.29478
GSM611090 Control mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: Control 2.99603
GSM611091 MPTP-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 3.2532
GSM611092 MPTP-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP-treated 3.11866
GSM611093 MPTP and acupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.37668
GSM611094 MPTP and acupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 3.18919
GSM611095 MPTP and nonacupoints acupuncture-treated mouse 1 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 3.24139
GSM611096 MPTP and nonacupoints acupuncture-treated mouse 2 cervical spinal cord regions gender: Male strain: C57BL/6 tissue: Cervical spinal cord tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 2.88456

ID GSE26364
Title Gene expression changes in alpha GABA receptors in the mice brains after prolonged ketamine administration
Organism Mus musculus
GSM Sample info Characteristics Value
GSM647254 Saline PFC 1 strain: ICR tissue: prefrontal cortex Sex: female 2.72455
GSM647255 Saline PFC 2 strain: ICR tissue: prefrontal cortex Sex: female 2.83419
GSM647256 Ketamine PFC 1 strain: ICR tissue: prefrontal cortex Sex: female 3.20328
GSM647257 Ketamine PFC 2 strain: ICR tissue: prefrontal cortex Sex: female 2.97721

ID GSE35138
Title Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM862520 Control mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 4.1164
GSM862521 Control mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.84917
GSM862522 MPTP-treated mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.79628
GSM862523 MPTP-treated mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.66794
GSM862524 MPTP and acupoints acupuncture-treated mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.84473
GSM862525 MPTP and acupoints acupuncture-treated mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.50217
GSM862526 MPTP and nonacupoints acupuncture-treated mouse 1 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.85574
GSM862527 MPTP and nonacupoints acupuncture-treated mouse 2 thalamic regions gender: Male strain: C57BL/6 tissue: thalamic tissues developmental stage: Adult 3.7382

ID GSE48293
Title Gene expression data from substantia nigral regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
GSM Sample info Characteristics Value
GSM1174263 Control mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: Control 6.22134
GSM1174264 Control mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: Control 7.74218
GSM1174265 MPTP-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP-treated 7.91171
GSM1174266 MPTP-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP-treated 7.80819
GSM1174267 MPTP and acupoints acupuncture-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 7.94828
GSM1174268 MPTP and acupoints acupuncture-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated 8.04194
GSM1174269 MPTP and nonacupoints acupuncture-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 7.67426
GSM1174270 MPTP and nonacupoints acupuncture-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated 7.36426