Gene symbol: Defa11

Organism: Rattus norvegicus

Summary: Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response in mucosa; and response to bacterium. Predicted to be active in extracellular space. Orthologous to human DEFA5 (defensin alpha 5). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 613225 Ensembl:ENSRNOG00000038133 AllianceGenome:RGD:1587186


GO Annotation


Category Term ID Term description
Process GO:0001906 Cell killing
Process GO:0002227 Innate immune response in mucosa
Process GO:0002237 Response to molecule of bacterial origin
Process GO:0002251 Organ or tissue specific immune response
Process GO:0002376 Immune system process
Process GO:0002385 Mucosal immune response
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0006955 Immune response
Process GO:0006959 Humoral immune response
Process GO:0009605 Response to external stimulus
Process GO:0009607 Response to biotic stimulus
Process GO:0009617 Response to bacterium
Process GO:0009620 Response to fungus
Process GO:0009987 Cellular process
Process GO:0010033 Response to organic substance
Process GO:0019730 Antimicrobial humoral response
Process GO:0019731 Antibacterial humoral response
Process GO:0031640 Killing of cells of another organism
Process GO:0032496 Response to lipopolysaccharide
Process GO:0033993 Response to lipid
Process GO:0035821 Modulation of process of another organism
Process GO:0042221 Response to chemical
Process GO:0042742 Defense response to bacterium
Process GO:0043207 Response to external biotic stimulus
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0045087 Innate immune response
Process GO:0050829 Defense response to Gram-negative bacterium
Process GO:0050830 Defense response to Gram-positive bacterium
Process GO:0050832 Defense response to fungus
Process GO:0050896 Response to stimulus
Process GO:0051673 Membrane disruption in another organism
Process GO:0051707 Response to other organism
Process GO:0051716 Cellular response to stimulus
Process GO:0061844 Antimicrobial humoral immune response mediated by antimicrobial peptide
Process GO:0070887 Cellular response to chemical stimulus
Process GO:0071216 Cellular response to biotic stimulus
Process GO:0071219 Cellular response to molecule of bacterial origin
Process GO:0071222 Cellular response to lipopolysaccharide
Process GO:0071310 Cellular response to organic substance
Process GO:0071396 Cellular response to lipid
Process GO:0098542 Defense response to other organism
Process GO:1901700 Response to oxygen-containing compound
Process GO:1901701 Cellular response to oxygen-containing compound
Component GO:0005576 Extracellular region
Component GO:0005615 Extracellular space
Component GO:0110165 Cellular anatomical entity

Pathway annotation


Category Term ID Term description
RCTM RNO-1461973 Defensins
RCTM RNO-1462054 Alpha-defensins
RCTM RNO-168249 Innate Immune System
RCTM RNO-168256 Immune System
RCTM RNO-6798695 Neutrophil degranulation
RCTM RNO-6803157 Antimicrobial peptides
KEGG rno04621 NOD-like receptor signaling pathway
KEGG rno05150 Staphylococcus aureus infection
KEGG rno05202 Transcriptional misregulation in cancer

Expression profile of Defa11 in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 3.1709907
GSM2685202 MX2 tissue: Myocardium gender: female 2.7523997
GSM2685203 MX3 tissue: Myocardium gender: female 3.2094963
GSM2685204 MX4 tissue: Myocardium gender: male 3.2715702
GSM2685205 DZ1 tissue: Myocardium gender: male 3.0181725
GSM2685206 DZ2 tissue: Myocardium gender: male 2.88342
GSM2685207 DZ3 tissue: Myocardium gender: female 3.5736196
GSM2685208 DZ4 tissue: Myocardium gender: female 2.8976543
GSM2685209 JJ1 tissue: Myocardium gender: male 3.4497826
GSM2685210 JJ2 tissue: Myocardium gender: female 3.6713765
GSM2685211 JJ3 tissue: Myocardium gender: female 2.538504
GSM2685212 JJ4 tissue: Myocardium gender: male 2.8770492
GSM2685213 NG1 tissue: Myocardium gender: male 2.58084
GSM2685214 NG2 tissue: Myocardium gender: female 2.7801125
GSM2685215 NG3 tissue: Myocardium gender: male 2.3262157
GSM2685216 NG4 tissue: Myocardium gender: female 3.8188136
GSM2685217 YL1 tissue: Myocardium gender: male 2.3701637
GSM2685218 YL2 tissue: Myocardium gender: male 4.8632097
GSM2685219 YL3 tissue: Myocardium gender: female 4.0637374
GSM2685220 YL4 tissue: Myocardium gender: female 2.5710938
GSM2685221 QC1 tissue: Myocardium gender: male 2.9836507
GSM2685222 QC2 tissue: Myocardium gender: male 2.6908123
GSM2685223 QC3 tissue: Myocardium gender: female 2.4377708
GSM2685224 QC4 tissue: Myocardium gender: female 3.5536363

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.614992024
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.188369554
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.484990798
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.738758105
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.97291375
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.260753664

ID GSE138454
Title Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4108997 Sample 1 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4108998 Sample 2 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4108999 Sample 3 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109000 Sample 4 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109001 Sample 5 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109002 Sample 6 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109003 Sample 7 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109004 Sample 8 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109005 Sample9 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109006 Sample10 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109007 Sample11 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109008 Sample12 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 1.0
GSM4109009 Sample13 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109010 Sample14 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109011 Sample 15 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109012 Sample16 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.404768
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.552219
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.533358
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 4.98142
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 4.667825
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 4.538689

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.0
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.0

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 4.79619
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 4.57127
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 4.77696
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 4.8478
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 4.19882
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 4.67545
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 4.83089
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 4.34652
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 3.94487
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 3.64251
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 4.29796
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 3.96192
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 4.22138
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 3.58859
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 4.13143
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 3.79235