In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.

           
Emotion Regulation
Depression
Acupuncture anesthesia is beneficial for patients with depression undergoing surgery, as it can help stabilize mood and reduce the emotional impact of surgery.
Anxiety
Acupuncture anesthesia has anxiolytic effects, calming preoperative anxiety, and promoting a more relaxed state for patients before surgery.
Sedation
Acupuncture anesthesia provides sedation, allowing patients to undergo surgery in a tranquil and comfortable state without the need for excessive sedative drugs.
Mood
By regulating the body's natural balance, acupuncture anesthesia can positively influence mood, contributing to a more positive surgical experience.

Acupuncture anesthesia for Emotion Regulation-Anxiety


PMID Evidence Source Keyword Type
11245510 Acupuncture, aromatherapy, and meditation may be useful for nausea/vomiting, for mild relaxation, and for pain/anxiety, respectively. Med J Aust. 2001 Jan 15;174(2):88-92. doi: 10.5694/j.1326-5377.2001.tb143161.x. Nausea and Vomiting Anxiety Review
11905768 There is evidence from randomised trials supporting the value of hypnosis for cancer pain and nausea; relaxation therapy, music therapy, and massage for anxiety; and acupuncture for nausea. Lancet Oncol. 2001 Apr;2(4):226-32. doi: 10.1016/S1470-2045(00)00293-X. Cancer Pain Nausea and Vomiting Anxiety Review
12391715 Evidence for the efficacy of kava kava, exercise, relaxation therapies, and acupuncture in treatment anxiety is reviewed. Prim Care. 2002 Jun;29(2):339-60, vii. doi: 10.1016/s0095-4543(01)00003-3. Anxiety Review
12418362 There is sufficient evidence, for example, to support the use of a) acupuncture for addiction problems and chronic musculoskeletal pain, b) hypnosis for cancer pain and nausea, c) massage therapy for anxiety, and the use of d) mind-body techniques such as meditation, relaxation, and biofeedback for pain, insomnia, and anxiety. Psychiatr Q. 2002 Winter;73(4):367-81. doi: 10.1023/a:1020472218839. Cancer Pain Insomnia Nausea and Vomiting Anxiety Review
15074998 Evidence from randomized trial supports the value of hypnosis for cancer pain and nausea; relaxation therapy and massage for anxiety; and acupuncture for nausea. Asian Pac J Cancer Prev. 2004 Jan-Mar;5(1):3-14. Cancer Pain Nausea and Vomiting Anxiety Review
15462640 There is more limited evidence to support the effectiveness of acupuncture, music, autogenic training and meditation for generalised anxiety; for inositol in the treatment of panic disorder and obsessive-compulsive disorder; and for alcohol avoidance by people with alcohol-use disorders to reduce a range of anxiety disorders. Med J Aust. 2004 Oct 4;181(S7):S29-46. doi: 10.5694/j.1326-5377.2004.tb06352.x. Anxiety Review
15911926 Although relatively few studies have been done on anxiety and depression, several researchers have found acupuncture to be just as effective as or more effective than antidepressants for patients without cancer. Integr Cancer Ther. 2005 Jun;4(2):131-43. doi: 10.1177/1534735405276419. Anxiety Depression Review
16092807 Other preliminary data also suggests acupuncture might be effective for chemotherapy-induced leukopenia, postchemotherapy fatigue, radiation therapy-induced xerostomia, insomnia, and anxiety. Semin Oncol Nurs. 2005 Aug;21(3):190-5. doi: 10.1016/j.soncn.2005.04.008. Insomnia Anxiety Review
16557449 Several consequences can be drawn from these studies: i) women anticipate postoperative pain more realistically and it occurs more often than in man; however, pain intensity and analgesic consumption are not different; ii) placebos elicit psychological phenomena (e. g. expectation) that trigger neurobiological processes (e. g. activation of endogenous opioid system); iii) COX-2 inhibitors increase the risk for thromboembolic complications (e. g. myocardial infarction, apoplex, pulmonary embolism) and perioperative mortality in patients undergoing aortocoronary bypass surgery; iv) NSAID as supplement to postoperative PCIA with opioids reduce the risk for PONV and sedation; v) preoperative administration of gabapentin reduces preoperative anxiety and postoperative pain; vi) epidural catheters situated at the site of major spinal surgery are promising approach to provide efficient postoperative analgesia; vii) in the literature contradictory results have been reported regarding the effect of perioperative acupuncture on intra- and postoperative consumption of anesthetics or analgesics; acupuncture appears to decrease the incidence of PONV, but no reduction in the postoperative use of antiemetic agents has not been shown yet; viii) laparoscopic versus open colectomy in patients with colon carcinoma results in prolongation of surgery, reduction of postoperative pain and analgesics, earlier mobilization and a reduced hospital stay, if conventional systemic opioid-based pain therapy was used postoperatively. Anasthesiol Intensivmed Notfallmed Schmerzther. 2006 Mar;41(3):184-92. doi: 10.1055/s-2006-925141. Anxiety Sedation Review
16850779 Recent evidence suggests that manual acupuncture is effective for reducing preoperative anxiety and for postoperative pain relief. Best Pract Res Clin Anaesthesiol. 2006 Jun;20(2):303-14. doi: 10.1016/j.bpa.2005.10.009. Pain Relief Anxiety Review
17006267 Small clinical trials document evidence of effectiveness for select therapies, such as acupuncture or ginger for nausea and vomiting, TRAUMEEL S for mucositis, and hypnosis and imagery for pain and anxiety. J Pediatr Hematol Oncol. 2006 Sep;28(9):601-15. doi: 10.1097/01.mph.0000212989.26317.52. Nausea and Vomiting Anxiety Review
17034678 Music therapy, massage, and hypnosis may have an effect on anxiety, and both acupuncture and massage may have a therapeutic role in cancer fatigue. Cancer J. 2006 Sep-Oct;12(5):425-31. doi: 10.1097/00130404-200609000-00011. Anxiety Review
17515023 The reviewed literature suggests 4 possible mechanisms by which acupuncture could improve the outcome of IVF: modulating neuroendocrinological factors; increasing blood flow to the uterus and ovaries; modulating cytokines; and reducing stress, anxiety, and depression. Altern Ther Health Med. 2007 May-Jun;13(3):38-48. Anxiety Depression Blood Flow Review
17641561 Acupuncture for anxiety and anxiety disorders--a systematic literature review. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 INTRODUCTION: The aim of this study was to evaluate the evidence for the efficacy of acupuncture in the treatment of anxiety and anxiety disorders by systematic review of the relevant research. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 Four RCTs focused on acupuncture in generalised anxiety disorder or anxiety neurosis, while six focused on anxiety in the perioperative period. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 In generalised anxiety disorder or anxiety neurosis, it is difficult to interpret the findings of the studies of acupuncture because of the range of interventions against which acupuncture was compared. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 Reporting of the studies of perioperative anxiety was generally better and the initial indications are that acupuncture, specifically auricular acupuncture, is more effective than acupuncture at sham points and may be as effective as drug therapy in this situation. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 CONCLUSIONS: Positive findings are reported for acupuncture in the treatment of generalised anxiety disorder or anxiety neurosis but there is currently insufficient research evidence for firm conclusions to be drawn. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 No trials of acupuncture for other anxiety disorders were located. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
17641561 There is some limited evidence in favour of auricular acupuncture in perioperative anxiety. Acupunct Med. 2007 Jun;25(1-2):1-10. doi: 10.1136/aim.25.1-2.1. Anxiety Review
18281839 Evidence for the use of acupuncture in treating anxiety disorders is becoming stronger, although there is currently minimal empirical evidence for the use of aromatherapy or mindfulness-based meditation. Curr Opin Psychiatry. 2008 Jan;21(1):37-42. doi: 10.1097/YCO.0b013e3282f2d814. Anxiety Review
18541122 In patients with systemic cancer, mind-body modalities such as meditation and relaxation therapy have been shown to be helpful in reducing anxiety and pain; acupuncture and hypnotherapy may also reduce both pain and nausea. Curr Neurol Neurosci Rep. 2008 May;8(3):264-8. doi: 10.1007/s11910-008-0040-z. Nausea and Vomiting Anxiety Review
18678172 Acupuncture and moxibustion treatment of anxiety neurosis and study on characteristics of acupoint selection. Zhongguo Zhen Jiu. 2008 Jul;28(7):545-8. Anxiety Review
18678172 Review and summarize the published literature since 1994 on treatment of anxiety neurosis with acupuncture and moxibustion, so as to provide evidence for standard acupuncture and moxibustion treatment program. Zhongguo Zhen Jiu. 2008 Jul;28(7):545-8. Anxiety Review
18678172 Acupuncture and moxibustion treatment of anxiety neurosis stresses the special function of acupoints in acupoint selection, reflecting the therapeutic characteristics of ""treatment based on the brain"" and ""treatment based on the heart"" for mental disorders, and emphasizing the important position of TCM Zang- and Fu-organs syndrome differentiation in treatment of anxiety neurosis. Zhongguo Zhen Jiu. 2008 Jul;28(7):545-8. Anxiety Review
18682338 Acupuncture can have positive effects on depression and anxiety, although evidence is still lacking as to its true efficacy for these conditions. Behav Med. 2008 Summer;34(2):55-64. doi: 10.3200/BMED.34.2.55-64. Anxiety Depression Review
19098695 If this is the case, acupuncture should preferably be applied repeatedly (ie in a learning process) before the start of the specific treatment to initiate the extinction of previous unpleasant associations like pain or anxiety. Acupunct Med. 2008 Dec;26(4):234-8. doi: 10.1136/aim.26.4.234. Anxiety Review
20304708 One RCT evaluated the effects of acupuncture in patients with minor depression or anxiety disorders and another RCT examined the effect of acupuncture on migraine patients. Auton Neurosci. 2010 Jun 24;155(1-2):5-13. doi: 10.1016/j.autneu.2010.02.003. Epub 2010 Mar 20. Anxiety Depression Review
20451469 Anxiety, depression and acupuncture: A review of the clinical research. Auton Neurosci. 2010 Oct 28;157(1-2):91-5. doi: 10.1016/j.autneu.2010.04.002. Epub 2010 May 6. Anxiety Depression Review
20451469 Acupuncture is widely used for treatment of anxiety and depression and use is increasing. Auton Neurosci. 2010 Oct 28;157(1-2):91-5. doi: 10.1016/j.autneu.2010.04.002. Epub 2010 May 6. Anxiety Depression Review
20451469 Trials in depression, anxiety disorders and short-term acute anxiety have been conducted but acupuncture interventions employed in trials vary as do the controls against which these are compared. Auton Neurosci. 2010 Oct 28;157(1-2):91-5. doi: 10.1016/j.autneu.2010.04.002. Epub 2010 May 6. Anxiety Depression Review
20605536 A potential role for acupuncture was found in the following cancer symptoms: pain, nausea and vomiting, xerostomia, hot flushes, fatigue, anxiety, depression and insomnia. Auton Neurosci. 2010 Oct 28;157(1-2):96-100. doi: 10.1016/j.autneu.2010.05.001. Insomnia Nausea and Vomiting Anxiety Depression Review
21078263 Acupuncture treatment is characterized by controlling anxiety and gastrointestinal discomfort. Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1014-7. doi: 10.3736/jcim20101102. Anxiety Review
21611904 Secondly, acupuncture can improve the outcome of IVF-ET, and the mechanisms may be related to the increased uterine blood flow, inhibited uterine motility, and the anesis of depression, anxiety and stress. Chin J Integr Med. 2011 May;17(5):386-95. doi: 10.1007/s11655-011-0611-8. Epub 2011 May 25. Anxiety Depression Blood Flow Review
22238805 However, limited evidence supports the use of meditation, relaxation training and/or breathing retraining, and mindfulness-based stress reduction for anxiety, as well as acupuncture for depression. Anxiety Depression Review
24215924 Acupuncture has traditionally been used for problems including anxiety, insomnia, stress, and depression in China and other East Asian countries. Int Rev Neurobiol. 2013;111:197-216. doi: 10.1016/B978-0-12-411545-3.00010-9. Insomnia Anxiety Depression Review
24501113 Acupuncture is being adopted by cancer patients for a wide range of cancer-related symptoms including highly prevalent psychological symptoms like depression, anxiety, insomnia, and impairment in quality of life. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24501113 All published studies that met our review criteria demonstrate a positive signal for acupuncture for the treatment of depression, anxiety, sleep disturbance, and for improving quality of life with most results showing statistical significance. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24501113 However, there are only a handful of acupuncture studies that were specifically designed to evaluate depression, sleep disturbance, and quality of life as primary outcomes, and no studies were found that looked at anxiety as a primary outcome in this population. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24501113 In conclusion, results are encouraging for the development of randomized trials to directly evaluate the therapeutic impact of acupuncture in cancer-related psychological symptoms, including depression, anxiety, sleep disturbance, and quality of life, but attention to acupuncture methodological specific challenges in the development of high-quality research is necessary. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24648110 Significantly lower anxiety was noted in one study with music and two using acupuncture. Urolithiasis. 2014 Jun;42(3):189-93. doi: 10.1007/s00240-014-0655-2. Epub 2014 Mar 20. Anxiety Review
24942321 Exclusion criteria included (a) studies aimed at reducing wait times and management of waiting lists only, (b) waiting in non-health care settings, (c) design of health care facilities with nonspecific strategies pertaining to waiting spaces, (d) strategies to reduce pain or anxiety during the course of medical procedures, and (e) interventions such as massage, acupuncture, or hypnosis that require dedicated staff and/or private waiting environments to administer. Anesth Analg. 2014 Aug;119(2):433-448. doi: 10.1213/ANE.0000000000000294. Anxiety Review
25906584 Mechanism on atrial natriuretic peptide receptor in anti-anxiety with acupuncture based on its tranquilizing effect. Zhongguo Zhen Jiu. 2015 Jan;35(1):101-4. Anxiety Review
25906584 Due to the efficacy of acupuncture for tranquilization, acupuncture displays its unique advantage on the treatment of anxiety disorder, but the relevant biological mechanism has not been elaborated. Zhongguo Zhen Jiu. 2015 Jan;35(1):101-4. Anxiety Review
25906584 Hence, focusing on the three aspects, named the anti-anxiety effect of acupuncture based on its tranquilizing effect, the anti-anxiety effect of ANP and the positive regulation of acupuncture on NP, the mechanism on ANP and its receptor was explored in anti-anxiety with acupuncture based on tranquilizing effect, and the idea was put forward on that the anti-anxiety effect of acupuncture was possibly based on its action of tranquilization through regulating the ANP and its receptor. Zhongguo Zhen Jiu. 2015 Jan;35(1):101-4. Anxiety Review
25906584 As a result, it is expected to provide the theoretic support for the mechanism study on anti-anxiety with acupuncture based on its tranquilizing effect. Zhongguo Zhen Jiu. 2015 Jan;35(1):101-4. Anxiety Review
26433805 Perioperative acupuncture is apparently effective in reducing preoperative anxiety, postoperative nausea and vomiting, and postoperative pain. J Acupunct Meridian Stud. 2015 Oct;8(5):264-9. doi: 10.1016/j.jams.2014.12.004. Epub 2015 Jan 20. Nausea and Vomiting Anxiety Review
26433805 The Pericardium-6 (P-6; Nei Guan), Yintang (Extra 1), and Shenmen acupuncture points are the most studied and effective acupuncture points in reducing preoperative anxiety, postoperative nausea and vomiting, and postoperative pain experiences. J Acupunct Meridian Stud. 2015 Oct;8(5):264-9. doi: 10.1016/j.jams.2014.12.004. Epub 2015 Jan 20. Nausea and Vomiting Anxiety Review
26968093 We also identified a significant difference in favor of acupuncture versus comparators for anxiety at post-intervention (SMD -0.74, -1.15 to -0.33; 6 RCTs). Drug Alcohol Depend. 2016 Jun 1;163:1-15. doi: 10.1016/j.drugalcdep.2016.02.034. Epub 2016 Mar 3. Anxiety Review
26968093 Results in favor of acupuncture for withdrawal/craving and anxiety symptoms are limited by low quality bodies of evidence. Drug Alcohol Depend. 2016 Jun 1;163:1-15. doi: 10.1016/j.drugalcdep.2016.02.034. Epub 2016 Mar 3. Anxiety Review
26970732 A potential role was found for massage and bright light therapy for depression in those with Bulimia Nervosa and a potential role for acupuncture and relaxation therapy, in the treatment of State Anxiety, for those with an eating disorder. Eat Behav. 2016 Apr;21:179-88. doi: 10.1016/j.eatbeh.2016.03.002. Epub 2016 Mar 6. Anxiety Depression Review
27355312 Effects from acupuncture in treating anxiety: integrative review. Rev Bras Enferm. 2016 Jun;69(3):602-9. doi: 10.1590/0034-7167.2016690325i. Anxiety Review
27355312 OBJECTIVE: to evaluate the scientific evidence that is available in the literature on the effects of acupuncture for treating anxiety and on the quality of such studies. Rev Bras Enferm. 2016 Jun;69(3):602-9. doi: 10.1590/0034-7167.2016690325i. Anxiety Review
27355312 Keywords anxiety, acupuncture therapy, acupuncture, and anxiety disorders were combined among themselves to ensure a wide search of primary studies. Rev Bras Enferm. 2016 Jun;69(3):602-9. doi: 10.1590/0034-7167.2016690325i. Anxiety Review
27355312 Its results showed positive and statistically significant effects from using acupuncture for treating subjects with anxiety. Rev Bras Enferm. 2016 Jun;69(3):602-9. doi: 10.1590/0034-7167.2016690325i. Anxiety Review
27355312 CONCLUSION: acupuncture seems to be a promising treatment for anxiety; however, there is a need for improving the methodological quality of the research on this field. Rev Bras Enferm. 2016 Jun;69(3):602-9. doi: 10.1590/0034-7167.2016690325i. Anxiety Review
27377488 The potential of acupuncture to allay opioid-associated depression and anxiety, and its possible use as an adjuvant treatment were evident. East Asian Arch Psychiatry. 2016 Jun;26(2):70-6. Anxiety Depression Review
28151093 This review aims to estimate effects of acupuncture on PTSD symptoms, depressive symptoms, anxiety symptoms, and sleep quality for adults with PTSD. J Trauma Dissociation. 2018 Jan-Feb;19(1):39-58. doi: 10.1080/15299732.2017.1289493. Epub 2017 Mar 9. Anxiety Sleep Quality Review
28151093 No significant differences were observed between acupuncture and comparators at post-intervention for depressive symptoms (SMD = -0.58, 95% CI [-1.18, 0.01], 6 RCTs, very low QoE), anxiety symptoms (SMD = -0.82, 95% CI [-2.16, 0.53], 4 RCTs, very low QoE), and sleep quality (SMD = -0.46, 95% CI [-3.95, 3.03], 2 RCTs, low QoE). J Trauma Dissociation. 2018 Jan-Feb;19(1):39-58. doi: 10.1080/15299732.2017.1289493. Epub 2017 Mar 9. Anxiety Sleep Quality Review
29231558 The effects of deqi (arrival of qi) on acupoint effects in patients with primary dysmenorrhea (PD) were evaluated.Ten literature databases,including China National Knowledge Infrastructure (CNKI),VIP Database,Wanfang Database,Chinese Biomedical Literature Database (CBM),Cochrane Library CENTRAL,MEDLINE,Embase,AMED, CINAHL Plus,PsycINFO were selected.In addition,5 registers of ongoing trials,the reference lists of included articles and grey literature website OpenGrey were added.The search time was from date of database establishment to August 2016;no restrictions were made on language or status of publication.All randomized controlled trials (RCTs) and quasi-randomized controlled trials (q-RCTs) which compared the effects of deqi and non-deqi on PD or compared the effects of different deqi elements on PD were included.The research quality was assessed according to Cochrane bias risk evaluation tool 5.1.0.The RevMan 5.3.5 was applied for quantitative analysis if insignificant clinical heterogenicity with I(2) anxiety regardless of deqi,and the effects of deqi on pain relief were superior or equivalent to that of none-deqi,and the effects of deqi on anxiety relief were similar to that of none-deqi;2 in circle the more intensity of deqi and higher number of acupoints selected,the better effects on pain alleviation,symptom relief and pain duration;3 in circle the higher rate of deqi had a better acupoint effect on alleviating anxiety,but was not on pain relief;4 in circle deqi appeared early and propagated to affected area could lead to faster onset on pain relief;⑤ the effects on relieving pain and symptoms was better when warm sensation in deqi or qi reaching affected area.Due to the few number,low quality and potential bias of included studies,it was not sufficient to draw clear conclusion regarding the effects of deqi on PD patients.This study protocol was registered in PROSPERO (CRD42016038518). Zhongguo Zhen Jiu. 2017 Jul 12;37(7):791-797. doi: 10.13703/j.0255-2930.2017.07.027. Pain Relief Anxiety Review
29705474 Acupuncture and electroacupuncture for anxiety disorders: A systematic review of the clinical research. Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. Anxiety Review
29705474 Clinical research studies render acupuncture as a valid treatment therapy for anxiety disorders without significant adverse effects. Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. Adverse Reactions Anxiety Review
29705474 The objective of this paper is to review the literature on the effectiveness of acupuncture and electroacupuncture for the treatment of patients with anxiety disorders in order to find strong scientific evidence for its regular practice in Western culture. Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. Anxiety Review
29705474 The systematic review of the clinical research was focused on published clinical trials (controlled, randomized and non-randomized) regarding the treatment of anxiety with acupuncture. Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. Anxiety Review
29705474 Overall, there is good scientific evidence encouraging acupuncture therapy to treat anxiety disorders as it yields effective outcomes, with fewer side effects than conventional treatment. Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. Side Effects Anxiety Review
30535303 Acupuncture has demonstrated beneficial roles in the regulation of gut dysbiosis, intestinal barrier function, visceral hypersensitivity, gut motor dysfunction, depression/anxiety, and pain, all of which are factors that can significantly impact quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2019 Jun 18;25(7):1129-1139. doi: 10.1093/ibd/izy371. Anxiety Depression Motor Function Review
30672210 We found ear-acupuncture are mainly used in treating nausea and vomiting caused by radiation and chemotherapy (shenmen (TF(4)), jiaogan (AH(6a)), wei (CO(4)), pi (CO(13)), etc), insomnia in the rehabilitation period (xin (CO(15)), pizhixia (AT(4)), shenmen (TF(4)), etc), depression and anxiety (pizhixia (AT(4)), shenmen (TF(4)), pi (CO(13)), wei (CO(4)), xin (CO(15)), gan (CO(12)), etc), and joint pain (pain point), etc. Zhongguo Zhen Jiu. 2018 Nov 12;38(11):1249-54. doi: 10.13703/j.0255-2930.2018.11.031. Insomnia Nausea and Vomiting Anxiety Depression Review
30935538 Acupuncture for treatment of anxiety, an overview of systematic reviews. Complement Ther Med. 2019 Apr;43:247-252. doi: 10.1016/j.ctim.2019.02.013. Epub 2019 Feb 16. Anxiety Review
30935538 PURPOSE: To evaluate the methodological quality and summarize evidence of important outcomes of systematic reviews (SRs)/Meta analyses (MAs) of acupuncture for anxiety. Complement Ther Med. 2019 Apr;43:247-252. doi: 10.1016/j.ctim.2019.02.013. Epub 2019 Feb 16. Anxiety Review
30935538 CONCLUSION: Although most of the included reviews indicated that acupuncture group was more effective than control group in the treatment of anxiety, more importantly, the methodological quality of the included reviews and the quality of evidence were low. Complement Ther Med. 2019 Apr;43:247-252. doi: 10.1016/j.ctim.2019.02.013. Epub 2019 Feb 16. Anxiety Review
31076901 Due to the multimorphism of cancer pain, certain mind-body therapies acting on anxiety, stress, depression, or mood disturbances (such as massage, acupuncture, healing touch, hypnosis, and music therapy) are efficient on cancer pain. Support Care Cancer. 2019 Aug;27(8):3119-3132. doi: 10.1007/s00520-019-04829-7. Epub 2019 May 11. Cancer Pain Anxiety Depression Mood Review
31257250 Meta-analysis of 19 out of 34 reviews showed the followings: (1) acupuncture had a beneficial effect on the frequency of hot flushes, (2) yoga had a beneficial effect on depression and health-related QOL, (3) mindfulness-based stress reduction (MBSR) had a beneficial effect on anxiety and depression, (4) combination of herbal medicine and chemotherapy synergistically improved clinical outcomes, (5) acupuncture did not show significant effect on the severity of hot flushes and cancer-related pain, (6) yoga was unable to be confirmed as having an effect on cancer-related pain and physical well-being. Yakugaku Zasshi. 2019;139(7):1027-1046. doi: 10.1248/yakushi.18-00215. Anxiety Depression Review
31801357 Results demonstrated that EA was superior to control treatment (Western medicine, sham-EA, blank control, acupuncture, and acupoint catgut embedding) according to the visual analog scale (VAS) score, frequency of headache attack (Western medicine, sham-EA, blank control), self-rating anxiety scale (SAS [blank control]), self-rating depression score (SDS [Western medicine and blank control]), and clinical efficiency (Western medicine and sham-EA) after treatment (P < 0.05). Am J Chin Med. 2019;47(8):1755-1780. doi: 10.1142/S0192415X19500897. Epub 2019 Dec 4. Anxiety Depression Review
32002940 In this chapter we focus specifically on clinically diagnosed (in line with the standard criteria) anxiety disorders and overview evidence of efficacy/safety of a range of CAM modalities: biologically based therapies (typically herbal preparations and less so nutraceuticals); manipulative and body-based therapies (acupuncture, aerobic exercise, massage, therapeutic touch, repetitive transcranial magnetic stimulation, balneotherapy, and others); mind-body therapies (yoga, Morita therapy, Tai Chi, reiki, Chinese cognitive therapy, religious and spiritual interventions, relaxation, mediation, and mindfulness-based interventions); and alternative medical systems (Ayurveda, homeopathy). Adv Exp Med Biol. 2020;1191:415-449. doi: 10.1007/978-981-32-9705-0_22. Anxiety Review
32430505 OBJECTIVE: Auricular acupuncture (AA) and extended auricular therapy (AT) are a part of acupuncture practice shown to benefit patients with pain, anxiety, and other conditions, with cost-effective access enhanced when given in a group setting. Pain Med. 2020 Jun 1;21(6):1276-1293. doi: 10.1093/pm/pnz379. Anxiety Review
32447860 The results of the meta-analysis showed that compared with the conventional western medicine group, the acupuncture group had a significantly higher total effective rate (risk ratio ［RR］=1.16, 95% CI［1.05,1.28］, P=0.005) and had significantly greater improvements in Hamilton Anxiety Scale score (mean difference ［MD］=-3.22, 95% CI［-6.05, -0.39］, P=0.03). Zhen Ci Yan Jiu. 2020 May 25;45(5):419-25. doi: 10.13702/j.1000-0607.190276. Anxiety Review
32640263 We performed a systematic review to look at the role of alternative or complementary medicine such as music, acupressure, acupuncture, transcutaneous electrical nerve stimulation (TENS) and audiovisual distractions to decrease analgesia requirement and alleviate anxiety during SWL. Urology. 2020 Nov;145:38-51. doi: 10.1016/j.urology.2020.06.035. Epub 2020 Jul 5. Anxiety Review
32769804 Person-centered, novel pain management modalities, such as auricular acupuncture, help to improve client experience, by addressing both pain and anxiety. Curr Opin Obstet Gynecol. 2020 Dec;32(6):424-430. doi: 10.1097/GCO.0000000000000654. Anxiety Review
33288487 Can acupuncture therapy reduce preoperative anxiety? A systematic review and meta-analysis. J Integr Med. 2021 Jan;19(1):20-28. doi: 10.1016/j.joim.2020.10.007. Epub 2020 Nov 18. Anxiety Review
33288487 BACKGROUND: Acupuncture therapy has shown promise for effectively relieving preoperative anxiety. J Integr Med. 2021 Jan;19(1):20-28. doi: 10.1016/j.joim.2020.10.007. Epub 2020 Nov 18. Anxiety Review
33288487 OBJECTIVE: This study systematically evaluates the efficacy and safety of acupuncture therapy for preoperative anxiety as well as the quality of evidence supporting this application. J Integr Med. 2021 Jan;19(1):20-28. doi: 10.1016/j.joim.2020.10.007. Epub 2020 Nov 18. Anxiety Review
33288487 INCLUSION CRITERIA: RCTs were included in the current study if they contained a comparison between a group of anxiety patients that received acupuncture therapy and a control group that received sham acupuncture. J Integr Med. 2021 Jan;19(1):20-28. doi: 10.1016/j.joim.2020.10.007. Epub 2020 Nov 18. Anxiety Review
33288487 Meta-analysis showed that, compared with the control group, patients who received acupuncture therapy had reduced State-Trait Anxiety Inventory Scale (STAI-S) score (mean difference [MD] = -9.07, 95% confidence interval [CI] [-13.19 to -4.96], P < 0.0001) and Visual Analogue Scale (VAS) score (MD = -1.37, 95% CI [-2.29 to -0.45], P = 0.003). J Integr Med. 2021 Jan;19(1):20-28. doi: 10.1016/j.joim.2020.10.007. Epub 2020 Nov 18. Anxiety Review
33288487 CONCLUSION: Acupuncture therapy may be able to decrease anxiety in preoperative patients, but the results need to be further verified due to the small sample sizes and the low quality of evidence to date. J Integr Med. 2021 Jan;19(1):20-28. doi: 10.1016/j.joim.2020.10.007. Epub 2020 Nov 18. Anxiety Review
33838089 The results showed that different CAM interventions (acupuncture, Traditional Chinese medicine [TCM], relaxation, Qigong) significantly improved various psychological symptoms (depression, anxiety, stress, sleep quality, negative emotions, quality of life) and physical symptoms (inflammatory factors, physical activity, chest pain, and respiratory function) in COVID-19 patients. Rev Environ Health. 2021 Apr 12;36(3):443-450. doi: 10.1515/reveh-2021-0012. Print 2021 Sep 27. Anxiety Depression Mood Sleep Quality Review
33907909 Acupuncture, guided imagery, and loving-kindness meditation have all shown potential efficacy in reducing both peri-operative pain and anxiety in retrospective studies and small randomized controlled trials. Curr Oncol Rep. 2021 Apr 28;23(6):73. doi: 10.1007/s11912-021-01051-9. Anxiety Review
33942405 CONCLUSION: Music, aromatherapy and acupuncture appeared to be effective for reducing preoperative anxiety and postoperative pain in women undergoing breast cancer surgery. J Clin Nurs. 2021 Dec;30(23-24):3369-3384. doi: 10.1111/jocn.15827. Epub 2021 May 3. Anxiety Review
34076496 Acupuncture and Acupressure have not been widely tested, but their effectiveness rate is 100% when it comes to reducing patient anxiety in various procedural settings. J Altern Complement Med. 2021 Sep;27(9):727-737. doi: 10.1089/acm.2020.0505. Epub 2021 Jun 1. Anxiety Review
34076531 Discussion: The following interventions were most successful, reducing anxiety in over 70% of experiments: music, CBT, relaxation, massage, acupuncture/acupressure, hypnosis, and natural sounds. J Altern Complement Med. 2021 Sep;27(9):717-726. doi: 10.1089/acm.2020.0504. Epub 2021 Jun 1. Anxiety Review
34517216 Acupuncture for treating chronic stable angina pectoris associated anxiety and depression: A systematic review and meta-analysis. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 BACKGROUND AND OBJECTIVE: Despite that acupuncture is effective in treating anxiety, depression and chronic stable angina pectoris (CSAP), it remains unclear whether acupuncture can treat CSAP, anxiety and depression simultaneously. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 This systematic review and meta-analysis aimed to investigate the efficacy of acupuncture on CSAP-associated anxiety and depression. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 Meta-analysis results showed that acupuncture combined with standard care was more effective in relieving anxiety and depression, reducing angina attack frequency, and angina pain intensity than sham acupuncture with standard care and standard care alone. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 The safety of acupuncture for CSAP-associated anxiety and depression was also high. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 CONCLUSION: Acupuncture may be used as an adjunctive therapy to treat CSAP-associated anxiety and depression. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34747880 Auricular acupuncture and transcutaneous electrical nerve stimulation (TENS) reduce pain and anxiety during first trimester abortions. Curr Opin Obstet Gynecol. 2021 Dec 1;33(6):440-444. doi: 10.1097/GCO.0000000000000754. Anxiety Review
35570176 Effect of acupuncture on IVF-related anxiety: a systematic review and meta-analysis. Reprod Biomed Online. 2022 Jul;45(1):69-80. doi: 10.1016/j.rbmo.2022.02.002. Epub 2022 Feb 10. Anxiety Review
35570176 Non-pharmacological interventions such as acupuncture may provide support, but its effect on IVF-related anxiety is unclear. Reprod Biomed Online. 2022 Jul;45(1):69-80. doi: 10.1016/j.rbmo.2022.02.002. Epub 2022 Feb 10. Anxiety Review
35570176 This was a systematic review and meta-analysis to examine the effect of acupuncture on IVF-related state anxiety. Reprod Biomed Online. 2022 Jul;45(1):69-80. doi: 10.1016/j.rbmo.2022.02.002. Epub 2022 Feb 10. Anxiety Review
35570176 Using the random effects model, the meta-analysis found small but significant effects on state anxiety with acupuncture versus any control (standardized mean difference -0.21, 95% confidence interval -0.39 to -0.04, representing very low certainty evidence). Reprod Biomed Online. 2022 Jul;45(1):69-80. doi: 10.1016/j.rbmo.2022.02.002. Epub 2022 Feb 10. Anxiety Review
35570176 Acupuncture is a drug-free and safe treatment that may benefit those who are burdened with IVF-related anxiety, but more investigation is needed for confirmation. Reprod Biomed Online. 2022 Jul;45(1):69-80. doi: 10.1016/j.rbmo.2022.02.002. Epub 2022 Feb 10. Anxiety Review
35729088 Data from both clinical trials and animal studies has shown that the integration of acupuncture into perioperative patient care leads to a reduction of perioperative complications such as preoperative anxiety, intraoperative hemodynamic instability, postoperative pain, postoperative cognitive dysfunction, and postoperative nausea and vomiting in surgical patients. Am J Chin Med. 2022;50(4):961-978. doi: 10.1142/S0192415X22500392. Cognitive Function Nausea and Vomiting Anxiety Review
35764526 The paper reviewed the relevant studies on dyspnea treated with acupuncture over the past 20 years, as well as the underlying neuroendocrine mechanism from the perspective of central and peripheral vagus nerves, neurotransmitter, respiratory muscle function and anti-depression-anxiety function. Zhen Ci Yan Jiu. 2022 Jun 25;47(6):559-64. doi: 10.13702/j.1000-0607.20210430. Anxiety Depression Review
36099656 Limited evidence showed inconsistent results on acupuncture for chemotherapy-induced peripheral neuropathy (3 SRs, 6 RCTs), depression and anxiety (3 SRs, 9 RCTs). Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. Anxiety Depression Review
36099656 For neuropathy, depression and anxiety, acupuncture should be used as an option based on individual conditions. Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. Anxiety Depression Review
36099656 More well-designed clinical trials of acupuncture are recommended on cancer-related depression and anxiety, arthralgia, xerostomia, gastrointestinal dysfunction and dysphagia. Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. Anxiety Depression Review
36812735 Moderate evidence showed that SAS could significantly decrease the anxiety of cancer patients (Acupuncture: [random effect model, SMD = -0.52, 95% CI = -0.79 to -0.24, p = 0.0002] and Acupressure: [random effect model, SMD = -0.89, 95% CI = -1.25 to -0.52, p < 0.00001. Complement Ther Clin Pract. 2023 May;51:101735. doi: 10.1016/j.ctcp.2023.101735. Epub 2023 Feb 13. Anxiety Review
37382085 Currently, there is already evidence of the use of acupuncture for the treatment of nausea and vomiting, fatigue, dry mouth, anxiety, depression, insomnia and pain. J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. Insomnia Nausea and Vomiting Anxiety Depression Review
37582238 RECOMMENDATIONS: Recommendations were made for mindfulness-based interventions (MBIs), yoga, relaxation, music therapy, reflexology, and aromatherapy (using inhalation) for treating symptoms of anxiety during active treatment; and MBIs, yoga, acupuncture, tai chi and/or qigong, and reflexology for treating anxiety symptoms after cancer treatment. J Clin Oncol. 2023 Oct 1;41(28):4562-4591. doi: 10.1200/JCO.23.00857. Epub 2023 Aug 15. Anxiety Review
37614142 Based on the thoracic surgery, this paper analyzes and summarizes the application effects of modern acupuncture anesthesia, focusing on preoperative anxiety relief and advanced analgesia； reduce the dosage of anesthetics, stable respiration and hemodynamics, anti-stress and organ protection during surgery； postoperative analgesia, prevention of nausea, vomiting and cognitive impairment, improvement of gastrointestinal function, prevention of cognitive impairment, and enhancement of immunity. Zhen Ci Yan Jiu. 2023 Aug 25;48(8):825-32. doi: 10.13702/j.1000 rectangle0607.20220655. Immunity Hemodynamics Nausea and Vomiting Anxiety Organ Protection Review
38035864 FINDINGS: Acupuncture can relieve clinical symptoms, improve exercise tolerance, anxiety, and nutritional status, as well as hemorheological changes (blood viscosity), reduce the inflammatory response, and reduce the duration and frequency of COPD in patients with COPD. Biomed Pharmacother. 2024 Jan;170:115926. doi: 10.1016/j.biopha.2023.115926. Epub 2023 Nov 29. Anxiety Review
38159534 Compared with usual care or other types of care, mindfulness and yoga had excellent effects against perceived stress, anxiety, and depression; self-regulation could reduce perceived stress and anxiety; exercise could reduce perceived stress; acupuncture could reduce the level of depression; mindfulness could improve the TNF-alpha level, and yoga can reduce the level of salivary cortisol and DNA damage. Complement Ther Clin Pract. 2023 Dec 19;54:101803. doi: 10.1016/j.ctcp.2023.101803. Anxiety Depression Review
8467518 Acupuncture anesthesia/analgesia for pain and anxiety control in dental practice. Part I: Theory and application. Compendium. 1993 Feb;14(2):182, 183-9. Anxiety Review
20824863 The authors report that for both anxiety and depression scores, there was no evidence for a group effect or a group-time effect, but there was for a time effect (in favour of acupuncture). Cochrane Database Syst Rev. 2010 Sep 8;(9):CD007575. doi: 10.1002/14651858.CD007575.pub2. Anxiety Depression Review
23067573 Based on the results of our review, acupuncture appears to be effective for treating headaches and, although more research is needed, seems to be a promising treatment option for anxiety, sleep disturbances, depression and chronic pain. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Insomnia Anxiety Depression Review
23067573 Although more quality research and safety information are needed to determine whether acupuncture is useful in treating TSR components (.that is, PTSD, sexual function, cognitive function, fatigue), the results of our review suggest that acupuncture may be a beneficial or promising treatment for some components (that is., headache, anxiety, sleep disturbances, depression, chronic pain) and not beneficial for others (that is, substance abuse). Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Cognitive Function Insomnia Anxiety Depression Review
23067573 Though more research is needed to determine whether acupuncture is useful in treating anxiety, sleep disturbances, depression and chronic pain, it does seem to be a promising treatment option. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Insomnia Anxiety Depression Review
24716183 Recent advances from published clinical trials have added evidence to support the use of acupuncture for management of symptoms such as pain, nausea and vomiting, xerostomia, hot flashes, fatigue, anxiety, depression, and insomnia. J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. Insomnia Nausea and Vomiting Anxiety Depression Review
25097658 Acupuncture has been reported to improve intelligence and ameliorate depression and anxiety in AD patients. Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. Anxiety Depression Review
25254059 Efficacy of Acupuncture in Reducing Preoperative Anxiety: A Meta-Analysis Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Acupuncture has been shown to reduce preoperative anxiety in several previous randomized controlled trials (RCTs). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 In the meta-analysis data were included from RCT studies in which groups receiving preoperative acupuncture treatment were compared with control groups receiving a placebo for anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Six publications, using the State-Trait Anxiety Inventory-State (STAI-S), reported that acupuncture interventions led to greater reductions in preoperative anxiety relative to sham acupuncture (mean difference = 5.63, P < .00001, 95% CI [4.14, 7.11]). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Further eight publications, employing visual analogue scales (VAS), also indicated significant differences in preoperative anxiety amelioration between acupuncture and sham acupuncture (mean difference = 19.23, P < .00001, 95% CI [16.34, 22.12]). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Acupuncture therapy aiming at reducing preoperative anxiety has a statistically significant effect relative to placebo or nontreatment conditions. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 The aim of this meta-analysis was to evaluate the efficacy of various types of acupuncture therapy with respect to reducing preoperative anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Keywords used to search for the RCTs were (anxiety OR anxioly∗ OR sedat∗ OR distress OR fear OR panic OR stress, psychological OR stress, physiological) AND (acupressure OR acupoint OR auriculotherapy OR meridians OR electroacupuncture OR acupuncture) AND (surgical OR procedure∗ OR preoperative care OR surgery) AND (randomized controlled trial [PT] OR randomized [AB] OR controlled clinical trial [PT] OR placebo [AB] OR clinical trial as topic [SH] OR randomly [AB] OR trial [TI]) in MEDLINE. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Included studies were restricted to RCTs that compared all forms of acupuncture-treated (delivered using classical sterile single-use needles, plastic balls, or occlusive press needles) and control groups, which included nontreatment or placebo treatment (sham acupuncture unrelated to known acupoints for treatment, using a superficial depth of acupuncture, or without electronic stimulation), with the aim of reducing preoperative anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 The primary outcome was the degree of reduction in preoperative anxiety produced by acupuncture in controlled trials involving a group to whom acupuncture was administered and a control group. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 A meta-analysis of six studies using the STAI-S to examine state anxiety in 378 participants revealed significantly lower state anxiety levels in participants who received real versus sham acupuncture interventions (MD = 5.63, P < .00001, 95% CI [4.14, 7.11], Figure 4(a)). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 When restricting the analysis to studies with 100 or more participants, acupuncture treatment was still associated with significantly decreased preoperative anxiety (MD = 5.2, P = .006, 95% CI [1.51, 8.89]). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 The pooled analysis demonstrated that acupuncture interventions led to greater reductions in VAS anxiety relative to sham acupuncture (MD = 19.23, P < .00001, 95% CI [16.34, 22.12], Figure 4(b)). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Two studies reported significant decreases in preoperative anxiety following acupuncture treatment versus nontreatment (MD = 27.34, P < .00001, 95% CI [18.07, 36.61]). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Acupuncture's association with reduced preoperative anxiety, in comparison to sham acupuncture, remained in place (MD = 34.59, P < .00001, 95% CI [26.68, 42.51]) following the exclusion of studies with lower-quality methodologies, where this exclusion also improved the homogeneity of results (I 2 = 0%). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 For both types of acupuncture instrument (needles and beads), acupoint location (body versus ear) had no impact on the primary outcome measure of preoperative anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 This meta-analysis demonstrates that acupuncture therapy, administered in isolation, can decrease preoperative anxiety in patients with scheduled surgery. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 To our knowledge, there have been no other systematic reviews or meta-analyses of RCTs conducted concerning acupuncture's efficacy in reducing preoperative anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Acupuncture was generally associated with greater reductions in anxiety prior to surgery relative to control (nontreatment) and sham treatment conditions. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 They concluded that, although the number of studies included was insufficient for meaningful analysis, auricular acupuncture and intranasal midazolam were similarly effective for the treatment of anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 The effects of parental acupuncture on children's anxiety remain unclear and were not evaluated in this study. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Assuming that acupuncture reduces preoperative anxiety, the potential mechanisms of action may be similar to those previously documented for acupuncture. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 In addition, we could not combine all of the results of the STAI-S in children owing to insufficient data, where postintervention anxiety scores in acupuncture treatment groups were occasionally not provided; in some instances, attempts to contact authors were also unsuccessful. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Even when considering the caveats described above, our analyses support the possibility that acupuncture treatment is able to reduce preoperative anxiety better than sham acupuncture. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Clinically important differences were observed in the reduction of preoperative anxiety between acupuncture-treated and control (nontreatment) conditions, although the overall sample size was small. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 The findings of our analyses are clinically important, in which the results support the proposition that acupuncture is beneficial in reducing preoperative anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 In conclusion, this meta-analysis suggests that acupuncture therapy aiming at reducing preoperative anxiety has some beneficial effects as compared to placebo or nontreatment alternatives. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Forest plot of acupuncture efficacy in reducing preoperative anxiety. Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25254059 Funnel plot of the mean difference (MD) in anxiety ratings between acupuncture treatment and control groups, versus standard error (SE). Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. Anxiety Review
25379462 Anxiety related to dental treatment is rife, and there is a clinical impression that acupuncture (針灸 Zhēn Jiǔ) can offer an alternative to the sedative drugs commonly used although no controlled Studies are available. J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. Anxiety Review
25379462 Several reports on the use of auricular acupuncture (針灸 Zhēn Jiǔ) for treating chronic and acute anxiety have shown promising results. J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. Anxiety Review
25379462 There was no difference in the efficacy of Midazolam and auricular acupuncture (針灸 Zhēn Jiǔ) in the management of anxiety related to dental treatment. J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. Anxiety Review
25530779 The search required at least one term from each of the following categories: (1) heroin, opiate, and opioid; (2) acupuncture and electroacupuncture; (3) withdrawal syndromes, retention, dropout, completion, positive urine, craving, abstinence, heroin use, depression, anxiety, and relapse. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 We pooled all continuous data from trials according to their control interventions (sham acupuncture, no treatment, or drug) and outcome measures (craving, anxiety, and depression) used. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 All of the four studies published in English language journals did not show favorable effects of acupuncture on psychological symptoms associated with opioid addiction (anxiety, depression, and craving). Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 11 of 12 studies published in Chinese language journals supported use of acupuncture for controlling psychological symptoms associated with opioid addiction: craving, anxiety, and depression. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 We identify and summarize the evidence about the possible clinical effectiveness of acupuncture on three psychological symptoms: heroin/opioid craving, depression, and anxiety. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 Our meta-analysis indicated a statistically significant benefit of acupuncture for improving depression and anxiety associated with opioid addiction. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 This raises the possibility that the acupuncture protocols designed for psychological symptoms associated with opioid addiction may be more effective for the treatment of cravings, anxiety, and depression. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 Meta-analysis of acupuncture for anxiety associated with opioid addiction. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Review
26149519 The results indicate that acupuncture, in the form of traditional needle acupuncture or laser acupuncture, may provide benefit with respect to PEF and perhaps FEV1, along with asthma-specific anxiety level. Ital J Pediatr. 2015 Jul 7;41:48. doi: 10.1186/s13052-015-0155-1. Anxiety Review
26522652 There was no drowsiness, anxiety or extrapyramidal reactions found in participants given acupuncture or droperidol. Cochrane Database Syst Rev. 2015 Nov 2;2015(11):CD003281. doi: 10.1002/14651858.CD003281.pub4. Anxiety Review
26823672 (2002) showed the significant improvements in the depression, anxiety, and functional status in all groups but no differences in the specific acupuncture, nonspecific acupuncture, and symptom-based acupuncture groups. Evid Based Complement Alternat Med. 2015;2015:495684. doi: 10.1155/2015/495684. Epub 2015 Dec 28. Anxiety Depression Review
26823672 There was a significant reduction of the numeric rating scale anxiety score (p < 0.01) and State-Trait Anxiety Inventory State anxiety score values (p < 0.005) in the real acupuncture group. Evid Based Complement Alternat Med. 2015;2015:495684. doi: 10.1155/2015/495684. Epub 2015 Dec 28. Anxiety Review
26823672 The Bispectral Index System score did not change after 5 minutes, but a significant decrease in anxiety was noted in the real acupuncture group. Evid Based Complement Alternat Med. 2015;2015:495684. doi: 10.1155/2015/495684. Epub 2015 Dec 28. Anxiety Review
27022303 Reports on the use of auricular acupuncture for treating chronic and acute anxiety have shown promising results. Clin Cosmet Investig Dent. 2016 Mar 10;8:35-50. doi: 10.2147/CCIDE.S63626. eCollection 2016. Anxiety Review
27022303 A randomized controlled trial comparing auricular acupuncture with intranasal midazolam for managing dental anxiety suggested that both treatment methods were similarly effective. Clin Cosmet Investig Dent. 2016 Mar 10;8:35-50. doi: 10.2147/CCIDE.S63626. eCollection 2016. Anxiety Review
27022303 Though inconclusive, systematic reviews have suggested acupuncture as a promising therapy for the management of anxiety disorders in a dental setting. Clin Cosmet Investig Dent. 2016 Mar 10;8:35-50. doi: 10.2147/CCIDE.S63626. eCollection 2016. Anxiety Review
27217981 Trials have also shown that acupuncture significantly alleviates depression, anxiety and stress by modulating both specific and non-specific neurological signalling and also neuromodulators such as cortisol, prolactin, epinephrine and beta endorphin. Curr Obstet Gynecol Rep. 2016;5:110-118. doi: 10.1007/s13669-016-0156-0. Epub 2016 Apr 25. Anxiety Depression Review
27358589 Numerous clinical trials of acupuncture indicate its potential role in fighting the following ailments: nausea and chemotherapy-induced vomiting, pain, xerostomia, vasomotor symptoms, neutropenia, fatigue, anxiety, insomnia, lymphoedema after mastectomy, and peripheral neuropathy. Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. Insomnia Nausea and Vomiting Anxiety Review
27531549 Acupuncture may help treat specific cancer-related symptoms, including pain, gastrointestinal side effects, hot flushes, fatigue, anxiety, and depression. Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. Side Effects Anxiety Depression Review
28239282 In our previous study we summarized possible use of acupuncture in management of cancer symptoms and treatment-related ailments, such as chemotherapy-induced nausea and vomiting, pain, xerostomia, vasomotor symptoms, neutropenia, fatigue, anxiety, insomnia, lymphoedema after mastectomy and peripheral neuropathy. Contemp Oncol (Pozn). 2016;20(6):453-457. doi: 10.5114/wo.2016.65604. Epub 2017 Jan 12. Insomnia Nausea and Vomiting Anxiety Review
28436999 Acupuncture is often used in the oncology setting for chemotherapy-induced nausea/vomiting (CINV), pain management, musculoskeletal complaints, hot flashes, fatigue, stress, anxiety and sleep disorders. CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. Nausea and Vomiting Anxiety Review
28436999 Acupuncture, massage and relaxation can be considered for use for anxiety and stress reduction (Grades C). CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. Anxiety Review
28436999 Three high-quality trials assessed acupuncture for anxiety and stress reduction, which were secondary outcomes. CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. Anxiety Review
28664077 Effects of acupuncture on depression and anxiety disorders Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Depression Review
28664077 Lee et al reported that acupuncture stimulation at acupoint Neiguan (PC6) significantly reduced chronic CORT-induced depression and anxiety-like behaviors, and increased neuropeptide Y expression in the hypothalamus. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Depression Review
28664077 That study suggested that acupuncture may be an effective treatment for stress-related disorders such as depression and anxiety, probably by modulating the HPA axis. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Depression Review
28664077 Chae et al reported that increases in the corticotrophin-releasing factor may be involved in the negative emotional state associated with nicotine withdrawal, and acupuncture at HT7 may attenuate anxiety-like behavior following nicotine withdrawal by modulating corticotrophin-releasing factor in the amygdala. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Mood Review
28930222 Results: After the review of literature and the approval of a Regional Resolution, some CM will be introduced in Cancer Departments in Tuscany to additionally treat cancer-related symptoms and side effects of conventional cancer therapy: acupuncture for nausea and post-chemotherapy and post-surgery vomiting, pain, hot flashes of iatrogenic menopause, xerostomia; homeopathy for hot flashes of iatrogenic menopause and the side effects of radiotherapy; herbal medicine for cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety, and depression. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Side Effects Nausea and Vomiting Anxiety Depression Review
28930222 ), the authors cite five studies that use acupuncture, and conclude that it can reduce anxiety, fatigue and stress associated with advanced cancer. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Anxiety Review
28930222 in their review of 2013 report that, although acupuncture is often used to manage anxiety and stress, relatively few studies have evaluated its use for these symptoms in cancer patients. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Anxiety Review
28930222 In 2014, Haddad and Palesh, in their review of 12 papers on acupuncture used for psychological symptoms related to cancer, report six studies for depressive symptoms and four for anxiety symptoms. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Anxiety Review
28930222 This paper used a new classification system of effectiveness divided into six levels (A, B, C, D, H, I): acupuncture is assigned grade C (at least a moderate certainty that there is a small benefit) for pain, hot flashes, anxiety, depression, and fatigue. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Anxiety Depression Review
28930222 For acupuncture and TCM, the areas of application are post-chemotherapy and post-surgical nausea and vomiting, pain in all of its phases, vasomotor disturbances of iatrogenic menopause and xerostomia; for homeopathy, the vasomotor disturbances of iatrogenic menopause and adverse effects of radiotherapy; for herbal medicine, cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety and depression. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Adverse Reactions Nausea and Vomiting Anxiety Depression Review
30416533 Acupuncture has proven to be effective for reducing drug addiction and stress-related psychiatric disorders, such as anxiety and depression. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Depression Review
30416533 Also, acupuncture has been proven to be an effective treatment for reducing stress, anxiety, and depression via modulation of brain stress and endocrine systems in preclinical and clinical studies. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Endocrinology Anxiety Depression Review
30416533 Indeed, neurochemical studies have shown that acupuncture reduced not only anxiety-like behavior by normalizing catecholamine levels in the amygdala but also behavioral withdrawal syndromes by normalizing dopamine release in the nucleus accumbens (NAc) in ethanol-dependent rat. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 Since the reduction of dopamine levels in the NAc during withdrawal from ethanol administration may be responsible for the negative affect such as anxiety and anhedonia, it seems reasonable to propose that acupuncture may reduce the motivated behavior in alcohol dependence by restoring the deficiency in dopamine release in the brain. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 Inhibitions of anxiety-like behavior and reductions in tyrosine hydroxylase mRNA expression in the VTA and tyrosine hydroxylase protein expression in the NAc by acupuncture in ethanol-withdrawn rats confirmed these results. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 This study showed that acupuncture inhibited anxiety-like behaviors by ameliorating the dysfunction of the mesolimbic dopamine pathway through inhibition of BDNF expression in the VTA in ethanol-dependent rats. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 It is well documented that acupuncture decreases anxiety levels and stress-related symptoms. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 Interestingly, one study has shown that acupuncture inhibited anxiety-like behavior and increases in plasma corticosterone and amygdaloid catecholamine in ethanol-withdrawn rats. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 Therefore, these results raise the possibility that acupuncture may attenuate anxiety-like behavior during ethanol withdrawal through suppression of CRF neurons in the amygdala. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 Consistent with this finding, acupuncture reduced anxiety-like behavior during nicotine withdrawal by inhibiting CRF expression in the amygdala. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Review
30416533 Acupuncture also has proven to be an effective treatment for reducing stress, anxiety, and depression via modulation of brain stress and endocrine systems in clinical studies. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Endocrinology Anxiety Depression Review
30557187 Level II reproducible evidence supports use of arnica to decrease postoperative edema after rhinoplasty, onion extract to improve scar pigmentation, hypnosis to alleviate perioperative anxiety, and acupuncture to improve perioperative nausea. Ann Plast Surg. 2019 Apr;82(4):459-468. doi: 10.1097/SAP.0000000000001676. Nausea and Vomiting Anxiety Review
30557187 The study of hypnosis and acupuncture as adjunct methods of sedation has demonstrated a lowered inflammatory response (interleukin 6) after surgery compared with general anesthesia, decreased preoperative anxiety, reduced intraoperative time, decreased postoperative analgesia use, and more rapid recovery. Ann Plast Surg. 2019 Apr;82(4):459-468. doi: 10.1097/SAP.0000000000001676. Anxiety Sedation Review
30622598 In addition, these findings showed that, compared to sham electroacupuncture (EA), EA had differences in alleviating symptoms of craving (SMD -0.50, 95% CI -0.94 to -0.05) and depression (SMD -1.07, 95% CI -1.88 to -0.25) and compared to sham transcutaneous acupoint electrical stimulation (TEAS), TEAS had differences in alleviating symptoms of insomnia (MD 2.31, 95% CI 1.97 to 2.65) and anxiety (MD -1.26, 95% CI -1.60 to -0.92) compared to no treatment/sham TEAS. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Insomnia Anxiety Depression Review
30622598 The combined result showed that acupuncture did not significantly reduce anxiety symptoms compared with sham acupuncture (n = 361; SMD, -0.56; 95% CI -1.37 to 0.25; p = 0.17; heterogeneity: X2 = 24.08, p < 0.00001, I2 = 92%; Figure 3(f)). Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Anxiety Review
30622598 The objective of this study is to assess the efficacy of various modes of acupuncture in OUD through intensity of withdrawal syndrome; duration of treatment; urine examination; intensity of pain, anxiety, depression, insomnia, and other associated symptoms; retention of treatment; and nature and rate of adverse effect. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Adverse Reactions Insomnia Anxiety Depression Review
30622598 just assessed the effect of acupuncture in treatment of psychological symptoms associated with OUD, and both studies agreed that acupuncture could be effective in improving anxiety and depression. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Anxiety Depression Review
30809158 The Effects of Acupuncture on Glutamatergic Neurotransmission in Depression, Anxiety, Schizophrenia, and Alzheimer's Disease: A Review of the Literature Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 In this review, we investigate the current evidence for the treatment efficacy of acupuncture in depression, anxiety, schizophrenia, and AD. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Numerous clinical reports from various sources, including the non-Western scientific literature, attest to the efficacy of acupuncture in depression, anxiety disorders, schizophrenia, and Alzheimer's disease (AD). Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Acupuncture for the Treatment of Anxiety Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 The effectiveness of acupuncture in anxiety has been widely investigated, using various sets of acupuncture points and treatment parameters. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 A narrative review published by the British Acupuncture Council reported that regular acupuncture and EA treatments improved anxiety symptoms. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 A more recent systematic literature review that included 32 English-language clinical and preclinical studies published between 2000 and 2010 also reported significant, positive results with acupuncture treatment for anxiety. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 Thus, acupuncture treatment may have positive effects on the symptoms of anxiety. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 Acupuncture may also be of benefit in anxiety-related insomnia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Insomnia Anxiety Review
30809158 A Canadian study reported that acupuncture significantly improved sleep quality in patients with anxiety and insomnia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Insomnia Anxiety Sleep Quality Review
30809158 At the end of acupuncture treatment, urine 6-sulfatoxymelatonin (a metabolite of melatonin) levels were normalized and several polysomnographic measures, as well as self-reported fatigue, sleepiness, anxiety, and level of depression, were significantly improved. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Interestingly, acupuncture treatment may also reduce anxiety levels in medical conditions other than neuropsychiatry. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 An early study reported that auricular acupuncture reduced state anxiety in patients waiting for surgery by a significantly greater extent than either body or sham acupuncture. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 Another study has reported that both body and auricular acupuncture effectively reduce preoperative anxiety; self-rated anxiety scores were significantly reduced from baseline in both groups. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Review
30809158 These results suggest that verum acupuncture modulates autonomic activity in response to alterations of internal and external environments, and thus reduces overall anxiety in patients with depression or anxiety. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 However, it should be recognized that the interpretation of results from clinical trials investigating acupuncture interventions in depression and anxiety disorders is complicated by different interventions, different comparators used against acupuncture interventions, and the small sample sizes in many trials. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Compared with depression and anxiety, relatively few studies have addressed the efficacy of acupuncture in schizophrenia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 As with the clinical evidence for acupuncture in depression and anxiety disorders, the clinical evidence is limited for the effectiveness of acupuncture as a treatment for schizophrenia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 In a US study that included 11 patients with dementia (10 with AD and 1 with vascular dementia), depression and anxiety scores improved significantly after acupuncture treatment. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 In summary, evidence indicates that acupuncture treatment may be of benefit in several neuropsychiatric disorders, including depression, anxiety, schizophrenia, and AD. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30855351 Acupuncture could relieve anxiety and stress during the preoperative stage. Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. Anxiety Review
30855351 Pre-operative acupuncture can relieve anxiety, optimize the preoperative state, and reduce the usage of anesthetics, while surgical acupuncture can aid in postoperative and intestinal function recoveries, postoperative pain management, reduce postoperative nausea and vomiting, and shorten the length of hospital stay. Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. Nausea and Vomiting Anxiety Review
30855351 First, acupuncture could reduce anxiety and stress in patients. Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. Anxiety Review
30855351 A meta-analysis involving eight published studies on the effect of acupuncture on preoperative anxiety suggested that acupuncture significantly reduced the preoperative anxiety status. Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. Anxiety Review
31016194 However, they suggested that combining acupuncture with psychotherapy would result in higher HADM, lower self-rating depression scale scores, and self-rating anxiety scale scores. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Anxiety Depression Review
31374032 There is a clinical basis for ear acupuncture, which may be effective for immediate pain relief, as well as psychiatric conditions such as substance abuse, insomnia, depression, and anxiety. Medicine (Baltimore). 2019 Aug;98(31):e16631. doi: 10.1097/MD.0000000000016631. Pain Relief Insomnia Anxiety Depression Review
31467579 have shown that amelioration of pain by electric acupuncture is associated with improved anxiety and mood disorders simultaneously, thereby promoting recovery. Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. Anxiety Mood Review
31497504 A review done by the Department of Veterans Affairs in 2014 showed overview of the evidence base of acupuncture for mental health such as depression, schizophrenia, anxiety, posttraumatic stress disorder (PTSD), addiction, and chronic fatigue syndrome. Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. Anxiety Depression Review
31702639 We use Insomnia Severity Index (ISI) as the main outcome of insomnia and Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale(HAMD) and Self-Rating Anxiety Scale (SAS) as secondary indicators to evaluate the efficacy and safety of acupuncture treatment of insomnia, we will use Revman v.5.3 software to calculate data synthesis, and if the results are appropriate, meta-analysis can also be carried out. Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. Insomnia Anxiety Depression Sleep Quality Review
31802723 Fifteen studies were included in the final review and findings tended to be in support of acupuncture and acupressure for symptoms such as agitation, anxiety, ADL function, sleep, mood, depression, and neuropsychological disturbances. West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. Anxiety Depression Mood Review
31814859 randomized 40 participants into acupuncture and sham acupuncture groups, with auricular stimulation at anxiety and gut areas in the acupuncture group, and allergy areas in the placebo group, totally 6 treatments over 3 weeks. Pain Res Manag. 2019 Nov 11;2019:2871505. doi: 10.1155/2019/2871505. eCollection 2019. Anxiety Review
32038351 Results demonstrated that overall, massage therapy, tai-chi, dance/movement therapy, functional relaxation, reflexology, acupuncture and emotional freedom technique seem to alleviate stress, depression, anxiety, bipolar disorder and facilitate pain reduction. Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. Anxiety Depression Mood Review
32080154 There is also some clinical evidence of the effectiveness of ear acupuncture in psychiatric conditions such as substance abuse, insomnia, depression, and anxiety as well as immediate pain relief. Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. Pain Relief Insomnia Anxiety Depression Review
32080154 Among the diagnosed PTSD patients after disaster, compared to baseline, ear acupuncture improved the overall PTSD symptoms assessed by CAPS or PCL-M, and also improved depression and anxiety as assessed by HAMD and HAMA, respectively. Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. Anxiety Depression Review
32375775 Our results do not show strong evidence for any non-filiform acupuncture techniques, only acupressure seams to improve dyspnoea and anxiety, based in low quality trials. BMC Complement Med Ther. 2020 May 6;20(1):138. doi: 10.1186/s12906-020-02899-3. Anxiety Review
32476804 Three studies assessed the anxiety and depression degrees by different questionnaires and showed improvement in mental status after acupuncture treatment (see Table 3). World J Gastroenterol. 2020 May 21;26(19):2440-2457. doi: 10.3748/wjg.v26.i19.2440. Anxiety Depression Review
32714410 Psychological factors, such fear and anxiety for pain or kinesiophobia, on the outcomes of acupuncture for DOMS were also measured by psychological questionnaires. Evid Based Complement Alternat Med. 2020 Jun 27;2020:5864057. doi: 10.1155/2020/5864057. eCollection 2020. Anxiety Review
32718258 In another, gabapentin was used with acupuncture to treat anxiety attacks and sleep disturbances. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. Insomnia Anxiety Review
32948909 Similarly, acupuncture has benefited cancer patients with vasomotor symptoms, anxiety, cancer-related pain, nausea, and vomiting. Semin Immunopathol. 2020 Dec;42(6):719-734. doi: 10.1007/s00281-020-00815-y. Epub 2020 Sep 18. Nausea and Vomiting Anxiety Review
33327222 Regarding nausea and vomiting, we found that acupuncture was associated with a statistically significant increase appetite and reduce the level of fatigue, anxiety, and depression. Medicine (Baltimore). 2020 Dec 11;99(50):e21820. doi: 10.1097/MD.0000000000021820. Nausea and Vomiting Anxiety Depression Review
33584181 We used the search string [pain(MeSH)] OR [headache(MeSH)] OR [osteoarthritis(MeSH)] OR [fibromyalgia(MeSH)] OR [cancer (MeSH)], AND [acupuncture(MeSH)], AND [psychological disorder(MeSH)], OR [mental disorder(MeSH)] OR [emotional (MeSH)], OR [anxiety(MeSH)], OR [depression(MeSH)] for PubMed and adapted it for Web of Science and Embase. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Mood Review
33584181 The majority of the studies suggest that acupuncture can significantly improve the emotional symptoms (such as anxiety and depression) in patients with chronic pain compared with both usual care and waiting list. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Mood Review
33584181 The prevalence of use of acupuncture and other complementary and alternative medicine approaches in chronic headaches was 62%, and the results were promising, particularly in patients with mood or anxiety disorders caused by headache. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Mood Review
33584181 After treatment, compared with the sham acupuncture group, electroacupuncture significantly improved the pain threshold in the neck and shoulder regions, anxiety, depression, and satisfaction with life (P < 0.05). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 It reported improved pain intensity (measured with Visual Analog Scale) and psychological stress (measured with Hospital Anxiety and Depression Scale) in the acupuncture group (acupuncture vs. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 After 1 month treatment, anxiety, as measured by the Fibromyalgia Impact Questionnaire and Multidisciplinary Pain Inventory, was significantly improved in the acupuncture group compared with the sham acupuncture group (P < 0.05). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Review
33584181 An RCT comparing acupuncture (one sessions per week for 6 weeks, each session lasted 20 min) with physiotherapy and standardized advice in 181 patients with severe osteoarthritic knee pain awaiting knee arthroplasty found no significant changes in knee pain (measured with the pain subscale of Western Ontario and McMaster Universities Osteoarthritis Index), anxiety, and depression (measured with Hospital Anxiety and Depression Scale) among the three groups. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 On the basis of several studies highlighted in this section, acupuncture may improve psychological symptoms caused by chronic cancer pain including tension, anxiety, and depression. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Cancer Pain Anxiety Depression Review
33584181 It found that acupuncture showed a significant reduction in numbness/tingling, anxiety, depression, and other psychological disorders (measured with Edmonton Symptom Assessment Scale) at the end of the treatment (P < 0.001). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 Tension/anxiety improved in the acupuncture group on postoperative Day 1 more than in the usual care group (P = 0.048), but these improvements were not maintained on postoperative Day 2 and postoperative Day 3. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Review
33584181 Acupuncture applied to chronic cancer pain conditions is also typically beneficial with respect to anxiety and depression. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Cancer Pain Anxiety Depression Review
33584181 Acupuncture may mediate its anti-pain, anti-anxiety, anti-depression, and other therapeutic effects via regulating brain regions and their related substances. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33608828 Seven randomized controlled trials attested the efficacy of acupuncture, music therapy, virtual reality, and pharmacological support in lowering anxiety levels. Neurosurg Rev. 2021 Dec;44(6):3047-3057. doi: 10.1007/s10143-021-01498-1. Epub 2021 Feb 19. Anxiety Review
33608828 Considering the findings reported by seven RCTs, also in relation to their quality and RoB, it emerges that several methods could be effectively applied to lower preoperative anxiety in patients awaiting brain surgery, both pharmacological, such as pregabalin, flupirtine, and oxazepam, and non-pharmacological, such as acupuncture, virtual reality, and music therapy; skin surface warming had no influence on anxiety in this group of patients. Neurosurg Rev. 2021 Dec;44(6):3047-3057. doi: 10.1007/s10143-021-01498-1. Epub 2021 Feb 19. Anxiety Review
33608828 Acupuncture could achieve up to 30% reduction of anxiety and it is easy to administer also by a non-specialist practitioner (such as medical students) and in a busy preoperative environment. Neurosurg Rev. 2021 Dec;44(6):3047-3057. doi: 10.1007/s10143-021-01498-1. Epub 2021 Feb 19. Anxiety Review
33859714 In fact, many practitioners who want to become professional acupuncturists lack practical training in performing acupuncture for anxiety about deep needling, lack feedback from actual patients, etc. Evid Based Complement Alternat Med. 2021 Mar 31;2021:8883598. doi: 10.1155/2021/8883598. eCollection 2021. Anxiety Review
33883931 Acupuncture is widely considered to be a potential effective therapy in treatment of depression and anxiety but has been involved in very limited studies concerning emotional disorders during PIPN, so further exploration is called for. J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. Anxiety Depression Mood Review
33917977 In behavioral evaluation, acupuncture, including manual acupuncture and electro-acupuncture, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated disturbance of spatial learning and memory of PTSD animal models. J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Learning and Memory Ability Anxiety Review
33917977 The use of acupuncture has been investigated not only in various pain conditions but also in psychiatric problems such as depression, insomnia, and anxiety disorders. J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Insomnia Anxiety Depression Review
33917977 In these studies, the effects and/or underlying mechanisms of acupuncture on anxiety and fear behaviors, depression behavior, sleep disturbance, cognitive symptoms (especially spatial learning and memory), and stress responses in PTSD animal models have been reported (Figure 3 and Table 2). J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Insomnia Stress Response Learning and Memory Ability Anxiety Depression Review
33917977 In behavioral evaluation, acupuncture, including MA and EA, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated the disturbance of spatial learning and memory in PTSD animal models. J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Learning and Memory Ability Anxiety Review
33917977 Particularly, effects on the hippocampus have been reported most often, suggesting that acupuncture may have the potential to reduce anxiety and fear symptoms by controlling the fear circuit plasticity of PTSD, which is related to conditioned fear and associative learning clinically. J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Anxiety Review
33917977 In behavioral evaluation, acupuncture, including MA and EA, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated the disturbance of spatial learning and memory of the PTSD animal models. J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Learning and Memory Ability Anxiety Review
34178633 Moreover, patients treated with acupuncture were more likely to experience improvements in hot flashes scores, fatigue, sleep disturbance, and anxiety compared to those in the control group, while the improvements in depression were comparable across both groups. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Insomnia Anxiety Depression Review
34178633 Current evidence suggests that acupuncture might improve BC treatment-related symptoms measured with PROs including QoL, pain, fatigue, hot flashes, sleep disturbance and anxiety. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Insomnia Anxiety Review
34178633 An earlier comprehensive systematic review of acupuncture in cancer care came up with the conclusion that the efficacy of acupuncture was not determined through its effects on symptoms such as pain, hot flashes, anxiety, or fatigue owing to the absence of the high-quality studies. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Review
34178633 The Society for Integrative Oncology (SIO) clinical practice guidelines on the evidence-based use of integrative therapies during and after BC treatment recommended that acupuncture could be considered for anxiety, depression, fatigue, pain, hot flashes and QoL, but the use of acupuncture should be based on professional judgment and patient preferences due to the fact that the net benefit is small. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 A meta-analysis of two articles suggested that acupuncture could improve the anxiety of BC patients compared with the control management strategies (SMD -0.37, 95%CI, -0.68 to -0.05, P=0.02, I2 = 0%) ( Figure 6 ). Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Review
34178633 Forest plot of the change of anxiety and depression in BC patients treated with acupuncture and control from the bassline to end of treatment. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 noticed similar changes in the severity of depression and anxiety between the acupuncture and control groups from the pre- to post-treatment period. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 drew the conclusion that acupuncture improved anxiety and depression using the HADS. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 This review pointed out that the use of acupuncture might improve the QoL, pain, hot flashes, fatigue, sleep disturbance and anxiety of BC patients compared with the use of control management strategies, while the difference in depression was not statistically significant between the two groups at EOT. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Insomnia Anxiety Depression Review
34178633 Relatively few studies had explored the effects of acupuncture for anxiety or depression in patients with cancer, and these syndromes were commonly used as secondary outcome measures in studies. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 In a nutshell, acupuncture might improve BC treatment-related complications based on the measurements obtained from PROs including the QoL, pain, fatigue, hot flashes, sleep disturbance, and anxiety. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Insomnia Anxiety Review
34367299 The role of acupuncture in reducing the anxiety and depression scores in patients with nausea during pregnancy has been reported previously. Evid Based Complement Alternat Med. 2021 Jul 27;2021:2731446. doi: 10.1155/2021/2731446. eCollection 2021. Nausea and Vomiting Anxiety Depression Review
34397828 However, Pei et al reported that acupuncture may reduce pain intensity, relieve anxiety, and improve quality of life in patients with PHN. Medicine (Baltimore). 2021 Aug 6;100(31):e26785. doi: 10.1097/MD.0000000000026785. Anxiety Review
34675729 A menopausal epidemiological study carried out in the US indicated that in women who primarily used alternative therapies including acupuncture to manage menopause-related depression, 1.0% were completely symptom free, 84.6% made symptoms get a little to a lot better, 12.5% showed no change in symptoms, and 1.9% reported the worsening of symptoms, which was slightly less effective than the conditions in women who primarily used anti-depressive or anti-anxiety agents for menopause-related depression (5.6% were completely symptom free, 88.6% made symptoms get a little to a lot better, 3.9% showed no change in symptoms, and 1.9% reported the worsening of symptoms). Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Anxiety Depression Review
34721179 A randomized controlled trial, a coping strategy, a questionnaire, Beck's depression inventory, and the State-Trait Anxiety Inventory were used to evaluate the therapeutic effects of acupuncture on chronic sciatica (Kim et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Anxiety Depression Review
34729102 The results regarding whether acupuncture could improve cancer-related anxiety and depression are controversial. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 24 for sham-acupuncture) revealed that acupuncture has no significant effect to improve anxiety and depression associated with the treatment of aromatase inhibitors (AIs); whereas another clinical trial showed that EA could significantly improve anxiety and depression associated with AIs treatment in breast cancer patients. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 Meanwhile, a clinical trial including 302 breast cancer patients showed that acupuncture could improve cancer-related anxiety and depression. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 In summary, large clinical trials assessing anxiety and depression as the primary outcome need to be conducted to evaluate the role of acupuncture in cancer-related anxiety and depression. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 This review summarized the application of acupuncture and EA in cancer patients for improving cancer-related symptoms and side-effects, such as fatigue, insomnia, chemotherapy-associated dyspepsia syndrome (CADS), radiation-induced xerostomia (RIX), anxiety and depression, and pain (Table 1). J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Side Effects Insomnia Anxiety Depression Review
34868943 However, in psychosomatic symptoms such as anxiety, sleep disturbance, and fatigue, acupuncture and exercise training did not result in significant improvements. Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. Insomnia Anxiety Review
34868943 The effect of acupuncture on anxiety and sleep disturbance was performed in a meta-analysis by using HADS-A and PSQI. Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. Insomnia Anxiety Review
34868943 The evidence suggests that both acupuncture and exercise result in little to no change in anxiety, sleep disturbance, and fatigue in patients suffering from psychosomatic symptoms, but the quality of the evidence for this outcome was not high, either. Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. Insomnia Anxiety Review
34868943 However, acupuncture or exercise training could not significantly improve some psychosomatic symptoms (such as anxiety, sleep disturbance, and fatigue). Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. Insomnia Anxiety Review
34983587 Acupuncture can be effective in the management of not only pain, but also symptoms such as insomnia, anxiety, and joint pain. Chin Med. 2022 Jan 5;17(1):8. doi: 10.1186/s13020-021-00558-4. Insomnia Anxiety Review
34989185 The findings revealed that acupuncture had a significant positive effect on memory and anxiety, and these benefits lasted for 6 months after treatment ended. J Menopausal Med. 2021 Dec;27(3):115-131. doi: 10.6118/jmm.21022. Anxiety Review
34989185 This is consistent with some previous trials that showed the effectiveness of acupuncture for alleviating psychological symptoms including anxiety in different target groups. J Menopausal Med. 2021 Dec;27(3):115-131. doi: 10.6118/jmm.21022. Anxiety Review
34989185 A meta-analysis of the effectiveness of acupuncture in the treatment of anxiety disorder found that acupuncture is safe and effective for the treatment of anxiety disorder. J Menopausal Med. 2021 Dec;27(3):115-131. doi: 10.6118/jmm.21022. Anxiety Review
35085351 Compared with sham acupuncture, acupuncture was not significantly better at relieving anxiety (standardized mean difference [SMD] -0.35, 95% CI −1.05 to 0.33) and depression (SMD -0.32, 95% CI −0.71 to 0.07) symptoms. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Compared with pharmacotherapy, acupuncture was significantly better at relieving anxiety (SMD -0.64, 95% CI -0.93 to -0.35) and depression (SMD -0.46, 95% CI -0.69 to -0.22) symptoms. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Evidence has shown that acupuncture can relieve gastrointestinal symptoms of FGIDs and emotional symptoms such as depression and anxiety. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Mood Review
35085351 The pooled results indicated that acupuncture was not significantly better at relieving anxiety symptoms than sham acupuncture (SMD -0.35, 95% CI −1.05 to 0.33, I2 = 85%, Fig 2A). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 In addition, the subgroup analysis based on disease showed that acupuncture may be superior to sham acupuncture in relieving anxiety symptoms in patients with IBS (SMD -0.5, 95% CI -0.95 to -0.06), but there was no significant relief of anxiety symptoms in patients with FD, FC or FDr (Fig 2A). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 It also showed that acupuncture was not more effective than sham acupuncture in reducing anxiety symptoms (S5 and S6 Figs in S1 File). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 Forest plot of comparison: Acupuncture versus sham acupuncture, outcome: Severity of anxiety and depression at the end of treatment. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 The pooled results indicated that acupuncture was significantly better at relieving anxiety symptoms than pharmacotherapy (SMD -0.64, 95% CI -0.93 to -0.35, I2 = 86%, Fig 3). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 Moreover, the subgroup analysis (Fig 3) showed that acupuncture was better than pharmacotherapy at relieving anxiety symptoms in patients with FD (SMD -1.47, 95% CI -2.46 to -0.48), IBS (SMD -0.64, 95% CI -1.17 to -0.11), FC (SMD -0.22, 95%CI -0.43 to -0.01) and FDr (SMD -0.53, 95% CI -0.78 to -0.29). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 Forest plot of comparison: Acupuncture versus pharmacotherapy, outcome: Severity of anxiety at the end of treatment. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 In addition, the subgroup analysis (Fig 3) showed that acupuncture was better than pharmacotherapy at relieving anxiety symptoms in patients with FD (SMD -1.13, 95% CI -1.82 to -0.44), IBS (SMD -0.33, 95% CI -0.64 to -0.02) and FDr (SMD -0.39, 95% CI -0.67 to -0.11), but not FC (SMD -0.11, 95%CI -0.32 to 0.10). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Review
35085351 The pooled results showed that acupuncture was relatively effective in relieving anxiety and depression symptoms in patients with FGIDs, but the current evidence does not explain whether this effect is a placebo effect. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Acupuncture at Tianshu, Zusanli, and Shangjuxu can regulate the balance of the gut microbiome, and gut microbiome dysbiosis is an important cause of depression and anxiety. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Compared with pharmacotherapy, acupuncture reduced anxiety and depressive symptoms in patients with FD, IBS and FDr and alleviated anxiety symptoms in patients with FC, but there was no significant difference in the scores for depression symptoms in patients with FC. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 This showed that acupuncture treatment for depression and anxiety symptoms in patients with FC was at least equivalent to mosapride. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35168522 An 8-week controlled clinical study with 60 patients to compare the effects of electroacupuncture and SSRIs in depressive patients found that electroacupuncture showed greater improvement in global clinical impression, anxiety/somatization, and feelings of despair than SSRIs. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Anxiety Review
35168522 However, a double-blind RCT involving 20 PPD women who received electroacupuncture or non-invasive sham acupuncture two sessions weekly for four weeks found that electroacupuncture and sham acupuncture both reduced the score of HDRS, Edinburgh Postnatal Depression Scale, Hospital Anxiety and Depression Scale and Clinical Global Impression and was no significant difference between two groups. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Anxiety Depression Review
35241146 In recent years, clinical trials of acupuncture registered and carried out worldwide involve the evaluation of limb motor function, limb spasm and pain, swallowing function, activities of daily living, quality of life, cognitive function, depression, and anxiety state, etc., both in acute and recovery phase of ischemic stroke. Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. Cognitive Function Anxiety Depression Motor Function Review
35380733 A retrospective study of patients with acute pain in the ED found that acupuncture produced a decrease in pain comparable to that produced by analgesics, with the additional benefits of reduction in anxiety as well as high acceptability among both medical providers and patients (Table 5). Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. Anxiety Review
35481320 studied breast cancer patients undergoing reconstructive surgery who were evaluated post operatively using visual analog scores (VAS) to determine pain, mood, energy, relaxation, insomnia, stress, anxiety, alertness, fatigue, and tension after massage alone or with the addition of acupuncture. Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. Insomnia Anxiety Mood Review
35481320 demonstrated that acupuncture in combination with massage resulted in decreased levels of anxiety, relaxation, nausea, fatigue, pain, and mood following breast reconstructive surgery compared to baseline. Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. Nausea and Vomiting Anxiety Mood Review
35481320 Although the benefits of this intervention were similar to the benefits of massage-only intervention in regards to fatigue, anxiety, relaxation, nausea, pain, and mood scores, the massage plus acupuncture intervention increased stress levels compared to massage alone. Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. Nausea and Vomiting Anxiety Mood Review
35494482 Currently, there are several assessment scales for acupuncture senses, such as Visual Analog Scales (VAS) that quantified the five acupuncture senses and the anxiety degree and the Massachusetts General Hospital Acupuncture Sensation Scale (MASS) that contains VAS and two subscales which are used to evaluate the acupuncture sensation spreading and patients' mood. Neural Plast. 2022 Apr 21;2022:5635596. doi: 10.1155/2022/5635596. eCollection 2022. Anxiety Mood Review
35547876 gave EA trigeminal nerve stimulation combined with body acupuncture for 8 weeks to breast cancer patients who had received cyclophosphamide and found that EA combined with body acupuncture could improve reverse digit breadth test (evaluation of attentional function and working memory) scores and decrease the incidence of diarrhea, loss of appetite, headache, and anxiety when compared with patients in the low-frequency EA group. Front Oncol. 2022 Apr 25;12:864046. doi: 10.3389/fonc.2022.864046. eCollection 2022. Anxiety Review
35547876 In gynecological cancer, 70 patients treated with carboplatin in combination with paclitaxel found a higher rate of complete remission of delayed-phase CINV, lower nausea index, and lower incidence of adverse events such as constipation and anxiety in the group of patients who received acupuncture at PC6 before chemotherapy, suggesting that acupuncture may be effective as an alternative therapy to prevent delayed-phase CINV. Front Oncol. 2022 Apr 25;12:864046. doi: 10.3389/fonc.2022.864046. eCollection 2022. Nausea and Vomiting Anxiety Review
35570887 Besides, acupuncture can reduce the anxiety level and regulate serum cortisol (CORT) and PRL, which simulate estradiol (E2) and progestin (P) independently. Front Public Health. 2022 Apr 28;10:858587. doi: 10.3389/fpubh.2022.858587. eCollection 2022. Anxiety Review
35586692 reported that acupuncture at Nei Guan (PC6) significantly reduced CORT-induced anxiety and depression behaviors in rats and increased the expression of neuropeptide Y in the hypothalamus. Evid Based Complement Alternat Med. 2022 May 9;2022:4807271. doi: 10.1155/2022/4807271. eCollection 2022. Anxiety Depression Review
35586692 This finding indicates that acupuncture may alleviate anxiety and depression in the patients by regulating the HPA axis, thus effectively treating ED. Evid Based Complement Alternat Med. 2022 May 9;2022:4807271. doi: 10.1155/2022/4807271. eCollection 2022. Anxiety Depression Review
35725779 Acupuncture has been used in managing various symptoms and diseases such as anxiety, depression, low back pain, inflammatory bowel disease, and cancer symptoms. Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. Anxiety Depression Inflammatory Pain Review
35726681 Both children and parents reported physical and physiological benefits such as a decrease in anxiety from acupuncture and yoga. Integr Cancer Ther. 2022 Jan-Dec;21:15347354221105563. doi: 10.1177/15347354221105563. Anxiety Review
35735746 Auricular acupuncture is a minimally invasive technique that can reduce general and preoperative anxiety. Aust Dent J. 2022 Mar;67 Suppl 1(Suppl 1):S3-S13. doi: 10.1111/adj.12926. Epub 2022 Jul 12. Anxiety Review
35735746 Auricular acupuncture relieves anxiety by modulating the autonomic nervous system, suppressing the sympathetic nervous system, and stimulating the parasympathetic nervous system, thus inhibiting noradrenaline production and reducing sympathetic hyperactivity. Aust Dent J. 2022 Mar;67 Suppl 1(Suppl 1):S3-S13. doi: 10.1111/adj.12926. Epub 2022 Jul 12. Anxiety Review
35735746 (2012) investigated whether auricular acupuncture effectively reduced anxiety before dental treatment. Aust Dent J. 2022 Mar;67 Suppl 1(Suppl 1):S3-S13. doi: 10.1111/adj.12926. Epub 2022 Jul 12. Anxiety Review
35735746 The results implied that auricular acupuncture at the relaxation, the tranquilizer and the master cerebral point, twenty minutes before ambulatory dental treatment, effectively reduces anxiety before dental treatment. Aust Dent J. 2022 Mar;67 Suppl 1(Suppl 1):S3-S13. doi: 10.1111/adj.12926. Epub 2022 Jul 12. Anxiety Review
35735746 The limited but sound quality evidence indicated acupuncture is beneficial in reducing anxiety before treatment. Aust Dent J. 2022 Mar;67 Suppl 1(Suppl 1):S3-S13. doi: 10.1111/adj.12926. Epub 2022 Jul 12. Anxiety Review
35922617 Recent studies have shown that acupuncture can reduce the adverse events related to surgery and anesthesia, such as anxiety, nausea, and vomiting, suggesting that acupuncture might be a potential complementary method to medication for colonoscopy. Pain Ther. 2022 Dec;11(4):1095-1112. doi: 10.1007/s40122-022-00415-8. Epub 2022 Aug 3. Nausea and Vomiting Anxiety Review
36011540 Acupuncture and dry needling therapies seems to be effective in patients with FM, since both reduced pain pressure thresholds, anxiety, depression, fatigue, sleep disturbances and disability in the short term. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Insomnia Anxiety Depression Review
36011540 The main findings of this meta-analysis were that dry needling could induce a short-term improvements in pain, quality of life, vitality, social function, psychological and severity in patients with FM in comparison with other techniques (e.g., manual myofascial release, cross tape) and that acupuncture, if combined with other treatments, is also an effective technique to reduce the ingestion of analgesics and to improve pain perception, quality of life, pain perception, depression and anxiety from the short-term to up to 12 months. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Anxiety Depression Review
36011540 The same level of evidence supports acupuncture as an effective complementary treatment to medication and exercise for improving FM severity and symptoms including pain, sleep quality, quality of life, depression, anxiety and fatigue. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Anxiety Depression Sleep Quality Review
36117653 One study reported reduced BMI, Ferriman-Gallway score, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores, while PCOS health-related quality of life questionnaire scores, serum sex hormone binding globulin (SHBG) levels and β -endorphin levels were elevated after acupuncture intervention in PCOS patients. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Anxiety Depression Review
36117653 Another secondary investigation to assess how electroacupuncture affected anxiety and sadness in unmarried women with PCOS found that acupuncture could alter serum norepinephrine (NE) and 5-HT levels and thereby lessen PCOS depression symptoms. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Anxiety Depression Review
36119472 (A) the changes measured by the Self-Rating Anxiety Scale in lung cancer patients treated with acupuncture-related intervention versus control from the baseline to the end of treatment; (B) the changes measured by Self-Rating Depression Scale in lung cancer patients treated with acupuncture-related intervention versus control from the baseline to the end of treatment. Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. Anxiety Depression Review
36119472 Compared with control groups such as usual care and pharmacotherapy, using acupuncture alone or in combination with other treatments can effectively relieve PROs, including postoperative chronic pain, and reduce anxiety and depression, so as to improve their QOL, which has a certain clinical application value. Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. Anxiety Depression Review
36148057 In recent years, with the development of the mechanism of acupuncture in analgesia, anti-inflammatory and nerve regulation, and effects in withdrawal syndrome, weight loss, and blood pressure regulation, acupuncture has become a potential therapeutic method for reducing cardiovascular disease risk factors, reducing the number of acute attacks, improving the results of electrocardiography, and alleviating anxiety and depression. Front Cardiovasc Med. 2022 Sep 6;9:920491. doi: 10.3389/fcvm.2022.920491. eCollection 2022. Cardiovascular Anxiety Blood Pressure Depression Review
36268156 TCM non-drug therapy (acupuncture, moxibustion, massage, and auricular point pressing beans) can significantly improve the PSQI score of patients after treatment and improve the degree of anxiety and depression of patients, with significant effect, which is worthy of clinical promotion. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Anxiety Depression Review
36268156 In this study, 16 high-quality RCT studies with a total of 1285 participants were included, and the results showed that non-drug therapy of TCM (acupuncture, moxibustion, massage, and auricular point pressing beans) could significantly improve the PSQI score of patients after treatment, the effective rate was significantly higher than that of the control group, and the improvement of anxiety and depression was better than that of the control group. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Anxiety Depression Review
36268156 The results showed that TCM non-drug therapy (acupuncture, moxibustion, massage, and auricular point pressing) could significantly improve the PSQI score of patients after treatment, with an effective rate significantly higher than that of the control group, and the improvement of anxiety and depression was better than that of the control group. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Anxiety Depression Review
36276855 Recent systematic evaluations have confirmed that acupuncture-related therapies (including fire acupuncture, acupuncture, electroacupuncture, and moxibustion) are effective for PHN and that they can reduce pain intensity, relieve anxiety, and improve quality of life in patients with PHN. Evid Based Complement Alternat Med. 2022 Oct 14;2022:3975389. doi: 10.1155/2022/3975389. eCollection 2022. Anxiety Review
36340786 Acupuncture has decreased anxiety and depression and increased self-esteem in migraineurs. Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Anxiety Depression Review
36340786 Decreased ALFF and increased ReHo values in the ACC after verum acupuncture treatment in different subtypes of migraine and showed associations with decreased self-reported anxiety, self-reporting depression, and VAS score. Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Anxiety Depression Review
36340786 Acupuncture has been discussed to have nonspecific modulation effects on a number of brain regions, implicated in the regulation of nociceptive perception and emotional disorders (e.g., anxiety and depression). Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Anxiety Depression Mood Review
36353235 It has been reported that acupuncture can improve depression and anxiety scores in women with PCOS. Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. Anxiety Depression Review
36353235 Our previous research manifested that acupuncture can effectively relieve anxiety and depression in patients with PCOS, and its mechanism may be related to the regulation of the levels of serum β-endorphin and androgen. Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. Anxiety Depression Review
36408345 Acupuncture, including electroacupuncture, can significantly inhibit pain sensation with the immediate analgesic effect and improve pain-induced negative emotions, including anxiety and depression accompanied by pain and cognitive changes. Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. Analgesic Effect Anxiety Depression Mood Review
36570846 According to a 2018 US survey, acupuncture is widely used to treat its indications of which the top 10 are lower back pain (LBP), depression, anxiety, headache, arthritis, allergy, systemic pain, female infertility, insomnia, and shoulder and neck pain, with pain ranking first among them. Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. Insomnia Anxiety Depression Review
36590284 Studies have shown that acupuncture can relieve pain, fatigue, hot flashes, anxiety and depression in cancer patients (Choi et al.,; Garcia et al.,; Posadzki et al.,). Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. Anxiety Depression Review
36620677 Acupuncture and related therapies for the anxiety and depression in irritable bowel syndrome with diarrhea (IBS-D): A network meta-analysis of randomized controlled trials Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 (1) Acupuncture-related therapies were used for intervention, but no indicators of anxiety and/or depression were reported; (2) Other types of IBS studies (such as IBS-C, IBS-M, IBS-U, among others); (3) The same group included three and more interventions; (4) Research with no clear original data reported and the author was not reachable; (5) similar research or reported the same results. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 Overall, MOX, ACU, and combined therapies had the highest benefit; (3) The ranking results revealed that MOX, ACU, combined therapies, and EA all had high SUCRA rankings for different outcome indicators, indicating that these interventions could serve as optimal interventions to improve anxiety and depression status in patients with IBS-D; (4) The results of adverse events depicted that the rate of adverse events was lower with acupuncture-related therapy than with drugs, establishing the safety of acupuncture-related therapy over pharmacotherapy. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 The NMA method utilized in this study can compensate for the lack of direct data by using indirect data which compares the efficacy of different acupuncture-related therapies against anxiety and depression status in patients with IBS-D. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 Meanwhile, we focused on the anxiety and depression status of IBS-D patients and selected suitable outcome indicators to evaluate the improvement of acupuncture-related therapies. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 In recent years, increasing studies have confirmed the efficacy of acupuncture for various types of depression, and these studies suggest that acupuncture has great potential for the treatment of anxiety and depression. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36626458 Efficacy of acupuncture for generalized anxiety disorder: A PRISMA-compliant systematic review and meta-analysis Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. Anxiety Review
36626458 Acupuncture is regarded as an effective way to relieve anxiety symptoms. Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. Anxiety Review
36626458 Acupuncture can effectively relieve the anxiety symptoms of generalized anxiety disorder patients with fewer side effects, but randomized controlled trials with large sample size and high quality are also required to support the result. Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. Side Effects Anxiety Review
36626458 Acupuncture is gradually becoming an alternative to relieve anxiety disorders during the epidemic. Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. Anxiety Review
36626458 In summary, the results of this study suggest that acupuncture has clear superiority in relieving anxiety symptoms compared with western medications or psychotherapy, so acupuncture is recommended for improving the quality of health for patients with generalized anxiety disorder during COVID-19. Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. Anxiety Review
36760099 Buchanan et al assessed auricular acupuncture therapy conducted 5 times for 30 min each session over 16 weeks, resulting in anxiety relief in different groups, such as healthy volunteers and post-surgical patients. Med Sci Monit. 2023 Feb 10;29:e938920. doi: 10.12659/MSM.938920. Anxiety Review
36760099 (1) The anti-anxiety effect of acupuncture may be related to the up-regulation of atrial natriuretic peptide (ANP) expression and the down-regulation of C-type natriuretic peptide (CNP) expression in peripheral adrenal medulla, thus inhibiting the release of corticosterone (CORT) and activity of the hypothalamus pituitary adrenal axis (HPA). Med Sci Monit. 2023 Feb 10;29:e938920. doi: 10.12659/MSM.938920. Anxiety Review
36778899 Apart from reducing pain, acupuncture may be beneficial for migraineurs with co-morbid problems such as anxiety, insomnia, and muscle tension. Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. Insomnia Anxiety Review
36852393 VA: verum acupuncture; SA: sham acupuncture; CBF: cerebral blood flow; ALFF: amplitude of low-frequency fluctuations; FC: functional connectivity; ReHo: regional homogeneity; ICA: independent components analysis; PET-CT: positron emission tomography-computed tomography; MRI: magnetic resonance imaging; fMRI: functional magnetic resonance imaging; PWI: perfusion-weighted imaging; ASL: arterial spin labeling; PPI: present pain intensity; PRI: pain rating index; STAI: state-trait anxiety inventory; BDI-II: beck depression inventory-II; MPQ: McGill pain questionnaire; NRS: numerical rating scale; CMSS: cox menstrual symptom scale; SAS: self-rating anxiety scale; SDS: self-rating depression scale; VAS: visual analog scale. Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. Anxiety Depression Blood Flow Review
36950225 Additionally, acupuncture is also reported to reduce anxiety, which is a common issue in patients with dental diseases as many patients fear intraoperative and postoperative pain, especially in relation to tooth removal, or suffer from a general anxiety about dental treatments and the pain that can be experienced. Jpn Dent Sci Rev. 2023 Dec;59:114-128. doi: 10.1016/j.jdsr.2023.02.005. Epub 2023 Mar 10. Anxiety Review
36950225 The authors suggested that mental relaxation (a reduced state of anxiety) after acupuncture and a concomitant reduction in the ""natural activation"" of the body's pain-inhibiting systems may explain the results. Jpn Dent Sci Rev. 2023 Dec;59:114-128. doi: 10.1016/j.jdsr.2023.02.005. Epub 2023 Mar 10. Anxiety Review
36950556 It can be seen that the covered groups with the need to treat cancer pain by acupuncture mainly existed in women, and their negative emotions were mainly anxiety and depression. Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. Cancer Pain Anxiety Depression Mood Review
36950556 Existing systematic reviews have proved that acupuncture can not only relieve pain in patients with BC, but also improve hot flashes, fatigue, sleep disturbance, anxiety, and especially the quality of patients with BC. Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. Insomnia Anxiety Review
36968497 Rather, clinical workers can understand IBS from a holistic bio-psycho-social model, which has the following five guiding implications for patients and researchers: (1) the combination of anti-anxiety and depression drugs can be used to treat irritable bowel syndrome in clinical work, providing a new way of thinking for the clinical treatment of the disease; (2) the treatment can be done from the perspective of treating the bowel from the brain; (3) acupuncture can be used to treat irritable bowel syndrome from the aspect of anxiety and depression; (4) keeping patients away from stressors to avoid long-term stimulation can be a treatment method; and (5) patients can be provided with stress training, psychological training, and positive meditation to prevent later relapse or frequent relapse. Front Neurosci. 2023 Mar 9;17:934341. doi: 10.3389/fnins.2023.934341. eCollection 2023. Anxiety Depression Review
36968499 In regard to the period from 2006 to 2010, the primary foci of the research were: (1) barostat testing, nutrient drink test, water load test, stool antigen test, 13C-octanoic acid breath test, gastric emptying scintigraphy, intraluminal electrical impedance, and electrogastrography; (2) H. pylori infection; (3) BMI and smoking; (4) GERD, hiatal hernia, atrophic gastritis, intestinal metaplasia, gastric adenocarcinoma, and duodenal ulcer; (5) duodenogastric reflux; (6) dysrhythmia; (7) gastric fundus tone, antroduodenal motility, impaired gastric accommodation, slow gastric emptying, and gastric acid secretion; (8) visceral hypersensitivity and visceral perception; (9) type 2 diabetes mellitus, insulin resistance, and impaired glucose tolerance; (10) metabolic syndrome; (11) chest pain, nausea, constipation, epigastric pain, heartburn, and gastric distension; (12) psychological factor, abuse history, and stress; (13) triple therapy, metronidazole, PPIs, baclofen, alosetron, atropine, prokinetic agent, serotonin reuptake inhibitor, psychotherapy, and nonsteroidal anti-inflammatory drug; (14) Mentha × piperita L., Glycyrrhiza glabra, Iberis amara, Matricaria recutita, Carum carvi, Chamomilla recutita, Chelidonium majus, caraway oil, Silybum marianum, Angelica archangelica, and STW5; (15) electrical stimulation and acupuncture; (16) diabetic gastroparesis and autonomic neuropathy; (17) stress, anxiety, and depression; (18) endocrine cell; (19) melatonin, leptin, 5-hydroxytryptamine (serotonin), and ghrelin; (20) cholecystokinin A receptor; (21) gut microbiota; (22) dietary fiber, gluten, high fat meal, lipid metabolism, and carbohydrate metabolism; (23) duodenal eosinophilia and oxidative stress; (24) antioxidant, arginine, nitric oxide, and glutathione; and (25) CagA and vacuolating cytotoxin. Front Neurosci. 2023 Mar 8;17:1109510. doi: 10.3389/fnins.2023.1109510. eCollection 2023. Endocrinology Nausea and Vomiting Anxiety Depression Review
36968499 Those author keywords with ongoing citation bursts (i.e., acupuncture, gut microbiota, duodenal eosinophilia, mast cell, and anxiety) suggest the topics that prove to be potentially of particular interest. Front Neurosci. 2023 Mar 8;17:1109510. doi: 10.3389/fnins.2023.1109510. eCollection 2023. Anxiety Review
37025199 For this purpose, this study analyzes in-depth the clinical studies on the treatment of anxiety and depression by acupuncture and moxibustion, by depicting how the employment of fMRI technology provides significant imaging changes in the brain regions. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Anxiety Depression Review
37025199 Some studies have been conducted on patients with post-traumatic stress disorder accompanied by anxiety and depression, and the results showed that the patients' symptoms improved after electroacupuncture treatment. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Anxiety Depression Review
37025199 Therefore, it can be inferred that the improvement in anxiety and depression symptoms in post-traumatic stress disorder by electroacupuncture may be related to (i) the enhancement of connectivity between the parietal lobe and the hippocampus, and (ii) the inhibition of connectivity between the hippocampus, parahippocampal gyrus, and amygdala, leading to indirect effects on the limb system. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Anxiety Depression Review
37187857 Homeless persons receiving acupuncture treatment at the Chicago Health Outreach Clinic to ease arthritis, headache, back pain, substance abuse, anxiety, fatigue, and other diagnoses reported favourable responses overall, where part of the study recorded a 97% positive response. Front Pain Res (Lausanne). 2023 Apr 28;4:1020038. doi: 10.3389/fpain.2023.1020038. eCollection 2023. Anxiety Review
37200784 Moreover, animal studies have shown that acupuncture treatment can reduce anxiety, depression, and fear responses; improve sleep architecture; reduce spatial learning and memory deficits; and ultimately improve PTSD (Kwon et al.,). Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Learning and Memory Ability Anxiety Depression Review
37200784 Another study showed that acupuncture improved anxiety, learning, and memory in a model by inhibiting the overexpression of key molecules of hippocampal endoplasmic reticulum stress as follows: GRP78, CHOP, Caspase-3, and Caspase-12 (Sun Y. et al.,). Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Review
37200784 Another study revealed that IL-6 levels were inversely related to cognitive levels (Gruol,), and acupuncture could reduce IL-6 levels in the PFC (Chen et al.,) and reduce anxiety and depression in PTSD model animals. Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Depression Review
37200784 A study found that acupuncture increased the expression of C-Fos in the vmPFC in PTSD model animals and that vmPFC inactivation eliminated the effect of acupuncture on anxiety-like behavior in PTSD model animals, indicating that the vmPFC is involved in the process of electro-targeting PTSD anxiety (Hou et al.,; Yang et al.,). Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Review
37200784 A recent study revealed that acupuncture increases DAGL and CB1R protein expression to improve anxiety behavior in PTSD model animals, implying that the eCB system may be a target for PTSD treatment (Chen et al.,; Xue et al.,). Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Review
37200784 Overexpression of the deacetylase Sirt1 activates MAO-A and decreases intracerebral 5-HT levels in PTSD model animals, but acupuncture was also reported to reverse this trend and alleviate anxiety behavior (Li et al.,). Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Review
37200784 (B) In the Keap1-Nrf2 signaling pathway, acupuncture increased the expression of Nrf2 and HO-1, which improved hippocampal neurogenesis and ameliorated anxiety-like behaviors in PTSD model animals. Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Review
37200784 Moreover, acupuncture also reduced the expression of nNOS and MAO-A while increasing the expression of DAGL and CB1R proteins, effectively alleviating the anxiety symptoms of PTSD models. Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Review
37260441 Acupuncture has clinical efficacy in the treatment of cardiovascular diseases, epilepsy, anxiety, circadian rhythm disorders, PCOS, low reproductive capacity, and autonomic nervous system diseases. Front Endocrinol (Lausanne). 2023 May 16;14:956772. doi: 10.3389/fendo.2023.956772. eCollection 2023. Cardiovascular Anxiety Review
37275921 Another study on a mouse model of PD also demonstrated a reduced neuroinflammatory response along with the improvement of motor symptoms and comorbid anxiety after acupuncture treatment at GB34 and ST36. Integr Med Res. 2023 Jun;12(2):100954. doi: 10.1016/j.imr.2023.100954. Epub 2023 May 11. Anxiety Review
37275921 BFC enhancement was also shown in the hippocampus and hypothalamus implying that acupuncture may improve non-motor symptoms of PD such as memory, cognition, anxiety, and sleep disorders. Integr Med Res. 2023 Jun;12(2):100954. doi: 10.1016/j.imr.2023.100954. Epub 2023 May 11. Anxiety Review
37289799 A number of studies regarding the effectiveness and safety of acupuncture as a treatment of PTSD, MDD, and anxiety disorder have been published. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Anxiety Review
37289799 Moreover, several previous studies have used acupuncture for the treatment of PTSD, MDD, and anxiety disorder among earthquake survivors. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Anxiety Review
37289799 (2020), which evaluated the quality of life among participants, found that acupuncture significantly improved some aspects of the EQ-5D, including mobility and pain/discomfort, but not self-care, usual activities, and anxiety/depression. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Anxiety Depression Review
37289799 Although PTSD is a common mental health problem after earthquakes, we believe that anxiety and depressive disorders among earthquake survivors may be understudied areas in acupuncture research considering the similarly high prevalence of depression and anxiety. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Anxiety Depression Review
37332744 Previous findings have shown that the use of acupuncture during ESWL could reduce analgesic requirement, alleviate anxiety, and improve the success rate of the procedure. Front Med (Lausanne). 2023 Jun 2;10:1114485. doi: 10.3389/fmed.2023.1114485. eCollection 2023. Anxiety Review
37332744 Although that study also systematically reviewed five RCTs focusing on acupuncture and related techniques in patients undergoing ESWL and described their efficacy for reducing pain score and anxiety in this patient population, no pooled evidence was generated to support their findings. Front Med (Lausanne). 2023 Jun 2;10:1114485. doi: 10.3389/fmed.2023.1114485. eCollection 2023. Anxiety Review
37363406 Acupuncture can also treat pain, fatigue, cognition, anxiety and other symptoms due to CFS by altering the neurotransmitter levels such as 5-hydroxytryptamine (5-HT), norepinephrine, dopamine, and neuropeptide Y in rats with CFS. World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. Anxiety Review
37385740 Statistically significant reductions in both state anxiety and trait anxiety (STAI) were reported following the auricular (around the ear) acupuncture intervention, and total work engagement scores as measured by the Utrecht Work Engagement Scale (UWES) also showed significant improvement for the 112 participants. BMJ Open. 2023 Jun 29;13(6):e071203. doi: 10.1136/bmjopen-2022-071203. Anxiety Review
37396891 Acupuncture is a promising technique for relieving patient's anxiety before an operation, reducing sedative consumption, postoperative pain, and adverse events, promoting the functional recovery of patients, as well as cutting the cost caused by sedative usage, which has shed new light on the research of gastrointestinal endoscopy techniques such as painless colonoscopy. Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. Anxiety Review
37397275 The research hotspots of acupuncture in perioperative medicine mainly focus on postoperative pain management and gastrointestinal functional recovery after surgery, especially for postoperative ileus and PONV, and the frontier topics mainly focus on POCD, cancer-related surgery (especially breast cancer), and psychological states (especially anxiety). J Pain Res. 2023 Jun 27;16:2189-2204. doi: 10.2147/JPR.S415998. eCollection 2023. Anxiety Review
37405111 With respect to psychological balance, acupuncture studies have been designed to relieve anxiety and depression through the regulation of circulating β-endorphins and androgens in patients with PCOS. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Depression Circulation Review
37405111 Studies 2 and 6 attended to the effect of acupuncture as a method to relieve the anxiety of women with PCOS with fertility issues and to manage anxiety and depression symptoms in unmarried women with PCOS, respectively. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Depression Review
37405111 Overall, study 2 revealed that acupuncture associated with clomiphene improved anxiety scoring as compared to the use of acupuncture or CC alone (Table 6). J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Review
37405111 The CG of this study (acupuncture treatment only) also exhibited a significant anxiety score reduction. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Review
37405111 Therefore, a CG with sham acupuncture and placebo would be important (as demonstrated in study 3, where the results indicated no anxiety improvement with active or sham acupuncture). J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Review
37405111 The SAS questionnaire assessment in study 6 presented not only an improvement of anxiety values in the group under electroacupuncture intervention, but also a worsening of values in the control group submitted to sham acupuncture. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Review
37405111 A worsening of anxiety through SAS assessment was also noted in the groups of study 3 with higher indications of anxiety in the group treated with CC intake only, followed by the group treated with acupuncture only, the group treated with acupuncture combined with CC, and finally, the group treated with sham acupuncture and placebo. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Review
37405111 Considering the aforementioned information, it is possible to justify the confirmed correlation between the reduction of anxiety and depression scores in women submitted to acupuncture intervention in study 6 with a physiological decrease in serotonin and gamma-aminobutyric acid (GABA), and the increase of norepinephrine after active acupuncture treatment. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Depression Review
37405111 Overall, the results of acupuncture treatment determined in studies 2, 3, and 6 were positive, with a significant improvement of anxiety management when combining acupuncture intervention with CC intake in women diagnosed with PCOS and aiming for pregnancy. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Review
37405111 Last but not least, when studying the effect of acupuncture intervention alone or in combination with other procedures on mental health issues related to PCOS, our review made it possible to infer that: 1) longer treatment period interventions seemed to worsen anxiety symptoms in the control groups; 2) a protocol of Shu points, such as BL18 and BL23 in combination with CV3, CV4, CV9 and CV12 was more effective addressing anxiety than protocols considering CV3 and CV6, plus stomach and spleen points and a few of sedative acupoints (GV20, PC6, and LR3); 3) a higher number of acupuncture sessions even performed for a shorter intervention period seemed to improve anxiety symptoms; 4) physiological decrease of serotonin and GABA, and an increase of norepinephrine after the active acupuncture treatment might be behind the positive effect on the psycho-emotional issues of women diagnosed with PCOS; and 5) a decrease of mental health status assessed through SF-36 could be attributed to several stress factors such as pressure for getting pregnant, external pressure of deadlines and diagnosis bureaucracy, lack of management time and resources to closely follow patients, which might lead to a sustained sympathetic activation of the nervous system that annuls the benefits of the acupuncture interventions. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Mood Review
37510483 Our results showed that acupuncture improved PD-related sleep disorders and depression but had no effect on anxiety and fatigue. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 While acupuncture is a popular alternative therapy for PD patients that has been shown to improve motor symptoms, its efficacy in treating non-motor symptoms, such as sleep disorders, depression, anxiety, and fatigue, remains controversial. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 Some studies suggest that acupuncture can improve sleep efficiency, depression, and anxiety in PD patients. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 Moreover, a randomized, double-blinded clinical trial found that real acupuncture for eight weeks improves anxiety in PD patients at the end of an 8-week follow-up period. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 The primary endpoint of our study is the effect of acupuncture on sleep quality, while the secondary endpoints are its impact on depression, anxiety, and fatigue. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Sleep Quality Review
37510483 The Secondary Outcomes of Acupuncture in Anxiety and Fatigue Improvement Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 Therefore, acupuncture did not show any improvements in anxiety and fatigue in PD patients (Figure 4A,B). Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 Acupuncture was found to have a small effect on depression, while showing no significant improvements in anxiety and fatigue in PD patients compared to the control group. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 The differential effectiveness of acupuncture on sleep and depression, as compared to anxiety and fatigue, may be attributed to the specific utilization of electroacupuncture for PD-related sleep and depression, while its application for anxiety and fatigue was not explored. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 (2022) reported that real acupuncture for 8 weeks does not improve PD-related anxiety at the end of treatment as compared with sham acupuncture. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 However, real acupuncture shows an improvement in anxiety during the 8-week follow-up period. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 Our meta-analysis also showed that acupuncture did not have a significant effect on anxiety at the end of treatment as compared to no acupuncture and sham. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 Therefore, PD patients experiencing anxiety and fatigue may consider acupuncture as a potential intervention to prevent further deterioration of their motor condition. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 Forest plot showing the secondary outcomes of acupuncture in anxiety and fatigue improvement in PD patients. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37510483 (A) Effects of acupuncture on anxiety improvement. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Review
37525791 However, more research is needed to establish a relationship between acupuncture and other symptoms like anxiety, loss of appetite, and fatigue. Cureus. 2023 Jun 30;15(6):e41203. doi: 10.7759/cureus.41203. eCollection 2023 Jun. Anxiety Review
37525791 Despite the small sample size, a 30-patient study selected participants that had undergone a mastectomy and concluded that acupuncture when delivered after the procedure can significantly reduce pain, nausea, and anxiety when compared to usual care. Cureus. 2023 Jun 30;15(6):e41203. doi: 10.7759/cureus.41203. eCollection 2023 Jun. Nausea and Vomiting Anxiety Review
37542321 The present results suggest that, compared with Western medicine and sham acupuncture, acupuncture seems to be able to effectively improve anxiety and depression in migraine patients.And it may be more effective in improving SF36-mental health, VAS and MSQ than shame acupuncture or Western medicine. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Review
37542321 In addition, acupuncture can effectively relieve migraine, adjust the mental and psychological state of patients and improve the depression/anxiety disorder of migraine patients. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Review
37542321 Since the purpose of this study was to investigate the effects of acupuncture on anxiety, depression and other emotional disorders in migraine patients, the main outcome indicators such as Pain-Related Mood Disorders (Zung Self-Rated Anxiety Scale (SAS), Zung Self-rating Depression Scale (SDS) and Short Form 36 Mental Health (MH) that can better reflect the improvement of mood were selected as the main outcome indicators. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Mood Review
37542321 The present results suggest that, compared with Western medicine and sham acupuncture, acupuncture seems to be able to effectively improve anxiety and depression in migraine patients. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Review
37568485 Likewise, the reduction of constipation seemed to correlate with reductions in anxiety and depressive mood, as recorded with HADS after massages and aerobic and resistance training, and the self-rating anxiety scale and self-rating depression scale after electro-acupuncture stimulation at the Tiensu point. J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. Anxiety Depression Mood Review
37568485 The self rating anxiety scale and the self-rating depression scale were used for electro-acupuncture stimulation. J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. Anxiety Depression Review
37637184 This has confirmed that acupuncture-related therapies can reduce symptoms such as depression and anxiety in patients with opioid dependence, and effectively reduce patients' methadone doses. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Depression Review
37637184 The overall results showed that acupuncture-related therapy could significantly improve the symptoms of protracted anxiety compared with sham acupuncture (SMD=−1.66, 95% CI [−2.71, −0.62], P = 0.002, I2=94%, Fig. 3C). Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Review
37637184 Six studies tested the effects of acupuncture for protracted anxiety symptom scores. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Review
37637184 The overall results showed that acupuncture-related therapy could significantly improve the symptoms of protracted anxiety symptom scores compared with sham acupuncture (SMD=−0.64, 95% CI [−1.06, −0.23], P = 0.002, I2=80%, Fig. 4C). Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Review
37637184 Three included studies showed that acupuncture-related treatment improved protracted anxiety symptom scores better than no treatment (SMD=−1.63, 95% CI [−2.17, −1.08], P<0.00001, I2=55%, Fig. 5B). Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Review
37637184 Significant evidence of efficacy was observed in the acupuncture group in improving anxiety, depression, sleep disorders, and somatic symptoms, compared to that in the control group. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Depression Review
37637184 Finally, previous reviews have shown that acupuncture can be effective in treating opioid use disorder; EA can alleviate cravings for opioids and depression, and TEAS can mitigate symptoms of insomnia and anxiety. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Insomnia Anxiety Depression Review
37644765 Acupuncture interventions also seem to ameliorate patient anxiety, elevate their quality of life, and exhibit low adverse event rates. Libyan J Med. 2023 Dec;18(1):2251640. doi: 10.1080/19932820.2023.2251640. Anxiety Review
37678839 From an intermediate neuron perspective, acupuncture relieves pain by up regulating GABAergic intermediate neurons in ACC and also relieves pain-related anxiety as well as depression. Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. Anxiety Depression Review
37712096 Electroacupuncture stimulation attenuates abnormal orofacial pain and anxiety-like behaviors in a TN mouse model by modulating synaptic plasticity in hippocampal CA1 neurons. Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. Anxiety Review
37732301 Acupuncture improves depression and anxiety symptoms by modulating the HPA axis. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37732301 Through the modulation of these factors, acupuncture can potentially alleviate IBS-related depression, anxiety, and VH symptoms. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37732301 The regulation of the HPA axis by acupuncture has been extensively reported, however, limited studies have demonstrated whether acupuncture by regulating the HPA axis can improve the VH induced by depression and anxiety in IBS. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37732301 A few studies have shifted their focus toward investigating whether acupuncture and moxibustion alleviate depression and anxiety by targeting the HPA axis, subsequently mitigating VH exacerbation. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37760483 The results suggest that several complementary therapies can improve health outcomes reported by patients with cancer, such as acupuncture to relieve pain, music interventions to reduce anxiety and yoga to improve cancer-related fatigue. Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. Anxiety Review
37760483 Considering psychological patient-reported outcomes, no significant effects were reported in meta-analyses assessing the effect of acupuncture on anxiety, depression and cognitive function. Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. Cognitive Function Anxiety Depression Review
37760483 One meta-analysis of two RCTs reports a significant negative effect of acupuncture on anxiety in patients with breast cancer, but in a pooled analysis of only high-quality articles the effect was not significant. Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. Anxiety Review
37760483 The results from the current overview seem consistent with several other existing clinical recommendations, such as music interventions to reduce anxiety, acupuncture to relieve neuropathy symptoms or yoga to improve quality of life. Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. Anxiety Review
37760483 For example, the included meta-analyses show the effectiveness of acupuncture to relieve pain, yoga to improve fatigue and music interventions to reduce anxiety. Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. Anxiety Review
37810368 Acupuncture treatment can inhibit immune inflammatory reactions, neuroinflammatory reactions, oxidative stress levels, and hypothalamus-pituitary-adrenal (HPA) axis activity, improve lung function, and relieve migraine, fatigue, anxiety, and depression. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Anxiety Depression Review
37810368 Other studies found that acupuncture treatment can inhibit immune inflammatory reactions, neuroinflammatory reactions, oxidative stress levels, and hypothalamus-pituitary-adrenal (HPA) axis activity; improve lung function, and relieve migraine, fatigue, anxiety, and depression.However, whether acupuncture treatment is suitable for the treatment of these symptoms in patients with COVID-19 still needs to be investigated. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Anxiety Depression Review
37810368 In 2018, ASCO proposed that acupuncture can be used to improve emotional disorders, anxiety, and depression in patients with breast cancer (level C). Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Anxiety Depression Mood Review
37810368 Several meta-analyses have shown that acupuncture can effectively relieve anxiety and depression in patients and that it is very safe. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Anxiety Depression Review
37810368 Acupuncture can play a role in relieving anxiety and depression and promoting sleep by regulating neurotransmitters, immune inflammatory reactions, and HPA axis activity. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Anxiety Depression Review
37810368 EA can reduce the concentration of corticotropin-releasing hormones (CRH) in the hypothalamus and pituitary, as well as the concentrations of CRH, adrenocorticotropic hormone (ACTH), and cortisol (CORT) in the serum, indicating that acupuncture can relieve anxiety, depression, and sleep difficulties by inhibiting the activity of the HPA axis. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Anxiety Depression Review
37810368 Moreover, acupuncture regulates neurotransmitter release, immune inflammatory reactions, and HPA axis activity to improve anxiety, depression, and insomnia. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Insomnia Anxiety Depression Review
37893778 Previous studies have shown that acupuncture improves emotional problems such as anxiety, depression, and mental stress in unspecified people with mental problems; therefore, it is expected to be effective in improving emotional problems in women with infertility. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Depression Mood Review
37893778 A systematic review of acupuncture treatment for emotional problems in women with infertility has been previously published; however, it only addressed anxiety among women with infertility, without exploring other emotional problems. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Mood Review
37893778 According to the meta-analysis results of three studies comparing acupuncture treatment with no treatment, anxiety in women with infertility measured using the SAS significantly decreased in the acupuncture group compared to that of the no treatment group (Figure 3, SMD −3.41, 95% CI −6.55 to −0.27). Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Review
37893778 The pooled data from two studies revealed that acupuncture treatment significantly decreased APAIS scores compared to the control treatments in anesthesia-related anxiety (Figure 4, SMD −1.24, 95% CI −1.57 to −0.90), surgery-related anxiety (Figure 5, SMD −0.83, 95% CI −1.06 to −0.61), and the need for information (Figure 6, SMD −0.70, 95% CI −1.09 to −0.32). Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Review
37893778 In two studies, acupuncture treatment was compared with no treatment, and a meta-analysis of these studies showed that acupuncture treatment significantly decreased APAIS scores in the areas of anesthesia-related anxiety (Figure 4, SMD −1.37, 95% CI −1.78 to −0.96), surgery-related anxiety (Figure 5, SMD −0.95, 95% CI −1.17 to −0.74), and the need for information compared to the no treatment group (Figure 6, SMD −0.83, 95% CI −1.33 to −0.33). Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Review
37893778 The meta-analysis indicated that acupuncture treatment was more effective in improving the anxiety-related assessment scores of the STAI, SAS, and APAIS and the depression-related assessment SDS scores than the control interventions. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Depression Review
37893778 Our review and meta-analysis suggest that acupuncture may be an effective and safe treatment for emotional problems, particularly anxiety and depression, in women with infertility. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Depression Mood Review
37954034 Existing evidence indicates that acupuncture as an adjunctive therapy can improve the total effective rate of SZ patients, reduce the incidence of adverse reactions, improve clinical symptoms, and alleviate depression and anxiety in SZ patients. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Adverse Reactions Anxiety Depression Review
37998449 Preclinical animal studies utilizing acupuncture to treat animal models of PTSD have shown promising results, including improvements in anxiety, fear, sleep disturbances, cognitive symptoms, and depression. Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. Insomnia Anxiety Depression Review
38027491 For example, acupuncture at the Dachangshu (BL 25) acupoint can alleviate depression anxiety-like behavior in a mouse model of visceral pain by regulating the expression of P2Y12 receptors in the PFC and cannabinoid receptors in the hippocampus. Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. Visceral Pain Anxiety Depression Review
38027491 Researchers have hypothesized that acupuncture could improve the clinical symptoms of pain and anxiety by regulating the activities of FC in relevant brain regions. Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. Anxiety Review
38027491 Acupuncture has been shown to relieve visceral pain, depression, anxiety, and other negative emotions by regulating the functional activities of certain brain regions, including the regulation of receptor expression and neurotransmitter release, including serotonin and epinephrine (Figure 1). Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. Visceral Pain Anxiety Depression Mood Review
38078016 A randomized controlled study found that acupuncture relieved physical and psychological fatigue and reduced the incidence of anxiety and depression. J Pain Res. 2023 Dec 5;16:4165-4180. doi: 10.2147/JPR.S442151. eCollection 2023. Anxiety Depression Review
38125513 This study showed that acupuncture can improve the depression and anxiety symptoms of T2DM and the glucose metabolism disorder, which helps control blood sugar. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Anxiety Depression Review
38189090 A few separate studies have reported the role of acupuncture treatment in common symptoms in patients with CKD, including intradialytic hypotension on dialysis, poor sleep quality, anxiety, depression, muscle cramps, and dialysis imbalance syndrome (supplemental Figure S6). Ren Fail. 2024 Dec;46(1):2301504. doi: 10.1080/0886022X.2023.2301504. Epub 2024 Jan 8. Anxiety Depression Sleep Quality Review
38200908 However, electro-acupuncture was more effective in improving defecation frequency, difficulty in defecation, and constipation, as well as relieving depression, anxiety, and other psychological symptoms. Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. Anxiety Depression Review
36858243 Secondary outcomes were the Amsterdam Preoperative Anxiety and Information Inventory Scale, used to evaluate patients' preoperative anxiety levels, and the 6-item State-Trait Anxiety Inventory (STAI-S6), used to assess anxiety before and after gastroscopy. Complement Ther Med. 2023 May;73:102936. doi: 10.1016/j.ctim.2023.102936. Epub 2023 Feb 28. Anxiety Clinic
36858243 CONCLUSION: EA can help relieve patients' anxiety, and improve their nausea and vomiting, throat discomfort, and agitation during gastroscopy. Complement Ther Med. 2023 May;73:102936. doi: 10.1016/j.ctim.2023.102936. Epub 2023 Feb 28. Nausea and Vomiting Anxiety Clinic
17388767 OBJECTIVE: To determine whether a combination of auricular and body acupuncture is effective as an adjunct for the preprocedural anxiety and pain management in patients undergoing lithotripsy procedures. J Altern Complement Med. 2007 Mar;13(2):241-6. doi: 10.1089/acm.2006.6262. Anxiety Clinic
17388767 OUTCOMES MEASUREMENT: Preprocedural anxiety, intraprocedural alfentanil consumption, visual analogue scale for pain. J Altern Complement Med. 2007 Mar;13(2):241-6. doi: 10.1089/acm.2006.6262. Anxiety Clinic
17388767 CONCLUSIONS: A combination of auricular and body acupuncture can be used as an adjunct treatment to decrease preprocedural anxiety and intraprocedural analgesia in patients undergoing lithotripsy. J Altern Complement Med. 2007 Mar;13(2):241-6. doi: 10.1089/acm.2006.6262. Anxiety Clinic
15608039 Well-being was evaluated with the State Trait Anxiety Inventory (STAI). Hum Reprod. 2005 Mar;20(3):728-35. doi: 10.1093/humrep/deh665. Epub 2004 Dec 17. Anxiety Clinic
6606153 M48 was significantly correlated with the VAS score (r = 0.62, P less than 0.001), and with the psychometric test scores for trait-anxiety (r = 0.70, P less than 0.001) and neuroticism (r = 0.67, P less than 0.001). Pain. 1983 Oct;17(2):179-188. doi: 10.1016/0304-3959(83)90141-0. Anxiety Clinic
23270318 Acupuncture on Yintang point decreases preoperative anxiety. J Altern Complement Med. 2013 May;19(5):420-4. doi: 10.1089/acm.2012.0494. Epub 2012 Dec 27. Anxiety Clinic
23270318 OBJECTIVES: The aim of this study was to investigate the effect of ear-press needle acupuncture on Yintang point for preoperative anxiety. J Altern Complement Med. 2013 May;19(5):420-4. doi: 10.1089/acm.2012.0494. Epub 2012 Dec 27. Anxiety Clinic
23270318 OUTCOME MEASURES: The efficacy of acupuncture was evaluated by means of the changes in bispectral index (BIS) and STAI (State-Trait Anxiety Index). J Altern Complement Med. 2013 May;19(5):420-4. doi: 10.1089/acm.2012.0494. Epub 2012 Dec 27. Anxiety Clinic
23270318 Mean values of state anxiety (STAI-S) decreased after acupuncture in the study group (p=0,018), while no change was observed in trait anxiety (STAI-T) (p=0.156). J Altern Complement Med. 2013 May;19(5):420-4. doi: 10.1089/acm.2012.0494. Epub 2012 Dec 27. Anxiety Clinic
23270318 CONCLUSIONS: Ear-press needle acupuncture on Yintang point reduces preoperative anxiety in adult surgical patients. J Altern Complement Med. 2013 May;19(5):420-4. doi: 10.1089/acm.2012.0494. Epub 2012 Dec 27. Anxiety Clinic
15633813 Needling of the extra 1 point decreases BIS values and preoperative anxiety. Am J Chin Med. 2004;32(5):789-94. doi: 10.1142/S0192415X04002363. Anxiety Clinic
15633813 We investigated the effect of acupuncture on the Bispectral Index (BIS) values and anxiety. Am J Chin Med. 2004;32(5):789-94. doi: 10.1142/S0192415X04002363. Anxiety Clinic
15633813 Anxiety level was assessed before and after acupuncture by a verbal score scale (VSS) (0 = no anxiety, 10 = worst anxiety). Am J Chin Med. 2004;32(5):789-94. doi: 10.1142/S0192415X04002363. Anxiety Clinic
15633813 In conclusion, needling the extra 1 point preoperatively significantly decreases the BIS values and the VSS for anxiety but needling of a control point decrease only VSS values. Am J Chin Med. 2004;32(5):789-94. doi: 10.1142/S0192415X04002363. Anxiety Clinic
11159266 Auricular acupuncture: a potential treatment for anxiety. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Anxiety Clinic
11159266 Acupuncture can be an effective treatment for chronic anxiety disorders. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Anxiety Clinic
11159266 The purpose of this study was to assess the effectiveness of acupuncture in reducing anxiety in a volunteer population. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Anxiety Clinic
11159266 If found effective, this modality could be introduced as a treatment of anxiety before surgery. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Anxiety Clinic
11159266 Press-acupuncture needles were inserted at the respective auricular areas for 48 h. State anxiety, blood pressure, heart rate, and electrodermal activity were assessed at 30 min, 24 h, and 48 h after insertion. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Heart Rate Anxiety Blood Pressure Clinic
11159266 Analyzing anxiety levels using repeated-measures analysis of variance has demonstrated a significant difference [F (2,51) =8.8, P = 0.001] between the three treatment groups. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Anxiety Clinic
11159266 We conclude that auricular acupuncture at the ""relaxation"" point can decrease the anxiety level in a population of healthy volunteers. Anesth Analg. 2001 Feb;92(2):548-53. doi: 10.1097/00000539-200102000-00049. Anxiety Clinic
11682391 The use of auricular acupuncture to reduce preoperative anxiety. Anesth Analg. 2001 Nov;93(5):1178-80, table of contents. doi: 10.1097/00000539-200111000-00024. Anxiety Clinic
11682391 Ear acupuncture can decrease preoperative anxiety in adults undergoing outpatient surgery. Anesth Analg. 2001 Nov;93(5):1178-80, table of contents. doi: 10.1097/00000539-200111000-00024. Anxiety Clinic
11932132 Alcohol use was assessed, along with depression, anxiety, functional status, and preference for therapy. J Subst Abuse Treat. 2002 Mar;22(2):71-7. doi: 10.1016/s0740-5472(01)00217-3. Anxiety Depression Clinic
17081902 PURPOSE: To assess the effectiveness of acupuncture in reducing anxiety in patients having cataract surgery under topical anesthesia. J Cataract Refract Surg. 2006 Nov;32(11):1951-4. doi: 10.1016/j.jcrs.2006.06.027. Anxiety Clinic
17081902 METHODS: In a prospective randomized double-blind controlled trial, anxiety levels before and after cataract surgery in 3 groups (A = no acupuncture, B = true acupuncture starting 20 minutes before surgery, C = sham acupuncture starting 20 minutes before surgery) were compared using the Visual Analog Scale (VAS). J Cataract Refract Surg. 2006 Nov;32(11):1951-4. doi: 10.1016/j.jcrs.2006.06.027. Anxiety Clinic
17081902 RESULTS: Preoperative anxiety levels were significantly lower only in Group B (P = .001). J Cataract Refract Surg. 2006 Nov;32(11):1951-4. doi: 10.1016/j.jcrs.2006.06.027. Anxiety Clinic
17081902 Anxiety in Group B was significantly lower than in Group A (P = .001) and Group C (P = .037). J Cataract Refract Surg. 2006 Nov;32(11):1951-4. doi: 10.1016/j.jcrs.2006.06.027. Anxiety Clinic
17081902 Regarding postoperative anxiety, the mean VAS score was 39 +/- 5 in Group A, 19 +/- 3 in Group B, and 31 +/- 4 in Group C. The difference was significant only between Group A and Group B (P = .003). J Cataract Refract Surg. 2006 Nov;32(11):1951-4. doi: 10.1016/j.jcrs.2006.06.027. Anxiety Clinic
17081902 CONCLUSION: Acupuncture was effective in reducing anxiety related to cataract surgery under topical anesthesia. J Cataract Refract Surg. 2006 Nov;32(11):1951-4. doi: 10.1016/j.jcrs.2006.06.027. Anxiety Clinic
28092106 A randomised controlled trial examining the effect of acupuncture at the EX-HN3 (Yintang) point on pre-operative anxiety levels in neurosurgical patients. Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 Pre-operative anxiety is an unpleasant state of psychological distress that occurs in up to 87% of patients awaiting neurosurgical procedures. Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 Acupuncture has previously been shown to reduce pre-operative anxiety, but studies involving neurosurgical patients are lacking. Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 This single-centre, prospective, randomised controlled trial was designed to determine the effect of acupuncture at the EX-HN3 (Yintang point) on pre-operative anxiety levels in neurosurgical patients. Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 After measuring baseline anxiety levels, 128 patients were randomly allocated in a 1:1 ratio by a web-based computer program to receive either acupuncture at the EX-HN3 (Yintang) point (acupuncture group) or no intervention (control group). Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 The primary outcome measure was anxiety level after 30 min, as measured by the six-item short form of the State-Trait Anxiety Inventory (possible score range 20-80). Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 Median (IQR [range]) anxiety State-Trait Anxiety Inventory score reduced significantly in the acupuncture group (46.7 (36.7-53.3 [23.3-70.0]) to 40.0 (30.0-46.7) [20.0-53.3]), p < 0.001), with no change seen in the control group (41.7 (33.3-53.3 [20.0-76.7]) to 43.3 (36.7-50.0 [20.0-76.7]), p = 0.829). Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
28092106 Acupuncture at the EX-HN3 point reduces pre-operative anxiety levels in patients awaiting neurosurgery. Anaesthesia. 2017 Mar;72(3):335-342. doi: 10.1111/anae.13785. Epub 2017 Jan 16. Anxiety Clinic
16820123 In the fixed frequency group, however, a higher level of anxiety (P < 0.05) before oocyte retrieval was seen, and a higher level of nausea after aspiration of one ovary (P < 0.01) was seen in the mixed frequency group. Reprod Biomed Online. 2006 Jul;13(1):120-5. doi: 10.1016/s1472-6483(10)62025-1. Nausea and Vomiting Anxiety Clinic
25047046 Secondary outcome measures will comprise pre-, intra- and postoperative variables (which are anxiety, pain, nausea and vomiting, concomitant medication). Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. Nausea and Vomiting Anxiety Clinic
25047046 We aim to investigate the effects of a three-day permanent needle acupuncture treatment, starting in the preoperative phase at seven different acupuncture points only - five of them bilaterally - on a comprehensive set of above mentioned variables important to anaesthetic recovery (which are, preoperative anxiety, improving anaesthetic protocols, awakening, nausea and vomiting, and postoperative pain). Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. Nausea and Vomiting Anxiety Clinic
25047046 ○ Preoperative anxiety (State-Trait Anxiety Inventory: STAI) Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. Anxiety Clinic
25047046 Third, several trials could already demonstrate its effectiveness in reducing preoperative anxiety, the amount of anaesthetic medications or postoperative pain. Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. Anxiety Clinic
25047046 It can be expected to provide valuable new information on the clinical effectiveness of acupuncture improving post anaesthetic recovery parameters, which are a) preoperative anxiety relief, b) perioperative variables of anaesthesia and narcotic guidance, c) the occurrence of postoperative pain and anaesthetic side effects such as PONV or shivering. Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. Side Effects Anxiety Clinic
29391879 These problems are specifically manifested as anxiety, personality change, memory loss, abnormal cognitive ability, and disorders of mental system. Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. Cognitive Function Anxiety Clinic
36034956 The pain level (visual analogue scale (VAS)), physical and mental stress (heart rate (HR), mean arterial pressure (MAP), depression scale (PHQ-9), and anxiety scale (GAD-7)), complications, rehabilitation quality, and analgesia satisfaction were observed. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Heart Rate Anxiety Depression Clinic
36034956 Physical and mental stress: heart rate (HR) and mean arterial pressure (MAP) were recorded at admission, 6 hours before surgery, and 6 hours and 24 hours after surgery, respectively, and psychological stress state was assessed by patient health questionnaire depression scale (PHQ-9) and generalized anxiety scale (GAD-7). Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Heart Rate Anxiety Depression Clinic
36034956 These indicated that multimodal analgesia combined with auricular application therapy could decrease the degree of physical and mental stress through reducing the preoperative pain, showing that the blood pressure, HR, and anxiety depression were decreased. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Heart Rate Anxiety Blood Pressure Depression Clinic
21448381 Comparing the treatment effectiveness of body acupuncture and auricular acupuncture in preoperative anxiety treatment J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Preoperative anxiety has become more frequent in preoperative patients and can bring negative impact on operation outcomes. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Many studies have reported the effect of body acupuncture in reducing anxiety syndromes. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 The aim of this study is to compare the treatment effect of body acupuncture and auricular acupuncture in preoperative patients with preoperative anxiety. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Zung Self-Rating Anxiety Scale (SAS) was used before and after the study. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Both auricular and body acupuncture treatment methods were effective in decreasing anxiety in preoperative patients. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Preoperative anxiety is a common phenomenon among surgical patients, and high preoperative anxiety can lead to adverse postoperative outcomes. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Studies reported that the incidence of preoperative anxiety in adults is nearly 80%. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Both pharmacologic and alternative interventions have been used in the literature as means of decreasing preoperative anxiety. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Many studies have reported the effect of body acupuncture in reducing anxiety syndromes. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Other researches also indicated that auricular acupuncture also could relieve anxiety. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Therefore, the objective of the present study is to compare the treatment effect of body acupuncture and auricular acupuncture in preoperative patients with preoperative anxiety by follow-up study design. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Anxiety symptoms were assessed using a translated and validated version of the Zung Self-Rating Anxiety Scale (SAS). J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 The scale is a well-known self-rating scale used worldwide for the measurement of anxiety. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Higher scores on the scale are indicative of more severe anxiety. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 A subject with a SAS score below 50 is considered normal, while a score of 50 or more is considered to be indicative of existence of anxiety. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Acupuncture is one of the effective Chinese medical treatments and has been used widely for treating anxiety disorder; in some studies preoperative patients reported significantly lower levels of anxiety after receiving acupuncture. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Although the mechanism of treating anxiety with acupuncture is not clear till now, more and more evidences have suggested the effect of acupuncture in anxiety treatment. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 So acupuncture on these points can relieve the anxiety and reduce the syndrome to some extent. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 Results showed that both of the acupuncture treatment methods had effect on decreasing anxiety in preoperative patients. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 At the same time, the difference of reducing anxiety level in the two position acupuncture did not reach statistically significant level. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
21448381 So, auricular acupuncture seems to have more wide usage in future anxiety treatments. J Res Med Sci. 2011 Jan;16(1):39-42. Anxiety Clinic
27688791 Considering that BP can be easily affected by psychological factors, participants filled out questionnaires for assessments of anxiety (State Trait Anxiety Inventory, STAI). Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. Anxiety Blood Pressure Clinic
27688791 The SPD was the specific module in QLICD-HY questionnaires, which could reflect the symptom of headache, dizziness, palpitation, shortness, and anxiety of drugs. Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. Anxiety Clinic
28658163 Postoperative cognitive dysfunction (POCD), a common complication of central nervous system (CNS) with the characteristics of insanity, anxiety, personality changes, memory impairing, and so on, is a major clinical issue in geriatric surgical patients after anesthesia in the elderly (xe2x89xa565 years). Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. Cognitive Function Anxiety Clinic
30356057 There is substantial evidence provided by systematic reviews for the effectiveness of acupuncture in reducing post-operative pain, cumulative opioid consumption, opioid related side effects as well as pre-operative anxiety. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Side Effects Anxiety Clinic
30356057 Patients were instructed to press the needles or plasters as often as wanted, especially when suffering from anxiety, pain or nausea and vomiting. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Nausea and Vomiting Anxiety Clinic
30356057 Acupuncture-related outcomes included pre-operative anxiety, depth of sedation (bispectral index; BIS), reaction times during emergence, time to extubation, post-operative analgesic consumption and pain intensity, and the occurrence of anaesthesia-related side effects. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Side Effects Anxiety Sedation Clinic
30356057 Influence of group x time of the state anxiety was assessed by ANOVA for repeated measures with group as between subject factor. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Change in State Anxiety to baseline. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 The figure displays mean changes with standard error of the mean (SEM) in state anxiety (in scoring points) from baseline in the three study groups (APU: press plaster acupressure, CON: control, ACU: press needle acupuncture). Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Positive changes indicate an increase in state anxiety. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Filled circles indicate changes in anxiety at the morning of the day of surgery. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Open squares indicate changes in anxiety prior to the induction anaesthesia, i.e. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Regarding pre-operative anxiety, there were no differences in state and trait anxiety between groups at baseline, nor at admission in the morning of the day of surgery or directly before induction (see Tablexc2xa04). Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Repeated measures ANOVA of state anxiety (timexe2x80x89xc3x97xe2x80x89group; 3xe2x80x89xc3x97xe2x80x893) revealed a trend towards an interaction between time and intervention group (pxe2x80x89=xe2x80x890.067). Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 Changes in state anxiety from baseline at the time point of induction showed clinically remarkable differences when comparing the CON (mean (SD) 9 (8)) to the ACU (5 (7)), or the APU group (3 (8); Fig.xc2xa03). Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 The increase of state anxiety during the period from admission to induction of anaesthesia was less pronounced in patients receiving acupuncture or acupressure than in patients in the control group (see Fig.xc2xa03). Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 The observed effects on anxiety are in line with previously reported effects of ear acupuncture on anxiety. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 A recent study showed the individualization of complementary treatments to be an important factor boosting the effect on pre-operative anxiety. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 It might thus be possible -as our patients indicated overall low levels in state and trait anxiety- that the general setting, and being taken care of by the study team, helped minimising anxiety. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
30356057 As reported previously, the point selection included points that had been described to reduce anxiety, promote awakening, and reduce pain and anaesthesia-related symptoms such as PONV. Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. Anxiety Clinic
32062864 Transcutaneous electrical acupoint stimulation (TEAS) is assumed to alleviate pain and anxiety and to modify the autonomic nervous system. Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. Anxiety Clinic
32062864 The acupuncturexe2x80x90drug compound anesthesia, referred to as transcutaneous electrical acupoint stimulation combined with general anesthesia, has been demonstrated to relieve perioperative anxiety, reduce intraoperative opioid consumption, and improve postoperative analgesic effect.3, 4 However, its application in modern lung surgery including videoxe2x80x90assisted thoracic surgery (VATS) has rarely been reported. Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. Analgesic Effect Anxiety Clinic
34682857 The exclusion criteria were as follows: (a) history of pituitary gland disorder; (b) history of organic pelvic or reproductive system disease(s); (c) history of mental disorder(s), such as major depressive disorder, bipolar disorder, general anxiety disorder, claustrophobia, or schizophrenia; (d) history of brain trauma or neurological disease(s), such as epilepsy, stroke, Parkinsonxe2x80x99s disease, or dementia; (e) history of or current pregnancy or plans to become pregnant; (f) presence of metal implants or a pacemaker; (g) use of oral contraceptives, psychiatric medicines, Chinese herbal medicine, or acupuncture treatment in the past 6 months, or taking analgesic drugs 24 h before the magnetic resonance imaging (MRI) scan; and (h) unsuited for acupuncture treatment, as determined by the physicians of the Department of Chinese Medicine Acupuncture, China Medical University Hospital, Taiwan. J Clin Med. 2021 Oct 15;10(20):4731. doi: 10.3390/jcm10204731. Anxiety Clinic
34682857 In addition, the Chinese version of Spielbergerxe2x80x99s State-Trait Anxiety Inventory (STAI) and the Chinese version of Beckxe2x80x99s Depression Inventory II (BDI II) were used to assess the level of anxiety and depression, respectively. J Clin Med. 2021 Oct 15;10(20):4731. doi: 10.3390/jcm10204731. Anxiety Depression Clinic
36098938 However, preoperative anxiety, intraoperative pneumoperitoneum, and postoperative pain-induced stress reactions can suppress gastrointestinal and immune functions, seriously affecting postoperative recovery. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Immunity Stress Response Anxiety Clinic
36749304 The surgical injury triggers a myriad of responses in the pain matrix, from sensitization of central pain pathways to anxiety and depression (Small & Laycock,). Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Anxiety Depression Clinic
29773696 The validated Korean version of the ODI was administered before treatment at assessments 2, 5, 9,10 and 11xc2xa0(weeks 1, 2, 4, 8 and 12).xc2xa0The validated Korean version of the EQ-5D includes generic questions about personal health-related quality of life and consists of five dimensions pertaining to mobility, self-care, usual daily activities, pain and discomfort, and anxiety/depression. BMJ Open. 2018 May 17;8(5):e018464. doi: 10.1136/bmjopen-2017-018464. Anxiety Depression Clinic
28254098 Anxiety, as a symptom commonly associated with depression, was also evaluated by measuring the number of head dips. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Anxiety Depression Mechanism
28254098 From this study, single acupuncture stimulation at either ""GV 20"" or ""Ex-HN3"" alleviated neither the state of depression nor the anxiety. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Anxiety Depression Mechanism
28254098 The water-immersion stress used to make the depression model rats was shown not to induce anxiety; however, the stress induced by immobilizing the rats for acupuncture stimulation did lead to anxiety. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Anxiety Depression Mechanism
15755522 The effect of acupuncture on anxiety and neuropeptide Y expression in the basolateral amygdala of maternally separated rats. Neurosci Lett. 2005 Apr 4;377(3):179-84. doi: 10.1016/j.neulet.2004.11.097. Epub 2005 Jan 6. Anxiety Mechanism
15755522 Neuropeptide Y (NPY) is involved in the regulation of various physiological functions such as the expression of anxiety. Neurosci Lett. 2005 Apr 4;377(3):179-84. doi: 10.1016/j.neulet.2004.11.097. Epub 2005 Jan 6. Anxiety Mechanism
15755522 Their anxiety-like behavior was evaluated using an elevated plus-maze at P62, and then NPY immunohistochemistry in the basolateral amygdala (BLA) was performed. Neurosci Lett. 2005 Apr 4;377(3):179-84. doi: 10.1016/j.neulet.2004.11.097. Epub 2005 Jan 6. Immunity Anxiety Mechanism
15755522 These findings suggest that acupuncture treatment might reduce anxiety-like behavior in adult rats following maternal separation by modulating the NPY system in the amygdala. Neurosci Lett. 2005 Apr 4;377(3):179-84. doi: 10.1016/j.neulet.2004.11.097. Epub 2005 Jan 6. Anxiety Mechanism
21643998 The maternal separation (MS) animal model has been widely used to study early life stress and several psychiatric conditions such as depression and anxiety. Cell Mol Neurobiol. 2011 Nov;31(8):1123-7. doi: 10.1007/s10571-011-9718-x. Epub 2011 Jun 5. Anxiety Depression Mechanism
21643998 In this study, we investigated the effect of acupuncture on anxiety-related behaviors and hypothalamic-pituitary-adrenal (HPA) system in MS-induced early life stress of Sprague-Dawley rat pups (14-21 postnatal days). Cell Mol Neurobiol. 2011 Nov;31(8):1123-7. doi: 10.1007/s10571-011-9718-x. Epub 2011 Jun 5. Anxiety Mechanism
21643998 For determining anxiety-related behaviors, the elevated plus-maze test was performed. Cell Mol Neurobiol. 2011 Nov;31(8):1123-7. doi: 10.1007/s10571-011-9718-x. Epub 2011 Jun 5. Anxiety Mechanism
21643998 In conclusion, acupuncture reduced anxiety-related behaviors and modulated the HPA system. Cell Mol Neurobiol. 2011 Nov;31(8):1123-7. doi: 10.1007/s10571-011-9718-x. Epub 2011 Jun 5. Anxiety Mechanism
37481143 The lateral hypothalamus' orexinergic system has been associated with anxiety-related behaviors, and electroacupuncture (EA) modifies orexin neurons to control the anti-anxiety process. Brain Res Bull. 2023 Sep;201:110712. doi: 10.1016/j.brainresbull.2023.110712. Epub 2023 Jul 20. Anxiety Mechanism
37481143 Furthermore, after administering SB334867 (an OXR1 antagonist) to MSPS model rats, the effects of EA therapy on anxiety-like behaviors (ALBs) were significantly diminished. Brain Res Bull. 2023 Sep;201:110712. doi: 10.1016/j.brainresbull.2023.110712. Epub 2023 Jul 20. Anxiety Mechanism
19429024 Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety. Neurosci Lett. 2009 Apr 10;453(3):151-6. doi: 10.1016/j.neulet.2009.01.076. Epub 2009 Feb 4. Anxiety Depression Mechanism
19429024 Acupuncture significantly reduced depression- and anxiety-like behavior and increased NPY expression in the hypothalamus. Neurosci Lett. 2009 Apr 10;453(3):151-6. doi: 10.1016/j.neulet.2009.01.076. Epub 2009 Feb 4. Anxiety Depression Mechanism
30204276 The PCOS rats presented with reproductive dysfunctions such as lack of regular oestrous cyclicity, metabolic disorders such as increased body weight and insulin resistance, and depression and anxiety-like behaviours. Exp Physiol. 2018 Dec;103(12):1618-1632. doi: 10.1113/EP087163. Epub 2018 Oct 23. Anxiety Depression Mechanism
31419458 Temporal effect of electroacupuncture on anxiety-like behaviors and c-Fos expression in the anterior cingulate cortex in a rat model of post-traumatic stress disorder. Neurosci Lett. 2019 Oct 15;711:134432. doi: 10.1016/j.neulet.2019.134432. Epub 2019 Aug 13. Anxiety Mechanism
31419458 Post-traumatic stress disorder (PTSD) is a psychiatric disease which leads to a series of anxiety-like behaviors. Neurosci Lett. 2019 Oct 15;711:134432. doi: 10.1016/j.neulet.2019.134432. Epub 2019 Aug 13. Anxiety Mechanism
31419458 In this study, we investigated the temporal effects of electroacupuncture (EA) at acupoint ST36 on anxiety-like behaviors and the expression of c-Fos in the anterior cingulate cortex (ACC) in a rat model of PTSD. Neurosci Lett. 2019 Oct 15;711:134432. doi: 10.1016/j.neulet.2019.134432. Epub 2019 Aug 13. Anxiety Mechanism
31419458 Open field test (OFT) and elevated plus maze (EPM) test were used to assess the success of the model and evaluate anxiety-like behaviors. Neurosci Lett. 2019 Oct 15;711:134432. doi: 10.1016/j.neulet.2019.134432. Epub 2019 Aug 13. Anxiety Mechanism
31419458 Compared to regular EA, timed EA exhibited superior therapeutic effects by attenuating anxiety-like behaviors in PTSD rats. Neurosci Lett. 2019 Oct 15;711:134432. doi: 10.1016/j.neulet.2019.134432. Epub 2019 Aug 13. Anxiety Mechanism
32827699 First, we observed that acupuncture treatment at acupoints GB34 and ST36 could improve motor functions and comorbid anxiety in PD mice. Brain Behav Immun. 2020 Oct;89:641-655. doi: 10.1016/j.bbi.2020.08.015. Epub 2020 Aug 19. Anxiety Motor Function Mechanism
32827699 Of them, Butyricimonas, Holdemania, Frisingicoccus, Gracilibacter, Phocea, and Aestuariispira showed significant correlations with anxiety as well as motor functions. Brain Behav Immun. 2020 Oct;89:641-655. doi: 10.1016/j.bbi.2020.08.015. Epub 2020 Aug 19. Anxiety Motor Function Mechanism
38145382 Recently, acupuncture has emerged as a promising therapeutic intervention for a range of neurological diseases, including anxiety and respiratory disorders. J Vis Exp. 2023 Dec 8;(202). doi: 10.3791/65784. Anxiety Mechanism
37519181 Chronic pain may restrict activities of daily living, including work, learning, social life, and can lead to anxiety, depression, and sleep disturbance. J Integr Neurosci. 2023 Jul 17;22(4):97. doi: 10.31083/j.jin2204097. Insomnia Anxiety Depression Mechanism
26896072 Pain behavior and awareness are characterized by heightened alertness and anxiety, which begin to disappear as soon as the curative process starts. J Acupunct Meridian Stud. 2016 Feb;9(1):16-21. doi: 10.1016/j.jams.2015.08.002. Epub 2015 Sep 1. Anxiety Mechanism
26419631 Besides, acupuncture therapy also showed good regulation on the important influencing factors of IBS, as anxiety, conflict behavior, dietary restriction and social response, etc. BMC Complement Altern Med. 2015 Sep 29;15:340. doi: 10.1186/s12906-015-0863-5. Anxiety Mechanism
32761882 Another study demonstrated that acupuncture with manipulation was superior to drug treatment in regulating blood vessels and improving depression and anxiety in stroke patients (Yu et al., 2014). Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. Anxiety Depression Mechanism
32796318 Anxiety-like behavioral tests Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Mechanism
32796318 Anxiety-like behaviors were evaluated using the open-field test (OFT) and elevated plus-maze (EPM) test at 6 months after PSNL. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Mechanism
32796318 In addition, Spearman rank correlation coefficient analyses were performed to investigate whether the changes in DNA methylation were correlated with changes in nociception, anxiety, depression, and cognitive function. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Cognitive Function Anxiety Depression Mechanism
32796318 Global DNA methylation in the PFC was negatively correlated with nociceptive and depression-like behaviors (r = −0.7470, P = 0.0052 for von Frey test; r = −0.6713, P = 0.0168 for acetone test; r = −0.6993, P = 0.0114 for TST), and positively correlated with anxiety-like behavior and cognitive dysfunction (r = 0.6702, P = 0.0171 for OFT; r = 0.8693, P = 0.0002 for EPM; r = 0.6294, P = 0.0283 for Y-maze; r = 0.7719, P = 0.0033 for NOR; Figs. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Cognitive Function Anxiety Depression Mechanism
32796318 Global DNA methylation in the PAG was negatively correlated with nociceptive and depression-like behaviors (r = −0.7399, P = 0.0059 for von Frey test; r = −0.6783, P = 0.0153 for acetone test; r = −0.6434, P = 0.0240 for TST), and positively correlated with anxiety-like behaviors (r = 0.6281, P = 0.0287 for OFT; r = 0.5442, P = 0.0674 for EPM). Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Depression Mechanism
32796318 DNA methylation in the hypothalamus was negatively correlated with anxiety-like behaviors (r = −0.5860, P = 0.0453 for OFT; r = −0.5301, P = 0.0763 for EPM), and positively correlated with depression-like behaviors (r = 0.6364, P = 0.0261 for TST). Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Depression Mechanism
32796318 Global DNA methylation in the HIP was positively correlated with nociceptive and depression-like behaviors (r = 0.6655, P = 0.0182 for von Frey test; r = 0.5105, P = 0.0899 for acetone test; r = 0.8042, P = 0.0016 for TST), and negatively correlated with anxiety-like behavior and cognitive dysfunction (r = −0.7439, P = 0.0055 for OFT; r = −0.7103, P = 0.0096 for EPM; r = −0.4615, P = 0.1309 for Y-maze; r = −0.6561, P = 0.0205 for NOR; Figs. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Cognitive Function Anxiety Depression Mechanism
32796318 Consistent with recent studies, PSNL mice with prolonged (6-month) mechanical hyperalgesia and cold allodynia showed both anxiety and depression in OFT, EPM, and TST tests, and working and recognition memory deficits in Y-maze and NOR tests. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Depression Mechanism
32796318 Interestingly, in PFC of mice with chronic stress, knockdown of Dnmt3a mRNA induces anxiety-like behavior, which is inhibited by overexpressed Dnmt3a mRNA. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Mechanism
37435647 Some studies have suggested that the combination of CRHR2 and its ligand (urocortin2) was involved in the regulation of feeding and intestinal motility, and could also induce anxiety. J Neurophysiol. 2023 Aug 1;130(2):380-391. doi: 10.1152/jn.00156.2023. Epub 2023 Jul 12. Anxiety Mechanism
37435647 Moreover, CRHR2 might have a regulatory function in response to CRHR1 stimulation of the HPA axis or anxiety, and CRHR2 played an important regulatory role in the process of visceral pain signaling. J Neurophysiol. 2023 Aug 1;130(2):380-391. doi: 10.1152/jn.00156.2023. Epub 2023 Jul 12. Visceral Pain Anxiety Mechanism
30089868 The present study investigated whether acupuncture improves depression- and anxiety-like behaviors induced using a single prolonged stress (SPS) as a PTSD rat model. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 We found that acupuncture at HT8 significantly alleviated both depression- and anxiety-like behaviors induced by SPS in rats, as assessed by the forced swimming, elevated plus maze, and open field tests; this alleviation was blocked by rapamycin. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 PTSD is often comorbid with depression and other anxiety disorders. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Several studies have substantiated its benefits for depression and anxiety. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Acupuncture administered at point HT7 has been found to relieve emotional problems, especially excessive anxiety and worry, and acupuncture at point HT8 has been reported to have therapeutic effects on mental disorders. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mood Mechanism
30089868 In addition, acupuncture is used for depression and anxiety, which are the most frequent complaints of psychiatric complaints in Complementary Alternative Medicine (CAM) clinic. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 In the SPS rat model, animals that were treated with predictable continuous trauma showed depression- and anxiety-like behaviors, which are psychological symptoms of PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Previous studies showed a loss in mTOR signaling in the hippocampus of subjects with depression and anxiety disorders. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 This study investigated whether acupuncture has beneficial effects on the depression- and anxiety-like behaviors in the SPS rat model of PTSD using the forced swimming test (FST), open field test (OFT), and elevated plus maze (EPM) test. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 SPS-induced depression- and anxiety- like behaviors, and acupuncture stimulation in the rats. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Effects of acupuncture at HT8 on depression- and anxiety-like behaviors and, blood levels of corticosterone and CRF expression in the PVN of the SPS model of PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 PTSD has diverse symptoms including depression and anxiety; therefore, this animal model was tested for two different behaviors simultaneously. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Effects of acupuncture at HT8 on depression- and anxiety-like behaviors in SPS-induced PTSD rats Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Effects of acupuncture at HT8 on depression- and anxiety-like behaviors and CRF expression in the PVN, and blood levels of corticosterone of the SPS model of PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 The OFT was used to study anxiety-like and exploratory behavior. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mechanism
30089868 To observe the anxiety-like behaviors, we assessed the rats during open arm exploration in the EPM. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mechanism
30089868 ), blocked depression- and anxiety- like behavior by acupuncture at HT8 in the hippocampus. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Taken together, these findings suggest that pretreatment with the mTOR inhibitor rapamycin significantly blocked the effect of HT8 on the depression- and anxiety-like behaviors. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Our findings show that depression- and anxiety-like behaviors in the SPS rat model of PTSD are alleviated by acupuncture at acupoint HT8, but not at other acupoints. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 To our knowledge, this study is the first to show the effects of acupuncture treatment on both depression- and anxiety-like behaviors and their underlying mechanism in the SPS-induced PTSD animal model. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 The SPS paradigm is considered to be an experimental model mimicking PTSD because it mirrors most of the neuronal deficits and psychological symptoms seen in patients with PTSD; depression- and anxiety-like behaviors are considered the main symptoms in the SPS-induced PTSD rat model. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 In this study, we found that SPS administration caused reduced time spent in the center of the OFT and in the open arms of the EPM, as well as increased immobility in the FST, reflecting characteristics of depression and anxiety that are frequent complaints in patients with PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Forced maintenance of high corticosterone levels is associated with the stress response and subsequent depression- and anxiety-like behaviors in patients with PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Stress Response Anxiety Depression Mechanism
30089868 The following measurements were taken: number of open arm entries, number of closed arm entries, percentage of open arm time, and anxiety index. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mechanism
30089868 Anxiety reduction, as manifested by open arm exploration in EPM test, was defined as an increase in the number of open arms compared to total entries into either open arm or closed arm, and an increase in the percentage of time spent in open arms. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mechanism
30089868 The anxiety index was calculated as follows: Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mechanism
30089868 Anxiety index values range from 0 to 1 where an increase in the index expresses increased anxiety-like behavior. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Mechanism
30089868 of each measure, in each group) to enable the comparison between different measures that depict depression- and anxiety-like symptoms. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
32956833 Additionally, some studies have shown that the modulation of SP binding to NK1R may be useful in the treatment of diseases, such as inflammatory conditions associated with the gastrointestinal tract, emesis, depression, cancer, and social anxiety disorder. Brain Behav Immun. 2021 Jan;91:683-694. doi: 10.1016/j.bbi.2020.08.016. Epub 2020 Sep 18. Gastrointestinal Tract Nausea and Vomiting Anxiety Depression Mechanism
36003380 In the present study, EA stimulation mitigated the SP-induced gut microbiome dysbiosis and microglia activation in the hippocampus, somatosensory cortex, and spinal cord, the central nervous system regions primarily associated with cognition and anxiety, and pain in mice. Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. Anxiety Mechanism
21695393 Additionally, it has been reported that acupuncture attenuated nicotine withdrawal-, maternal separation-, and chronic corticosterone-induced anxiety-like behavior assessed with an elevated plus maze. Neurochem Res. 2011 Nov;36(11):2104-10. doi: 10.1007/s11064-011-0534-y. Epub 2011 Jun 22. Anxiety Mechanism
33384922 Ethanol users commonly have comorbid affective disorders such as depression and anxiety. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Anxiety Depression Mechanism
33384922 Among acupuncture points, the Shenmen (HT7) acupuncture point is the source point of the heart meridian and has frequently been used to treat mental disorders, including drug addiction, anxiety, and depression. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Anxiety Depression Mechanism
33384922 According to recent studies, HT7 stimulation attenuates anxiety-like behavior during ethanol withdrawal through regulation of the neuroendocrine system and amygdaloid neuropeptide Y reversals. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Anxiety Mechanism
28672928 Such negative emotions as tension, worry, fear, depression and anxiety; and social environment, diet, daily life and movement conditions are external factors. Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. Anxiety Depression Mood Mechanism
25861363 Rgs9 knockout rats exhibit normal locomotor activity, anxiety-like behavior, cued and contextual fear conditioning, startle threshold, and prepulse inhibition which suggest that Rgs9-2 is a potential therapeutic target for disorders involving motor or cognitive dysfunction. Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Cognitive Function Anxiety Mechanism
37066940 Our previous studies confirmed that PTSD model rats showed significant emotional disturbances, such as anxiety, depression, and fear, as well as obvious declines in learning and memory. Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. Learning and Memory Ability Anxiety Depression Mood Mechanism
37066940 Microarray analysis of rats exposed to stress, fear and anxiety showed that LincRNA was differentially expressed in brain regions represented by hippocampus , and subsequent enrichment analysis  indicated that lincRNAs were involved with many biological functions including neuroactive ligand receptors, interactions, calcium signalling, and the PI3K-AKT pathway. Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. Anxiety Mechanism
36636219 Long-term insomnia increases the incidence of hypertension, coronary heart disease, Alzheimer's disease, anxiety, depression, neurosis, menopausal syndrome, chronic indigestion, anemia, atherosclerosis and other related diseases and seriously affects human lifespan. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Insomnia Anxiety Depression Mechanism
36636219 People with insomnia are five times more likely to suffer from depression and anxiety than the general population, have a multiplied risk of cardiovascular disease, and have a significantly higher risk of death. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Cardiovascular Insomnia Anxiety Depression Mechanism
36636219 Compared with the control group, the model group had more frequent movements and more intensive movement trajectories in the open field, indicating that the model rats had increased anxiety in the open field. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Anxiety Mechanism
36636219 In contrast, the motor trajectories were sparse in the DHS and 7,8-DHF intervention groups compared to the model group, indicating that rats experienced significantly less anxiety in the open field. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Anxiety Mechanism
36636219 Similarly, compared with the PCPA group, the movement trajectories of the rats in the DHS or 7,8-DHF intervention groups were sparse, indicating that the anxiety of the rats in the open field was significantly reduced (Figure 1C, D). Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Anxiety Mechanism
36636219 Of course, perhaps the same diseases that affect monoclonal neurotransmitters, such as Alzheimer's disease, tinnitus, anxiety, and chronic fatigue, can also be treated with electroacupons. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Anxiety Mechanism
36636219 CORT can induce depression and is involved in the occurrence and development of comorbidities of insomnia, anxiety and depression. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Insomnia Anxiety Depression Mechanism
34621320 We aimed to produce FD rat models with the specific set of characteristics: presence of anxiety-like behaviour resulting in decreased appetite and water intake, reduction in activity, decrease of coat luster, increased knots in fur, and delayed gastric emptying. Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. Anxiety Mechanism
34621320 Successful models of both FD model and FD acupuncture groups were confirmed through monitoring of decreasing point measurements of general observations, increased anxiety-like behaviour, and infighting, resulting in decreased body weight and food and water intake, and through delayed gastric emptying rates which were measured subsequent to rs-fMRI scans. Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. Anxiety Mechanism
37128191 Moreover, non-motor symptoms of PD, including anxiety, depression, and hyposmia, have been associated with impaired neurogenesis. J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. Anxiety Depression Mechanism
37096024 We found that in the open field experiment, the VPA-induced rat model was more willing to stay in the surrounding area compared with the WT and acupuncture group, which suggested that the basic anxiety level of the model rats was increased and acupuncture could significantly improve their anxiety level, which was consistent with the research results of Zhang Xuejie et al The total length movement and average speed in VPA group were smaller than those in WT group, suggesting that the VPA group had reduced locomotor capacity, which was improved by acupuncture to some extent. Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. Anxiety Mechanism
24527041 Importantly, the depression and anxiety that occur during morphine addition and morphine abstinence often lead to a relapse in humans. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 The depression and anxiety associated with morphine withdrawal can be alleviated by the administration of antidepressant or anxiolytic drugs such as fluoxetine or agmatine. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 A number of studies have found that acupuncture is an effective remedy for depression and anxiety and may be as effective as antidepressant drugs. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 SP6 (Sanyinjiao) is one of the most commonly used acupoints in acupuncture treatment to alleviate psychic and psychosomatic dysfunction such as depressive symptoms and anxiety disorders. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Recent animal studies have found that acupuncture and low frequency electroacupuncture stimulation exhibit antidepressant-like activity in the forced swimming test (FST), reduce anxiety-like behavior in the elevated plus maze (EPM) test, and restore the expression levels of neuropeptide Y and c-Fos in the brain. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 However, the underlying mechanism of acupuncture in the treatment of psychiatric disorders, including the withdrawal-induced despair-related, anxiety-like, and aberrant social behaviors associated with morphine use, has not been examined in animal models. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 The aim of the present study was to investigate the effects of acupuncture stimulation on despair-related, anxiety-like, and social behaviors in rats exposed to repeated morphine administration. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 One or 4 weeks following the final morphine injection, despair-related, anxiety-like, and aberrant social behaviors in rats exposed to abstinence were evaluated using the FST, the EPM test, and the OFT. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 This study was designed to explore the efficacy of acupuncture stimulation for healing repeated morphine administration and withdrawal-induced despair-related, anxiety-like, and aberrant social behaviors in an animal model using behavioral and neurobiological methodologies. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Animals conduct anxiety-like behaviors usually show the reductions both in the number of entries and in the time spent in the open arms, along with an increase in the amount of time spent in the closed arms in the EPM. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Anxiety reduction, indicated by open arm exploration in the EPM, was defined as an increase in the numbers of entries into the open arms relative to total entries into either open or closed arm and an increase in the proportion of time spent in the open arms relative to total spending time in either open or closed arm. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Social interaction test has been pharmacologically validated as an experimental paradigm to measure depression or anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Despair- and Anxiety-Like Behaviors during Protracted Abstinence following Repeated Morphine Administration Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Anxiety expressed as a decrease in open-arm exploration in the EPM test was also analyzed. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Therefore, anxiety behavior was increased following exposure to chronic morphine, and, importantly, these effects were strong only after a prolonged abstinence period. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Following withdrawal from morphine administration, the anxiety-like symptoms persisted for 4 weeks. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Effects of Acupuncture Stimulation of SP6 on Morphine-Induced Despair- and Anxiety-Like Behavior during Protracted Abstinence Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 These findings indicate that acupuncture stimulation of SP6, but not of TE5 or the tail, during protracted abstinence significantly ameliorates anxiety-like behavior. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 The absence of significant differences in the number of closed-arm entries among the groups in the EPM test suggests that this anxiety-like behavior in morphine-treated rats cannot be attributed to differences in locomotor activity (P = 0.229; Figure 7(f)). Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 This finding suggests that acupuncture stimulation of SP6 during the 4-week abstinence period is able to prevent the development of anxiety-like behavior. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Many studies have shown that CRF levels are correlated with anxiety in animal models of depression, suggesting a possible link between high level expression of CRF and predisposition to anxiety or morphine withdrawal-induced depression. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 It has been proposed that clinical anxiety or depression may be the result of alterations in the activity of the LC in central noradrenergic system. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 The present results demonstrate that protracted abstinence following repeated morphine administration increased despair-related, anxiety-like, and aberrant social behaviors in rats. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Moreover, in the present study, there was a decrease in the expression of BDNF mRNA in the rat hippocampus as well as an increase in depression- and anxiety-like symptoms following protracted abstinence from repeated morphine administration. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Protracted abstinence from repeated morphine administration elicits despair-related, anxiety-like, and aberrant social behaviors in the rats, as assessed by the FST, the EPM, and the social interaction test. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Thus, changes in depression- and anxiety-like behaviors may be observed 4 weeks after abstinence. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Although the FST provides information about mood (i.e., depression and anxiety) in rodents, it is important to use caution when extrapolating the data to humans. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mood Mechanism
24527041 Anxiety is another complex feature of depression, and anxiety-like symptoms in chronically stressed animals are not surprising. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 It should be noted that a heightened anxiety level was observed in morphine-treated rats at 4 weeks, and this anxiogenic-like effect influenced social and despair behaviors, as morphine-treated rats showed similar social interaction times and immobility in the FST. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 However, acupuncture stimulation of SP6 during protracted abstinence for 4 weeks significantly reduced anxiety-like behaviors in the EPM test, as indicated by an increase in the percentage of time spent into the open arms. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Accordingly, these results suggest that chronic acupuncture stimulation of SP6 ameliorates anxiety-related behaviors that persist for 4 weeks in rats after withdrawal from repeated morphine administration. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Alternatively, decreased social interaction may also result from increased levels of anxiety, but this seems unlikely under the current experimental conditions. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 Low light and familiar conditions that are not expected to generate anxiety were deliberately used. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 The present data suggest that CRF circuits in the hypothalamus were potently activated by morphine administration, and this activation might be responsible for inducing depression and anxiety related to morphine withdrawal. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Furthermore, many studies have shown that withdrawal from morphine leads to extreme anxiety, which is accompanied by several physical disturbances, most of which are linked to the activation of brainstem regions such as the LC. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Mechanism
24527041 TH is an enzyme involved in the response to morphine withdrawal-related psychopathological conditions, such as depression and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Therefore, the current results are consistent with previous reports indicating that depression- and anxiety-like behaviors induced by morphine withdrawal are the result of alterations in the central noradrenergic system. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Thus, acupuncture stimulation of SP6 is capable of attenuating complex behaviors associated with depression and anxiety via the modulation of the central noradrenergic system. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 In the present study, acupuncture stimulation of SP6 restored the decreased expression level of BDNF mRNA in the hippocampus and ameliorated depression- and anxiety-like behaviors in rats experiencing protracted abstinence from morphine administration. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 These results suggest that stimulation of the acupuncture point spreads throughout the body at a rapid rate and its effect is highly point specific, at least for modulating the depression- and anxiety-like symptoms associated with morphine discontinuation. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Currently, acupuncture is a relevant therapy in complementary and alternative medicine for managing various psychosomatic diseases such as drug abuse, stress, depression, and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 These results demonstrate that acupuncture stimulation of SP6 reduces the depression- and anxiety-like symptoms strongly associated with morphine abstinence, probably by modulating hypothalamic CRF and the noradrenergic system that underlies mood disruption. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mood Mechanism
24527041 This indicates that acupuncture stimulation of SP6 might be effective in preventing patients with drug addiction from relapsing into drug seeking while trying to quit, by relieving some of the discomfort of morphine withdrawal symptoms including depression and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Therefore, acupuncture stimulation may be a useful therapy in the development of alternative medicines for treating morphine withdrawal-related symptoms, such as depression and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Experimental schedule for study of morphine withdrawal-induced depression- and anxiety-like behaviors in rats. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
28672900 Emotional behavior was quantified using the OF test and EZM test, which are generally used to evaluate depression and anxiety. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mood Mechanism
28672900 EA reduces anxiety-like behavior in rats with pain-depression dyad via 5-HT Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 In certain rodent models of depression, anxiety-like responses are observed. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 To determine whether anxiety-like behaviors accompany the pain-depression dyad, rats were subjected to the EZM test. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 Pain-depression dyad is a complex illness with symptoms of pain overlapping with emotional disorders such as depression and anxiety. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mood Mechanism
28672900 Reserpine-injected rats, an ideal model of pain-depression dyad, display hyperalgesia, allodynia and depressive behaviors accompanied with anxiety. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 As the reserpine-injected rats exhibited not only depressive-like but also anxiety-like behavior in the EZM test, it was indicated that the pain-depression dyad model was successfully established. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 Effects of EA on the anxiety-like behavior in rats quantified by the EZM test on day 5. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Mechanism
28837077 A case study from Japan describes the successful treatment of an 81-year-old woman with PD who received manual acupuncture treatment five days per week based on TCM principles for the relief of non-motor symptoms (hot flashes and paroxysmal sweating, depression and anxiety), using the LR3, LI4, KI5, KI7, SP6, GB34, BL18, BL15, and GB20 acupuncture points. Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. Anxiety Depression Mechanism
37383281 Some patients also have anxiety, depression, and other negative psychological emotions. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Anxiety Depression Mood Mechanism
37383281 Clinical studies have found that acupuncture at Back-Shu point has an excellent therapeutic effect on insomnia, effectively improving depression, anxiety, memory loss, immunity decline and other clinical symptoms caused by insomnia. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Immunity Insomnia Anxiety Depression Mechanism
35251208 Posttraumatic stress disorder (PTSD) is a mental disorder in which fear memory and anxiety reactions appear after exposure to a previously experienced traumatic event (e.g., a car accident, disaster, abuse, or extreme stress). Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. Anxiety Mechanism
35251208 Unlike general stress, PTSD causes fear memory disorders to appear even in safe situations when the traumatic event has disappeared; it can cause serious pathological changes such as anxiety disorders, depression, flashbacks, and cognitive memory dysfunction. Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. Anxiety Depression Mechanism
35251208 Some studies have reported that low-frequency electrical stimulation of a specific acupoint (Shenmen or heart meridian, HT7) significantly improves anxiety-like behavior by reducing the stress-induced chronic production of CORT in rats; it also restores the expression of the neuropeptide Y and the gene c-Fos in the paraventricular nucleus of the hypothalamus. Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. Anxiety Mechanism
27594888 Generally, it is common to use drugs for FGID including antacids, prokinetic agents, antianxiety or antidepression drugs, digestants, and anti-HP treatment. Evid Based Complement Alternat Med. 2016;2016:1935372. doi: 10.1155/2016/1935372. Epub 2016 Aug 3. Anxiety Depression Mechanism
31312613 In recent years, acupuncture has been widely used among cancer patients as a none-drug therapy against many cancer-related symptoms including cancer-related pain, vomiting, postoperative intestinal obstruction, dry mouth, fatigue, hot flashes, anxiety, insomnia and others. Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. Insomnia Nausea and Vomiting Anxiety Mechanism
31737064 EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Visceral hypersensitivity is the main performance of IBS, which is associated with anxiety, depression, etc.. Furthermore, the latest release of Rome IV suggests that the pathogenesis of IBS is mainly due to disorders of gut-brain interaction. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Our previous polycentric randomized controlled trial showed that EA is effective against IBS and is superior to loperamide in relieving anxiety. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Mechanism
31737064 Accumulating evidence has shown that CRF, which is mainly produced in the hypothalamic paraventricular nucleus, can induce altered bowel habits, visceral hypersensitivity, and emotional disorders, such as anxiety-like or depression-like behaviours, by combining with central CRF-R1. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mood Mechanism
31737064 Behavioural Assessment of Anxiety-Depression Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Effect of EA on Anxiety and Depression-Like Behaviours Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Additionally, 20% to 60% of IBS patients have mental disorders such as anxiety and depression, which are positively correlated with IBS. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 As for mental disorders, rats' anxiety-like behaviours were evaluated by OT% of EMPT and depression-like behaviours by SP%. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 This result is consistent with the following finding: EA can enhance the SP% of depressing rats and relieve rats' anxiety and depression-like behaviours, with a similar effect to PB, an antidepressant medicine. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 As a result, EA was effective in downregulating CRF-R1 expression in the hypothalamus and IMMC, decreasing the expression of hypothalamus CRF, alleviating rats' visceral hypersensitivity and anxiety and depression-like behaviours, and meeting with Wu HG's research. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31785199 Depression is a mood disorder characterized by a persistent depressed mood, a feeling of helplessness, and can be associated with anxiety. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Anxiety Depression Mood Mechanism
31785199 treated patients with anxiety and depression following an acute stroke with acupuncture of the 13 ghost acupoints and showed a significant improvement in symptoms. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Anxiety Depression Mechanism
31045558 As a common means of PTSD, acupuncture has high efficiency, long duration of action, and low side effects, it can effectively reduce anxiety-like behaviors and improve the impaired learning-memory ability in PTSD rats . Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Side Effects Learning and Memory Ability Anxiety Mechanism
31045558 Acupuncture can improve clinical symptoms such as anxiety, panic and low learning and memory in patients with PTSD, and its efficacy is even better than that of paroxetine . Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Learning and Memory Ability Anxiety Mechanism
31045558 In addition, there are studies confirmed that LTP in the hippocampal amygdala (especially the basolateral amygdala) may be the neural basis of stress-induced anxiety and the neural basis of conditional fear, it works together with other brain regions to collectively regulate the situation-specific fear regression . Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Anxiety Mechanism
31045558 The test was used to investigate for anxiety-like behaviors as reported previously . Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Anxiety Mechanism
31045558 Anxiety-like behavior was evaluated using the test as described previously . Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Anxiety Mechanism
31045558 The above findings suggested that electroacupuncture significantly increased locomotor activity and reduced levels of anxiety-like behavior in PTSD rats. Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Anxiety Mechanism
31045558 According to the relevant data of the behavioral test, it can be known that the two modeling methods can obviously induce anxiety, depression and fear-like behaviors and can significantly reduce spatial learning and memory ability in rats. Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Learning and Memory Ability Anxiety Depression Mechanism
37179843 The elevated plus maze test was performed to estimate the anxiety-like behavior of depressive rats as reported in previous studies. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Anxiety Mechanism
27381504 Moreover, this chronic pain is associated with fatigue, depression, memory problems, anxiety, sleep disturbances, and headaches. Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. Insomnia Anxiety Depression Mechanism
26770252 Persistent neuropathic pain is associated with anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Neuropathic Pain Anxiety Mechanism
26770252 The phosphorylation of extracellular signal-regulated kinase (p-ERK) in the anterior cingulate cortex (ACC) plays an important role in pain-induced anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Acupuncture is widely used for pain and anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 However, little is known about which acupuncture technique is optimal on pain-induced anxiety and the relationship between acupuncture effect and p-ERK. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 The pain withdrawal thresholds (PWTs) and anxiety behavior were measured, and p-ERK protein expression and immunoreactivity cells in ACC were detected. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Immunity Anxiety Mechanism
26770252 Meanwhile, anxiety-like behavior was improved significantly in the sMA and mMA groups. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 The effect of different acupuncture techniques on pain-induced anxiety may arise from the regulation of p-ERK in ACC. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Anxiety and depression often coexist with persistent pain. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Depression Mechanism
26770252 In humans, patients with persistent pain frequently suffer from a series of aversive emotions including anxiety, fear, depression, loneliness, and misanthropy, which can be more distressing than the pain itself. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Depression Mood Mechanism
26770252 In last decades, preclinical and clinical researches have demonstrated that MA and EA are, respectively, effective for neuropathic pain and anxiety; however, it is unknown whether they have an effective role for neuropathic pain-induced negative mood. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Neuropathic Pain Anxiety Mood Mechanism
26770252 Therefore, it is important to determine the functional significance of changes in the ACC when studying persistent pain-induced anxiety and other mood disorders. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mood Mechanism
26770252 Accumulating evidence has shown that extracellular signal-regulated kinase (ERK), a family member of mitogen-activated protein kinases (MAPKs), in the ACC is activated in the chemical inflammatory pain or neuropathic pain model and suggested that pain-induced anxiety is regulated by the ERK activation in the ACC after incision. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Neuropathic Pain Anxiety Inflammatory Pain Mechanism
26770252 Moreover, inhibition of ERK1/2 activation in ACC after acetic acid injection by subcutaneous injection of the mitogen-activating extracellular kinase (MEK) inhibitor, SL327, attenuates visceral pain-induced anxiety-like behavior. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Visceral Pain Anxiety Mechanism
26770252 All of these data demonstrate that ERK activity in the ACC may be an important hub for various types of pain-induced anxiety and thus constitutes a critical target for revealing the underlying mechanism. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 In the present work, we hypothesized that mMA, sMA, and EA have differential effects on pain-induced anxiety and that the cellular mechanism underlying such anxiety involves ERK phosphorylation in the ACC. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 To test these hypotheses, we used the L5 spinal nerve ligation (SNL) rat model of persistent pain to assess the changes in pain-induced anxiety and phosphorylated- (p-) ERK levels in the ACC and to investigate the effect of mMA, sMA, and EA on these measures (Table 1). Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Anxiety-Like Behavioral Testing Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Repeated exposure to test conditions may significantly decrease anxiety-like behaviors. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Therefore, in the present study, anxiety-like behavior was tested only once, 12 days after SNL. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Pain-Induced Anxiety Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 The elevated zero maze (EZM) is widely used to assess anxiety-like behavior in rodents. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 The present study is the first to show that both sMA and EA stimulation significantly relieve mechanical hypersensitivity in a rat model of neuropathic pain, and both sMA and mMA stimulation significantly reduce anxiety-like behavior. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Neuropathic Pain Anxiety Mechanism
26770252 The changes in anxiety-like behavior correlate with ERK activation in ACC neurons. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Hence, sMA might be the treatment of choice in cases of neuropathic pain accompanied by anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Neuropathic Pain Anxiety Mechanism
26770252 Many studies on persistent pain have paid considerable attention to its effects on anxiety-like behavior. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 SNL is a common model for mechanical hyperalgesia and pain-induced anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 However, clinical evidence has not been conclusive on the effects of manual acupuncture or EA on anxiety, despite the fact that both are increasingly used for the treatment of anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 In basic research, a few studies examining the effects of manual acupuncture and EA on anxiety have indicated that the technique might reduce anxiety-like behavior in adult rats. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Twelve days after SNL, rats displayed increased anxiety behavior. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Interestingly, sMA and mMA stimulation alleviated pain-induced anxiety in the EZM test, whereas EA stimulation was without effect. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 These results indicate that sMA is considerably more effective than mMA and EA in relieving both mechanical hypersensitivity and concomitant anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 To examine this possible mechanism underlying the effects of sMA stimulation on pain-induced anxiety, we explored p-ERK expression in the ACC. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 ERK activation in the ACC was required for the expression of pain-induced anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Another study hypothesized that attenuation of p-ERK1/2 overactivity in the ACC represented a potentially valuable therapeutic strategy for the relief of pain-induced anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Pain Relief Anxiety Mechanism
26770252 In our study, ERK1/2 activation in the ACC of rats after SNL was significantly stronger than in non-SNL control rats, and this coincided with changes in anxiety-like behavior. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Accordingly, sMA and mMA stimulation downregulated ERK1/2 activation in ACC neurons and also improved anxiety-like behavior, suggesting a mechanism behind the effect of sMA and mMA on pain-induced anxiety. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 Differences in stimulation strength and method may lead to differences in treatment results; the parameters used in manual acupuncture and EA when treating anxiety are not yet clear and are worthy of further study. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
26770252 In summary, sMA stimulation may relieve both mechanical hyperalgesia and pain-induced anxiety in a rat model of neuropathic pain, while mMA only reduces anxiety and EA only alleviates mechanical hypersensitivity. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Neuropathic Pain Anxiety Mechanism
26770252 The effect of different acupuncture stimulation on anxiety-like behavior may arise from the regulation of p-ERK in ACC neurons. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Mechanism
34039946 Depression is an affective disorder characterized by persistent sadness, feelings of inferiority and helplessness, and anxiety. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Anxiety Depression Mechanism
34039946 For example, continuous administration of Lactobacillus rhamnosus for 4 weeks improved the anxiety and depression-like behavior of mice. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Anxiety Depression Mechanism
34039946 The elevated plus maze test is a widely used method to assess anxiety behavior of rodents. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Anxiety Mechanism
32547407 Some clinical symptoms of PCOS such as hyperandrogen, high blood pressure, and anxiety are highly related to the sympathetic nerve system or imbalance of sympathetic and the parasympathetic nerve. Front Physiol. 2020 May 29;11:474. doi: 10.3389/fphys.2020.00474. eCollection 2020. Anxiety Blood Pressure Mechanism
37384285 TRPV1 channels play a major role in various disorders, such as pain, depression, stress, obesity and anxiety, and are known to be involved in various acupuncture effects. Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023. Anxiety Depression Mechanism
38164490 Chronic extensive pain is the main syndrome upsetting individuals with fibromyalgia (FM), accompanied by anxiety, obesity, sleep disturbances, and depression, Transient receptor potential vanilloid 1 (TRPV1) has been reported to transduce inflammatory and pain signals to the brain. Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. Insomnia Anxiety Depression Inflammatory Pain Mechanism
38164490 The beneficial effects of acupuncture in FM extend to its capacity to diminish anxiety, depression, and sleep disturbance. Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. Insomnia Anxiety Depression Mechanism
38164490 FM is a chronic pain accompanied by complicated symptoms such as anxiety, exhaustion, sleep disruption, and depression. Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. Anxiety Depression Mechanism
36277498 Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating synaptic plasticity of the CA1 hippocampal region in a mouse model of trigeminal neuralgia Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuralgia Anxiety Mechanism
36277498 Trigeminal neuralgia (TN), one of the most severe and debilitating chronic pain conditions, is often accompanied by mood disorders, such as anxiety and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuralgia Anxiety Depression Mood Mechanism
36277498 This study aimed to investigate whether EA ameliorates abnormal TN orofacial pain and anxiety-like behavior by altering synaptic plasticity in the hippocampus CA1. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Stable and persistent orofacial allodynia and anxiety-like behaviors induced by pT-ION were related to changes in hippocampal synaptic plasticity. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 EA attenuated pT-ION-induced orofacial allodynia and anxiety-like behaviors and effectively reversed the abnormal changes in dendritic spines and synapse of the hippocampal CA1 region. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 EA modulates synaptic plasticity of hippocampal CA1 neurons, thereby reducing abnormal orofacial pain and anxiety-like behavior. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 TN is a chronic neuropathic pain which often causes mood disorders, such as anxiety and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuropathic Pain Anxiety Depression Mood Mechanism
36277498 However, whether the alterations in hippocampal CA1 synaptic plasticity participate in the pathogenesis of pain and anxiety in TN is unknown. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 In the current study, we used the mouse TN model of partially transecting the infraorbital nerve (pT-ION), which has been shown to induce stable pain and anxiety-like behaviors in our previous studies. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 The results showed that persistent orofacial allodynia and anxiety-like behaviors induced by pT-ION were related to changes in hippocampal CA1 synaptic plasticity. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Repeated EA treatment improved pain- and anxiety-related behaviors and effectively reversed the abnormal changes in synaptic plasticity of the CA1 hippocampal region in pT-ION mice. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 The OFT and EPM tests were executed to assess anxiety-like behaviors of mice. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 pT-ION induces unilateral orofacial nociceptive hypersensitivity and anxiety-like behavior in mice Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 To study whether and when pT-ION mice show anxiety-like behavior, the EPM and OFT test were performed on the 7th, 14th, and 21st days after nerve injury. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 These results suggested that pT-ION group show anxiety-like behaviors from day 14 to day 21 after nerve injury. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Electroacupuncture attenuates orofacial allodynia and anxiety-like behaviors induced by pT-ION Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Electroacupuncture (EA) attenuates pT-ION-induced anxiety-like behavior. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 As expected, EA significantly attenuated anxiety-like behavior induced by nerve injury, whereas sham EA had no significant effect. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Chronic pain can cause emotional disturbances like anxiety, depression, and fear in affected patients. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Depression Mood Mechanism
36277498 Thus, it adds to the probability of inducing mood disorders, including anxiety and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Depression Mood Mechanism
36277498 Meanwhile, the phenomenon of TN inducing anxiety-like behaviors has been confirmed in the pT-ION and CCI-ION models. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Consistent with these studies, the current study also used the OF and EPM test to assess the anxiety-like behaviors of mice. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Our results showed that the pT-ION model induced anxiety-like behaviors on days 14 and 21 but not on day 7, postoperatively. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 These parameters have been proved to have good validity in detecting anxiety-like behavior in animals. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 In this study, EA had immediate alleviating effects on mechanical allodynia on postoperative day 7, and repeated EA alleviated the pT-ION-induced allodynia and anxiety-like behaviors on day 21 after nerve injury. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 Behavioral symptoms of anxiety and depression are closely related to the decrease in hippocampal volume and synaptic loss. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Depression Mechanism
36277498 However, whether EA alleviates orofacial pain and anxiety-like behaviors of TN by improving the synaptic plasticity of hippocampus is still unclear. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Mechanism
36277498 This study demonstrates that EA has significant analgesic and anxiolytic effects on pT-ION-induced neuropathic pain and related anxiety-like behaviors. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuropathic Pain Anxiety Mechanism
25206816 Acupuncture combined with psychological desensitization could improve sleep and anxiety disorders. Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. Anxiety Mechanism
34393735 NT-3 is thought to play a role in the neurobiological processes associated with mood and anxiety disorders. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Anxiety Mood Mechanism
29636708 And it has been identified that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders, including depression, schizophrenia, and anxiety disorder. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Anxiety Depression Mechanism
29636708 These partly overlap with the region differently methylated in various neuropsychiatric disorders, including depression, anxiety disorder, and schizophrenia. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Anxiety Depression Mechanism
35478723 In addition, the patients with cervical spondylosis show mental tension, anxiety, and insomnia. Front Surg. 2022 Apr 11;9:778608. doi: 10.3389/fsurg.2022.778608. eCollection 2022. Insomnia Anxiety Mechanism
29946236 Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Anxiety Depression Mechanism
29946236 The behavior tests including open field test and forced swimming test, which are widely used to assess depressive and anxiety-like behavior were performed on the Monday and Tuesday of the eleventh week. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Anxiety Mechanism
29946236 These results suggest EA treatment could reverse the CUS-induced depressive- and anxiety-like behavior, substantiating the evidence for antidepressant-like and anxiolytic effects of EA treatment. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Anxiety Mechanism
29946236 The present study demonstrated that 10 weeks of CUS-induced depressive- and anxiety-like behavior, which are described as a dramatic increase in the immobility time in FST and a significant decrease in the rearing frequency and total distance traveled as well as less central square entries and duration in OFT (Figure 2H). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Anxiety Mechanism
29946236 Meanwhile, EA treatment ameliorated the depressive- and anxiety-like behavior. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Anxiety Mechanism
25530777 Animal behavioral studies and a human study suggest that Gal has a role in stress, depression like behavior, and anxiety. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Anxiety Depression Mechanism