- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Body System Protection
- Brain Protection
- Acupuncture anesthesia plays a vital role in brain surgeries, ensuring precise and safe anesthesia, reducing the risk of neurological complications, and supporting optimal cognitive function.
- Lung Protection
- Acupuncture anesthesia reduces post-operative lung complications, aiding in rapid lung function recovery, particularly beneficial for lung surgeries.
- Neuroprotection
- Acupuncture anesthesia is crucial for safeguarding the nervous system, reducing nerve injuries, and preventing the progression of neurological disorders.
- Kidney
- Acupuncture anesthesia alleviates stress on the kidneys, reducing the risk of kidney injury, particularly valuable in kidney surgeries.
- Gastrointestinal Tract
- Acupuncture anesthesia supports gastrointestinal health, reducing the risk of post-operative digestive issues, and ensuring a smoother recovery.
- Cardiovascular
- Acupuncture anesthesia eases the cardiovascular system's burden, reducing the risk of cardiovascular complications, especially in cardiac surgeries.
- Myocardium
- Acupuncture anesthesia aids in protecting the myocardium, minimizing adverse effects on heart muscle, ensuring cardiac health.
- Cognitive Function
- Through emotional stability and neuroprotection, acupuncture anesthesia helps preserve cognitive function, reducing the risk of post-operative cognitive impairment.
- Motor Function
- Acupuncture anesthesia improves motor function, aiding in post-operative mobility, and enhancing overall quality of life.
- Language Function
- Acupuncture anesthesia supports language function rehabilitation, assisting patients in regaining their communication skills.
- Learning and Memory Ability
- Acupuncture anesthesia, by reducing post-operative pain and emotional instability, enhances learning and memory ability, promoting a speedy recovery.
Acupuncture anesthesia for Body System Protection-Cognitive Function
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 17351025 | Acupuncture for chemotherapy-associated cognitive dysfunction: a hypothesis-generating literature review to inform clinical advice. | Integr Cancer Ther. 2007 Mar;6(1):36-41. doi: 10.1177/1534735406298903. | Cognitive Function | Review |
| 17351025 | A clinical question thus arises: What should physicians advise their patients regarding the use of acupuncture to alleviate or ameliorate chemotherapy-associated cognitive dysfunction? | Integr Cancer Ther. 2007 Mar;6(1):36-41. doi: 10.1177/1534735406298903. | Cognitive Function | Review |
| 17351025 | The authors review and synthesize 2 bodies of relevant research literature: (1) the developing literature on the etiology and nature of chemotherapy-associated cognitive dysfunction and (2) the literature concerning acupuncture for neurological diseases and psychological issues. | Integr Cancer Ther. 2007 Mar;6(1):36-41. doi: 10.1177/1534735406298903. | Cognitive Function | Review |
| 17351025 | There is evidence that acupuncture may be effectively used to manage a range of psychoneurological issues, some of which are similar to those experienced by patients with chemotherapy-associated cognitive dysfunction. | Integr Cancer Ther. 2007 Mar;6(1):36-41. doi: 10.1177/1534735406298903. | Cognitive Function | Review |
| 17351025 | Given evidence of possible efficacy combined with evidence of demonstrated safety, we suggest that physicians should support patient decisions to use acupuncture services for chemotherapy-associated cognitive dysfunction, especially given the lack of proven alternatives. | Integr Cancer Ther. 2007 Mar;6(1):36-41. doi: 10.1177/1534735406298903. | Cognitive Function | Review |
| 18160929 | We have observed that not only pain but also sleep and cognitive dysfunction may be ameliorated in response to acupuncture, suggesting that these variables should be taken into account when evaluating the effects of acupuncture in FMS. | Acupunct Med. 2007 Dec;25(4):184-97. doi: 10.1136/aim.25.4.184. | Cognitive Function | Review |
| 24215923 | In Alzheimer's patients, functional brain images demonstrated that acupuncture increased in the activity in the temporal lobe and prefrontal lobe which are related to the memory and cognitive function. | Int Rev Neurobiol. 2013;111:181-95. doi: 10.1016/B978-0-12-411545-3.00009-2. | Cognitive Function | Review |
| 24665599 | The present article is focused on the description of the humoral, neurotransmitter and electrophysiological mechanisms through which the positive effects of acupuncture on the cognitive function of the patients with various diseases are mediated. | Vopr Kurortol Fizioter Lech Fiz Kult. 2014 Jan-Feb;(1):44-56. | Cognitive Function | Review |
| 26268326 | It is suggested that acupuncture improves cognitive function of Alzheimer's disease by regulating glucose metabolism, enhancing neurotransmission as well as reducing oxidative stress, Abeta protein deposition, and neuronal apoptosis. | Curr Top Med Chem. 2016;16(5):574-8. doi: 10.2174/1568026615666150813144942. | Cognitive Function | Review |
| 32356637 | The most commonly used acupuncture points for the treatment of motor disorders are GV20, GB20, LI4, ST36, SP6, LI11, GB39, and motor scalp area; those for the treatment of cognitive dysfunction are GV20 and EX-HN-1, and those for the treatment of dysphagia are GV20, GV16, and CV23. | Vopr Kurortol Fizioter Lech Fiz Kult. 2020;97(2):68-77. doi: 10.17116/kurort20209702168. | Cognitive Function | Review |
| 33280396 | Acupuncture for post-operative cognitive dysfunction: a systematic review and meta-analysis of randomized controlled trials. | Acupunct Med. 2021 Oct;39(5):423-431. doi: 10.1177/0964528420961393. Epub 2020 Dec 6. | Cognitive Function | Review |
| 35580471 | These results indicated that acupuncture improved cognitive function, activities of daily living (ADLs), and motor function and relieved the degree of USN in patients with USN after stroke. | Geriatr Nurs. 2022 Jul-Aug;46:13-20. doi: 10.1016/j.gerinurse.2022.04.022. Epub 2022 May 14. | Cognitive Function Motor Function | Review |
| 35580471 | CONCLUSION: Acupuncture could promote the rehabilitation of cognitive function, ADLs, and motor function and relieve the symptoms of USN in patients with USN after stroke. | Geriatr Nurs. 2022 Jul-Aug;46:13-20. doi: 10.1016/j.gerinurse.2022.04.022. Epub 2022 May 14. | Cognitive Function Motor Function | Review |
| 35729088 | Data from both clinical trials and animal studies has shown that the integration of acupuncture into perioperative patient care leads to a reduction of perioperative complications such as preoperative anxiety, intraoperative hemodynamic instability, postoperative pain, postoperative cognitive dysfunction, and postoperative nausea and vomiting in surgical patients. | Am J Chin Med. 2022;50(4):961-978. doi: 10.1142/S0192415X22500392. | Cognitive Function Nausea and Vomiting Anxiety | Review |
| 36790017 | CONCLUSIONS: Acupuncture intervention for MCI appears to change the plasticity of brain function and improve the cognitive function of patients. | Acupunct Med. 2023 Oct;41(5):259-267. doi: 10.1177/09645284221146199. Epub 2023 Feb 15. | Cognitive Function | Review |
| 38150809 | CONCLUSION: Evidence suggests that acupuncture is generally effective and relatively safe for cognitive function and activities of daily living in neurodegenerative diseases. | Asian J Psychiatr. 2024 Jan;91:103882. doi: 10.1016/j.ajp.2023.103882. Epub 2023 Dec 21. | Cognitive Function | Review |
| 23067573 | Given that adverse events were not reported and results were unable to be interpreted, no recommendation can be made as to whether or not acupuncture is a viable treatment option for cognitive functioning. | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Cognitive Function | Review |
| 23067573 | Although more quality research and safety information are needed to determine whether acupuncture is useful in treating TSR components (.that is, PTSD, sexual function, cognitive function, fatigue), the results of our review suggest that acupuncture may be a beneficial or promising treatment for some components (that is., headache, anxiety, sleep disturbances, depression, chronic pain) and not beneficial for others (that is, substance abuse). | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Cognitive Function Insomnia Anxiety Depression | Review |
| 25097658 | Meanwhile, the content of 8-OHdG could be decreased and cognitive function and quality of life were improved after acupuncture treatment. | Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. | Cognitive Function | Review |
| 26039131 | Acupuncture may be more effective than drugs and may enhance the effect of drugs for treating AD in terms of improving cognitive function. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 26039131 | In recent years, acupuncture has been used for treating AD and reported to have effectiveness to improve the cognitive function. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 26039131 | Acupuncture has shown effectiveness in improving cognitive function, and is progressively being used in more clinical practices. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 26039131 | Therefore, evidence on the effectiveness of acupuncture in improving the cognitive function of AD patients was not powerful enough. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 26039131 | The MMSE score of 5 RCTs out of the included 10 RCTs compared with the baseline score was improved by more than 3.72 points, (Ke YM, MD, unpublished data, June 2014) which means the treatment of AD with acupuncture was clinically meaningful with respect to improving cognitive function. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 26039131 | In general, the results of the meta-analysis were meaningful for clinical practice, and indicate that acupuncture may be better than drugs and may enhance the effect of donepezil in terms of improving the cognitive function of AD patients. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 26039131 | In conclusion, the results of the meta-analysis indicate that acupuncture may be more effective than drugs, and may also enhance the effect of donepezil in improving the cognitive function of patients with AD. | Medicine (Baltimore). 2015 Jun;94(22):e933. doi: 10.1097/MD.0000000000000933. | Cognitive Function | Review |
| 30424749 | Acupuncture may be effective in improving cognitive function in vascular dementia animal models. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Cognitive Function | Review |
| 30424749 | Until now, no systematic meta-analysis has been published to analyze the effects of acupuncture on enhancing cognitive function in vascular dementia animal models. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Cognitive Function | Review |
| 30424749 | Of the sixteen included studies, fifteen described possible mechanisms of acupuncture in ameliorating cognitive function. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Cognitive Function | Review |
| 30424749 | This finding suggests that acupuncture may play a potential role in ameliorating cognitive dysfunction in animal models. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Cognitive Function | Review |
| 30424749 | The included studies investigated several signaling pathways to gain a better understanding of the mechanism of improving cognitive function via acupuncture, including modulating the production and degradation of free radicals to reduce brain damage, exerting anti-apoptotic effects by up-regulating B-cell lymphoma-2 (Bcl-2) and counter-regulating Bcl-2-associated X protein (Bax) to protect neurons, enhancing glucose metabolism in the brain, reducing tumor protein P53 and Noxa expression to protect pyramidal cells from apoptosis, increasing cerebral blood flow for increased glucose and oxygen supply to neurons, exerting neuroprotective effects via an antioxidative pathway mediated by nuclear factor erythroid2-related factor 2 (Nrf2), and increasing complex enzymes to protect neurons from oxidative stress. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Neuroprotection Cognitive Function Blood Flow | Review |
| 30424749 | Acupuncture may play a potential role in ameliorating cognitive dysfunction in animal models. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Cognitive Function | Review |
| 30809158 | Evidence shows that acupuncture can increase a patient's verbal and motor skills and improve mood and cognitive function. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Cognitive Function Mood | Review |
| 30809158 | In a small pilot study, 1 month of acupuncture treatment improved cognitive function in 8 patients with mild-to-moderate AD. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Cognitive Function | Review |
| 30809158 | More recently, a larger clinical trial involving 87 patients with mild-to-moderate AD reported that acupuncture may significantly improve cognitive function. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Cognitive Function | Review |
| 30809158 | The improvement in cognitive function was observed for up to 12 weeks after the end of acupuncture treatment. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Cognitive Function | Review |
| 30855351 | Moreover, acupuncture could prevent postoperative cognitive dysfunction. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Cognitive Function | Review |
| 30855351 | It was found that electroacupuncture could significantly improve the cognitive dysfunction induced by myocardial ischemia-reperfusion, inhibit neuronal apoptosis, and reduce the oxidative stress and inflammation reaction. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Cognitive Function | Review |
| 30855351 | Also, the electroacupuncture at rat Baihui (DU20) and Dazhui (DU14) demonstrated the changes in cognitive function after left lateral lobectomy; the behavioral tests found that electroacupuncture could significantly improve the postoperative cognitive dysfunction potentially through microglia TLR2/4 signaling pathway which downregulated the level of proinflammatory cytokines in the hippocampus. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Cognitive Function | Review |
| 30855351 | Additional studies were conducted to observe the effects of electroacupuncture at Baihui and Dazhui on postoperative cognitive dysfunction (POCD) and the expression of angiotensin II (Ang II) and type 1 receptor (AT1R) in the hippocampus after partial hepatectomy in D-galactose-induced senility in rats. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Cognitive Function | Review |
| 31304087 | Acupuncture is safe and improves cognitive function and depressive disorder without obvious serious adverse events for post stroke patients. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function | Review |
| 31304087 | Acupuncture incorporation with electrotherapy also improves cognitive function and synaptic plasticity by attenuating left cortex, hippocampus, corpus striatum, and thalamus lesions and increasing the density of dendritic spines and number of CA1 synapse in the hippocampus of middle cerebral artery occlusion induced cognitive deficit rats. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function | Review |
| 31304087 | Furthermore, there has been no overview of systematic reviews to analyze the effectiveness and safety of acupuncture for improving cognitive function and depression in post-stroke patient. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function Depression | Review |
| 31304087 | Cognitive function and depressive disorder were the two major outcomes for evaluating the effectiveness of acupuncture. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function | Review |
| 31304087 | Four SRs evaluated the evidence of acupuncture for improving cognitive function in post-stroke patient versus cognitive rehabilitation. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function | Review |
| 31304087 | The evidence compiled by this overview indicated that acupuncture in addition to conventional intervention could improve cognitive function. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function | Review |
| 31304087 | From the available evidence, acupuncture may be beneficial for improving cognitive function and depressive disorder without obvious serious adverse events for post-stroke patients in the convalescent stage. | Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. | Cognitive Function | Review |
| 31379957 | In addition to medication, acupuncture has been reported to improve cognitive function and the global clinical status of patients with AD without causing major adverse effects. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Cognitive Function Adverse Reactions | Review |
| 31692669 | Generally, acupuncture is protective, or improves the phenotypes (cognitive function in AD, tremor in PD) through brain functional activity in neurodegenerative disease. | Integr Med Res. 2019 Dec;8(4):234-239. doi: 10.1016/j.imr.2019.08.003. Epub 2019 Aug 29. | Cognitive Function | Review |
| 31802723 | A systematic review by supports that acupuncture is a safe and reliable non-pharmacologic therapy for improving cognitive function in people with dementia. | West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. | Cognitive Function | Review |
| 31802723 | In addition, MRI studies demonstrate activation of areas of the brain responsible for cognitive function in people with dementia with the use of acupuncture. | West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. | Cognitive Function | Review |
| 31802723 | Because the aim of this review was to explore the effects of acupuncture or acupressure therapy on BPSD rather than cognitive function, at least one behavioral or psychological symptom needed to be included as an outcome of interest in the studies to be included in this review. | West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. | Cognitive Function | Review |
| 32148660 | Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far? | Oxid Med Cell Longev. 2020 Feb 13;2020:9641904. doi: 10.1155/2020/9641904. eCollection 2020. | Immunity Cognitive Function | Review |
| 32215037 | The treatment of acupuncture at the ST36 could decrease brain injury and improve cognitive dysfunction, by preventing microglial activation (downregulating toll-like receptor-4 (TLR-4) and NF-κB expression) and attenuating inflammation (decreasing TNF-α, interleukin-6 (IL-6) levels in serum and hippocampus, and reducing neuron-specific enolase (NSE) level in serum), oxidative stress (lower MDA, higher SOD, and catalase (CAT) in serum and hippocampus), and reducing apoptosis. | Evid Based Complement Alternat Med. 2020 Mar 7;2020:3620741. doi: 10.1155/2020/3620741. eCollection 2020. | Cognitive Function | Review |
| 32337259 | Acupuncture is effective in improving cognitive functions in AD animal models, and this benefit is more than just a placebo effect. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Cognitive Function | Review |
| 32337259 | A systematic review published in 2009 implied insufficient evidence to prove acupuncture was effective on both cognitive function and activities of daily living (ADL) among patients with AD. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Cognitive Function | Review |
| 32337259 | However, another systematic meta-analysis published in 2015 suggested that acupuncture was not only more effective than drugs but also might further enhance the effects of drugs in improving both cognitive function and ADL. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Cognitive Function | Review |
| 32337259 | Thus, we aimed to evaluate the effectiveness of verum-acupuncture compared with sham-acupuncture on cognitive dysfunctions in AD animals. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Cognitive Function | Review |
| 32337259 | The following questions remained to be answered: Does the selection of acupoints (more or less) or/and the intervention duration directly affect the effects of acupuncture on AD-induced cognitive dysfunction? | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Cognitive Function | Review |
| 32337259 | Acupuncture might be effective in ameliorating cognitive dysfunction in AD animals, and this benefit is more than just a placebo effect. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Cognitive Function | Review |
| 33178387 | found that acupuncture exerted an antioxidant effect to improve the cognitive function by upregulating the expressions of total SOD, CuZn-SOD, and Mn-SOD, as well as simultaneously elevating the ratio of reduced to oxidized glutathione (GSH/GSSG) in mitochondria. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Cognitive Function | Review |
| 33178387 | Acupuncture dramatically decreased the O2âgeneration and NOX expression, as well as improved the cognitive function. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Cognitive Function | Review |
| 33327222 | Further, studies on cognitive impairment and gastrointestinal symptoms demonstrated significant effects of acupuncture, including in cognitive function, levels of BDNF, incidence of diarrhea, constipation, nausea, and vomiting. | Medicine (Baltimore). 2020 Dec 11;99(50):e21820. doi: 10.1097/MD.0000000000021820. | Cognitive Function Nausea and Vomiting | Review |
| 33408601 | Several systematic reviews and meta-analyses have concluded that acupuncture alone (Huang et al.,), acupuncture plus herbal medicine (Zhou et al.,), or acupuncture plus western drugs (Wang et al.,) provide more beneficial effects for cognitive function in AD patients than western drugs alone. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33408601 | There is evidence that acupuncture can increase NGF levels and alleviate cognitive dysfunction in animal models of cerebral ischemia (Chen et al.,; Ding et al.,; Zhao J. et al.,). | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33408601 | Acupuncture-induced rescue of cognitive dysfunction in AD mice is associated with elevation of BDNF levels (Li et al.,; Lin et al.,). | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33408601 | Furthermore, it was demonstrated that acupuncture upregulated the expression of hippocampal cytokines involved in NSC proliferation and differentiation, including BDNF, basic fibroblast growth factor, and epidermal growth factor, thereby promoting the repair of injured neurons and improving cognitive function (Zhao et al.,). | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33408601 | found that acupuncture improved cognitive function and attenuated inflammation in SAMP8 mice via inhibition of the PI3K/PDK1/Npkc/Rac1 signaling pathway. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33408601 | found that acupuncture rescued cognitive dysfunction in SAMP8 mice by inhibiting the astrocytic phospholipase A2-arachidonic acid pathway, which resulted in increased blood flow in the prefrontal lobe and hippocampus. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function Blood Flow | Review |
| 33408601 | Acupuncture at the Tiaoshen Yizhi acupoints, a combination of acupoints based on Chinese acupuncture theory comprising EX-HN1, EX-HN3, PC6, KI3, ST40, and LR3, improved cognitive function in patients with MCI by increasing functional connectivity among cognition-related brain areas including the insula, dorsolateral prefrontal cortex, hippocampus, thalamus, inferior parietal lobule, and anterior cingulate cortex (Tan et al.,). | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33408601 | In a functional near-infrared spectroscopy (fNIRS) study investigating the longitudinal effects of acupuncture in MCI patients, increased functional connectivity in the prefrontal cortex induced by acupuncture contributed to improved cognitive function (Ghafoor et al.,). | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Cognitive Function | Review |
| 33505460 | One clinical trial showed that combined scalp acupuncture and cognitive training could improve the cognitive function and BDNF levels of peripheral blood in patients with stroke during the recovery stage. | Neural Plast. 2021 Jan 12;2021:8868447. doi: 10.1155/2021/8868447. eCollection 2021. | Cognitive Function | Review |
| 33505460 | These molecular mechanisms support acupuncture as a potentially promising therapy for the treatment of cognitive dysfunction in patients with VD or VCI. | Neural Plast. 2021 Jan 12;2021:8868447. doi: 10.1155/2021/8868447. eCollection 2021. | Cognitive Function | Review |
| 33505460 | Mechanisms involved in acupuncture regulating neuroplasticity to improve cognitive function. | Neural Plast. 2021 Jan 12;2021:8868447. doi: 10.1155/2021/8868447. eCollection 2021. | Cognitive Function | Review |
| 33553365 | A prospective cohort study of post-chemotherapy cancer patients found patients treated with acupuncture scores higher on a neurocognitive assessment and outperformed the control group concerning cognitive function after adjusting for age, menopause, cancer stage, and a dose of a chemotherapy regimen. | Ann Transl Med. 2021 Jan;9(1):72. doi: 10.21037/atm-20-6443. | Cognitive Function | Review |
| 33553365 | In summary, exercise, EEG biofeedback therapy, and acupuncture can improve memory, processing speed, and other cognitive functions. | Ann Transl Med. 2021 Jan;9(1):72. doi: 10.21037/atm-20-6443. | Cognitive Function | Review |
| 34397902 | Some studies compared 2 kinds of acupuncture methods, and found that specific acupuncture methods were superior to conventional acupuncture in improving sleep-related parameters, cognitive function and TER. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Cognitive Function | Review |
| 34397902 | Also, some other studies compared 2 kinds of acupuncture methods, and found that specific acupuncture methods were superior to conventional acupuncture in improving sleep-related parameters, cognitive function and TER. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Cognitive Function | Review |
| 34675729 | Although there is no direct evidence investigating the effect of acupuncture on 8-OHdG in PMD populations, MA was found to improve cognitive function and mood in patients with vascular dementia, along with significant decline in urinary 8-OHdG. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Cognitive Function Mood | Review |
| 34840581 | We retrieved diverse randomized controlled trials of various physical therapies combined with acupuncture for the treatment of cognitive dysfunction after stroke. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | Acupuncture is a traditional Chinese medical method whose curative effect has been widely recognized, and many clinical studies have verified that it can effectively ameliorate cognitive dysfunction after stroke. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | At present, there have been many meta-analyses of acupuncture or physiotherapy intervention on poststroke cognitive function, and the results show its excellent clinical effectiveness. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | Clinical studies have proved that acupuncture combined with physical therapy is more effective than single therapy such as pure acupuncture or pure physical therapy in improving cognitive function. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | This study found that acupuncture combined with HBO may be the best combination to improve cognitive function after PSCI. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | Combined with the results of this study, acupuncture combined with HBO may be the best choice for patients with a significant decline in cognitive function after stroke. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | Acupuncture and moxibustion not only has a clear effect on improving the cognitive function after stroke but also has been verified clinically and experimentally as an effective measure to treat limb dysfunction after stroke. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | Combined with the results of this study, acupuncture combined with TMS may be the best choice for patients with decreased cognitive function and motor dysfunction after stroke. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function Motor Function | Review |
| 34840581 | According to a comprehensive ranking of key indicators, this study found that acupuncture combined with HBO may be the best combination to improve cognitive function after PSCI, whereas acupuncture combined with TMS may be the best intervention to improve the quality of life and achieve overall clinical effectiveness after PSCI. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | However, compared with these two, acupuncture combined with HBO is more targeted in the treatment of cognitive function. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 34840581 | According to the results of the network meta-analysis, acupuncture combined with HBO can significantly improve cognitive function after PSCI, while acupuncture combined with TMS can improve the quality of daily life after PSCI compared with other physical therapies. | Evid Based Complement Alternat Med. 2021 Nov 18;2021:1101101. doi: 10.1155/2021/1101101. eCollection 2021. | Cognitive Function | Review |
| 35168522 | This review suggested that acupuncture is safe and improves cognitive function and depressive disorder without obvious serious adverse events for PSD. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Cognitive Function | Review |
| 35241146 | In recent years, clinical trials of acupuncture registered and carried out worldwide involve the evaluation of limb motor function, limb spasm and pain, swallowing function, activities of daily living, quality of life, cognitive function, depression, and anxiety state, etc., both in acute and recovery phase of ischemic stroke. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Cognitive Function Anxiety Depression Motor Function | Review |
| 35449821 | maintained that for stroke patients in the subacute or chronic phase, acupuncture may mitigate neurological deficits, such as motor function, cognitive function, depression, swallowing function, pain, and spasticity. | Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. | Cognitive Function Depression Motor Function | Review |
| 35449821 | 's meta-analysis revealed that acupuncture can be used to ameliorate cognitive function. | Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. | Cognitive Function | Review |
| 35655620 | Acupuncture in particular is safe and improves cognitive function and depressive disorder in post-stroke patients. | Front Neurol. 2022 May 17;13:885095. doi: 10.3389/fneur.2022.885095. eCollection 2022. | Cognitive Function | Review |
| 35968313 | ST36 acupuncture is popular for analgesia, cognitive function and cerebral circulation improvement, and gastrointestinal disease regulation in modern practices. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Cognitive Function Circulation | Review |
| 35983251 | The data of CNKI, CBM, CQVIP, Wanfang, and the libraries of Pubmed and Cochrane were searched by computer, and the related literatures about acupuncture combined with cognitive rehabilitation training in the treatment of cognitive dysfunction after stroke were searched. | Biomed Res Int. 2022 Aug 9;2022:8663356. doi: 10.1155/2022/8663356. eCollection 2022. | Cognitive Function | Review |
| 36211826 | According to a meta-analysis of randomized controlled trials, acupuncture-related treatments lasting for at least 6 weeks can effectively improve the cognitive function of AD patients. | Oxid Med Cell Longev. 2022 Sep 28;2022:6080282. doi: 10.1155/2022/6080282. eCollection 2022. | Cognitive Function | Review |
| 36291216 | showed that acupuncture could enhance the interregional interaction between the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) to improve memory and cognitive ability. | Brain Sci. 2022 Sep 23;12(10):1282. doi: 10.3390/brainsci12101282. | Cognitive Function | Review |
| 36439200 | Furthermore, in this review, 13 trials were conducted to evaluate the improvement of cognitive function by acupuncture, using the Mini-Mental State Examination, Montreal Cognitive Assessment Scale, and Revised Hasegawa Dementia Scale. | Front Cell Neurosci. 2022 Nov 10;16:817732. doi: 10.3389/fncel.2022.817732. eCollection 2022. | Cognitive Function | Review |
| 36439200 | The results showed that acupuncture was superior to non-acupuncture in the improvement of cognitive function in convalescent stroke patients. | Front Cell Neurosci. 2022 Nov 10;16:817732. doi: 10.3389/fncel.2022.817732. eCollection 2022. | Cognitive Function | Review |
| 36439200 | have documented that acupuncture at GV20 and ST36 restored cognitive dysfunction in the rat two-vessel occlusion (2VO) model. | Front Cell Neurosci. 2022 Nov 10;16:817732. doi: 10.3389/fncel.2022.817732. eCollection 2022. | Cognitive Function | Review |
| 36670425 | Another study analyzed and compared 15 RCTs concerning acupuncture treatment for MCI, involving 1051 subjects, and found that compared with the control group, acupuncture treatment resulted in better clinical efficacy rates, as well as improved MMSE, Montreal Cognitive Assessment, clock-drawing task, and ADL scores, indicating that acupuncture is beneficial for improving cognitive function in elderly people with MCI. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Cognitive Function | Review |
| 36670425 | It has been reported that acupuncture might promote correct folding in potentially toxic proteins; for example, acupuncture at Danzhong (CV17), Zhongwan (CV12), Qihai (CV6), Xuhai (SP10), and ST36 improved cognitive function and increased neuronal numbers in senescence-accelerated mouse prone 8 (SAMP8) mice, accompanied by increased expression of HSP84 and HSP86. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Cognitive Function Toxic Side Effects | Review |
| 36670425 | reported that acupuncture at GV20 improved cognitive dysfunction induced by scopolamine, alleviated the decline in hippocampal ChAT levels, and restored the expression of the hippocampal choline transporter 1 and vesicular acetylcholine transporter, suggesting that acupuncture may regulate ACh metabolism, and may contribute to the circulation of choline from the synaptic cleft back to the presynaptic terminal, and improve the efficiency of vesicle filling. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Cognitive Function Circulation | Review |
| 36686535 | Acupuncture, part of traditional Chinese medicine, has been widely used as a non-pharmaceutical therapy for various cognitive dysfunctions, including MCI, postoperative cognitive impairment, vascular cognitive impairment, and so on. | Front Neurol. 2023 Jan 6;13:1091125. doi: 10.3389/fneur.2022.1091125. eCollection 2022. | Cognitive Function | Review |
| 36686535 | Numerous systematic reviews/meta-analyses (SRs/MAs) showed that acupuncture is an effective treatment for patients with MCI by improving cognitive function. | Front Neurol. 2023 Jan 6;13:1091125. doi: 10.3389/fneur.2022.1091125. eCollection 2022. | Cognitive Function | Review |
| 36686535 | The control group included conventional medicine (CM), which could enhance the cognitive ability of patients (such as Donepezil, Nimodipine, and Ginkgo biloba extract), regardless of the contents; and sham acupuncture (SA) (contact with skin without penetrating the exact acupoints; or insert into non-acupoints). | Front Neurol. 2023 Jan 6;13:1091125. doi: 10.3389/fneur.2022.1091125. eCollection 2022. | Cognitive Function | Review |
| 36686535 | We explored 10 RCTs for the beneficial effects of acupuncture on overall cognitive function (OCF) in subjects with MCI using MMSE (Figure 3A). | Front Neurol. 2023 Jan 6;13:1091125. doi: 10.3389/fneur.2022.1091125. eCollection 2022. | Cognitive Function | Review |
| 36686535 | Meanwhile, in this study, acupuncture can play a pivotal role in improving global cognitive function. | Front Neurol. 2023 Jan 6;13:1091125. doi: 10.3389/fneur.2022.1091125. eCollection 2022. | Cognitive Function | Review |
| 36686535 | However, evidence for the efficacy of acupuncture on these specific cognitive functions is very scarce. | Front Neurol. 2023 Jan 6;13:1091125. doi: 10.3389/fneur.2022.1091125. eCollection 2022. | Cognitive Function | Review |
| 36823586 | Acupuncture, a commonly used non-pharmacological method in China, has long been used to treat cognitive dysfunction in China. | BMC Complement Med Ther. 2023 Feb 23;23(1):63. doi: 10.1186/s12906-023-03888-y. | Cognitive Function | Review |
| 36823586 | Based on the ts-fMRI studies, nine neuroimaging studies reported that the activated brain areas after acupuncture concerned the processing of cognitive function, including the memory regions (e.g., the hippocampus, inferior frontal gyrus, superior frontal gyrus, and superior temporal gyrus), auditory speech area (e.g., the superior temporal gyrus, transverse temporal gyrus, and inferior parietal lobule), language function region (e.g., the middle frontal gyrus, middle temporal gyrus, and cerebellum), spatial attention region (e.g., the superior parietal lobule), affective-emotional processing areas of cognitive function (e.g., the insula, cingulate cortex, and thalamus), motor function region (e.g., the precentral gyrus), and sensory function region (e.g., the postcentral gyrus). | BMC Complement Med Ther. 2023 Feb 23;23(1):63. doi: 10.1186/s12906-023-03888-y. | Cognitive Function Mood Language Function Motor Function | Review |
| 36873742 | Additionally, acupuncture stimulation to specific points may affect the functional activity of large-scale brain networks, which may account for improvements in cognitive function in persons with AD. | Front Aging. 2023 Feb 16;4:1143408. doi: 10.3389/fragi.2023.1143408. eCollection 2023. | Cognitive Function | Review |
| 36873742 | Systematic reviews suggest the potential for acupuncture to serve as a safe and effective intervention for cognitive decline to improve cognitive function. | Front Aging. 2023 Feb 16;4:1143408. doi: 10.3389/fragi.2023.1143408. eCollection 2023. | Cognitive Function | Review |
| 36873742 | They found that acupuncture had beneficial effects on effectiveness, cognitive ability, and activities of daily living for persons with dementia. | Front Aging. 2023 Feb 16;4:1143408. doi: 10.3389/fragi.2023.1143408. eCollection 2023. | Cognitive Function | Review |
| 36873742 | They found that when compared to western medicine, acupuncture was more beneficial for global cognitive function, and there was no difference in adverse effects between the acupuncture and control groups. | Front Aging. 2023 Feb 16;4:1143408. doi: 10.3389/fragi.2023.1143408. eCollection 2023. | Cognitive Function Adverse Reactions | Review |
| 36875696 | Acupuncture appears to be an effective method for cognitive function improvement in MCI patients. | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function | Review |
| 36875696 | Neural plasticity remaining in the MCI brain implies that acupuncture-associated benefits may not be limited to the cognitive function. | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function | Review |
| 36875696 | Nonetheless, the mechanism by which acupuncture promotes cognitive function remains largely unknown. | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function | Review |
| 36875696 | The following phrases were used for searches of the literature: (1) clinical condition: mild cognitive impairment, cognitive dysfunction, and MCI; (2) acupuncture terms: acupuncture, electronic acupuncture, acupuncture moxibustion, warm needling, scalp needle, meridian, and acupoint; and (3) study type: neuroimaging trial. | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function | Review |
| 36875696 | Conversely, one study revealed that ReHo decreased after acupuncture therapy in brain areas involved in processing cognitive function, including memory regions (e.g., the inferior frontal gyrus, temporal lobe) and executive/language function regions (e.g., the posterior cerebellar lobe, inferior temporal gyrus). | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function Language Function | Review |
| 36875696 | In addition, two articles reported increased ReHo or ALFF after instant acupuncture in brain areas involved in the processing of cognitive function, including the memory regions (e.g., the parahippocampal gyrus, precuneus), affective-emotional processing areas of cognitive function (e.g., the cingulate cortex, thalamus), and executive/language function region (e.g., the middle frontal gyrus). | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function Mood Language Function | Review |
| 37335660 | Evasion latency is the main behavioral outcome to evaluate the efficacy of acupuncture in alleviating cognitive dysfunction in VD rats. | Medicine (Baltimore). 2023 Jun 9;102(23):e33989. doi: 10.1097/MD.0000000000033989. | Cognitive Function | Review |
| 37335660 | Our research aimed to show that acupuncture can significantly improve the cognitive ability of animal models of VD, and acupuncture was better than the impaired and non-acupoint groups in alleviating the mechanisms of oxidative stress, inflammation, and apoptosis. | Medicine (Baltimore). 2023 Jun 9;102(23):e33989. doi: 10.1097/MD.0000000000033989. | Cognitive Function | Review |
| 37360179 | We speculate that acupuncture at ST36 could not only improve cognitive function but also regulate movement, auditory processing, and so on. | Front Neurosci. 2023 Jun 9;17:1180434. doi: 10.3389/fnins.2023.1180434. eCollection 2023. | Cognitive Function | Review |
| 37363406 | The above studies suggested that acupuncture may reduce the inflammatory infiltration and apoptosis of the hippocampus and hypothalamus, improve its cell morphology and tissue structure, thus improve fatigue, learning and memory ability, and cognitive dysfunction of CFS rats. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Cognitive Function Learning and Memory Ability | Review |
| 37363406 | Tang investigated the effect of acupuncture on improving fatigue and cognitive function of brain and its central neural biochemistry by BOLD-fMRI and MRS in patients with CFS. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Cognitive Function | Review |
| 37363406 | It was suggested that acupuncture may relieve pain and fatigue symptoms and regulate the central nervous metabolism of patients with CFS and improve cognitive function possibly by activating the cognitive-related brain areas, including the occipital lobe. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Cognitive Function | Review |
| 37363406 | With the application of laboratory tests and neuroimaging technology, it was gradually revealed that acupuncture may reduce central nerve inflammatory infiltration and oxidative and nitrite stress and apoptosis, regulate the nerve biochemical material metabolism, local blood flow and functional connection, and restore cell morphology and tissue structure, in order to improve clinical symptoms of CFS patients, including central fatigue, sleep disorders, autonomic dysfunction, cognitive difficulty, pain, etc. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Cognitive Function Blood Flow | Review |
| 37396891 | Considerably more work will need to be done using the scales above to assess postoperative cognitive function recovery of acupuncture combined with sedation, especially psychomotor function. | Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. | Cognitive Function Motor Function Sedation | Review |
| 37396891 | Further studies, which combine short-term assessment with long-term follow-up, will need to be undertaken when exploring the effects of acupuncture combined with sedation on cognitive function. | Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. | Cognitive Function Sedation | Review |
| 37397275 | The research of acupuncture for postoperative cognitive dysfunction, cancer-related surgery, and psychological states were the main frontiers topics and may be the focus in the future. | J Pain Res. 2023 Jun 27;16:2189-2204. doi: 10.2147/JPR.S415998. eCollection 2023. | Cognitive Function | Review |
| 37397275 | Trial, postoperative cognitive dysfunction, acupuncture analgesia, stimulation, and TEN were the five strongest citation bursts of keywords according to the analysis of burst words. | J Pain Res. 2023 Jun 27;16:2189-2204. doi: 10.2147/JPR.S415998. eCollection 2023. | Cognitive Function | Review |
| 37397457 | Acupuncture combined with other therapies can also have a synergistic effect on improving cognitive function. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37397457 | Acupuncture can help improve neuroinflammation (whether it is central or peripheral inflammatory response) after stroke and mediate the improvement of cognitive function. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37397457 | A large amount of clinical evidence of traditional Chinese medicine shows that acupuncture can improve the cognitive function of stroke patients. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37397457 | But research on how acupuncture regulates these processes to improve CBF and improve cognitive function can be conducted in the future. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37397457 | From the clinical studies we have included, acupuncture appears to be safe and effective at improving cognitive function after stroke and may have a role as a complementary therapy for PSCI. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37397457 | To observe the therapeutic effect of acupuncture and to find the most effective point combinations, some studies have compared the effects of ST36 + GV20, GV20 + GV24, and ST36 + SP10 on the improvement of cognitive function in 2VO-induced rats. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37397457 | During the early rehabilitation treatment of patients with cerebral infarction, acupuncture treatment can effectively promote the self-repair of the damaged cerebral cortex and better restore cognitive function. | Front Neurosci. 2023 Jun 15;17:1211044. doi: 10.3389/fnins.2023.1211044. eCollection 2023. | Cognitive Function | Review |
| 37501979 | In recent years, research has focused on investigating the role of CACR, and some researchers have explored the combination of CACR and acupuncture to promote cognitive function restoration through central nerve stimulation and external cognitive stimulation. | Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. | Cognitive Function | Review |
| 37501979 | Specifically, the aim of this study was to determine whether the combination of scalp acupuncture and CACR improves the cognitive function and quality of life of stroke patients. | Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. | Cognitive Function | Review |
| 37501979 | The findings of this study suggest that the combination of scalp acupuncture and computer-assisted cognitive training may offer a more effective approach for improving cognitive function in stroke patients compared to computer-assisted cognitive training alone. | Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. | Cognitive Function | Review |
| 37501979 | Further studies are needed to replicate these findings and elucidate the underlying mechanisms by which scalp acupuncture and computer-assisted cognitive training may interact to promote cognitive function. | Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. | Cognitive Function | Review |
| 37501979 | According to the research so far, combining scalp acupuncture with CACR is a successful treatment for improving cognitive function in stroke patients. | Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. | Cognitive Function | Review |
| 37505150 | Finally, it was found that the acupuncture method of regulating mind combined with Bushen Huoxue Shugan Decoction could improve the clinical symptoms of PD patients with depression, and the curative effect was exact, at the same time, it could reduce the inflammatory reaction and promote the recovery of cognitive function, which was safe and reliable. | Medicine (Baltimore). 2023 Jul 28;102(30):e34278. doi: 10.1097/MD.0000000000034278. | Cognitive Function Depression | Review |
| 37712096 | Acupuncture treatment significantly improved abnormal pain and pain-induced cognitive dysfunction in PSNL mice. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Cognitive Function | Review |
| 37712096 | These results suggest that acupuncture can modulate synaptic efficacy by enhancing the expression of synapse-related proteins in the hippocampus, thereby improving NP-associated pain and cognitive function. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Cognitive Function | Review |
| 37712096 | In addition to the analgesic effects, acupuncture may improve neuropathic pain-induced mood/cognitive dysfunction by restoring overall DNA methylation in the PFC. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect Neuropathic Pain Cognitive Function Mood | Review |
| 37760483 | Considering psychological patient-reported outcomes, no significant effects were reported in meta-analyses assessing the effect of acupuncture on anxiety, depression and cognitive function. | Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. | Cognitive Function Anxiety Depression | Review |
| 38213582 | found that patients who received acupuncture treatment without ADHD medications demonstrated significantly better cognitive function compared with the control group. | Heliyon. 2023 Nov 23;9(12):e22799. doi: 10.1016/j.heliyon.2023.e22799. eCollection 2023 Dec. | Cognitive Function | Review |
| 24617242 | [Impacts of the different frequencies of electroacupunctrue on cognitive function in patients after abdominal operation under compound anesthesia of acupuncture and drugs]. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | OBJECTIVE: To observe the impacts of different frequencies of electroacupuncture (EA) on post-operative cognitive function and the change in serum S-100beta protein under the compound anesthesia of acupuncture and drugs. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | Mini-mental state examination (MMSE) was adopted to evaluate and record the changes in cognitive function 1 day before operation and on the 3rd day after operation. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | The conditions of post-operative cognitive dysfunction (POCD) in the patients and the changes in serum S-100beta protein were monitored before and at the end of operation. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | CONCLUSION: The general anesthesia assisted with EA at different frequencies reduces the incidence of cognitive dysfunctionand, decreases the level of serum S-100beta protein after intestinal cancer resection. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 25137842 | OBJECTIVE: To explore the effect of acupuncture-anesthetic composite anesthesia (AACA) on the incidence of postoperative cognitive dysfunction (POCD) and changes of TNF-alpha, IL-1beta, and IL-6 in elderly patients. | Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jul;34(7):795-9. | Cognitive Function | Clinic |
| 25137842 | The cognitive function of all patients was assessed before operation and at day 3 after operation using mini-mental state examination (MMSE). | Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jul;34(7):795-9. | Cognitive Function | Clinic |
| 24617242 | [Impacts of the different frequencies of electroacupunctrue on cognitive function in patients after abdominal operation under compound anesthesia of acupuncture and drugs]. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | OBJECTIVE: To observe the impacts of different frequencies of electroacupuncture (EA) on post-operative cognitive function and the change in serum S-100beta protein under the compound anesthesia of acupuncture and drugs. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | Mini-mental state examination (MMSE) was adopted to evaluate and record the changes in cognitive function 1 day before operation and on the 3rd day after operation. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | The conditions of post-operative cognitive dysfunction (POCD) in the patients and the changes in serum S-100beta protein were monitored before and at the end of operation. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 24617242 | CONCLUSION: The general anesthesia assisted with EA at different frequencies reduces the incidence of cognitive dysfunctionand, decreases the level of serum S-100beta protein after intestinal cancer resection. | Zhongguo Zhen Jiu. 2013 Dec;33(12):1109-12. | Cognitive Function | Clinic |
| 25137842 | OBJECTIVE: To explore the effect of acupuncture-anesthetic composite anesthesia (AACA) on the incidence of postoperative cognitive dysfunction (POCD) and changes of TNF-alpha, IL-1beta, and IL-6 in elderly patients. | Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jul;34(7):795-9. | Cognitive Function | Clinic |
| 25137842 | The cognitive function of all patients was assessed before operation and at day 3 after operation using mini-mental state examination (MMSE). | Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 Jul;34(7):795-9. | Cognitive Function | Clinic |
| 29391879 | Combined acupuncture and general anesthesia on immune and cognitive function in elderly patients following subtotal gastrectomy for gastric cancer | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Immunity Cognitive Function | Clinic |
| 29391879 | This study investigated the effects of acupuncture combined with general anesthesia on postoperative immune and cognitive functions in elderly patients undergoing subtotal gastrectomy. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Immunity Cognitive Function | Clinic |
| 29391879 | One day after surgery, the experimental group showed better protection of cognitive function than the control group (P<0.05). | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function | Clinic |
| 29391879 | Post-operative cognitive dysfunction (POCD) is one of the most distressing surgical problems. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function | Clinic |
| 29391879 | Here, we analyzed the immune and cognitive functions after general anesthesia in elderly patients undergoing subtotal gastrectomy, providing the basis for fast recovery and the prevention of POCD post-surgery. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Immunity Cognitive Function | Clinic |
| 29391879 | The Montreal Cognitive Assessment (MoCA) scale and Mini-Mental State Examination (MMSE) were used to evaluate the cognitive function one day before and one day after surgery. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function | Clinic |
| 29391879 | Score <26 indicated impairment of cognitive functions. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function | Clinic |
| 29391879 | Cognitive function | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function | Clinic |
| 29391879 | POCD is a mild neurocognitive dysfunction that is reversible. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function | Clinic |
| 29391879 | These problems are specifically manifested as anxiety, personality change, memory loss, abnormal cognitive ability, and disorders of mental system. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Cognitive Function Anxiety | Clinic |
| 35647012 | In addition, acupuncture can also reduce the penetration of pro-inflammatory factors into the blood-brain barrier, reduce the occurrence of inflammatory reactions in the central nervous system, promote blood perfusion in brain regions, and enhance oxygen supply capacity in the brain, thereby alleviating the cascade reactions of inflammatory injury and protecting cognitive function. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Cognitive Function | Clinic |
| 36034956 | Exclusion criteria include the following: cognitive dysfunction; people allergic to analgesic drugs; and patients with acute or chronic serious diseases. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Cognitive Function | Clinic |
| 27688791 | suggested that microcapillary hemorrhage or inflammation may be associated with mild cognitive impairment in hypertensive rats, and the frontal lobe was closely related to cognitive function. | Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. | Cognitive Function Bleeding | Clinic |
| 27688791 | considered the mechanisms of cognitive dysfunction in hypertensive patients may be because of abnormality in frontal lobe function connections. | Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. | Cognitive Function | Clinic |
| 28658163 | Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | This study was designed to evaluate the effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | Mini-Mental State Examination was applied to evaluate the cognitive function of patients at 1 day before surgery and 7th and 30th day after surgery. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | The present study suggests that preconditioning of electro-acupuncture could improve the postoperative cognitive function, and the reduction of inflammatory reaction and brain injury may be involved in the mechanism. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | Postoperative cognitive dysfunction (POCD), a common complication of central nervous system (CNS) with the characteristics of insanity, anxiety, personality changes, memory impairing, and so on, is a major clinical issue in geriatric surgical patients after anesthesia in the elderly (xe2x89xa565 years). | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function Anxiety | Clinic |
| 28658163 | Gonda et al found that persistent cognitive dysfunction is also important clinically, because it decreases coping capacities and influences therapeutic compliance and cooperation as well. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | Studies showed that treatment with EA could improve cognitive function in patients with Alzheimer disease. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | Our previous study suggested that preconditioning of EA could reduce the incidence the postoperative cognitive dysfunction in aged rats. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | However, whether it could improve the cognitive function of elderly patients is still confused. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | The purpose of this study is to evaluate the effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly, and the results could provide a new direction for the prevention of POCD in elderly. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | Inclusion criteria of the present study were as follows: American Society of Anesthesiologistsxe2x80x99 physical status classes I and II; no history of traumatic brain injury, neurological diseases, and alcohol abuse; no cognitive dysfunction; no severe vision or hearing impairment and no obvious abnormality of heart, lung, liver, and kidney function. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function Kidney | Clinic |
| 28658163 | At 1 day before surgery and 7th and 30th day after surgery, cognitive function of patients was tested using Mini-Mental State Examination (MMSE) by a well-trained investigator who was blind to the study grouping. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | MMSE is a scale of cognitive function which could evaluate patientsxe2x80x99 time-directed force, site-directed force, immediate memory, attention and computing power, delayed memory, language, and visual space. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | The total scores less than 27 indicate cognitive dysfunction. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | In the present study, we found that preconditioning of EA could improve the cognitive function of aged patients receiving spine surgery and reduce the total dose of anesthetic. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | This study was undertaken to investigate the effects of preconditioning of EA on postoperative cognitive dysfunction in elderly. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | Postoperative cognitive dysfunction is 1 of the common complications in elderly receiving spine surgery. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | So the effects of preconditioning of EA on postoperative cognitive dysfunction in patients of other age groups or receiving other surgeries need further study. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 28658163 | In conclusion, preconditioning of EA could improve the postoperative cognitive function and the reduction of inflammatory reaction, and brain injury may be involved in the mechanism. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Cognitive Function | Clinic |
| 30425466 | The mini-mental state examination (MMSE) was administered to screen for preoperative cognitive function 1 day before the surgery. | Clin Interv Aging. 2018 Oct 24;13:2127-2134. doi: 10.2147/CIA.S183698. eCollection 2018. | Cognitive Function | Clinic |
| 30425466 | Perioperative opioids have been linked to sleep disturbances, which may negatively impact cognitive function. | Clin Interv Aging. 2018 Oct 24;13:2127-2134. doi: 10.2147/CIA.S183698. eCollection 2018. | Cognitive Function Insomnia | Clinic |
| 31915045 | To date, multiple studies have demonstrated that TEAS could reduce the use of intra-operative opioid drugs and the incidence of postoperative nausea and vomiting (PONV), and improve postoperative cognitive function. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function Nausea and Vomiting | Clinic |
| 31915045 | Exclusion criteria were recent use of TEAS or acupuncture, neural damage or infection along the meridian at which the acupoints lay, use of antiemetic in the previous week, regular use of opioids, hepatic dysfunction, confirmed renal impairment, diabetes mellitus, cognitive dysfunction and conversion to laparotomy during gynecologic laparoscopy. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function Kidney | Clinic |
| 31915045 | The primary end points were postoperative quality of recovery and cognitive functioning, and the secondary endpoint was anesthesia-related side effects, including pain scores, the incidence of nausea and vomiting and use of postoperative pain medications and antiemetics. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function Side Effects Nausea and Vomiting | Clinic |
| 31915045 | The Mini-Mental State Examination (MMSE) is one of the most widely used assessment instruments of postoperative cognitive functioning, and screens domains of orientation to time and place, attention and memory, concentration, language and praxis. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function | Clinic |
| 31915045 | Patient cognitive function was assessed using the MMSE on days T0, T1 and T2. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function | Clinic |
| 31915045 | There were no significant differences in the baseline (T0) MMSE score for cognitive functioning in the two groups; however, the scores were significantly lower in the TEAS group compared with the Con group (Pxc2xa0=xe2x80x890.048 and Pxc2xa0=xe2x80x890.02 for T1 and T2, respectively); when T0 was used as a covariate for a repeated measures model of T1 and T2, the significances for the interaction of group and time course were 0.007 and 0.046, respectively (Fig.xc2xa05). | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function | Clinic |
| 31915045 | In the present study, we found that TEAS at Baihui (GV20), Yingtang (EX-HN3), Zusanli (ST36) and Neiguan (PC6) for 30xe2x80x89min before anesthesia could promote the quality of early recovery, improve cognitive function, ameliorate postoperative pain and reduce the incidence of nausea and vomiting in patients undergoing gynecological laparoscopic surgery. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function Nausea and Vomiting | Clinic |
| 31915045 | We speculated that TEAS might be an effective method to improve postoperative cognitive function. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function | Clinic |
| 31915045 | In conclusion, we found that TEAS significantly promoted the quality of early recovery, improved cognitive function, ameliorated postoperative pain and reduced the incidence of nausea and vomiting within the first 24 of surgery. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function Nausea and Vomiting | Clinic |
| 33154688 | Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patientxe2x80x99s physical condition. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Cognitive Function | Clinic |
| 36749304 | CAL, surrounded by the primary visual cortex, is related to cognitive function (Yang etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Cognitive Function | Clinic |
| 36749304 | Although all participants in this study showed normal cognitive function, the decreased functional activities in the above brain regions may lead to the experience of intense pain in patients, further reducing their brain activities and weakening cognitive function (Huang etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Cognitive Function | Clinic |
| 36749304 | The angular gyrus is implicated in cognitive functions, including attention and spatial cognition, default mode network, and social cognition (Seghier,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Cognitive Function | Clinic |
| 30381011 | The eligibility criteria were as follows: (1) patients who provided consent; (2) patients aged more than 18 years; (3) patients with an American Society of Anesthesiology physical status classification grade I or II; and (4) patients with sufficient cognitive function and language skills for the study. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Cognitive Function Language Function | Clinic |
| 31736488 | Alzheimer' Disease (AD) is characterized by a progressive loss of memory and cognitive function. | J Vis Exp. 2019 Oct 29;(152). doi: 10.3791/60055. | Cognitive Function | Mechanism |
| 32304687 | To investigate the effect of electroacupuncture (EA) on cognitive function and insulin resistance (IR) in an Al/D-gal-induced aging model for Alzheimer's disease (AD) using Ostuka Long-Evans Tokushima Fatty (OLETF) rats. | Brain Res. 2020 Aug 1;1740:146834. doi: 10.1016/j.brainres.2020.146834. Epub 2020 Apr 15. | Cognitive Function | Mechanism |
| 32304687 | Cognitive function was assessed using the Morris water maze (MWM). | Brain Res. 2020 Aug 1;1740:146834. doi: 10.1016/j.brainres.2020.146834. Epub 2020 Apr 15. | Cognitive Function | Mechanism |
| 32304687 | In conclusion, EA improves cognitive function and insulin resistance in rat models of AD. | Brain Res. 2020 Aug 1;1740:146834. doi: 10.1016/j.brainres.2020.146834. Epub 2020 Apr 15. | Cognitive Function | Mechanism |
| 27558235 | Results showed that acupuncture pre- and post-NSCs transplantation significantly improved senescence-induced cognitive dysfunction (P < 0.05); upregulated the expression of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and brain-derived neurotrophic factor (BDNF) (P < 0.05); and also increased the count of neuron-specific nuclear protein (NeuN)- and glial fibrillary acidic protein (GFAP)-positive cells (P < 0.05). | Mol Neurobiol. 2017 Sep;54(7):5120-5130. doi: 10.1007/s12035-016-0054-5. Epub 2016 Aug 24. | Cognitive Function | Mechanism |
| 31412703 | Neuromuscular coordination and cognitive function of the mice were evaluated by the tightrope test and Morris water maze test, respectively. | Acupunct Med. 2019 Dec;37(6):340-347. doi: 10.1136/acupmed-2017-011577. Epub 2019 Aug 15. | Cognitive Function | Mechanism |
| 31412703 | After acupuncture treatment, the success rate for the tightrope test was elevated, cognitive function was improved, neuron numbers were enhanced, levels of SOD and GSH-Px were increased, levels of superoxide anion and protein carbonyl were decreased, and Hsp84 and Hsp86 mRNA and protein expression were increased in the Pa mice when compared with the Pc and Psa groups (all P<0.05). | Acupunct Med. 2019 Dec;37(6):340-347. doi: 10.1136/acupmed-2017-011577. Epub 2019 Aug 15. | Cognitive Function | Mechanism |
| 38145382 | Acupuncture Treatment in a Mouse Model of Chronic Hypoxia-Induced Cognitive Dysfunction. | J Vis Exp. 2023 Dec 8;(202). doi: 10.3791/65784. | Cognitive Function | Mechanism |
| 38145382 | However, the potential of acupuncture in treating cognitive dysfunction induced by chronic hypoxia has not yet been explored. | J Vis Exp. 2023 Dec 8;(202). doi: 10.3791/65784. | Cognitive Function | Mechanism |
| 38145382 | By employing this protocol, researchers can conduct systematic studies to thoroughly evaluate the therapeutic potential of acupuncture for cognitive dysfunction. | J Vis Exp. 2023 Dec 8;(202). doi: 10.3791/65784. | Cognitive Function | Mechanism |
| 37992796 | Our previous studies have demonstrated that electroacupuncture (EA) can ameliorate both beta-amyloid (Abeta) pathology and cognitive function in APP/PS1 mice. | Brain Res. 2024 Jan 15;1823:148683. doi: 10.1016/j.brainres.2023.148683. Epub 2023 Nov 20. | Cognitive Function | Mechanism |
| 30726543 | A Y-maze was used to test cognitive function (learning and memory). | J Mol Neurosci. 2019 Mar;67(3):456-466. doi: 10.1007/s12031-018-1253-5. Epub 2019 Feb 6. | Cognitive Function Learning and Memory Ability | Mechanism |
| 26895770 | Cognitive function was evaluated by Morris water maze (MWM) testing. | Acupunct Med. 2016 Dec;34(6):449-456. doi: 10.1136/acupmed-2015-010894. Epub 2016 Feb 19. | Cognitive Function | Mechanism |
| 38126262 | Electroacupuncture at GB20 improves cognitive ability and synaptic plasticity via the CaM-CaMKII-CREB signaling pathway following cerebral ischemia-reperfusion injury in rats. | Acupunct Med. 2024 Feb;42(1):23-31. doi: 10.1177/09645284231202805. Epub 2023 Oct 15. | Cognitive Function | Mechanism |
| 38126262 | CONCLUSION: EA treatment at GB20 may ameliorate the negative effects of MCAO on cognitive function in rats by enhancing synaptic plasticity. | Acupunct Med. 2024 Feb;42(1):23-31. doi: 10.1177/09645284231202805. Epub 2023 Oct 15. | Cognitive Function | Mechanism |
| 32761882 | Morris Water Maze was selected to assess the effect of acupuncture on cognitive function and Nissl staining indicated the hippocampal neuronal damage in VD rats. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Cognitive Function | Mechanism |
| 32761882 | Vascular dementia (VD) is a heterogeneous group of brain disorders associated with loss of memory and cognitive function resulting from vascular lesions. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Cognitive Function | Mechanism |
| 32761882 | So far, various clinical trials (Zhou, Peng, Xu, Li, & Liu, 2015) and animal experiments (Du et al., 2018; Li et al., 2015, 2016; Xiao et al., 2018) indicated that acupuncture was effective to improve the cognitive function in VD. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Cognitive Function | Mechanism |
| 32761882 | Acupuncture with a 10 min retention of the needle has been commonly used and had therapeutic effects on cognitive function in VD rats (Ye et al., 2017). | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Cognitive Function | Mechanism |
| 32761882 | To observe the effect of needle retention on cognitive function and hippocampal neuronal damage in VD rats, 48 rats were randomized into four groups (n = 12 each group): A sham group, 2VO group (without treatment), needle retention group (2VO + acupuncture with 10 min of needle retention), and a nonretention group (2VO + acupuncture without needle retention). | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Cognitive Function | Mechanism |
| 32761882 | The current experiments demonstrated that acupuncture improved cognitive function and attenuated the neuronal damage of hippocampus in VD rats. | Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. | Cognitive Function | Mechanism |
| 32796318 | Chronic pain reduces life quality and is an important clinical problem associated with emotional and cognitive dysfunction. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Mood | Mechanism |
| 32796318 | Acupuncture treatment for 6 months (3 days/week) improved mechanical/cold allodynia and the emotional/cognitive dysfunction caused by left partial sciatic nerve ligation (PSNL)-induced neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Cognitive Function Mood | Mechanism |
| 32796318 | Cognitive function tests | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function | Mechanism |
| 32796318 | Cognitive function tests were measured using the novel object recognition (NOR) and Y-maze test at 6 months after PSNL operation. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function | Mechanism |
| 32796318 | Effects of acupuncture on cognitive functions measured by Y-maze and NOR tests. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function | Mechanism |
| 32796318 | In addition, Spearman rank correlation coefficient analyses were performed to investigate whether the changes in DNA methylation were correlated with changes in nociception, anxiety, depression, and cognitive function. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Anxiety Depression | Mechanism |
| 32796318 | Global DNA methylation in the PFC was negatively correlated with nociceptive and depression-like behaviors (r = â0.7470, P = 0.0052 for von Frey test; r = â0.6713, P = 0.0168 for acetone test; r = â0.6993, P = 0.0114 for TST), and positively correlated with anxiety-like behavior and cognitive dysfunction (r = 0.6702, P = 0.0171 for OFT; r = 0.8693, P = 0.0002 for EPM; r = 0.6294, P = 0.0283 for Y-maze; r = 0.7719, P = 0.0033 for NOR; Figs. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Anxiety Depression | Mechanism |
| 32796318 | However, DNA methylation in the PAG was not correlated with cognitive dysfunction (r = 0.2378, P = 0.4586 for Y-maze; r = 0.4737, P = 0.1198 for NOR; Figs. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function | Mechanism |
| 32796318 | However, DNA methylation in the hypothalamus was not correlated with nociceptive behaviors or cognitive dysfunction (r = 0.1947, P = 0.5443 for von Frey test; r = 0.1259, P = 0.6967 for acetone test; r = â0.2308, P = 0.4705 for Y-maze; r = â0.3228, P = 0.3061 for NOR; Figs. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function | Mechanism |
| 32796318 | Global DNA methylation in the HIP was positively correlated with nociceptive and depression-like behaviors (r = 0.6655, P = 0.0182 for von Frey test; r = 0.5105, P = 0.0899 for acetone test; r = 0.8042, P = 0.0016 for TST), and negatively correlated with anxiety-like behavior and cognitive dysfunction (r = â0.7439, P = 0.0055 for OFT; r = â0.7103, P = 0.0096 for EPM; r = â0.4615, P = 0.1309 for Y-maze; r = â0.6561, P = 0.0205 for NOR; Figs. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Anxiety Depression | Mechanism |
| 32796318 | The central sensitization induced by peripheral nerve injury contributes to neuropathic pain, and has a pernicious effect on affective processing and cognitive function in both patients and animal models. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Cognitive Function | Mechanism |
| 32796318 | By contrast, acupuncture resulted in normalized emotional processing and cognitive function and allodynia. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Mood | Mechanism |
| 32796318 | Moreover, restoration of DNA methylation levels in PFC by oral administration of S-adenosylmethionine, a methyl donor, improves emotional and cognitive functions impaired by spared nerve injury. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Mood | Mechanism |
| 24886495 | Zhou concluded that exciting ST36 could improve the cognitive ability of AD patients and that the mechanism may involve the activation of the cognition-related regions of the frontal and temporal lobes and the marginal system, as well as the cognition-related region of the cerebellum . | BMC Complement Altern Med. 2014 May 31;14:178. doi: 10.1186/1472-6882-14-178. | Cognitive Function | Mechanism |
| 34659396 | For example, cognitive dysfunction in cerebral ischemia is related to cholinergic neuron loss in the hippocampus. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Cognitive Function | Mechanism |
| 34659396 | As already established, the hippocampus plays a critical role in cognitive function. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Cognitive Function | Mechanism |
| 34659396 | We speculated that the improved cognitive function was related to the replacement of partial dead hippocampal neurons by MGE neural progenitor transplantation. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Cognitive Function | Mechanism |
| 36422883 | On the other hand, some argued that inhibition of autophagy activation can effectively promote the recovery of cognitive function after TBI. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Cognitive Function | Mechanism |
| 31600836 | Among multiple thalamic subdivisions responsible for sensory, motor and cognitive functions differently, the VP mainly receives neuronal input from spinothalamic tracts, and projects to the S. In the present study, we found that MA at P6 increases c-Fos expression in the VP, particularly in its lateral part that processes sensory information from the body including the forelimb where P6 is located. | J Comp Neurol. 2020 Apr;528(6):953-971. doi: 10.1002/cne.24789. Epub 2019 Nov 12. | Cognitive Function | Mechanism |
| 36003380 | However, such association is complicated because analgesics used to treat postoperative pain may cause cognitive dysfunction. | Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. | Cognitive Function | Mechanism |
| 36003380 | Dendritic spine turnover is associated with cognitive function. | Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. | Cognitive Function | Mechanism |
| 36816326 | A Morris water maze (MWM) test was used to assess cognitive function for rats in all groups. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | Consequently, the therapeutic benefits of such acupuncture treatment may be attributable to the regulation of the Th17/Treg balance and associated improvements in cognitive function. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | Inflammation can further exacerbate neuronal injury, contributing to additional BBB degeneration and impairing cognitive function. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | Several studies have demonstrated that the impairment of Treg functionality can contribute to the exacerbation of ischemic stroke-related injury and the incidence of cognitive dysfunction, whereas, the transplantation of these T cells can alleviate such cognitive impairment. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | Acupuncture is a branch of traditional Chinese medicine that has been demonstrated to improve cognitive function in patients affected by VD. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | As such, in the present study we sought to explore whether modulating the Th17/Treg balance via acupuncture would be sufficient to improve spatial learning and memory in VD model rats in an effort to better define the therapeutic effects of acupuncture on both immunological function and cognitive impairment. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Immunity Cognitive Function Learning and Memory Ability | Mechanism |
| 36816326 | Following treatment for 21 days, the MWM test was used to evaluate the cognitive function and spatial learning of all rats as detailed in our previous study. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | In initial hidden platform tests, the escape latency values for rats in the Gi group were increased as compared to those of rats in the Gs group (PÂ <Â 0.05), consistent with the impairment of learning and cognitive function in these VD model animals. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | In visible platform trial, there were no obvious differences in escape latency between the three groups (PÂ >Â 0.05), suggesting that the experiments were not affected by the difference in motivation and motor activities and could objectively reflect the cognitive function of all rats. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | We still need enough evidence to support the conclusion that acupuncture can alleviate the cognitive function by regulating Th17/Treg balance in the further study. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 36816326 | This suggests that acupuncture-mediated modulation of this Th17/Treg balance may represent an effective approach to improving cognitive function. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Cognitive Function | Mechanism |
| 34630618 | Electroacupuncture Synergistically Inhibits Proinflammatory Cytokine Production and Improves Cognitive Function in Rats with Cognitive Impairment due to Hepatic Encephalopathy through p38MAPK/STAT3 and TLR4/NF-κB Signaling Pathways | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | To investigate the effect of electroacupuncture (EA) on cognitive dysfunction in rats with hepatic encephalopathy and its underlying mechanism. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | EA ameliorated the production of excessive proinflammatory cytokines in the hippocampus of rats with cognitive dysfunction secondary to hepatic encephalopathy, which also gave rise to subsequent changes such as reduced blood ammonia level, brain-protective activated astrocytes, and lower degree of brain tissue injury. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Brain Protection Cognitive Function | Mechanism |
| 34630618 | It is characterized by extensive neuropsychiatric changes, consciousness disorders, behavioral abnormalities, and a series of dysfunction ranging from subclinical changes to coma, which is a continuous process of neurocognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | However, therapeutic strategy to effectively improve cognitive dysfunction in patients with hepatic encephalopathy after cirrhosis remains to be discovered. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | Relevant studies have shown that anti-inflammatory treatment can reduce portal vein pressure and improve cognitive function in mice by mitigating inflammatory cytokines. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | showed that lactulose can improve patients' cognitive function and reduce the incidence of symptomatic HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | Moreover, as a noninvasive alternative therapy, acupuncture can directly affect the nerve damage in the brain and improve cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | A prospective clinical study has revealed a dose-dependent relationship between serum ammonia and cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | However, few studies have investigated the specific mechanism of acupuncture therapy in mitigating HE-related cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | Preliminary clinical and preclinical studies have demonstrated the efficacy of acupuncture at Baihui and Shenting acupoints in the treatment of cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | Elevated osmotic pressure in the brain leads to swelling of neurons, causing brain edema and further cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function Inflammatory Pain | Mechanism |
| 34630618 | These results indicate that abnormal brain metabolism shown by MRS is reversible, and EA may protect neurons and improve cognitive function by regulating the metabolism of NAA, Glx, and Cho in rats with HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Neuroprotection Cognitive Function | Mechanism |
| 34630618 | A recent study has confirmed that immune inflammatory response is involved in the occurrence and development of cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Immunity Cognitive Function | Mechanism |
| 34630618 | Hyperammonemia can stimulate the expression of nitric oxide synthase (iNOS), upregulate the production of nitric oxide (NO), and increase cerebral blood flow, thus leading to edema of astrocytes and damage to the central nervous system, which ultimately causes cognitive dysfunction. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function Blood Flow | Mechanism |
| 34630618 | Based on findings that the TLR4/MyD88/NF-κB signaling pathway plays an important role in mediating inflammatory response and that EA can inhibit inflammatory response through the NF-κB signaling pathway, we speculate that EA may inhibit intracerebral inflammatory response through the TLR4/MyD88/NF-κB signaling pathway, thereby improving the cognitive dysfunction in HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | Studies have reported that signaling pathways including p38MAPK play an important role in the pathogenesis and treatment of HE and that inhibition of MAPKs can improve the cognitive function in animal models of HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | In conclusion, the synergistic role of inflammation and hyperammonemia can further aggravate the impaired cognitive function in HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 34630618 | Future studies should adopt multimodal function imaging techniques, expand the sample size, and design rigorous experimental approaches to further explore the mechanism of acupuncture in improving cognitive dysfunction in HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Cognitive Function | Mechanism |
| 30136700 | The pathological features associated with cognitive dysfunction are neurofibrillary tangles and senile plaques, combined with neuronal loss primarily in the hippocampus and other important cortical and subcortical brain regions (Hane et al., 2017). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Cognitive Function | Mechanism |
| 30136700 | A systematic review has also concluded that Chinese acupuncture was safe and effective for treating AD in terms of improving cognitive function (Zhou et al., 2015). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Cognitive Function | Mechanism |
| 30136700 | Clinical trials have also shown that acupuncture at GV20 and BL23 can improve the cognitive ability and activities of daily living in patients with AD (Peng and Dong, 2009; Zhu et al., 2010). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Cognitive Function | Mechanism |
| 31836020 | To evaluate the effects of EA treatment on cognitive functions, novel object recognition and Y-maze tests were performed with non-Tg, 5XFAD (Tg), and EA-treated 5XFAD (Tg + KI3) mice. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 31836020 | To evaluate whether EA treatment activates the prefrontal cortex region involved in cognitive functions, we investigated glucose metabolism levels using microPET to measure brain functions in 5XFAD mice. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 31836020 | These results indicate that EA treatment modulates the abnormal hypothalamic metabolism and contributes to the energy metabolism, thus improving cognitive functions in 5XFAD mice. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 31836020 | reported that adiponectin regulates glucose and lipid metabolism, as well as insulin sensitivity in the hypothalamus, hippocampus, and cerebral cortex, and improves cognitive functions by an increase in synaptic functions and LTP in 5XAFD mice. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 31836020 | Therefore, we suggest that cortex and hypothalamus activation by EA treatment may increase adiponectin production and glucose metabolism thus leading to improved cognitive functions in 5XFAD mice. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 31836020 | demonstrated that EA treatment improves cognitive impairments by alleviating neuroinflammation via the microglial TLR2/4 signaling pathway in an animal model of post-operative cognitive dysfunction. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 31836020 | Reduction in neuroinflammation is the therapeutic target of EA in AD, and EA may ameliorate Aβ-related pathologies and activate signaling pathways responsible for the improvement of cognitive functions in AD mice. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Cognitive Function | Mechanism |
| 25861363 | Rgs9 knockout rats exhibit normal locomotor activity, anxiety-like behavior, cued and contextual fear conditioning, startle threshold, and prepulse inhibition which suggest that Rgs9-2 is a potential therapeutic target for disorders involving motor or cognitive dysfunction. | Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. | Cognitive Function Anxiety | Mechanism |
| 28852400 | Alzheimer's disease (AD) is characterized by progressive memory loss and cognitive dysfunction. | Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. | Cognitive Function | Mechanism |
| 36636219 | However, these treatments have negative impacts on patient cognitive function and can cause addiction and central nervous system depression. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Cognitive Function Depression | Mechanism |
| 25206697 | A previous study showed that brain-derived neurotrophic factor suppressed the decrease of dopaminergic neurons, but improved cognitive functions. | Neural Regen Res. 2013 Feb 25;8(6):540-9. doi: 10.3969/j.issn.1673-5374.2013.06.007. | Cognitive Function | Mechanism |
| 33328963 | Our findings suggest that acupuncture protects cognitive function of BCCAO rats by improving white matter perfusion and integrity. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Cognitive Function | Mechanism |
| 33328963 | The selection of acupoints was based on our previous study in VaD rats, which suggests that the combination of GV20 + ST36 has better attenuating effects on cognitive dysfunction. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Cognitive Function | Mechanism |
| 33328963 | Nevertheless, they may not be effective acupoints for cognitive dysfunction (non-specific effect). | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Cognitive Function | Mechanism |
| 33328963 | These outcomes indicate that acupuncture can improve cognitive dysfunction of VaD rats by increasing the white matter CBF. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Cognitive Function | Mechanism |
| 33328963 | Previous studies prove that these functional networks could be considered neuroimaging evidence of acupuncture effects on cognitive function. | Front Aging Neurosci. 2020 Nov 23;12:582904. doi: 10.3389/fnagi.2020.582904. eCollection 2020. | Cognitive Function | Mechanism |
| 33269744 | (2008) also demonstrated that the PI3K signaling pathway plays an important role in the regulation of cognitive dysfunction associated with cerebral ischemia and hypoxia. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Cognitive Function | Mechanism |
| 29623942 | Thus, the above combination therapy might be the best way to improve cognitive function in SAMP8 mice after NSCs transplantation. | Neural Regen Res. 2018 Mar;13(3):541-548. doi: 10.4103/1673-5374.228760. | Cognitive Function | Mechanism |
| 26654890 | Among markers of oxidative damage, iPF2α, a sensitive and specific marker of lipid peroxidation, is elevated in the hippocampus and correlates with cognitive and functional impairment in patients with AD. | Acupunct Med. 2016 Jun;34(3):215-22. doi: 10.1136/acupmed-2015-010865. Epub 2015 Dec 9. | Cognitive Function | Mechanism |
| 35722406 | To observe cognitive function in rats with VaD, and the changes in frontal lobe neurons and their postsynaptic scaffold proteins, chronic ischemia was established in 42 4-week-old rats using the 2-VO model while 12 rats were used as the sham group. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Cognitive Function | Mechanism |
| 35251208 | We confirmed that this treatment improved fear memory, cognitive function, and spatial memory by modulating the neuroinflammation and expression of brain-derived neurotrophic factor (BDNF) mRNA in the brain. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 35251208 | This neuroinflammation causes fear memory and impairments of both cognitive function and spatial memory in PTSD. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 35251208 | The present behavioral and neurochemical study analyzed the effects of acupuncture treatment on fear memory, cognitive function, and spatial memory impairment after single prolonged stress (SPS) in an animal model of PTSD. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 35251208 | Our results confirmed the effects of acupuncture treatment on the fear memory, cognitive function, and spatial memory impairments caused by neuroinflammation in an animal model of PTSD. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 35251208 | However, the regulation of BDNF in the Hipp by acupuncture focused on the HT7 acupoint was sufficient to alleviate the fear-induced abnormal behavior and restore both cognitive function and spatial memory; these changes were related to the anti-inflammatory effect of this acupuncture approach. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 35251208 | In our study, we showed that fear extinction failure and impairments of both cognitive function and spatial memory were associated with neuroinflammation and reduced BDNF expression. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 35251208 | Our results suggest that acupuncture is a potential treatment for PTSD-induced fear memory and impairments of both cognitive function and spatial memory in an SPS model. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Cognitive Function | Mechanism |
| 28860844 | Cognitive dysfunction is a common complication of chronic neuropathic pain, which involves changes in both nerve electrophysiology and anatomy of the brain. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 28860844 | All these studies suggest that EA may be a cost-effective alternative in relieving neuropathic pain and improving cognitive function. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 28860844 | However, there are various hypotheses regarding the treatment of persistent pain and the effects on cognitive function. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Cognitive Function | Mechanism |
| 28860844 | Cognitive dysfunction is a common finding in chronic pain. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Cognitive Function | Mechanism |
| 28860844 | Moreover, the electrophysiological LTP experiment in the hippocampal area of the brain confirmed changes consistent with decreased cognitive function in rats. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Cognitive Function | Mechanism |
| 28860844 | These findings suggest that EA stimulation may improve the cognitive dysfunction of rats associated with cobra venom-induced trigeminal neuropathic pain, whereas pregabalin does not. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 28860844 | These results suggest that improvement in the synaptic transmission efficiency and vacuolation degeneration in the hippocampal neurons may be related to the mechanism of EA in improving the cognitive dysfunction in this experimental model. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Cognitive Function | Mechanism |
| 28860844 | Reduction in chronic pain may well result in amelioration of pain-induced cognitive dysfunction. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Cognitive Function | Mechanism |
| 28860844 | Nonetheless, the relationship between trigeminal neuralgia, cognitive dysfunction and treatment options requires further study. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuralgia Cognitive Function | Mechanism |
| 28860844 | However, pregabalin only ameliorated the trigeminal neuropathic pain behavior induced by cobra venom without affecting the cognitive dysfunction induced by this experimental model. | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Neuropathic Pain Cognitive Function | Mechanism |
| 29980225 | These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function | Mechanism |
| 29980225 | The early accumulation of Aβ may lead a series of downstream events including neuronal degeneration, then evolved into volume atrophy and cognitive functional damage of the corresponding brain area gradually. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function | Mechanism |
| 29980225 | The hippocampus plays an important role in cognitive function in the nervous system, and neurons in hippocampus are the main cells responsible for learning and memory. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function Learning and Memory Ability | Mechanism |
| 29980225 | Our previous researches have demonstrated that electroacupuncture (EA) at Baihui (DU20) acupoint could significantly improve the cognitive function and revers the aberrant cell death in 4Â month-old APP/PS1 double transgenic mice, and promote the level of uptake rate of glucose in 12Â month-old. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function | Mechanism |
| 29980225 | The change of metabolites in the brain may alter the intracellular metabolic environment, tissue structure, and affect cognitive function. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function | Mechanism |
| 29980225 | It might be the mechanism underlying EA improve learning and memory and it also provides the foundation for the clinical treatment and research of cognitive dysfunction in the future. | Biol Res. 2018 Jul 6;51(1):21. doi: 10.1186/s40659-018-0166-7. | Cognitive Function Learning and Memory Ability | Mechanism |
| 30106051 | Therefore, we speculated that the effect of acupuncture on improving cognitive function may be associated with reduced dendritic damage in the brain. | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Cognitive Function | Mechanism |
| 30106051 | Acupuncture might improve cognitive function by reducing oxidative stress, amyloid beta (Aβ) protein deposition, and apoptosis, as well as regulating glucose metabolism and enhancing neurotransmission and autophagy (Leung et al., 2014; Cao et al., 2016; Lai et al., 2016). | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Cognitive Function | Mechanism |
| 30106051 | In this study, we examined the relationship of acupuncture with cognitive function and dendrites in AD. | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Cognitive Function | Mechanism |
| 30106051 | In this study, 8-month-old SAMP8 mice were examined, with our results showing visibly impaired cognitive function in the SAMP8 group compared with the SAMR1 group, which is consistent with a previous study (Jin et al., 2016). | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Cognitive Function | Mechanism |
| 30431067 | Acupuncture is a traditional Chinese medicinal therapy, which is used for the amelioration of cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | For this purpose, we used the middle cerebral artery occlusion (MCAO) method to induce cognitive dysfunction in rats. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | The production of pro-oxidative stress factors, including nitric oxide (NO) and inducible nitric oxide synthase (iNOS), was also blocked along with the amelioration of cognitive function, while the production of adenosine triphosphate (ATP), superoxide dismutase (SOD) and cyclooxygenase (COX) was restored. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Whereas a number of studies have been conducted to examine and identify the individuals who are at a high risk of suffering from cognitive dysfunction, the mechanisms of action and the effectiveness of drugs and rehabilitation treatments remain unclear. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Given the poor effectiveness of modern medicine in treating cognitive dysfunction, a number of patients have begun to turn to alternative and complementary medicinal therapies for assistance. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | In clinical practice in China, acupuncture has been used as an alternative therapy for patients with AD and stroke-related dementia to improve the quality of life and for the prevention of cognitive function decline in patients. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Thus, a comprehensive exploration of the mechanisms driving the effectiveness of acupuncture on cognitive dysfunction is imperative to promote the practical application of acupuncture therapy. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Furthermore, according to Caselli et al and Roses et al, TOMM40 also influences the performance of age-related memory, which indicates the potential of TOMM40 as a promising therapeutic target for cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Accordingly, the restoration of mitochondrial function is critical to the successful management of nerve disorders, particularly cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Establishment of cognitive dysfunction model using the MCAO method | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | In the current study, cognitive dysfunction was induced using the MCAO method. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Upon completion of the culture, all the rats were subjected to the Morris water maze (MWM) test for the evaluation of their cognitive function. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | The results of the MWM test revealed that acupuncture treatment improved the learning and memorizing ability of the rats with cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | 1A and B, the latency time of the rats in the MCAO + Acupuncture group was lower than that of the rats in the MCAO group, and the difference was statistically significant (P<0.05), thereby representing the restoration of the cognitive function of the rats. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | 2, the induction of cognitive dysfunction was associated with aging (cytoplasm stained dark pink by H&E staining and stained blue by Nissl staining) and the deterioration of the regular structure of the cells when compared with the sham-operated group. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | In this study, the results from flow cytometric analysis revealed that the induction of cognitive dysfunction initiated membrane depolarization in the brain mitochondria (Fig. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | As illustrated by immunochemical detection, following the establishment of the cognitive dysfunction model, the production and distribution of TOMM40, TIMM17A and Aβ were all increased in the rat brain tissues (Fig. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Immunity Cognitive Function | Mechanism |
| 30431067 | As regards brain disorders, numerous studies have been conducted to validate its potential for improvement of not only the function of brain cells, but also the cognitive function of patients. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Being recognized as the one of the most severe impairments of brain disorders, cognitive dysfunction severely affects the quality of life of patients with AD, PD and vascular dementia, and poses a great threat to public health worldwide. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Fortunately, the effectiveness of acupuncture treatment on cognitive dysfunction in recent years offers an inspirable hint that the treatment can improve the prognosis of patients with brain disorders. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | In the current study, the membrane potential of the mitochondria was depolarized following the induction of cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | The expression of COX was decreased both at the mRNA and protein levels following the induction of cognitive dysfunction, whereas the expression of Aβ increased. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | We also demonstrated the mechanisms involved in the effects of acupuncture on cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | It was found that both indicators were upregulated in the rats with cognitive dysfunction. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 30431067 | Based the results of the current study, TIMM17A may also participate in the effects of acupuncture on cognitive dysfunction, although the detail mechanisms warrant further investigation. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Cognitive Function | Mechanism |
| 33229729 | Therefore, we hypothesized that preventive electroacupuncture might improve cognitive functions during aging by regulating epigenetic modifications. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Cognitive Function | Mechanism |
| 33229729 | These neurons project to several brain areas associated with cognitive function, such as the frontal cortex, hippocampus, septum, striatum and amygdala (Hornung, 2003). | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Cognitive Function | Mechanism |
| 33229729 | Accumulating evidence indicates that abnormal DNA methylation could contribute to the pathogenesis of AD and lead to cognitive dysfunction (Qazi et al., 2018). | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Cognitive Function | Mechanism |
| 33229729 | Additionally, accumulating experimental evidence suggests that acupuncture can ameliorate cognitive dysfunction in transgenic AD mice by reducing senile plaque burden (Tang et al., 2019), attenuating neuroinflammation (Cai et al., 2019), prompting hippocampal neurogenesis (Li et al., 2014), and enhancing hippocampal glucose metabolism (Cao et al., 2017). | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Cognitive Function | Mechanism |
| 33229729 | In addition, PEA was more effective than PMA in alleviating cognitive dysfunction in rats with D-gal-induced aging. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Cognitive Function | Mechanism |
| 35656078 | These kinases have been reported in neuronal plasticity, central sensitization, and cognitive function. | Iran J Basic Med Sci. 2022 Apr;25(4):451-459. doi: 10.22038/IJBMS.2022.60121.13327. | Cognitive Function | Mechanism |
| 22110373 | Although NMDA antagonists are highly effective in reducing neuropathic pain, these agents cause side effects at therapeutic doses including hallucination, dysphoria, and impairment of cognitive function. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain Cognitive Function Side Effects | Mechanism |
| 36181105 | It is characterized by a progressive decline in memory and cognitive function, changes in personality and behavior, and other neuropsychiatric syndromes. | Medicine (Baltimore). 2022 Sep 30;101(39):e30858. doi: 10.1097/MD.0000000000030858. | Cognitive Function | Mechanism |
| 36181105 | Li et al showed that EA decreases cognitive function, decreases aβ deposits, up-regulates BDNF expression, and promotes neurogenesis in APP/PS1 transgenic mice. | Medicine (Baltimore). 2022 Sep 30;101(39):e30858. doi: 10.1097/MD.0000000000030858. | Cognitive Function | Mechanism |
| 25810743 | Acupuncture could enhance the hippocampal connectivity, activate certain cognitive-related regions in AD patients, and has potential therapeutic effects on improving cognitive function and self-managing ability of vascular dementia. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Cognitive Function | Mechanism |
| 25810743 | Improvement of cognitive function was only observed in the EA group and not in the sham-EA group. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Cognitive Function | Mechanism |
| 36277498 | Studies have demonstrated that EA has an analgesic effect on chronic pain and can modulate mood changes and cognitive dysfunction through central and peripheral mechanisms. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect Cognitive Function Mood | Mechanism |
| 29636708 | Numerous studies have associated BDNF with reward-related processes, learning and memory, cognitive function, and circuit formation. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Cognitive Function Learning and Memory Ability | Mechanism |
| 29636708 | The findings for association of BMI in key white matter (WM) tracts that are crucial to mood regulation and neurocognitive functioning has suggested that BMI might contribute to the pathophysiology of bipolar disorder (BD) through a detrimental action on structural connectivity in critical cortico-limbic networks. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Cognitive Function Mood | Mechanism |
| 30105072 | The cells involved in this inflammatory response are astrocytes and microglia which can produce a variety of cytokines, such as interleukin 1α (IL-1α), interleukin 1β (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor (TNF), interleukin 8 (IL-8), macrophage inflammatory protein 1α, and monocyte chemo attractant protein 1, resulting in chronic inflammation, neuronal necrosis, and apoptosis, and eventually leading to impairment of cognitive function. | Evid Based Complement Alternat Med. 2018 Jul 12;2018:8296824. doi: 10.1155/2018/8296824. eCollection 2018. | Cognitive Function | Mechanism |
| 25530777 | Therefore, we speculated that the reason which EA treatment could increase the expression of Gal might be that EA could activate GalR2 in the dorsal area of hippocampus to protect and promote the formation of cognitive function then to antidepression. | Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. | Cognitive Function Depression | Mechanism |
| 30766475 | Our data represent a significant contribution to the identification of the effectiveness of MA in improving cognitive ability and CBF in a mouse model of AD. | Front Neurosci. 2019 Jan 31;13:37. doi: 10.3389/fnins.2019.00037. eCollection 2019. | Cognitive Function | Mechanism |